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Evaluation of the Healthy Living after Cancer text message-delivered, extended contact intervention using the RE-AIM framework

BMC Cancer volume 21, Article number: 1081 (2021) Cite this article

Abstract

Background

Text message-delivered interventions have potential to prevent weight regain and maintain diet and physical activity behaviours through extending contact with participants following initial weight loss, lifestyle interventions. Using the RE-AIM Framework, this study evaluated the adoption, reach, implementation, effectiveness, and maintenance of an extended contact text-message intervention following the Healthy Living after Cancer (HLaC) program. HLaC was a 6-month, telephone-delivered intervention targeting healthy diet, physical activity and weight loss for adult cancer survivors, offered by Cancer Councils (CCs) in Australia.

Methods

HLaC completers (n = 182) were offered extended contact via text messages for 6-months (HLaC+Txt). Text message content/frequency was individually tailored to participant’s preferences, ascertained through two telephone-tailoring interviews with CC staff. Adoption (HLaC+Txt uptake among eligible CCs), reach (uptake by HLaC completers) and implementation (intervention cost/length; text dose) were assessed. The effectiveness of extended contact relative to historic controls was quantified by pre-to-post HLaC+Txt changes in self-reported: weight, moderate-vigorous physical activity (MVPA), fruit and vegetable intake, fat and fibre behaviour. Maintenance, following 6-months of noncontact for the intervention cohort, was assessed for these same variables. Semi-structured interviews with CC staff and participants contextualised outcomes.

Results

HLaC+Txt was adopted by all four CCs who had delivered HLaC. In total, 115 participants commenced HLaC+Txt, with reach ranging across CCs from 47 to 80% of eligible participants. The mean number of weeks participants received the text message intervention ranged across CCs from 18.5–22.2 weeks. Participants received (median, 25th,75th percentile) 83 (48, 119) texts, ranging across CCs from 40 to 112. The total cost of HLaC+Txt delivery was on average $AUD85.00/participant. No meaningful (p < 0.05) differences in self-reported outcomes were seen between HLaC+Txt and control cohorts. After 6-months no contact the intervention cohort had maintained weight, fruit intake, fat and fibre index scores relative to end of HLaC+Txt outcomes. Participants/CC staff perceived an important intervention component was maintaining accountability.

Conclusions

While feasible to implement, HLaC+Txt was not effective in the short term. However, intervention effects during the non-contact period suggest the program supports longer term maintenance of weight and diet behaviour. Intervention delivery in this real-world context highlighted key considerations for future implementation.

Trial registration

Australian and New Zealand Clinical Trials Registry (ANZCTR) - ACTRN12615000882527 (registered on 24/08/2015).

Peer Review reports

Background

Worldwide, there is a positive trend towards improved rates of survival for people diagnosed with breast, colorectal, prostrate, melanoma and endometrial cancer [1]. In Australia the overall cancer survival rate was 69% in 2011–2015, a substantial increase from 48% in 1984–1988 [2, 3]. For those diagnosed with the most prevalent cancers (i.e. breast, prostate, bowel), many are now more likely to die from causes other than cancer (i.e. cardiovascular disease) compared to other non-cancer survivor populations [4]. To reduce the risk of cancer recurrence and comorbidities, lifestyle modifications are recommended, including achieving a healthy weight, being physically active and increasing the intake of wholegrains, vegetables and fruit [3,4,5,6].

Lifestyle interventions for cancer survivors have been effective for supporting weight loss and achieving improvements in diet and physical activity behaviours [7,8,9,10,11,12,13,14]. However, as with interventions in the general population, maintaining dietary and physical activity behaviour changes following intervention completion remains a challenge [7, 10].

Extended contact interventions can provide continued support to prevent weight regain and to maintain the healthy physical activity and diet behaviours [15, 16], with meta-analyses supporting their effectiveness [16,17,18]. Extended contact interventions are delivered after more intensive initial interventions and typically have a tapered intervention dose and a behavioural maintenance focus [9, 19,20,21,22]. Most extended contact intervention trials have implemented contact modalities that were used during the initial intervention contact, such as telephone support [9], group conference calls [22] and face-to-face groups with telephone or email support [20]. To date, two published extended contact interventions following a lifestyle intervention have been delivered by text message: one in a general adult population [23], and one among cancer survivors [19]. Both trials showed some promising results and have progressed into implementation trials, as a key benefit of utilizing text messages is that they offer a low cost, broad reach method of delivery of extended contact by community partners. However, literature on the implementation of extended contact interventions in community settings remains limited [24, 25].

Using the RE-AIM framework [26], this paper describes the outcomes of a text message-delivered, extended contact intervention for Healthy Living after Cancer (HLaC). HLaC was a 6-month, telephone-delivered health coaching intervention targeting physical activity, diet and weight loss in cancer survivors who had previously been treated with curative intent [27, 28]. The intervention was delivered by Cancer Councils (CCs) across Australia and evaluated in the context of a dissemination and implementation trial [27, 28]. Following completion of the HLaC program, clients were offered HLaC+Txt, a 6-month text message-delivered, extended contact intervention. It was hypothesised that, on average, those who had received HLaC+Txt would maintain or improve weight, diet and physical activity behaviour outcomes, while those who did not receive HLaC+Txt would regress towards baseline levels, resulting in a significant between cohort difference in intervention effect at the end of HLaC+Txt.

Methods

Study design

A historical control design was used to evaluate the addition of HLaC+Txt to the HLaC intervention. HLaC+Txt was compared to the standard HLaC protocol (i.e. no further intervention contact) (Fig. 1). Recruitment into HLaC commenced in June 2015 and participants completing the HLaC telephone-coaching program between December 2015 and January 2017 and who consented to completing an additional assessment (6-months after completing HLaC) formed the historical control cohort. All participants who completed HLaC between February 2017 and July 2018 and who owned a mobile telephone were invited to receive HLaC+Txt, with an additional follow-up evaluation 6 months after HLaC+Txt completion (Fig. 1). Ethical clearance was approved by the human research ethics committees of The University of Queensland (2,014,001,106/HREC 1407), the participating CCs and by referring clinical sites.

Fig. 1
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HLaC+Txt Trial Study Design

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Study context

The initial HLaC program was delivered via telephone with up to 12 calls from CC nurses/ allied health professionals and was supplemented with a printed Participant Workbook [27]. The coaches were experienced in cancer care and trained to deliver the HLaC program using motivational interviewing techniques [27, 28]. During HLaC, participants were guided to develop skills in behaviour change techniques for improving physical activity and dietary behaviours including: goal setting, self-monitoring, problem solving, identifying social support, stimulus control, positive self-talk and self-reward [29]. Four of the five CCs in Australia took up the initial HLaC program and 786 eligible cancer survivors participated in HLaC (88.7% overall uptake), with outcomes reported elsewhere [28].

