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  1. Cancer imposes substantial burdens on cancer suffers, their families and the health system, especially in the end of life (EOL) of care patients. There are few developing country studies of EOL health care cos...

    Authors: Anli Leng, Jun Jing, Stephen Nicholas and Jian Wang
    Citation: BMC Cancer 2019 19:39
    Content type: Research article Published on:

  3. Single nucleotide polymorphisms (SNPs) in 3′-untranslated region (UTR) of genes related with cell-matrix adhesions and migration might affect miRNA binding and potentially affect the risk of cancer. The presen...

    Authors: Shouchun Yan, Rong Sun, Shan Wu, Tianbo Jin, Shanshan Zhang, Fanglin Niu, Jingjie Li and Mingwei Chen
    Citation: BMC Cancer 2019 19:35
    Content type: Research article Published on:

  5. Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to exp...

    Authors: Gui-Cen Liu, Yun-Fei Zhou, Xiao-Chao Su and Jun Zhang
    Citation: BMC Cancer 2019 19:24
    Content type: Research article Published on:

  6. Male Breast Cancer (MBC) is rare, which makes its understanding and treatment be extrapolated from what is known about the occurrence in women, with few epidemiological studies. Therefore, the aim of the prese...

    Authors: Jean Henri Maselli-Schoueri, Fernando Alves Affonso-Kaufman, Claudia Vaz de Melo Sette, Francisco Winter dos Santos Figueiredo and Fernando Adami
    Citation: BMC Cancer 2019 19:23
    Content type: Research article Published on:

  7. Neuroendocrine cervical carcinoma (NECC) is a rare but aggressive form of cervical cancer representing less than 3% of all cervical cancer cases. The objective of this study is to evaluate the effects of the c...

    Authors: Xiaojing Zhang, Zunfu Lv and Hanmei Lou
    Citation: BMC Cancer 2019 19:22
    Content type: Research article Published on:

  8. The eighth TNM classification for gastric cancer categorizes N3 as N3a and N3b in the final pathologic stage. The cutoff for N3a/N3b is defined as 15 metastatic lymph nodes, but the rationale for this cutoff r...

    Authors: Man-Qiang Lin, Jia-Bin Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Qing-Liang He and Chang-Ming Huang
    Citation: BMC Cancer 2019 19:21
    Content type: Research article Published on:

  9. Shikonin, a natural naphthoquinone, is abundant in Chinese herb medicine Zicao (purple gromwell) and has a wide range of biological activities, especially for cancer. Shikonin and its analogues have been repor...

    Authors: Shoude Zhang, Qiang Gao, Wei Li, Luwei Zhu, Qianhan Shang, Shuo Feng, Junmei Jia, Qiangqiang Jia, Shuo Shen and Zhanhai Su
    Citation: BMC Cancer 2019 19:20
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:461

  10. We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on...

    Authors: Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee and Dae Seog Heo
    Citation: BMC Cancer 2019 19:19
    Content type: Research article Published on:

  11. Salvage radiotherapy (SRT) for prostate cancer (PCa) recurrence after prostatectomy offers long-term biochemical control in about 50–60% of patients. SRT is commonly initiated in patients with serum PSA levels...

    Authors: Jeremie Calais, Johannes Czernin, Wolfgang P. Fendler, David Elashoff and Nicholas G. Nickols
    Citation: BMC Cancer 2019 19:18
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:97

  12. A prospective, randomised phase II study demonstrated clinical benefit of axitinib dose titration in a subset of treatment-naïve patients treated with axitinib for metastatic renal cell carcinoma. This analysi...

    Authors: Yoshihiko Tomita, Hirotsugu Uemura, Mototsugu Oya, Nobuo Shinohara, Tomonori Habuchi, Yosuke Fujii, Yoichi Kamei, Yoshiko Umeyama, Angel H. Bair and Brian I. Rini
    Citation: BMC Cancer 2019 19:17
    Content type: Research article Published on:

  13. Nutrition labeling has been found to affect the amount and type of food intake, with certain groups in the population, such as cancer survivors, being more aware of this information. A higher awareness of nutr...

