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  1. Expression of matrix metalloproteases 2, 9 and 14 (MMP-2, MMP-9, MMP-14), tissue inhibitors of metalloprotease 1 and 2 (TIMP-1, TIMP-2) and vascular endothelial growth factor A (VEGF-A) is involved in tumor in...

    Authors: Jordana Maria Azevedo Martins, Silvia Helena Rabelo-Santos, Maria Cristina do Amaral Westin and Luiz Carlos Zeferino
    Citation: BMC Cancer 2020 20:660
    Content type: Research article Published on:

  2. Targeted treatment with Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) is superior to systemic chemotherapy in non-small cell lung cancer (NSCLC) patients with EGFR gene mutations. Dete...

    Authors: Phyu Sin Aye, Sandar Tin Tin, Mark James McKeage, Prashannata Khwaounjoo, Alana Cavadino and J. Mark Elwood
    Citation: BMC Cancer 2020 20:658
    Content type: Research article Published on:

  3. The introduction of complete mesocolic excision (CME) with central vascular ligation (CVL) for right-sided colon cancer has improved the oncologic outcomes. Recently, we have introduced a modified CME (mCME) p...

    Authors: Seung Yoon Yang, Min Jung Kim, Bong-Hyeon Kye, Yoon Dae Han, Min Soo Cho, Seung-Yong Jeong, Hyeon-Min Cho, Hyunki Kim, Gyeong Hoon Kang, Seung Ho Song, Jun Seok Park, Ji-Seon Kim, Soo Yeun Park, Jin Kim and Byung Soh Min
    Citation: BMC Cancer 2020 20:657
    Content type: Study protocol Published on:

  4. Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) are used for the treatment of various cancer types. However, immune-related adverse events (irAEs) occur in patients treated...

    Authors: Hiroshi Matsuoka, Takahiro Hayashi, Karen Takigami, Kazuyoshi Imaizumi, Ryoichi Shiroki, Naoki Ohmiya, Kazumitsu Sugiura, Kenji Kawada, Akira Sawaki, Koutaro Maeda, Yousuke Ando and Ichiro Uyama
    Citation: BMC Cancer 2020 20:656
    Content type: Research article Published on:

  5. Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is associated with an increased risk of cardiac dysfunction and functional disability. Observ...

    Authors: Stephen J. Foulkes, Erin J. Howden, Yoland Antill, Sherene Loi, Agus Salim, Mark J. Haykowsky, Robin M. Daly, Steve F. Fraser and Andre La Gerche
    Citation: BMC Cancer 2020 20:655
    Content type: Study protocol Published on:

  6. Systematic retroperitoneal lymphadenectomy has been widely used in the surgical treatment of advanced ovarian cancer patients. Nevertheless, the corresponding therapeutic may not provide a survival benefit. Th...

    Authors: Chenyan Fang, Yingli Zhang, Lingqin Zhao, Xi Chen, Liang Xia and Ping Zhang
    Citation: BMC Cancer 2020 20:654
    Content type: Research article Published on:

  7. HER2 dual-blockade combined with aromatase inhibitors (AI) is a promising strategy to improve progression-free survival (PFS) in hormone receptor (HR) positive, metastatic breast cancer (MBC). Pyrotinib is a n...

    Authors: Changjun Wang, Yan Lin, Yidong Zhou, Feng Mao, Hanjiang Zhu, Jinghong Guan, Xiaohui Zhang, Songjie Shen, Xin Huang, Chang Chen, Ru Yao, Jialin Zhao and Qiang Sun
    Citation: BMC Cancer 2020 20:653
    Content type: Study protocol Published on:

  8. Paclitaxel is a standard of care for patients with primary cutaneous angiosarcoma of the scalp and face. However, no standard second-line treatment for paclitaxel-resistant patients has ever been established. ...