Recruitment

Participants eligible for HLaC were adults (18+ years) diagnosed with any form of localised cancer (non-metastatic) who had been treated with curative intent [28]. CC delivery staff recruited participants for the HLaC+Txt trial during their final HLaC coaching call or the post-HLaC assessment, and if participants agreed, recorded verbal or written consent was obtained.

Intervention cohort treatment

As outlined in Table 1, HLaC+Txt participants received two tailoring interviews (initial and 12-weeks) and tailored text messages over 24 weeks. The content, frequency and timing of the texts were tailored based on information collected from participants during two scripted, telephone tailoring interviews conducted by CC delivery-staff.

Table 1 HLaC+Txt Intervention components
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Tailoring interviews

Based on available CC resources, the person delivering the tailoring interviews at each CC was either the CC HLaC coach (i.e. nurse or allied health professional), or CC research assistant who had conducted the pre- and post-HLaC program assessments. All CC delivery staff were trained by a researcher to deliver HLaC+Txt via telephone-delivered training session/s (approximately 30 min in length) and were emailed a Training Manual which outlined HLaC+Txt and how to conduct the tailoring interviews.

The initial tailoring interview was conducted with each participant at baseline HLaC+Txt (after completion of HLaC) and repeated approximately 12 weeks later. Key behaviour change techniques incorporated into the tailoring interview scripted conversations were problem solving and relapse prevention which are challenging to do via text messaging and are more easily targeted through conversation [33, 34]. At the 12-week tailoring interview participants’ text message response rates (over the first 12 weeks of the program) were prefilled in the script to give the CC delivery-staff context of how often the participant was interacting with the texts. Feedback questions were included to facilitate participants’ thoughts on their experiences with the text messages over the previous 12 weeks to encourage the choice of appropriate content for the tailoring variables for the remainder of the intervention.

HLaC+txt text messages

HLaC+Txt text messages reinforced strategies based on behaviour change techniques (BCT) discussed by the HLaC coaches during the initial 6-month telephone coaching program which support weight, and diet and physical activity behaviour maintenance (e.g. monitoring of weight, diet and physical activity behavior, problem solving and goal setting) [35,36,37]. These BCT were targeted across six different types of texts with a total of 245 different texts available to send during the program (Table 2). Minimal abbreviations were used in the text messages (i.e., to ‘2’; you ‘u’; your ‘ur’; for ‘4’). A researcher (JJ) was responsible for monitoring any text message replies from participants, and the CC, therefore, requested that the text messages were signed off using the researcher’s name (not the HLaC coach’s name).

Table 2 Examples of each type of HLaC+Txt text message and frequency of delivery
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Text messages, limited to 160 characters, were automatically generated and sent using a researcher-developed platform (www.propelo.com.au). Data from the tailoring interviews were imported from the database into the platform by a researcher, enabling individually tailored texts to be pre-programmed and sent, tailored to schedules for each participant. This system was programmed to automatically recognise participant goal check “yes” or “no” replies and trigger automatic responses (goal check replies). However, if participants replied with any other text (in addition to or instead of “yes” or “no”) an email was sent to the researcher, who would trigger the appropriate goal check response or tailor a response in cases when the goal check response frameworks were not appropriate. Participants were able to modify their weight or behavioural goals or their text message tailoring preferences (e.g., timing, frequency) by replying to goal check texts and these replies were also emailed automatically to the researcher, who made the appropriate adjustments to the tailoring data. If the participant reported any health or medical issues, the participant was asked via text if they wished to adjust their goals, and corresponding changes to the tailoring data were made. Participants were able to opt out of the program at any time by replying “STOP” to any text.

Control cohort treatment

This cohort of participants received no further contact following the completion of the HLaC coaching calls, except from the researchers to conduct the post-HLaC+Txt trial assessment and to receive the written feedback from this assessment.

Data collection

Data collected and assessment tools for each of the RE-AIM dimensions are reported in Table 3. The RE-AIM dimensions are reported in chronological order (i.e. adoption, reach, implementation, effectiveness, maintenance) rather than the acronym order.

Table 3 RE-AIM evaluation indicators of the HLaC+Txt extended contact intervention
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Participant outcome data were collected via telephone at the HLaC+Txt trial pre-program assessment (HLaC post-program assessment) and HLaC+Txt trial post-program assessment (completion of HLaC+Txt for the intervention cohort and 6-months post HLaC completion for control cohort - see Fig. 1) [27, 28]. Maintenance participant outcome data were assessed in the HLaC+Txt follow-up survey following 6-months of no-contact for the HLaC+Txt intervention cohort (see Fig. 1). CC staff conducted the HLaC+Txt trial pre-program assessments and the first author (JJ) conducted the HLaC+Txt trial post-program and follow-up assessments [27, 28]. Assessors were not blinded to the participant’s treatment. All participants were given the option of receiving a written summary of the dietary and physical activity feedback from the assessments, by email or post.

All participants were asked to rate overall satisfaction with and usefulness of the texts for meeting goals on a 5-point scale from “not at all” to “extremely” useful/satisfied, and to provide feedback on the program in an open-ended question.

Semi-structured, in-depth qualitative interviews were conducted with the CC delivery staff during and at the completion of the intervention via telephone (Additional File 1: Staff Interview Guide). In addition, a random sample of participants were interviewed at the HLaC+Txt trial post-program assessment to gather data on their experience with the HLaC+Txt intervention & how the program fit with longer-term cancer care (Additional File 2: Participant Interview Guide). Participants interviewed included those who had completed the entire intervention & those who had withdrawn from intervention prior to completion. Interviews continued until saturation of themes occurred. All qualitative interviews were conducted by a researcher (JJ) via telephone using a semi-structured interview technique, recorded and transcribed verbatim using F4 software (audiotranskription.de, Marburg, Germany). Idiosyncrasies (e.g., um, ahh) and word repetitions were then removed from the transcripts and the data were coded, categorised and themes identified independently by the interviewer (JJ) and another author (BF) using an inductive approach [38, 39]. These two authors then discussed identified themes and agreed on common themes, which were supported by example quotes from the interview scripts.

The cost (AUD$) of delivery of the intervention was calculated from the cost for staff time (for delivering tailoring interviews, training, entering tailoring data into software and manually triggering goal check replies), and the cost of sending text messages. Staff time for delivery of the tailoring interviews was tracked in real-time in the CC databases [27, 28] and the remainder of the staff time for intervention delivery tasks was tracked manually by a researcher (JJ).

