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  1. Given the differences in embryonic origin, vascular and nervous supplies, microbiotic burden, and main physiological functions of left and right colons, tumor location is increasingly suggested to dictate tumo...

    Authors: Kavitha Mukund, Natalia Syulyukina, Sonia Ramamoorthy and Shankar Subramaniam
    Citation: BMC Cancer 2020 20:317
    Content type: Research article Published on:

  2. We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics.

    Authors: Han Na Kang, Jae-Hwan Kim, A-Young Park, Jae Woo Choi, Sun Min Lim, Jinna Kim, Eun Joo Shin, Min Hee Hong, Kyoung-Ho Pyo, Mi Ran Yun, Dong Hwi Kim, Hanna Lee, Sun Och Yoon, Da Hee Kim, Young Min Park, Hyung Kwon Byeon…
    Citation: BMC Cancer 2020 20:316
    Content type: Research article Published on:

  3. The enrichment of cancer stem cell-like cells (CSCs) has been considered to be responsible for tumor progression after an initial response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ...

    Authors: Wenxiu Yao, Liyang Wang, Huan Huang, Xin Li, Pinjia Wang, Kun Mi, Jia Cheng, Huifen Liu, Cuirong Gu, Lingxiao Huang and Jianming Huang
    Citation: BMC Cancer 2020 20:315
    Content type: Research article Published on:

  5. Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in ...

    Authors: Man-Yee Chan, Bor-Jen Lee, Po-Sheng Chang, Han-Yu Hsiao, Li-Ping Hsu, Chia-Hua Chang and Ping-Ting Lin
    Citation: BMC Cancer 2020 20:310
    Content type: Research article Published on:

  6. Sepsis and cancer are both leading causes of death, and occurrence of any one, increases the likelihood of the other. While cancer patients are susceptible to sepsis, survivors of sepsis are also susceptible t...

    Authors: Himanshu Tripathi, Samanwoy Mukhopadhyay and Saroj Kant Mohapatra
    Citation: BMC Cancer 2020 20:309
    Content type: Research article Published on:

  7. For novel cancer treatments, effectiveness in clinical practice is not always aligned with clinical efficacy results. As such it is important to understand a treatment’s real-world effectiveness. We examined r...

    Authors: Wei Fang Dai, Jaclyn M. Beca, Ruth Croxford, Wanrudee Isaranawatchai, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Timothy P. Hanna and Kelvin K.W. Chan
    Citation: BMC Cancer 2020 20:304
    Content type: Research article Published on:

  8. Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has...

    Authors: Hai-Bo Sun, Wen-Qun Xing, Xian-Ben Liu, Yan Zheng, Shu-Jun Yang, Zong-Fei Wang, Shi-Lei Liu, Yu-Feng Ba, Rui-Xiang Zhang, Bao-Xing Liu, Cheng-Cheng Fan, Pei-Nan Chen, Guang-Hui Liang, Yong-Kui Yu, Qi Liu, Hao-Ran Wang…
    Citation: BMC Cancer 2020 20:303
    Content type: Study protocol Published on:

  9. Following publication of the original article [1], the authors reported an error in the author group.

    Authors: Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Tetsuro Hikichi, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida and Masahiro Toda
    Citation: BMC Cancer 2020 20:301
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:196

  10. Cancer immunotherapy via immune-checkpoint inhibition (ICI) by antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and cell death protein 1 (PD-1) have significantly improved the outcome of...

    Authors: J. Boegeholz, C. S. Brueggen, C. Pauli, F. Dimitriou, E. Haralambieva, R. Dummer, M. G. Manz and C. C. Widmer
    Citation: BMC Cancer 2020 20:300
    Content type: Research article Published on:

  11. RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK...

    Authors: Zulipiyamu Tuoheti, Lili Han, Sulaiya Husaiyin, Xiaoxi Liu, Chunhua Ma and Mayinuer Niyazi
    Citation: BMC Cancer 2020 20:299
    Content type: Research article Published on:

  12. To screen and analyze differentially expressed genes in pancreatic carcinoma tissues taken from Mongolian and Han patients by Affymetrix Genechip. Methods: Pancreatic ductal cell carcinoma tissues were collect...