    Authors: Kohei Oashi, Taro Shibata, Kenjiro Namikawa, Akira Takahashi, Kenji Yokota, Eiji Nakano, Yukiko Teramoto, Arata Tsutsumida, Taku Maeda and Naoya Yamazaki
    Citation: BMC Cancer 2020 20:652
    Content type: Study protocol Published on:

  9. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of malignancies with a nearly equal incidence and mortality rates in patients. Pancreatic stellate cells (PSCs) are critical players ...

    Authors: Shatovisha Dey, Sheng Liu, Tricia D. Factora, Solaema Taleb, Primavera Riverahernandez, Lata Udari, Xiaoling Zhong, Jun Wan and Janaiah Kota
    Citation: BMC Cancer 2020 20:651
    Content type: Research article Published on:

  10. The identification of pathologically altered neutrophil granulocyte migration patterns bears strong potential for surveillance and prognostic scoring of diseases. We recently identified a strong correlation be...

    Authors: Lea Bornemann, Marc Schuster, Saskia Schmitz, Charlyn Sobczak, Clara Bessen, Simon F. Merz, Karl-Heinz Jöckel, Thomas Haverkamp, Matthias Gunzer and Joachim R. Göthert
    Citation: BMC Cancer 2020 20:650
    Content type: Research article Published on:

  11. The recommended starting dose of cabazitaxel for castration-resistant prostate cancer (CRPC) is 25 mg/m2 in Japan and Europe. Although lower doses are established alternatives based on randomized controlled trial...

    Authors: Hideyasu Matsuyama, Nobuaki Matsubara, Hirotaka Kazama, Takeshi Seto, Shoko Tsukube and Kazuhiro Suzuki
    Citation: BMC Cancer 2020 20:649
    Content type: Research article Published on:

  12. Fibroepithelial lesions of the breast include fibroadenoma (FA) and phyllodes tumor (PT). Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of dis...

    Authors: Santosh Tummidi, Kanchan Kothari, Mona Agnihotri, Leena Naik and Prashant Sood
    Citation: BMC Cancer 2020 20:648
    Content type: Research article Published on:

  13. IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, ...

    Authors: Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Kenny Misael Calvillo-Rodriguez, Karla Maria Alvarez-Valadez, Ashanti C. Uscanga-Palomeque, Reyes S. Tamez-Guerra and Cristina Rodríguez-Padilla
    Citation: BMC Cancer 2020 20:647
    Content type: Research article Published on:

  14. The clinical value of combined local radiation and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) for medically inoperable and TKI-naïve early-stage lung adenocarcinoma patients with...

    Authors: Yuemei Sun, Mengwan Wu, Mingxiu Zhou, Xing Luo, Yan Guo, Hansong Bai, Zican Zhang, Wei Tian, Xiaoshan Wang, Yifeng Bai, Xueqiang Zhu, Haixia Pan, Ying Deng, Honglin Hu, Jianling Xia, Xinbao Hao…
    Citation: BMC Cancer 2020 20:646
    Content type: Research article Published on:

  15. Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase popul...

    Authors: Riina Aarnio, Ellinor Östensson, Matts Olovsson, Inger Gustavsson and Ulf Gyllensten
    Citation: BMC Cancer 2020 20:645
    Content type: Research article Published on:

  16. Breast cancer is one of the most common tumors for women globally. Various miRNAs have been reported to play a crucial role in breast cancer, however the clinical significance of miR-1908-3p in breast cancer r...

    Authors: Youzhi Zhu, Qingshui Wang, Yun Xia, Xiaoxue Xiong, Shuyun Weng, Huizhen Ni, Yan Ye, Ling Chen, Junyu Lin, Yajuan Chen, Haitao Niu, Xiangjin Chen and Yao Lin
    Citation: BMC Cancer 2020 20:644
    Content type: Research article Published on:

  17. For the first time, we present regional-level cancer incidence and world-standardized mortality rates for cancers for Martinique, Guadeloupe and French Guiana.