Sample size

The target sample size for HLaC+Txt was a total of 204 participants (n = 102 controls, n = 102 HLaC+Txt participants). Sample size calculations used standard deviations and correlations derived from outcomes of an interim analysis on the first 314 participants from the initial HLaC intervention. This sample size provided 80% power to detect differences between the control and intervention cohorts of: 1.0 kg body weight assuming a standard deviation of 18.0 kg and a pre-post correlation of 0.99. A sample size of 102 for each cohort was also adequate (power ≥ 80%) to detect a difference between the control and intervention cohort in changes of 0.4 serves of fruit per day (SD = 1.09 serves/day, r = 0.41), 0.7 serves of vegetables per day (SD = 1.8 serves/day, r = 0.43), a score of 0.2 on the fat score (SD = 0.51 points, r = 0.67), a score of 0.2 on the fibre score (SD = 0.50 points, r = 0.63), 80 min of MVPA/week (SD = 235 min, r = 0.62), 2.6 cm waist circumference (SD = 16.43 cm, r = 0.92), 4 units mental quality of life (SD = 9.8, r = 0.50) and 4 units physical quality of life (SD = 10.5, r = 0.48).

Data analysis

The participant flow through the trial was described (Fig. 2). Reach (participation rates for those eligible for HLaC+Txt) was compared between CCs (referred to as CC1–4 to de-identify) by Chi-square test (p < 0.05). Effectiveness data were analysed according to control or intervention cohort regardless of the intervention received [40] (excluding those with missing data at post- and follow-up HLaC+Txt trial assessments). Differences between the two cohorts in HLaC baseline data were compared by t-test (p < 0.05) to identify potential confounding variables. Estimated mean changes in outcomes within groups from baseline to 6-month (HLaC+Txt trial pre- to post-survey) and the effect of intervention (HLaC+Txt less control cohort) were assessed using linear regression models (p < .05). Within group maintenance was assessed for the HLaC+Txt intervention group (i.e. estimated mean change between post- and follow-up- surveys) (p < .05). Analysis was adjusted for baseline (HLaC+Txt) values of the outcome, CC and gender (regardless of significance), and other potential confounders that were significant as determined via backwards elimination (p < 0.20) (Additional File 3). Maintenance was also adjusted for years since cancer diagnosis (regardless of significance). For context, outcomes at baseline HLaC (mean, SD) and changes during HLaC (pre- to post-program assessment) (paired t-test: unadjusted, p < 0.05) are presented for the control and intervention cohorts. A sensitivity analysis with imputed data for missing post-program and follow-up assessment values was conducted using chained equations [41] in SPSS with the adjusted models to test the sensitivity of the conclusions to missing data (m = 20 imputations, except m = 25 for FFBQ fibre post- and follow-up assessment values and for mental quality of life follow-up assessment values). Analysis was performed using SPSS Statistics version 22 (IBM Corp. Armonl, NY), Stata version 13 (StataCorp. Texas, USA), SAS version 9.4 (SAS Institute Inc. NC, USA).

Fig. 2
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Flow chart of participants in the HLaC+Txt trial

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Interpretation of findings

The aim of extended contact interventions is for participants to maintain or improve outcomes, and therefore no change within the intervention cohort would be interpreted as a positive finding. Therefore, it was only when findings were statistically significant that cohorts were claimed to have on average “worsened” or “improved” for within cohort changes or claimed to be “better” or “worse” than controls for between-cohort differences. Non-significant findings can indicate either no change/difference in outcome or an insufficient sample size to show a conclusive finding. Therefore, we only described outcomes as “maintained” or cohorts as being “similar” when the finding was both non-significant and the likely true effect size for the change/difference (as seen by the 95% confidence interval) was less than the minimum difference of interest (MDI) [23]. MDI’s were: weight 1.0 kg; waist circumference 1.0 cm; MVPA 30 min; fruit and vegetables 0.5 serves/day; FFBQ fat and fibre index scores 0.2 units; physical and mental quality of life 1.0 unit.

Results

Adoption outcomes

All four CCs delivering the HLaC program were approached and agreed to deliver the HLaC+Txt intervention (CC Victoria, CC South Australia, CC New South Wales and CC Western Australia). The CCs each made their own decisions regarding which staff would conduct the tailoring interviews, with two CCs using the HLaC telephone coaches who had been trained in motivational interviewing and two using research assistants who had no motivational interviewing training. These decisions were based on the resources available at each CC.

Reach outcomes

Of the participants approached to join HLaC+Txt across the four CCs (n = 189), 96% (n = 182) were eligible and 64% of these (n = 115) consented to participate (Fig. 2). There were statistically significant differences in reach across CCs (Chi Square p = .004) ranging from 47% in CC4 to 80% in CC1 (Additional File 4). Of the 115 participants who commenced the HLaC+Txt intervention, 88 (77%) completed the intervention. The overall retention rate for assessments from pre- to post-HLaC+Txt trial assessments was 89% (316/356) (intervention cohort 97%, 111/115; control cohort 86%, 144/167). The retention rate for the follow-up assessment after 6-months no-contact for the HLaC+Txt intervention cohort was 81%, 93/115.

Participants in the HLaC+Txt trial (n = 282) were mostly female (n = 253/90%) survivors of breast cancer (n = 181, 64%), who were on average 1.9 years (SD ±3.0) since diagnosis and had a mean age of 58.3 (SD ± 10.9) years and at the pre-HLaC assessment, had a mean BMI of 27.7 kg/m2 (SD ± 5.7). Those in the control cohort (n = 167) were largely similar to those in the HLaC+Txt intervention cohort (n = 115) (Table 4), but had a significantly higher intake of vegetables (serves/day) (p < .05) at the pre-HLaC+Txt trial assessment and received a slightly lower (yet statistically significant) number of intervention calls (10.0, SD ±1.6) during the HLaC program than the intervention cohort (10.6, SD ±1.5) (Additional File 5). Those who declined intervention participation (n = 67) and those in the control cohort had lower scores for symptom interference than the intervention cohort and a lower number of intervention calls during the HLaC program, and those who declined intervention participation had lower scores for fat intake than the intervention cohort (Additional Files 5 and 6). When compared with the cancer survivor population in Australia [42] the trial participants (n = 282) were more likely to be female (90% v 44%, p < .001), and the females were more likely to have breast cancer (72% v 36%, p < .001) and the males more likely to have lymphoma (21% v 5%, p < .001) (Additional File 7).

Table 4 Baseline health and demographic characteristics (at Pre-HLaC trial assessment) of HLaC+Txt trial participants
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Implementation outcomes

Staff training

All 16 staff (100%) who delivered the tailoring interviews attended the first 30-min telephone-delivered tailoring interview training session and four staff (25%) attended the second 12-week tailoring interview training session (the two HLaC telephone coaches with motivational interviewing training and two research assistants who had no motivational interviewing training).