    Authors: Jiasheng Xu, Kaili Liao, Zhonghua Fu and Zhenfang Xiong
    Citation: BMC Cancer 2020 20:298
    Content type: Research article Published on:

  14. Caregiving for childhood cancer survivors may be burdensome for caregivers and affect their physical health and health behaviors. However, studies examining health behaviors in caregivers of childhood cancer s...

    Authors: In Young Cho, Nack-Gyun Chung, Hee Jo Baek, Ji Won Lee, Ki Woong Sung, Dong Wook Shin, Jung Eun Yoo and Yun-Mi Song
    Citation: BMC Cancer 2020 20:296
    Content type: Research article Published on:

  15. New Rural Cooperative Medical Scheme (NRCMS) was developed to improve the health security for rural residents. This study aimed to assess the trend of disparity between coastland and inland in medical expendit...

    Authors: Rong Fu, Zheng Lin, Fei He, Yixian Jiang, Zhenquan Zheng and Zhijian Hu
    Citation: BMC Cancer 2020 20:295
    Content type: Research article Published on:

  16. Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues is replicated in peripheral leukocytes. This study ai...

    Authors: Giselle M. Faria, Igor D. P. Soares, Marcela D’Alincourt Salazar, Marcia R. Amorim, Bruno L. Pessoa, Clovis O. da Fonseca and Thereza Quirico-Santos
    Citation: BMC Cancer 2020 20:294
    Content type: Research article Published on:

  17. Persistent infection with high-risk Human Papillomavirus (HPVs) is associated with the development of cervical cancer. The transforming capacity of these viruses relies on the cooperative action of the E6 and ...

    Authors: María Paula Dizanzo, Federico Marziali, Clarisse Brunet Avalos, Marina Bugnon Valdano, Santiago Leiva, Ana Laura Cavatorta and Daniela Gardiol
    Citation: BMC Cancer 2020 20:293
    Content type: Research article Published on:

  18. Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion ...

    Authors: Neal Shah, Zhongwei Liu, Rachel M. Tallman, Afroz Mohammad, Samuel A. Sprowls, Pushkar A. Saralkar, Schuyler D. Vickers, Mark V. Pinti, Weimin Gao and Paul R. Lockman
    Citation: BMC Cancer 2020 20:292
    Content type: Research article Published on:

  19. Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for testing, genetic markers are rapidly expanding. Simultane...

    Authors: Elisabeth M. P. Steeghs, Leonie I. Kroeze, Bastiaan B. J. Tops, Leon C. van Kempen, Arja ter Elst, Annemiek W. M. Kastner-van Raaij, Sandra J. B. Hendriks-Cornelissen, Mandy J. W. Hermsen, Erik A. M. Jansen, Petra M. Nederlof, Ed Schuuring, Marjolijn J. L. Ligtenberg and Astrid Eijkelenboom
    Citation: BMC Cancer 2020 20:291
    Content type: Technical advance Published on:

  20. Identifying molecular differences between primary and metastatic colorectal cancers—now possible with the aid of omics technologies—can improve our understanding of the biological mechanisms of cancer progress...

    Authors: Stephany Orjuela, Mirco Menigatti, Peter Schraml, Patryk Kambakamba, Mark D. Robinson and Giancarlo Marra
    Citation: BMC Cancer 2020 20:290
    Content type: Research article Published on:

  21. Solute Carrier Family 6 Member 1 (SLC6A1) has been identified as a cancer-promoting gene in various human cancers, such as clear cell renal cell carcinoma and ovarian cancer. However, its roles in prostate can...

    Authors: Chaojiang Chen, Zhiduan Cai, Yangjia Zhuo, Ming Xi, Zhuoyuan Lin, Funeng Jiang, Zezhen Liu, Yueping Wan, Yu Zheng, Jianxin Li, Xing Zhou, Jianguo Zhu and Weide Zhong
    Citation: BMC Cancer 2020 20:289
    Content type: Research article Published on:

  22. Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in adults less than 50 years of age, is increasing. To confirm findings and identify contemporary trends worldwide, we conducted a sys...