    Authors: Ji Sung Yoo, Kyu-Tae Han, Seung Hyun Chung and Eun-Cheol Park
    Citation: BMC Cancer 2019 19:16
    Content type: Research article Published on:

  14. Metastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. Previous studies have proved the prog...

    Authors: Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang and Wenhua Li
    Citation: BMC Cancer 2019 19:15
    Content type: Research article Published on:

  15. Gastric cancer (GC) is a common malignant disease worldwide. Aberrant miRNAs expression contributes to malignant cells behaviour, and in preclinical research, miRNA targeting has shown potential for improving ...

    Authors: Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu and Jianlin Ren
    Citation: BMC Cancer 2019 19:14
    Content type: Research article Published on:

  16. The clinical value of total hysterectomy for patients with hydatidiform mole (HM) being at least 40 years old remains highly controversial. Since the practice of hysterectomy has been applied globally for deca...

    Authors: Peng Zhao, Yongchao Lu, Wei Huang, Baoqin Tong and Weiguo Lu
    Citation: BMC Cancer 2019 19:13
    Content type: Research article Published on:

  17. Radium-223, a targeted alpha therapy, is used to treat symptomatic patients with castration-resistant prostate cancer (CRPC) and bone metastases. Data for radium-223 in asymptomatic CRPC patients with bone met...

    Authors: Axel Heidenreich, Silke Gillessen, Daniel Heinrich, Daniel Keizman, Joe M. O’Sullivan, Joan Carles, Manfred Wirth, Kurt Miller, John Reeves, Monica Seger, Sten Nilsson and Fred Saad
    Citation: BMC Cancer 2019 19:12
    Content type: Research article Published on:

  18. Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ap...

    Authors: Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland and Anders Molven
    Citation: BMC Cancer 2019 19:11
    Content type: Research article Published on:

  19. Gallbladder cancer (GBC) is likely to be diagnosed at progressive stages and shows a very poor prognosis. Combination therapy with gemcitabine and cisplatin (GEMCIS) has been widely used as first-line palliati...

    Authors: Min su You, Ji Kon Ryu, Young Hoon Choi, Jin Ho Choi, Gunn Huh, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim
    Citation: BMC Cancer 2019 19:10
    Content type: Research article Published on:

  20. Dung beetle glycosaminoglycan is known to possess anti-aging activities. However, its anti-cancer mechanisms are not fully elucidated yet. The objective of this study was to evaluate the anti-cancer effect of ...

    Authors: Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jang Mi Jin, Hyung Joo Yoon, Jae Sam Hwang and Kun-Koo Park
    Citation: BMC Cancer 2019 19:9
    Content type: Research article Published on:

  21. In this retrospective study, we aimed to demonstrated that three-port single-intercostal (SIC) thoracoscopic lobectomy is an effective choice for lung cancer by comparing the perioperative outcomes of patients...

    Authors: Zixiang Wu, Qi Wang, Cong Wu, Tianwei Zhan, Lingjun Dong, Shuai Fang, Xuyang Peng, Lian Wang, Saibo Pan and Ming Wu
    Citation: BMC Cancer 2019 19:8
    Content type: Research article Published on:

  22. More than 60% of women diagnosed with early stage breast cancer receive (neo)adjuvant chemotherapy. Breast cancer patients receiving chemotherapy often experience symptoms such as nausea, vomiting and loss of ...

    Authors: J. Th. C. M. de Kruif, M. Visser, M. M. G. A. van den Berg, M. J. M. Derks, M. R. de Boer, H. W. M. van Laarhoven, J. H. M. de Vries, Y. C. de Vries, E. Kampman, R. W. Winkels and M. J. Westerman
    Citation: BMC Cancer 2019 19:7
    Content type: Study protocol Published on:

  23. Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estroge...

    Authors: Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park and Eui-Ju Hong
    Citation: BMC Cancer 2019 19:6
    Content type: Research article Published on:

  24. The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging of non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.

    Authors: Gustavo Werutsky, Bruno Hochhegger, José Antônio Lopes de Figueiredo Pinto, Jeovany Martínez-Mesa, Mara Lise Zanini, Eduardo Herz Berdichevski, Eduardo Vilas, Vinícius Duval da Silva, Maria Teresa Ruiz Tsukazan, Arthur Vieira, Leandro Genehr Fritscher, Louise Hartmann, Marcos Alba, Guilherme Sartori, Cristina Matushita, Vanessa Bortolotto…
    Citation: BMC Cancer 2019 19:5
    Content type: Research article Published on:

  25. BRCA1/2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma. However, these variants have not been extensively characterized in patients with ovarian can...