Intervention delivery

The mean number of weeks participants received the text message intervention ranged from 18.5–22.2 weeks across CCs (mean 21.1, SD = 1.7) (Additional File 8) with some CC adapting the 24-week intervention based on their perceptions at the 12-week tailoring interview of participants’ needs. Participants received a mean of 83 text messages over the length of the intervention ranging from 40 for CC4 to 112 for CC1. The mean (±SD) call duration of the initial tailoring interview was 25.9 (±15.1) minutes and the second tailoring interview was 20.0 (±11.4) minutes. Of the 115 participants who completed the first tailoring interview, 97 (84%) completed the second, ranging from 82 to 91% across CCs. Participants did not receive the second tailoring interview if they withdrew or discontinued from the intervention prior to the second tailoring interview, they were unable to be contacted, or a decision was made at the second tailoring interview that they did not wish to continue with the intervention (early graduation). Withdrawal/graduation rates varied across CCs from 18% (CC1) to 48% (CC4) (Additional File 4). The percent of goal checks participants responded to was a median (25th, 75th percentile) of 70% (50.0, 85.0) and a median (25th, 75th percentile) of 30% (10.0, 55.6) required a goal check response to be triggered by the researcher. Sixty five percent of participants (n = 75) replied to the goal re-set texts sent at weeks 6 and 18. At the 12-week tailoring interview 84% (n = 97) of participants changed their preference for text message content, frequency and/or timing. The median (25th, 75th percentile) number of texts per fortnight chosen by particpants at the first tailoring interview was 8.2 (7.0, 11.0) and at the 12-week tailoring 6.1 (3.0, 9.0). Of the 115 participants in the program, 25 put the text-messages on hold for between one and 7 weeks for holidays (n = 21) or illness (n = 4). No participant changed the timing or frequency of the texts via a text message to the coach, apart from 10 participants notifying via text message that they no longer wished to receive the texts.

Qualitative interviews with staff

Interviews were conducted with seven delivery staff (two health coaches and five research assistants) (Additional File 9). A key theme was that staff perceptions about implementation aligned with differences in the qualifications of the staff conducting the intervention (i.e. CC HLaC telephone coaches versus CC research assistants). The HLaC coaches felt the tailoring interview flowed well from discussions with participants during the telephone-coaching program, about maintaining lifestyle behaviour changes, “it helps guide.... their goals going forward”. In contrast, the CC research assistants identified that their lack of coaching contact with participants meant that they had greater challenges with delivering the tailoring interviews. The qualitative interviews also highlighted differences between the coaches in their support for participant graduation from the intervention at the 12-week tailoring interview. One coach reported that participants “on a whole” were keen to receive the full 6 months of text messages as per the intervention protocol, whereas another coach graduated some participants at the 12-week interview “I think three months is the limit, I think that beyond that I don’t know that they need it as much”.

Participant satisfaction with program

At the post-HLaC+Txt trial assessment most participants were ‘satisfied’ or ‘extremely satisfied’ (77%, 90/110) with the text message program and found the texts ‘useful’ or ‘extremely useful’ for supporting them to meet their behaviour goals (68%, 75/110). Qualitative interviews were conducted with 28 participants (Additional File 10). Participants perceived that HLaC+Txt provided: reminders for maintaining their diet and physical activity behaviours established during HLaC and provided a continuing connection with the program. For some, the switch of coach from the HLaC telephone coach to the researcher who signed off the texts caused a loss of accountability to the program. A common theme throughout the qualitative interviews with participants were reported personal stressors or barriers to achieving their diet, physical activity and weight goals, such as: social issues (employment, finances, family); ongoing treatment side effects and cancer-related symptoms (disturbed sleep, fatigue, cravings, taste changes, mental health issues and joint pain); and chronic conditions such as arthritis.

Cost of delivery

A researcher spent a total of 8.5 h training 16 CC staff in the delivery of the HLaC+Txt tailoring interviews. CC delivery staff spent an average of 30 min per participant preparing for and delivering the initial tailoring interview (n = 115) and 28 min per participant for the second tailoring interview (n = 95). A researcher spent an average of 25 min per participant to enter the data from the first tailoring interview into the text messaging platform and 15 min per participant to enter the second tailoring interview data. A researcher spent an average of one minute/response (n = 613) to manually trigger replies to goal checks which were not automatically recognised by the platform. A total of 9502 text messages were sent during the intervention at a cost of $AUD0.15 per text message for a total of $AUD1425.30 (an average of $AUD12.39 per participant). Staff time was costed at $43.85/h. The total cost per participant for delivering HLaC+Txt was on average $AUD85.00.

Effectiveness outcomes

Within-cohort changes

Both HLaC+Txt and control cohorts had significantly worsened outcomes for body weight, MVPA, vegetable intake, and fat and fibre index scores between the pre- and post-HLaC+Txt trial assessments (Table 5). The intervention cohort maintained fruit intake while fruit intake worsened for the control cohort. Whilst there was no significant change in waist circumference for the intervention cohort, and physical and mental quality of life outcomes for both cohorts, the confidence intervals for these changes were greater than the MDI and the results were therefore inconclusive.

Table 5 Anthropometric/behavioural data: HLaC+Txt intervention and control cohorts: baseline HLaC#, change from: HLaC pre- to post-survey#, HLaC+Txt trial pre- to post-survey, HLaC+Txt trial post- to follow-up-survey and HLaC+Txt trial intervention effects
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Between-cohort effects

No significant intervention effects were seen for changes between the pre- and post-HLaC+Txt trial assessment in any of the anthropometric, dietary, MVPA or quality of life measures (Table 5). Results, however, were inconclusive for MVPA and quality of life as the confidence intervals included the MDI.

Sensitivity analysis

The results of the multiple imputation analyses (Additional File 11) generally supported the main analyses results, except, that due to slightly narrower confidence intervals in the multiple imputation analyses the increase in waist circumference in controls and decrease in physical activity in both cohorts was ‘inconclusive’ (rather than ‘worsened’) as the change was not significant. Fibre intake in the intervention cohort was ‘maintained’ rather than ‘worsened’ and physical quality of life in the control cohort ‘worsened’ rather than being ‘inconclusive’.

Maintenance outcomes (participant level)

Within-cohort change

The HLaC+Txt cohort maintained outcomes for weight, fruit intake, and fat and fibre index scores between post-HLaC+Txt and follow-up (after 6-months no contact) (Table 5). Results during this same time period were inconclusive for waist circumference, MVPA, physical and mental quality of life outcomes for the intervention cohort as the confidence intervals included the MDI.

Sensitivity analysis

The results of the multiple imputation analyses (Additional File 11) supported the main analyses results for changes during 6-months no contact for the HLaC+Txt cohort.

Maintenance outcomes (setting level)

To date, the initial HLaC program is being adapted and offered by three CC at a reduced scale or in a web-based format [28]. The CCs are funding the delivery of these adapted programs, as the research grant funding is complete and at the time of publishing this manuscript no CCs were continuing to offer text-message delivered extended contact.

Discussion

Using the RE-AIM framework, this implementation trial evaluated a text message-delivered, extended contact intervention targeting healthy weight, diet and physical activity, for cancer survivors. Importantly, this program was delivered by the major community-based cancer support, non-profit organisation in Australia. All four CCs adopted the HLaC+Txt intervention and the program was feasible to implement, however reach and implementation results varied greatly across CCs. The intervention was not effective when outcomes were compared to a historical control cohort at the completion of the intervention, although data collected at the HLaC+Txt trial follow-up assessment (6 months after text message completion) suggests that the benefits of the extended contact intervention may have been delayed.