    Authors: Khalid Saad El Din, Jonathan M. Loree, Eric C. Sayre, Sharlene Gill, Carl J. Brown, Hallie Dau and Mary A. De Vera
    Citation: BMC Cancer 2020 20:288
    Content type: Research article Published on:

  23. The effects of dietary factors on prognosis of esophageal cancer remain unclear. This systematic review and meta-analysis aimed to assess the association between dietary intake and the risk of mortality among ...

    Authors: Li-Ping Sun, Lu-Bin Yan, Zhen-Zhen Liu, Wen-Jing Zhao, Cai-Xia Zhang, Yu-Min Chen, Xiang Qian Lao and Xudong Liu
    Citation: BMC Cancer 2020 20:287
    Content type: Research article Published on:

  24. The objective of the IMPROVE study was patients’ preference for either endocrine-based therapy or combined chemo- and anti-angiogenic therapy in advanced HR-positive/HER2-negative breast cancer.

    Authors: Thomas Decker, Ulrike Söling, Antje Hahn, Christoph Maintz, Christian Martin Kurbacher, Ursula Vehling-Kaiser, Dagmar Sent, Peter Klare, Volker Hagen, Marco Chiabudini, Julia Falkenstein, Martin Indorf, Eva Runkel and Karin Potthoff
    Citation: BMC Cancer 2020 20:286
    Content type: Research article Published on:

  25. Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic drug resistance in AML. Studies rega...

    Authors: Sook-Kyoung Heo, Eui-Kyu Noh, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi and Jae-Cheol Jo
    Citation: BMC Cancer 2020 20:285
    Content type: Research article Published on:

  27. To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy ...

    Authors: Dongqing Wang, Shui Yu, Limin Zhai, Jin Xu and Baosheng Li
    Citation: BMC Cancer 2020 20:283
    Content type: Research article Published on:

  29. Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with one of the highest world incidences in the Eastern Cape region of South Africa. Several genome wide studies have been performed on ESCC co...

    Authors: Jacqueline Brown, Andrzej J. Stepien and Pascale Willem
    Citation: BMC Cancer 2020 20:281
    Content type: Research article Published on:

  31. While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients’ quality of life...

    Authors: Kazumi Sano, Kazuhiko Nakadate and Kazuhiko Hanada
    Citation: BMC Cancer 2020 20:279
    Content type: Research article Published on:

  32. There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite the sizable percentage of these patients in clinical practice. This stu...

    Authors: Nan Bi, Lipin Liu, Jun Liang, Shixiu Wu, Ming Chen, Changxing Lv, Lujun Zhao, Anhui Shi, Wei Jiang, Yaping Xu, Zongmei Zhou, Jingbo Wang, Wenqing Wang, Dongfu Chen, Zhouguang Hui, Jima Lv…
    Citation: BMC Cancer 2020 20:278
    Content type: Research article Published on:

  33. The prevalence of programmed death-ligand 1 (PD-L1) and PD-L2 expression on tumor cells and tumor-infiltrating immune cells in primary central nervous system lymphoma (PCNSL) remains unclear. In the present st...

    Authors: Motomasa Furuse, Hiroko Kuwabara, Naokado Ikeda, Yasuhiko Hattori, Tomotsugu Ichikawa, Naoki Kagawa, Kenichiro Kikuta, Sho Tamai, Mitsutoshi Nakada, Toshihiko Wakabayashi, Masahiko Wanibuchi, Toshihiko Kuroiwa, Yoshinobu Hirose and Shin-Ichi Miyatake
    Citation: BMC Cancer 2020 20:277
    Content type: Research article Published on:

  34. To evaluate the value of new therapies for non-small cell lung cancer (NSCLC), it is necessary to understand overall survival (OS) rates associated with previous standard therapies and how these rates have evo...

    Authors: Ryan N. Hansen, Yiduo Zhang, Brian Seal, Kellie Ryan, Candice Yong, Annie Darilay and Scott D. Ramsey
    Citation: BMC Cancer 2020 20:276
    Content type: Research article Published on:

  35. Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy ...