    Authors: Clarisse Joachim, Jacqueline Véronique-Baudin, Laure Desroziers, Édouard Chatignoux, Sophie Belliardo, Juliette Plenet, Jonathan Macni, Stephen Ulric-Gervaise, Jessica Peruvien, Bernard Bhakkan-Mambir and Jacqueline Deloumeaux
    Citation: BMC Cancer 2020 20:643
    Content type: Research article Published on:

  18. The prognosis of patients with combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CHC) is usually poor, and effective adjuvant therapy is missing making it important to investigate whether ...

    Authors: Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan and Ying-Hong Shi
    Citation: BMC Cancer 2020 20:642
    Content type: Research article Published on:

  19. The COVID-19 pandemic has caused a global health crisis. Numerous cancer patients from non-Western countries, including the United Arab Emirates (UAE), seek cancer care outside their home countries and many ar...

    Authors: Humaid O. Al-Shamsi, Ibrahim Abu-Gheida, Shabeeha K. Rana, Neil Nijhawan, Ahmed S. Abdulsamad, Sadir Alrawi, Mohamed Abuhaleeqa, Taleb M. Almansoori, Thamir Alkasab, Essa M. Aleassa and Martine C. McManus
    Citation: BMC Cancer 2020 20:641
    Content type: Review Published on:

  20. The skeleton is the first and most common distant metastatic site for breast cancer. Such metastases complicate cancer management, inducing considerable morbidities and decreasing patient survival. Osteomimeti...

    Authors: L. Absil, F. Journé, D. Larsimont, J. J. Body, L. Tafforeau and D. Nonclercq
    Citation: BMC Cancer 2020 20:640
    Content type: Research article Published on:

  21. Sentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the sa...

    Authors: Yilin Shao, Xin Liu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhiguo Luo and Xichun Hu
    Citation: BMC Cancer 2020 20:639
    Content type: Research article Published on:

  22. Many studies have found that use of aspirin can lengthen survival in patients with gastrointestinal cancer. The aim of this study was to assess the survival benefit of aspirin use compared with non-aspirin use...

    Authors: Ju-Li Lin, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin and Chang-Ming Huang
    Citation: BMC Cancer 2020 20:638
    Content type: Research article Published on:

  23. The incidence of thyroid cancer is increasing worldwide. This is not accompanied by a corresponding increase in mortality. In contrast, in most populations’ thyroid cancer mortality has been decreasing in rece...

    Authors: Enrique López Gavilanez, Noemí Bautista Litardo, Manuel Navarro Chávez, Mario Hernández Bonilla and Angel Segale Bajaña
    Citation: BMC Cancer 2020 20:637
    Content type: Correspondence Published on:

  24. Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a dismal response to single-use of immune checkpoint inhibitors (ICIs). ICIs combined with systemic therapy has shown efficacy and safety in vari...

    Authors: Lin Shui, Ke Cheng, Xiaofen Li, Pixian Shui, Xiaohan Zhou, Jian Li, Cheng Yi and Dan Cao
    Citation: BMC Cancer 2020 20:636
    Content type: Study protocol Published on:

  25. In its 2006 report, From cancer patient to cancer survivor: lost in transition, the U.S. Institute of Medicine raised the need for a more coordinated and comprehensive care model for cancer survivors. Given the e...

    Authors: Barbara M. Wollersheim, Kristel M. van Asselt, Henk G. van der Poel, Henk C. P. M. van Weert, Michael Hauptmann, Valesca P. Retèl, Neil K. Aaronson, Lonneke V. van de Poll-Franse and Annelies H. Boekhout
    Citation: BMC Cancer 2020 20:635
    Content type: Study protocol Published on:

  26. Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and...

    Authors: Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou and Tao Ren
    Citation: BMC Cancer 2020 20:634
    Content type: Research article Published on:

  27. Pancreatic cancer has a poor prognosis and few choices of therapy. For patients with adequate performance status, FOLFIRINOX or gemcitabine plus nab-paclitaxel are preferred first-line treatment. 5-Fluorouraci...