Three key reasons are suggested for the lack of effectiveness findings at the end of the intervention: 1) the variability between CCs in adoption, reach and implementation, 2) the lack of intervention focus on holistic support for the social and mental health requirements of this cohort of cancer survivors, and 3) the disconnect in accountability and rapport between the initial HLaC and the HLaC+Txt programs.

Variations in HLaC+Txt program delivery across the CCs were driven by differences in CC resources leading to variations in the qualifications and experience of the intervention delivery staff [43,44,45]. Ensuring delivery staff are skilled in motivational interviewing [46], and techniques to provide participant support for coping with barriers to maintaining diet and physical activity [47] may be a key area for consideration with future implementation. Further, a protocol for a shorter intervention delivery period (i.e. 12 weeks) could be explored by comparing the effectiveness of a 12-week and 6-month intervention trial period using a randomized controlled trial.

In addition, as suggested by the qualitative data, the needs of the participants for social and mental health support may not have been met by the behaviour-change focused, text message-delivered program [48]. As well as a previous cancer diagnosis, participants had an average of two co-morbidities, and many reported mental health conditions similar to those seen in cross sectional Australian data of cancer survivors [49,50,51]. The most frequently reported unmet need of cancer survivors, following treatment completion is support for psychosocial issues [52]. Incorporating the option for mental health support into the text message frameworks and the option for participants to choose mental health goals targeting stress, depression, anxiety and sleep may improve intervention acceptability for this population [53] and have potential for supporting the mental health of cancer survivors. Alternatively, a program that incorporates text messages which are supplemented with additional telephone support for emotional and social well-being may address this deficit and may be a more appropriate extended contact modality for some participants [47, 54, 55]. Furthermore, with recent developments, this support may be feasible through triaging levels of intervention intensity via artificial intelligence [56, 57].

The loss of connection, rapport and accountability established between the coach and client during HLaC, may have further exacerbated the lack of support participants experienced for social and mental health issues. The text messages were signed-off with a researcher’s name (rather than the HLaC coach’s name). Qualitative feedback suggests this influenced the acceptability and effectiveness of the text messages for some participants who had lost the connection with their original HLaC coach and CC. A previous review of extended contact interventions suggested that the contact with the interventionist is a key component of the success of these interventions [16]. Other researchers have hypothesized that established relationships enhance the effectiveness and implementation of lifestyle interventions into practice and reduce attrition [58,59,60]. The existing program is a way to “step down” the intensity of the relationship and wean the participant on to a more cost-effective means of communication. However, continuity of care between the coach and client may still be required for such programs to be effective.

After 6 months of no contact following the end of HLaC+Txt weight, fruit intake and fat and fibre outcomes were maintained by the intervention cohort. This suggests that the text messages may have influenced participants’ ability to maintain changes in diet and exercise behaviour in the longer term. A similar effect has been reported in breast cancer survivors [19] and adults [61] who received a text message-delivered, extended contact intervention following a lifestyle intervention. The text messages may have promoted longer-term maintenance of self-regulation skills such as self-monitoring and encouraged BCTs including engaging support, goal setting and techniques for forming habits [62, 63]. Alternatively, the improved follow-up outcomes may have been a result of the additional 6 months that participants had to adjust their behaviour in response to the weight gain experienced at the end of extended contact.

Strengths

Evaluating this extended contact, text message-delivered intervention in a service delivery setting adds to the broader evidence on dissemination and implementation outcomes, where interventions are delivered in real world, rather than optimal research conditions [64]. This research was conducted in partnership with the CCs who took ownership of the program. Participant engagement with the intervention was positive and there was low participant attrition. Although participants were more likely to be female, breast cancer survivors compared to the general survivor population in Australia, the program did reach participants with a range of previous cancer diagnosis types, meeting an identified need in the community [14]. The qualitative feedback added to our understanding of the important components of extended contact interventions for this population, including: the background and experience of the delivery staff; the importance of the continuity in the delivery staff across telephone and text modalities to maintain rapport with participants; and the additional social, health and mental support requirements of this target group [65].

Limitations

HLaC+Txt was not included in the initial research protocol for HLaC [27] and a historical control study design was used due to timeline restrictions. Participants in the control cohort may have been referred to other services in the community (e.g. ENRICH [66], dietitians) and thus the between-cohort effectiveness findings of HLaC+Txt may have been attenuated. The research design relied on self-report data, as objective measures are a challenge in a program covering four states of Australia and targeting both urban and rural participants. Outcome assessments were completed at 18 months from baseline for the HLaC+Txt intervention cohort, but not the control cohort, due to limited researcher resources.

Conclusions

Although feasible to deliver and generally well accepted by staff and participants, this implementation study revealed that a text message-delivered extended contact intervention was not effective in the short term at supporting maintenance of behaviour change in a sample of cancer survivors. The benefit of such interventions, however, may be observed longer term. Collaboration with community partners has strengthened our understanding of the core program components that will inform future implementation. Maintaining support for participants based on ongoing relationships with CC coaching staff skilled in motivational interviewing may improve accountability and outcomes. In addition, offering a program that is responsive to participant’s changes in health and social circumstances is likely to improve acceptability.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

BMI:

Body Mass Index

CC:

Cancer Council

FFBQ:

Fat and Fibre Behaviour Questionnaire

HLaC:

Healthy Living after Cancer

HLaC+Txt:

Healthy Living after Cancer + Text

MDI:

Minimum Difference of Interest

QoL:

Quality of Life

RE-AIM:

Reach, Effectiveness, Adoption, Implementation, Maintenance

MVPA:

Moderate-to-Vigorous Physical Activity

SMART:

Specific, Measureable, Achievable, Realistic, Time-based

SD:

Standard Deviation

References

  1. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet (London, England). 2015;385(9972):977–1010.

    Article  Google Scholar 

  2. Australian Institute of Health and Welfare. Cancer in Australia: Australian Government; 2019 [Available from: https://www.aihw.gov.au/reports/cancer/cancer-in-australia-2019/contents/table-of-contents.

  3. World Cancer Research Fund/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective 2018 [Continuous Update Project Expert Report 2018]. Available from: dietandcancerreport.org.

  4. Robien K, Demark-Wahnefried W, Rock CL. Evidence-based nutrition guidelines for cancer survivors: current guidelines, knowledge gaps, and future research directions. J Am Diet Assoc. 2011;111(3):368–75. https://doi.org/10.1016/j.jada.2010.11.014.