    Authors: Mercedes Delgado-García, Birgit Weynand, Lourdes Gómez-Izquierdo, María José Hernández, Ángela María Blanco, Mar Varela, Xavier Matias-Guiu, Ernest Nadal, Bélgica Márquez-Lobo, Ana Alarcão, Enrique de Álava and Michele Biscuola
    Citation: BMC Cancer 2020 20:275
    Content type: Research article Published on:

  36. Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.

    Authors: Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi and Wansheng Long
    Citation: BMC Cancer 2020 20:274
    Content type: Research article Published on:

  38. Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in cc...

    Authors: Ju-Yoon Yoon, Craig Gedye, Joshua Paterson and Laurie Ailles
    Citation: BMC Cancer 2020 20:272
    Content type: Research article Published on:

  39. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco
    Citation: BMC Cancer 2020 20:271
    Content type: Case report Published on:

  40. In the past four decades, the incidence of cholangiocarcinoma, especially intrahepatic cholangiocarcinoma (ICC), has raised rapidly worldwide. Completeness of resection, max size of tumor and etc. are widely r...

    Authors: Zeyu Zhang, Yufan Zhou, Kuan Hu, Dong Wang, Zhiming Wang and Yun Huang
    Citation: BMC Cancer 2020 20:270
    Content type: Research article Published on:

  41. Colon cancer is one of the most common malignancies and the fourth leading cause of cancer-related mortality in the world. Colibactin, which is synthesized by the pks genomic island of E. coli interfere with the ...

    Authors: Faezah Kosari, Mohammad Taheri, Abbas Moradi, Reza Hakimi Alni and Mohammad Yousef Alikhani
    Citation: BMC Cancer 2020 20:267
    Content type: Research article Published on:

  42. Infiltrating immune and stromal cells are vital components of the bladder cancer (BC) microenvironment, which can significantly affect BC progression and outcome. However, the contribution of each subset of tu...

    Authors: Ye Zhang, De-hua Ou, Dong-wu Zhuang, Ze-feng Zheng and Ming-en Lin
    Citation: BMC Cancer 2020 20:265
    Content type: Research article Published on:

  43. The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benig...

    Authors: Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff and Anna Trauzold
    Citation: BMC Cancer 2020 20:264
    Content type: Research article Published on:

  44. Chromodomain helicase DNA-binding protein 4 (CHD4) has been shown to contribute to DNA repair and cell cycle promotion; however, its roles in cancer initiation and progression remain largely unknown. This stud...

    Authors: Nuo Xu, Fanglei Liu, Shengdi Wu, Maosong Ye, Haiyan Ge, Meiling Zhang, Yuanlin Song, Lin Tong, Jian Zhou and Chunxue Bai
    Citation: BMC Cancer 2020 20:262
    Content type: Research article Published on:

  46. The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associ...

    Authors: Fränce Hardtstock, David Myers, Tracy Li, Diana Cizova, Ulf Maywald, Thomas Wilke and Frank Griesinger
    Citation: BMC Cancer 2020 20:260
    Content type: Research article Published on:

  47. Combination of gemcitabine and nab-paclitaxel has superior clinical efficacy than gemcitabine alone. Nevertheless, health-related quality of life. (QoL) associated with this combination therapy when administer...

    Authors: Suayib Yalcin, Faysal Dane, Berna Oksuzoglu, Nuriye Yildirim Ozdemir, Abdurrahman Isikdogan, Metin Ozkan, Guzin Gonullu Demirag, Hasan Senol Coskun, Bulent Karabulut, Turkkan Evrensel, Mehmet Ali Ustaoglu, Feyyaz Ozdemir, Hande Turna, Tugba Yavuzsen, Faruk Aykan, Alper Sevinc…
    Citation: BMC Cancer 2020 20:259
    Content type: Research article Published on:

  48. Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for the majority of the skin-cancer-related deaths. Despite great development and evolution have been made in surgery, ra...

    Authors: Fei Liu, Lanting Hu, Yi Pei, Ke Zheng, Wei Wang, Shenglong Li, Enduo Qiu, Guanning Shang, Jiaming Zhang and Xiaojing Zhang
    Citation: BMC Cancer 2020 20:258
    Content type: Research article Published on:

  50. Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the fi...

    Authors: John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski and Naris Nilubol
    Citation: BMC Cancer 2020 20:256
    Content type: Case report Published on:

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