    Authors: Deborah Porto Cotrim, Adriana Regina Gonçalves Ribeiro, Daniele Paixão, Diogo Cordeiro de Queiroz Soares, Rima Jbili, Natasha Carvalho Pandolfi, Camila Cezana, Carine de Cássia Mauro, Henrique Mantoan, Graziele Bovolim, Louise de Brot, Giovana Tardin Torrezan, Dirce Maria Carraro, Glauco Baiocchi, Maria Nirvana da Cruz Formiga and Alexandre A. B. A. da Costa
    Citation: BMC Cancer 2019 19:4
    Content type: Research article Published on:

  26. Metachronous cancer in patients with head and neck cancer (HNC) is common and is associated with a poor prognosis. We aimed to evaluate the incidence of metachronous cancer at different sites according to age ...

    Authors: Taro Iwatsubo, Ryu Ishihara, Toshitaka Morishima, Akira Maekawa, Kentaro Nakagawa, Masamichi Arao, Masayasu Ohmori, Hiroyoshi Iwagami, Kenshi Matsuno, Shuntaro Inoue, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi…
    Citation: BMC Cancer 2019 19:3
    Content type: Research article Published on:

  27. Existing evidence demonstrates that 1:1 personal training (PT) improves many adverse effects of androgen deprivation therapy (ADT). Whether less resource-intensive exercise delivery models are as effective rem...

    Authors: Shabbir M. H. Alibhai, Daniel Santa Mina, Paul Ritvo, George Tomlinson, Catherine Sabiston, Murray Krahn, Sara Durbano, Andrew Matthew, Padraig Warde, Meagan O’Neill, Narhari Timilshina, Roanne Segal and Nicole Culos-Reed
    Citation: BMC Cancer 2019 19:2
    Content type: Research article Published on:

  28. Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for ...

    Authors: Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro and Rosa Noguera
    Citation: BMC Cancer 2019 19:1
    Content type: Research article Published on:

  29. The GTPase KRas4B has been utilized as a principal target in the development of anticancer drugs. PDE6δ transports KRas4B to the plasma membrane, where it is released to activate various signaling pathways req...

    Authors: Diana Casique-Aguirre, Paola Briseño-Díaz, Ponciano García-Gutiérrez, Claudia Haydée González-de la Rosa, Reyna Sara Quintero-Barceinas, Arturo Rojo-Domínguez, Irene Vergara, Luis Alberto Medina, José Correa-Basurto, Martiniano Bello, Rosaura Hernández-Rivas, María del RocioThompson-Bonilla and Miguel Vargas
    Citation: BMC Cancer 2018 18:1299
    Content type: Research article Published on:

  30. Even clearly resectable pancreatic cancer still has an unfavorable prognosis. Neoadjuvant or perioperative therapies might improve the prognosis of these patients. Thus, evaluation of perioperative chemotherap...

    Authors: Thomas J. Ettrich, Andreas W. Berger, Lukas Perkhofer, Severin Daum, Alexander König, Andreas Dickhut, Uwe Wittel, Kai Wille, Michael Geissler, Hana Algül, Eike Gallmeier, Jens Atzpodien, Marko Kornmann, Rainer Muche, Nicole Prasnikar, Andrea Tannapfel…
    Citation: BMC Cancer 2018 18:1298
    Content type: Study protocol Published on:

  31. Despite increasing use, symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheter (PICC) is a common complication in nonmetastatic nasopharyngeal carcinoma (NPC) patients.

    Authors: Yu-Jing Liang, Lin-Quan Tang, Xue-Song Sun, Yu-Ying Fan, Jin-Jie Yan, Yu-Yun Du, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Sai-Lan Liu, Qing-Nan Tang, Xiao-Yun Li, Hai-Qiang Mai and Qiu-Yan Chen
    Citation: BMC Cancer 2018 18:1297
    Content type: Research article Published on:

  32. Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been imp...

    Authors: Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick and Andrew J. Wagner
    Citation: BMC Cancer 2018 18:1296
    Content type: Case report Published on:

  33. Breast cancer is the most common cancer in women worldwide. Around 50% of breast cancer familial risk has been so far explained by known susceptibility alleles with variable levels of risk and prevalence. The ...