    Article  PubMed  Google Scholar 

  5. Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, et al. American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol. 2014;32(31):3568–74. https://doi.org/10.1200/JCO.2014.58.4680.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Cormie P, Atkinson M, Bucci L, Cust A, Eakin E, Hayes S, et al. Clinical oncology Society of Australia position statement on exercise in cancer care. Med J Aust. 2018;209(4):184–7. https://doi.org/10.5694/mja18.00199.

    Article  PubMed  Google Scholar 

  7. Chlebowski RT, Reeves MM. Weight loss randomized intervention trials in female Cancer survivors. J Clin Oncol. 2016;34(35):4238–48. https://doi.org/10.1200/JCO.2016.69.4026.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Reeves MM, Terranova CO, Eakin EG, Demark-Wahnefried W. Weight loss intervention trials in women with breast cancer: a systematic review. Obes Rev. 2014;15(9):749–68. https://doi.org/10.1111/obr.12190.

    Article  CAS  PubMed  Google Scholar 

  9. Goodwin PJ, Segal RJ, Vallis M, Ligibel JA, Pond GR, Robidoux A, et al. Randomized trial of a telephone-based weight loss intervention in postmenopausal women with breast cancer receiving letrozole: the LISA trial. J Clin Oncol. 2014;32(21):2231–9. https://doi.org/10.1200/JCO.2013.53.1517.

    Article  PubMed  Google Scholar 

  10. Hoedjes M, van Stralen MM, Joe ST, Rookus M, van Leeuwen F, Michie S, et al. Toward the optimal strategy for sustained weight loss in overweight cancer survivors: a systematic review of the literature. J Cancer Surviv. 2017;11(3):360–85. https://doi.org/10.1007/s11764-016-0594-8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Demark-Wahnefried W, Morey MC, Sloane R, Snyder DC, Miller PE, Hartman TJ, et al. Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors. J Clin Oncol. 2012;30(19):2354–61. https://doi.org/10.1200/JCO.2011.40.0895.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Goode AD, Lawler SP, Brakenridge CL, Reeves MM, Eakin EG. Telephone, print, and web-based interventions for physical activity, diet, and weight control among cancer survivors: a systematic review. J Cancer Surviv. 2015;9(4):660–82. https://doi.org/10.1007/s11764-015-0442-2.

    Article  PubMed  Google Scholar 

  13. Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity for women with breast cancer after adjuvant therapy. Cochrane Database Syst Rev. 2018;1:Cd011292.

    PubMed  Google Scholar 

  14. Groen WG, van Harten WH, Vallance JK. Systematic review and meta-analysis of distance-based physical activity interventions for cancer survivors (2013–2018): we still haven’t found what we’re looking for. Cancer Treat Rev. 2018;69:188–203. https://doi.org/10.1016/j.ctrv.2018.07.012.

    Article  PubMed  Google Scholar 

  15. Middleton KR, Anton SD, Perri MG. Long-term adherence to health behavior change. Am J Lifestyle Med. 2013;7(6):395–404. https://doi.org/10.1177/1559827613488867.

    Article  PubMed  Google Scholar 

  16. Middleton KM, Patidar SM, Perri MG. The impact of extended care on the long-term maintenance of weight loss: a systematic review and meta-analysis. Obes Rev. 2012;13(6):509–17. https://doi.org/10.1111/j.1467-789X.2011.00972.x.

    Article  PubMed  Google Scholar 

  17. Dombrowski SU, Knittle K, Avenell A, Araujo-Soares V, Sniehotta FF. Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials. BMJ (Clinical research ed). 2014;348:g2646.

  18. Job JR, Fjeldsoe BS, Eakin EG, Reeves MM. Effectiveness of extended contact interventions for weight management delivered via text messaging: a systematic review and meta-analysis. Obes Rev. 2017;19(4):538–49. https://doi.org/10.1111/obr.12648.

    Article  PubMed  Google Scholar 

  19. Spark LC, Fjeldsoe BS, Eakin EG, Reeves MM. Efficacy of a text message-delivered extended contact intervention on maintenance of weight loss, physical activity, and dietary behavior change. JMIR Mhealth Uhealth. 2015;3(3):e88. https://doi.org/10.2196/mhealth.4114.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, et al. Reducing breast cancer recurrence with weight loss, a vanguard trial: the exercise and nutrition to enhance recovery and good health for you (ENERGY) trial. Contemp Clin Trials. 2013;34(2):282–95. https://doi.org/10.1016/j.cct.2012.12.003.

    Article  PubMed  Google Scholar 

  21. Rock CL, Flatt SW, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, et al. Results of the exercise and nutrition to enhance recovery and good health for you (ENERGY) trial: a behavioral weight loss intervention in overweight or obese breast Cancer survivors. J Clin Oncol. 2015;33(28):3169–76. https://doi.org/10.1200/JCO.2015.61.1095.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Befort CA, Klemp JR, Sullivan DK, Shireman T, Diaz FJ, Schmitz K, et al. Weight loss maintenance strategies among rural breast cancer survivors: the rural women connecting for better health trial. Obesity (Silver Spring, Md). 2016;24:2070.

    Article  Google Scholar 

  23. Fjeldsoe BS, Goode AD, Phongsavan P, Bauman A, Maher G, Winkler E, et al. Evaluating the maintenance of lifestyle changes in a randomized controlled trial of the ‘get healthy, stay healthy’ program. JMIR Mhealth Uhealth. 2016;4(2):e42. https://doi.org/10.2196/mhealth.5280.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Akers JD, Estabrooks PA, Davy BM. Translational Research: Bridging the Gap between Long-Term Weight Loss Maintenance Research and Practice. J Am Diet Assoc. 2010;110(10):1511–22.e3.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Demark-Wahnefried W, Schmitz KH, Alfano CM, Bail JR, Goodwin PJ, Thomson CA, et al. Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin. 2018;68(1):64–89. https://doi.org/10.3322/caac.21441.

    Article  PubMed  Google Scholar 

  26. Glasgow RE, Klesges LM, Dzewaltowski DA, Bull SS, Estabrooks P. The future of health behavior change research: what is needed to improve translation of research into health promotion practice? Ann Behav Med. 2004;27(1):3–12. https://doi.org/10.1207/s15324796abm2701_2.

    Article  PubMed  Google Scholar 

  27. Eakin EG, Hayes SC, Haas MR, Reeves MM, Vardy JL, Boyle F, et al. Healthy living after Cancer: a dissemination and implementation study evaluating a telephone-delivered healthy lifestyle program for cancer survivors. BMC Cancer. 2015;15(1):992. https://doi.org/10.1186/s12885-015-2003-5.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Eakin EG, Reeves MM, Goode AD, Winkler EAH, Vardy JL, Boyle F, et al. Translating research into practice: outcomes from the healthy living after Cancer partnership project. BMC Cancer. 2020;20(1):963. https://doi.org/10.1186/s12885-020-07454-4.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Michie S, Abraham C, Whittington C, McAteer J, Gupta S. Effective techniques in healthy eating and physical activity interventions: a meta-regression. Health Psychol. 2009;28(6):690–701. https://doi.org/10.1037/a0016136.

