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Table 2 Gene Ontology analysis of differentially expressed genes in lung adenocarcinoma

From: Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis

Expression Category Term Count % p-Value FDR
Downregulated GOTERM_BP_DIRECT GO:0001525 ~ angiogenesis 10 6.2 3.06E-07 4.71E-04
GOTERM_BP_DIRECT GO:0001570 ~ vasculogenesis 7 4.3 3.34E-06 0.005135
GOTERM_BP_DIRECT GO:0007165 ~ signal transduction 12 7.4 1.26E-04 0.193754
GOTERM_BP_DIRECT GO:0031623 ~ receptor internalization 5 3.1 1.45E-04 0.222577
GOTERM_BP_DIRECT GO:0001755 ~ neural crest cell migration 5 3.1 3.69E-04 0.566138
GOTERM_CC_DIRECT GO:0016021 ~ integral component of membrane 49 30.3 1.48E-04 0.16707
GOTERM_CC_DIRECT GO:0005886 ~ plasma membrane 25 15.4 8.82E-04 0.993318
GOTERM_CC_DIRECT GO:0005578 ~ proteinaceous extracellular matrix 6 3.7 0.008111 8.80424
GOTERM_CC_DIRECT GO:0005911 ~ cell-cell junction 4 2.5 0.047922 42.63677
GOTERM_MF_DIRECT GO:0030215 ~ semaphorin receptor binding 4 2.5 2.31E-04 0.280668
GOTERM_MF_DIRECT GO:0045499 ~ chemorepellent activity 4 2.5 8.56E-04 1.037711
GOTERM_MF_DIRECT GO:0008201 ~ heparin binding 4 2.5 0.040365 39.47803
Upregulated GOTERM_BP_DIRECT GO:0030574 ~ collagen catabolic process 3 11.1 0.003145 3.886365
GOTERM_BP_DIRECT GO:0006508 ~ proteolysis 5 18.5 0.003709 4.568267
GOTERM_BP_DIRECT GO:0007605 ~ sensory perception of sound 3 11.1 0.012967 15.14675
GOTERM_BP_DIRECT GO:0048701 ~ embryonic cranial skeleton morphogenesis 2 7.4 0.039861 40.06517
GOTERM_CC_DIRECT GO:0005615 ~ extracellular space 8 29.6 0.001014 0.992618
GOTERM_CC_DIRECT GO:0005576 ~ extracellular region 8 29.6 0.002863 2.780239
GOTERM_CC_DIRECT GO:0070062 ~ extracellular exosome 9 33.3 0.017782 16.17818
GOTERM_CC_DIRECT GO:0005578 ~ proteinaceous extracellular matrix 3 11.1 0.044503 36.09452
GOTERM_MF_DIRECT GO:0004866 ~ endopeptidase inhibitor activity 3 11.1 0.001227 1.243792
GOTERM_MF_DIRECT GO:0004252 ~ serine-type endopeptidase activity 4 14.8 0.004242 4.240205
GOTERM_MF_DIRECT GO:0004867 ~ serine-type endopeptidase inhibitor activity 3 11.1 0.007004 6.913304