    Authors: Zev A. Wainberg, Kynan Feeney, Myung Ah Lee, Andrés Muñoz, Antonio Cubillo Gracián, Sara Lonardi, Baek-Yeol Ryoo, Annie Hung, Yong Lin, Johanna Bendell and J. Randolph Hecht
    Citation: BMC Cancer 2020 20:633
    Content type: Research article Published on:

  28. Chemokine (C-C motif) ligand 18 (CCL18) affects the malignant progression of varying cancers by activating chemokine receptors. Our previous work has shown that CCL18 promotes hyperplasia and invasiveness of o...

    Authors: Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen and Jianjiang Zhao
    Citation: BMC Cancer 2020 20:632
    Content type: Research article Published on:

  30. Spinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There is currently a lack of consensus regarding post-operative treatment. Clinical data on the activity of s...

    Authors: Jietao Lin, Ling Yu, Yuanfeng Fu, Hanrui Chen, Xinting Zheng, Shutang Wang, Chan Gao, Yang Cao and Lizhu Lin
    Citation: BMC Cancer 2020 20:630
    Content type: Case report Published on:

  31. Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, the activity and m...

    Authors: Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam and Claire H. Seedhouse
    Citation: BMC Cancer 2020 20:629
    Content type: Research article Published on:

  32. Gastric cancer is the fifth most common cancer worldwide. Along with environmental factors, such as Helicobacter pylori (H. pylori) infection, genetic changes play important roles in gastric tumor formations. miR...

    Authors: Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani and Kamran Ghaedi
    Citation: BMC Cancer 2020 20:621
    Content type: Research article Published on:

  33. Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) con...

    Authors: Linus D. Kloker, Susanne Berchtold, Irina Smirnow, Julia Beil, Andreas Krieg, Bence Sipos and Ulrich M. Lauer
    Citation: BMC Cancer 2020 20:628
    Content type: Research article Published on:

  34. Emerging evidence has demonstrated the limited access to metabolic substrates as an effective approach to block cancer cell growth. The mechanisms remain unclear. Our previous work has revealed that miR-221/22...

    Authors: Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu, Yuan Li, Lixiao Zhen, Qian Zhao, Yuefan Guo, Zhaohui Wang, Evelyne Bischof and Zuoren Yu
    Citation: BMC Cancer 2020 20:627
    Content type: Research article Published on:

  35. The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes ...

    Authors: Baili Xia, Lijun Hou, Huan Kang, Wenhui Chang, Yi Liu, Yanli Zhang and Yi Ding
    Citation: BMC Cancer 2020 20:626
    Content type: Research article Published on:

  36. Sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Epidemiological studies on sarcoma from Australia are lacking, as previous studies have focused on a sarcoma type (e.g. soft t...

    Authors: Cameron M. Wright, Georgia Halkett, Richard Carey Smith and Rachael Moorin
    Citation: BMC Cancer 2020 20:625
    Content type: Research article Published on:

  37. The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...

    Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen
    Citation: BMC Cancer 2020 20:552
    Content type: Research article Published on:

  38. Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is characterized by early lymph node metastases and bad prognosis. Most therapies targeting advanced or metastatic ccRCC are based, as...

    Authors: Marcela García, Maria Belen Palma, Jerome Verine, Santiago Miriuka, Ana M. Inda, Ana L. Errecalde, François Desgrandchamps, Edgardo D. Carosella and Diana Tronik-Le Roux
    Citation: BMC Cancer 2020 20:624
    Content type: Research article Published on:

  39. The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, m...

    Authors: Seri Jeong, Seom Gim Kong, Da Jung Kim, Sangjin Lee and Ho Sup Lee
    Citation: BMC Cancer 2020 20:623
    Content type: Research article Published on:

  40. Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibilit...