    Article  PubMed  Google Scholar 

  30. Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, et al. European guidelines for obesity management in adults. Obes Facts. 2015;8(6):402–24. https://doi.org/10.1159/000442721.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the Obesity Society. Circulation. 2014;129(25 Suppl 2):S102–38. https://doi.org/10.1161/01.cir.0000437739.71477.ee.

    Article  PubMed  Google Scholar 

  32. Michie S, Johnston M, Rothman A, Kelly M, de Briun M. BCTTv1_PDF_version. London: University College London. 2017;http://www.bct-taxonomy.com.

  33. Perri MG, McAdoo WG, Spevak PA, Newlin DB. Effect of a multicomponent maintenance program on long-term weight loss. J Consult Clin Psychol. 1984;52(3):480–1. https://doi.org/10.1037/0022-006X.52.3.480.

    Article  CAS  PubMed  Google Scholar 

  34. Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, et al. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. Jama. 2008;299(10):1139–48. https://doi.org/10.1001/jama.299.10.1139.

    Article  CAS  PubMed  Google Scholar 

  35. Perri MG, Nezu AM, McKelvey WF, Shermer RL, Renjilian DA, Viegener BJ. Relapse prevention training and problem-solving therapy in the long-term management of obesity. J Consult Clin Psychol. 2001;69(4):722–6. https://doi.org/10.1037/0022-006X.69.4.722.

    Article  CAS  PubMed  Google Scholar 

  36. Elfhag K, Rossner S. Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev. 2005;6(1):67–85. https://doi.org/10.1111/j.1467-789X.2005.00170.x.

    Article  CAS  PubMed  Google Scholar 

  37. Wing RR, Tate DF, Gorin AA, Raynor HA, Fava JL. A self-regulation program for maintenance of weight loss. N Engl J Med. 2006;355(15):1563–71. https://doi.org/10.1056/NEJMoa061883.

    Article  CAS  PubMed  Google Scholar 

  38. Kitto SC, Chesters J, Grbich C. Quality in qualitative research. Med J Aust. 2008;188(4):243–6. https://doi.org/10.5694/j.1326-5377.2008.tb01595.x.

    Article  PubMed  Google Scholar 

  39. Daly J, Willis K, Small R, Green J, Welch N, Kealy M, et al. A hierarchy of evidence for assessing qualitative health research. J Clin Epidemiol. 2007;60(1):43–9. https://doi.org/10.1016/j.jclinepi.2006.03.014.

    Article  PubMed  Google Scholar 

  40. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010;8(1):18. https://doi.org/10.1186/1741-7015-8-18.

    Article  PubMed  PubMed Central  Google Scholar 

  41. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med. 2011;30(4):377–99. https://doi.org/10.1002/sim.4067.

    Article  PubMed  Google Scholar 

  42. Australian Institute of Health and Welfare. Cancer in Australia 2017: Australian government; 2017 [updated February 2017. Available from: https://www.aihw.gov.au/reports/cancer/cancer-in-australia-2017/contents/table-of-contents.

  43. Bopp M, Saunders RP, Lattimore D. The Tug-of-War: Fidelity Versus Adaptation Throughout the Health Promotion Program Life Cycle. J Prim Prev. 2013;34(3):193–207. https://doi.org/10.1007/s10935-013-0299-y.

    Article  PubMed  Google Scholar 

  44. McCrabb S, Lane C, Hall A, Milat A, Bauman A, Sutherland R, et al. Scaling-up evidence-based obesity interventions: a systematic review assessing intervention adaptations and effectiveness and quantifying the scale-up penalty. Obes Rev. 2019;20(7):964–82. https://doi.org/10.1111/obr.12845.

    Article  PubMed  Google Scholar 

  45. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4(1):50. https://doi.org/10.1186/1748-5908-4-50.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Rollnick S, Butler CC, Kinnersley P, Gregory J, Mash B. Motiv Interviewing. BMJ (Clinical research ed). 2010;340:c1900.

    Article  Google Scholar 

  47. Gell NM, Tursi A, Grover KW, Dittus K. Female cancer survivor perspectives on remote intervention components to support physical activity maintenance. Support Care Cancer. 2019;28(5):2185–94. https://doi.org/10.1007/s00520-019-05038-y.

    Article  PubMed  Google Scholar 

  48. Grant AR, Koczwara B, Morris JN, Eakin E, Short CE, Beatty L. What do cancer survivors and their health care providers want from a healthy living program? Results from the first round of a co-design project. Support Care Cancer. 2021;29(8):4847–58. https://doi.org/10.1007/s00520-021-06019-w.

    Article  PubMed  Google Scholar 

  49. Berry NM, Miller MD, Woodman RJ, Coveney J, Dollman J, Mackenzie CR, et al. Differences in chronic conditions and lifestyle behaviour between people with a history of cancer and matched controls. Med J Aust. 2014;201(2):96–100. https://doi.org/10.5694/mja13.10701.

    Article  PubMed  Google Scholar 

  50. Eakin EG, Youlden DR, Baade PD, Lawler SP, Reeves MM, Heyworth JS, et al. Health behaviors of cancer survivors: data from an Australian population-based survey. Cancer Causes Control. 2007;18(8):881–94. https://doi.org/10.1007/s10552-007-9033-5.

    Article  PubMed  Google Scholar 

  51. Ng HS, Roder D, Koczwara B, Vitry A. Comorbidity, physical and mental health among cancer patients and survivors: an Australian population-based study. Asia Pac J Clin Oncol. 2018;14(2):e181–e92. https://doi.org/10.1111/ajco.12677.

    Article  PubMed  Google Scholar 

  52. Lisy K, Langdon L, Piper A, Jefford M. Identifying the most prevalent unmet needs of cancer survivors in Australia: a systematic review. Asia Pac J Clin Oncol. 2019;15(5):e68–78. https://doi.org/10.1111/ajco.13176.

    Article  PubMed  Google Scholar 

  53. Berrouiguet S, Baca-Garcia E, Brandt S, Walter M, Courtet P. Fundamentals for future Mobile-health (mHealth): a systematic review of Mobile phone and web-based text messaging in mental health. J Med Internet Res. 2016;18(6):e135. https://doi.org/10.2196/jmir.5066.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Singleton A, Partridge SR, Raeside R, Regimbal M, Hyun KK, Chow CK, et al. A text message intervention to support women’s physical and mental health after breast cancer treatments (EMPOWER-SMS): a randomised controlled trial protocol. Random Control Trial. 2019;19(1):660.