    Authors: Yosr Hamdi, Mariem Ben Rekaya, Shan Jingxuan, Majdi Nagara, Olfa Messaoud, Amel Benammar Elgaaied, Ridha Mrad, Lotfi Chouchane, Mohamed Samir Boubaker, Sonia Abdelhak, Hamouda Boussen and Lilia Romdhane
    Citation: BMC Cancer 2018 18:1295
    Content type: Research article Published on:

  34. MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Ther...

    Authors: Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang and Xingsheng Yang
    Citation: BMC Cancer 2018 18:1294
    Content type: Research article Published on:

  35. The Epstein-Barr virus (EBV) is closely associated with several types of malignancies. EBV is normally present in the latent state in the peripheral blood B cell compartment. The EBV latent-to-lytic switch is ...

    Authors: Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li and Juanjuan Xiang
    Citation: BMC Cancer 2018 18:1293
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:189

  36. Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian can...

    Authors: William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir and Robert Ilaria Jr
    Citation: BMC Cancer 2018 18:1292
    Content type: Research article Published on:

  37. There are no published studies on the simultaneous effect of extent and location of positive surgical margins (PSMs) on biochemical recurrence (BCR) after robot-assisted laparoscopic prostatectomy (RALP). The ...

    Authors: Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini and Charles H. Rochat
    Citation: BMC Cancer 2018 18:1291
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:124

  38. Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based...

    Authors: Juan Zhao, Chunxiu Hu, Cheng Wang, Wei Yu, Yinglu Guo, Minghan Shi, Yongjie Shui and Qichun Wei
    Citation: BMC Cancer 2018 18:1290
    Content type: Research article Published on:

  39. Physical fitness and psychosocial function is often reduced in children during or shortly after cancer treatment. This study evaluates the effect of a combined physical exercise and psychosocial intervention o...

    Authors: Katja I. Braam, Elisabeth M. van Dijk-Lokkart, Gertjan J. L. Kaspers, Tim Takken, Jaap Huisman, Laurien M. Buffart, Marc B. Bierings, Johannes H. M. Merks, Marry M. van den Heuvel-Eibrink, Margreet A. Veening and Eline van Dulmen-den Broeder
    Citation: BMC Cancer 2018 18:1289
    Content type: Research article Published on:

  41. Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,

    Authors: Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani and Seyed Abdolrahim Rezaee
    Citation: BMC Cancer 2018 18:1287
    Content type: Research article Published on:

  42. Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear...

    Authors: Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang and Huanzhou Xue
    Citation: BMC Cancer 2018 18:1286
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2021 21:594

  43. The prevalence and distribution of histologically diagnosed breast disease are not well documented in low income countries, Uganda inclusive. Although the greater majority of breast lesions globally are benign...

    Authors: Salvatore Ssemmanda, Eric Katagirya, Phiona Bukirwa, David Alele, Robert Lukande and Samuel Kalungi
    Citation: BMC Cancer 2018 18:1285
    Content type: Research article Published on:

  44. Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such...

    Authors: Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright and Mark D. Temple
    Citation: BMC Cancer 2018 18:1284
    Content type: Research article Published on:

  45. Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic o...

    Authors: Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi and Rakesh K. Singh
    Citation: BMC Cancer 2018 18:1283
    Content type: Research article Published on:

  46. Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the...

    Authors: Haruko Takuwa, Wakako Tsuji, Masayuki Shintaku and Fumiaki Yotsumoto
    Citation: BMC Cancer 2018 18:1282
    Content type: Case report Published on:

  47. Palliative care, as a relatively young field within medicine, has increasingly used original research to validate and standardize its practice. In particular, palliative care has been incorporated into oncolog...

    Authors: Corbin Eule, Nizar Bhulani, Elizabeth Paulk, Ramona Rhodes and Muhammad Shaalan Beg
    Citation: BMC Cancer 2018 18:1281
    Content type: Research article Published on:

  49. Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tum...

    Authors: Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke and David Anz
    Citation: BMC Cancer 2018 18:1278
    Content type: Research article Published on:

  50. Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangement in tissue specimens has been approved by US FDA (Food and Drug Administration) to select treatment for non–small-cell lung ca...

    Authors: Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao and Zhi Hui Zhang
    Citation: BMC Cancer 2018 18:1277
    Content type: Research article Published on:

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