    Authors: Lidia Delrieu, Amélie Anota, Olivier Trédan, Damien Freyssenet, Aurélia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Béatrice Fervers, Vincent Pialoux, David Pérol and Olivia Pérol
    Citation: BMC Cancer 2020 20:622
    Content type: Study protocol Published on:

  41. Several studies have investigated the associations between the podocalyxin-like protein (PODXL) expression quantity or locations and cancers survival, but the results were far from conclusive. Therefore, we pr...

    Authors: Siying He, Wenjie Du, Menglan Li, Ming Yan and Fang Zheng
    Citation: BMC Cancer 2020 20:620
    Content type: Research article Published on:

  42. We assessed the mechanism of hematopoietic stem cell (HSC) mobilization using etoposide with granulocyte-colony stimulating factor (G-CSF), and determined how this mechanism differs from that induced by cyclop...

    Authors: Ka-Won Kang, Seung-Jin Lee, Ji Hye Kim, Byung-Hyun Lee, Seok Jin Kim, Yong Park and Byung Soo Kim
    Citation: BMC Cancer 2020 20:619
    Content type: Research article Published on:

  44. Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence. To tar...

    Authors: Jérôme Ruhnau, Jonas Parczyk, Kerstin Danker, Britta Eickholt and Andreas Klein
    Citation: BMC Cancer 2020 20:617
    Content type: Research article Published on:

  45. There is already evidence that the faecal immunochemical test (FIT) is a useful tool for the diagnosis of colorectal cancer (CRC) that helps to identify symptomatic patients requiring early colonoscopy. Althou...

    Authors: María Angeles Gutierrez-Stampa, Vanessa Aguilar, Cristina Sarasqueta, Joaquín Cubiella, Isabel Portillo and Luis Bujanda
    Citation: BMC Cancer 2020 20:616
    Content type: Research article Published on:

  46. Breast cancer is a global health problem – it is the most common malignancy among women. Triple negative breast cancers (TNBC) account for 10–20% of female breast cancer. Most TNBC cases confer poor prognosis....

    Authors: Tamás Mezei, Melinda Hajdu, Gábor Czigléczki, Gábor Lotz, Judit Kocsis, Janina Kulka and Anna Horváth
    Citation: BMC Cancer 2020 20:615
    Content type: Case report Published on:

  47. Microvascular invasion (MVI) is considered to be one of the important prognostic factors that affect postoperative recurrence in patients with hepatocellular carcinoma (HCC) with variable results across their ...

    Authors: Liming Wang, Weihu Wang, Weiqi Rong, Zhuo Li, Fan Wu, Yunhe Liu, Yiling Zheng, Kai Zhang, Tana Siqin, Mei Liu, Bo Chen and Jianxiong Wu
    Citation: BMC Cancer 2020 20:614
    Content type: Research article Published on:

  48. Respiratory motion management with breath hold for patients with hepatobiliary cancers remain a challenge in the precise positioning for radiotherapy. We compared different image-guided alignment markers for e...

    Authors: Tzu-Jie Huang, Yun Tien, Jian-Kuen Wu, Wen-Tao Huang and Jason Chia-Hsien Cheng
    Citation: BMC Cancer 2020 20:613
    Content type: Research article Published on:

  49. Feasibility testing of a simultaneous sparing approach of hippocampus, hypothalamus and pituitary gland in patients undergoing whole-brain radiotherapy (WBRT) with and without a concomitant boost to metastatic...

    Authors: P. Mehta, S. Janssen, F. B. Fahlbusch, S. M. Schmid, J. Gebauer, F. Cremers, C. Ziemann, M. Tartz and D. Rades
    Citation: BMC Cancer 2020 20:610
    Content type: Research article Published on:

  50. Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the...

    Authors: Sivan Shamai, Zach Rozenbaum, Ofer Merimsky, Matthew Derakhshesh, Yonatan Moshkovits, Joshua Arnold, Yan Topilsky, Yaron Arbel and Michal Laufer-Perl
    Citation: BMC Cancer 2020 20:609
    Content type: Research article Published on:

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