    CAS  Google Scholar 

  55. Job JR, Spark LC, Fjeldsoe BS, Eakin EG, Reeves MM. Women's perceptions of participation in an extended contact text message-based weight loss intervention: an explorative study. JMIR Mhealth Uhealth. 2017;5(2):e21. https://doi.org/10.2196/mhealth.6325.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Stein N, Brooks K. A fully automated conversational artificial intelligence for weight loss: longitudinal observational study among overweight and obese adults. JMIR Diabetes. 2017;2(2):e28. https://doi.org/10.2196/diabetes.8590.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Forman EM, Kerrigan SG, Butryn ML, Juarascio AS, Manasse SM, Ontanon S, et al. Can the artificial intelligence technique of reinforcement learning use continuously-monitored digital data to optimize treatment for weight loss? J Behav Med. 2019;42(2):276–90. https://doi.org/10.1007/s10865-018-9964-1.

    Article  PubMed  Google Scholar 

  58. Grekin ER, Beatty JR, Ondersma SJ. Mobile health interventions: exploring the use of common relationship factors. JMIR Mhealth Uhealth. 2019;7(4):e11245. https://doi.org/10.2196/11245.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Brannon EE, Cushing CC, Walters RW, Crick C, Noser AE, Mullins LL. Goal feedback from whom? A physical activity intervention using an N-of-1 RCT. Psychol Health. 2018;33(6):701–12. https://doi.org/10.1080/08870446.2017.1385783.

    Article  PubMed  Google Scholar 

  60. Whittemore R. A systematic review of the translational research on the diabetes prevention program. Transl Behav Med. 2011;1(3):480–91. https://doi.org/10.1007/s13142-011-0062-y.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Fjeldsoe BS, Goode AD, Phongsavan P, Bauman A, Maher G, Winkler E, et al. Get healthy, stay healthy: evaluation of the maintenance of lifestyle changes six months after an extended contact intervention. JMIR Mhealth Uhealth. 2019;7(3):e11070. https://doi.org/10.2196/11070.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Murray JM, Brennan SF, French DP, Patterson CC, Kee F, Hunter RF. Mediators of behavior change maintenance in physical activity interventions for young and middle-aged adults: a systematic review. Ann Behav Med. 2018;52(6):513–29. https://doi.org/10.1093/abm/kay012.

    Article  PubMed  Google Scholar 

  63. Kindred MM, Pinto BM, Dunsiger SI. Mediators of physical activity adoption and maintenance among breast cancer survivors. J Behav Med. 2019;43(4):605–13. https://doi.org/10.1007/s10865-019-00085-6.

    Article  PubMed  Google Scholar 

  64. Green LW, Glasgow RE. Evaluating the relevance, generalization, and applicability of research: issues in external validation and translation methodology. Eval Health Prof. 2006;29(1):126–53. https://doi.org/10.1177/0163278705284445.

    Article  PubMed  Google Scholar 

  65. Stirman SW, Miller CJ, Toder K, Calloway A. Development of a framework and coding system for modifications and adaptations of evidence-based interventions. Implement Sci. 2013;8(1):65. https://doi.org/10.1186/1748-5908-8-65.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Cancer Council. ENRICHing Survivorship – A free exercise & nutrition program for cancer survivors Cancer Council NSW [Available from: https://www.cancercouncil.com.au/enrich/. Accessed 2021.

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Acknowledgements

We would like to acknowledge the significant contribution and strong support provided by Cancer Councils New South Wales, Victoria, South Australia, and Western Australia. Their partnership was instrumental to the successful national delivery of the Healthy Living after Cancer+Text program. We thank all the Cancer Council nurses, health coaches, research assistants and managers for their passion and commitment. We would like to acknowledge Dr. Elisabeth Winkler who assisted with the data preparation and the statistical analysis of work reported in this thesis.

Funding

Healthy Living after Cancer is a National Health and Medical Research Council (NHMRC) Partnership Project (APP10743456) and was supported by funding from the NHMRC and Cancer Councils in New South Wales, Victoria, South Australia and Western Australia. JRJ was supported by an Australian Government Research Training Program Scholarship and a Medibank Health Research Fund PhD scholarship.

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Authors and Affiliations

  1. Faculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Australia

    Jennifer R. Job, Elizabeth G. Eakin, Marina M. Reeves & Brianna S. Fjeldsoe

  2. CHSRI, The University of Queensland, RBWH, Level 8, Health Sciences Building, Herston, Q 4029, Australia

    Jennifer R. Job

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Contributions

JRJ, EGE, MMR, BSF were extensively involved in the development of the HLaC+Txt concept and design and also provided project governance. JRJ performed the main statistical analyses. JRJ drafted the manuscript and all authors were involved in critically revising the manuscript and also read and approved the final manuscript.

Corresponding author

Correspondence to Jennifer R. Job.

Ethics declarations

Ethics approval and consent to participate

Ethics approval was obtained from the human research ethics committees of Cancer Council Victoria, Cancer Council New South Wales, the University of Western Australia and the University of Queensland (2014001106/HREC1407). Verbal (audio-recorded) or written informed consent was provided by all participants prior to study participation.

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Not applicable.

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The authors declare that they have no competing interests.

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Supplementary Information

Additional file 1.

Qualitative Interview Script - Staff – Completion of HLaC+Txt.

Additional file 2.

Qualitative Interview Script - Participants – Completion of HLaC+Txt.

Additional file 3: Table 1.

Confounders considered and adjusted for in main and sensitivity analyses.

Additional file 4: Table 2.

Rates of participant eligibility, participation, withdrawal/graduation and completion across the four Cancer Councils.

Additional file 5: Table 3.

Anthropometric and behavioural characteristics (at pre-HLaC+Txt trial assessment) and number of HLaC intervention calls received.

Additional file 6: Table 4.

Baseline characteristics of HLaC participants who declined the HLaC+Txt trial.

Additional file 7: Table 5.

Gender, cancer type and age of the Australian cancer survivor population and the HLaC+Txt trial participants.

Additional file 8: Table 6.

Length of intervention and average text message dose sent and received per participant by Cancer Council.

Additional file 9: Table 7.

Themes identified from the qualitative feedback from HLaC+Txt intervention staff interviews.

Additional file 10: Table 8.

Themes identified from the qualitative feedback from HLaC+Txt intervention participants at the interviews.

Additional file 11: Table 9.

Anthropometric and behavioural outcomes within the HLaC+Txt intervention (n = 115) and control cohorts (n = 167): from pre- to post-HLaC+Txt trial assessments, post-HLaC+Txt trial to follow-up assessment and HLaC+Txt intervention effects using multiple imputation for missing data.

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Job, J.R., Eakin, E.G., Reeves, M.M. et al. Evaluation of the Healthy Living after Cancer text message-delivered, extended contact intervention using the RE-AIM framework. BMC Cancer 21, 1081 (2021). https://doi.org/10.1186/s12885-021-08806-4

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  • DOI: https://doi.org/10.1186/s12885-021-08806-4

Keywords

  • Text messages
  • Extended contact
  • Diet
  • Physical activity
  • Weight
  • Maintenance
  • RE-AIM

BMC Cancer

ISSN: 1471-2407

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