Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in individuals receiving neurotoxic chemotherapy

  • The Correction to this article has been published in BMC Cancer 2019 19:438



Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. The purpose of this paper is to compare self-reported physical function in individuals receiving neurotoxic chemotherapy between Electronic Symptom Assessment-Cancer (ESRA-C) intervention group (e.g., opportunity for symptom screening, self-care recommendations, communication coaching, and symptom tracking) and control group participants (i.e., electronic assessment alone). Secondary outcomes include pain intensity, sensory/motor CIPN, depression, fatigue, and insomnia.


The data used in this paper are a subset of a randomized controlled trial that examined the impact of the ESRA-C intervention on symptom distress in individuals receiving cancer treatment. Since the interest in this analysis is on the effects of neurotoxic chemotherapy on physical function, subjects were included if they received platinum and/or taxane-based chemotherapy and completed the baseline and end-of-treatment measures. Participants completed standardized questionnaires of physical function, CIPN, fatigue, depression, pain intensity, and insomnia prior to treatment, 3–6 weeks after treatment initiation, and after the completion of treatment. Changes in mean scores are compared between groups using linear mixed models adjusting for age.


Intervention group participants reported significantly less reduction in physical functioning (baseline: 87.4/100; end-of-treatment: 84.5/100) relative to the control (baseline: 90.2/100; end-of-treatment: 81.8/100) (p = 0.011). For secondary measures, significantly less depression (p = 0.005) was observed in the intervention group as compared to the control, but otherwise, there were no between-group differences. Among participants who received high cumulative doses of neurotoxic chemotherapy, the intervention group reported significantly less severe sensory (p = 0.007) and motor CIPN (p = 0.039) relative to the control.


Use of the ESRA-C intervention led to less reduction in physical function in comparison to the control in individuals receiving neurotoxic chemotherapy. Further research is needed to confirm our findings and to identify how electronic symptom assessment technology may mediate physical function preservation.

Trial registration

ClinicalTrials.Gov NCT00852852. Registered 27 February 2009.

Peer Review reports


Approximately 4600 individuals are diagnosed with new hematological and/or oncological malignancies each day [1], of which many will require neurotoxic chemotherapy (e.g., platinums or taxanes) for the treatment of the cancer [2]. Chemotherapy-induced peripheral neuropathy (CIPN) occurs in up to 68% of individuals receiving neurotoxic chemotherapy [3] and results from chemotherapy-induced damage to peripheral nerves (e.g., “dying back” axon degeneration) [4]. Patients with CIPN symptoms may experience numbness, tingling, pain (sensory symptoms), or reductions in strength (motor symptoms) that present in a stocking-glove distribution [2]. CIPN may linger long after treatment completion if not adequately assessed and managed during neurotoxic chemotherapy treatment [5].

Several recent studies have investigated the impact of CIPN symptoms on physical function during and after neurotoxic chemotherapy treatment [6,7,8,9]. Overall, the data suggest that individuals with sensory and/or motor CIPN symptoms report a decrease in physical function and an increase in the number of falls in comparison to individuals without CIPN symptoms. Specifically, Kolb et al. [6] reported that of 116 individuals receiving neurotoxic chemotherapy, individuals with sensory CIPN symptoms (n = 32) were 2.7 times more likely to have a fall or near fall event than those without sensory CIPN symptoms. Decreased physical function due to unmanaged CIPN symptoms may result in 1) increased health care utilization (e.g., cost of care) [10], 2) the inability to return to work immediately following treatment [11], and 3) difficulty completing daily activities [12]. However, despite the known negative effects of unmanaged CIPN symptoms on physical function, CIPN is not routinely assessed in clinical practice [13, 14]. Novel interventions are needed that prioritize the early identification of CIPN symptoms to provide prompt treatment (e.g., chemotherapy dose modification or supportive care strategies such as duloxetine) [15, 16] and referral to rehabilitation services [17,18,19] to reduce the impact of unmanaged CIPN symptoms on physical function [9].

Electronic care planning systems that 1) facilitate patient-clinician discussions about cancer treatment-related toxicities, 2) provide recommendations for self-care and referral to other support services, and 3) promote patients’ activation in cancer symptom management have shown promise in improving the assessment and management of cancer-related symptoms, such as CIPN, in clinical practice [20,21,22,23]. The Electronic Symptom Assessment – Cancer (ESRA-C) [23] is a web-based symptom self-report and self-care intervention that collects patient reported data through the administration of standardized questionnaires in between and prior to the patients’ clinic visits. In addition, based on the patient’s symptoms and/or quality of life issues, the platform provides patients with self-care education, instructions about how to communicate symptoms to the provider, and the ability to monitor symptom progression over time (e.g., graphs, journal). Further, the platform creates a summary of reports for clinicians about symptoms (i.e., based on severity scores associated with patient reported outcome measures). The use of these embedded tools may facilitate the early identification and management of CIPN symptoms via increased patient self-report and patient-provider communication about CIPN symptoms. Despite inclusion of physical function and CIPN assessment and self-care strategies, a formal comparison of the benefits of the ESRA-C have not been reported for patients receiving platinum or taxane-based chemotherapy.


The purpose of this analysis is to compare self-reported physical function of participants receiving platinum and taxane-based chemotherapy regimens randomized to the ESRA-C intervention or electronic symptom assessment alone. Secondary measures include pain intensity, sensory CIPN, motor CIPN, fatigue, depression, and insomnia.



Subjects included in this analysis are a subset of those who participated in a multicenter, randomized-controlled trial [23]. Participants are included if they received a platinum (i.e., oxaliplatin or cisplatin) or taxane-based (i.e., paclitaxel or docetaxel) chemotherapy regimen and completed the baseline (T1) and end-of-treatment (T3/4) time points. Participants were recruited from two large comprehensive cancer centers in Seattle, WA and Boston, MA. All data in this analysis came from participants receiving care in Boston because Seattle participation was limited to bone marrow transplant recipients.


European organisation for research and treatment of cancer quality of life core questionnaire 30 (EORTC QLQ C-30)

The QLQ C-30 is a 30-item measure that consists of 15 functional and/or symptom scales [24]. To evaluate the impact of neurotoxic chemotherapy on physical function, we used the five-item Physical Functioning Scale. The Physical Functioning Scale measures patient’s perceptions of difficulty with activities of daily living, strenuous activity, and walking over the past week. Each of the five items is rated on an 1–4 scale. The total score is transformed to a 0–100 scale, with higher scores representing greater physical function [25]. The QLQ C-30 Physical Functioning Scale was used as the primary measure of physical function in this analysis (physical functioning impairments due to CIPN were measured separately) because the scale is the most commonly administered measure of physical function in cancer clinical trials [26] and a myriad of co-occurring symptoms (e.g., anxiety, depression, fatigue, pain, insomnia) related to chemotherapy administration may lead to reductions in physical function [27,28,29], not CIPN alone. The 3-item fatigue and 1-item insomnia symptom scales were used to measure the secondary measures of fatigue and insomnia, respectively. The Fatigue Symptom Scale measures self-reported feelings of tiredness (e.g., need for rest) during the day over the past week. The Insomnia Symptom Scale asks participants if they had trouble sleeping during the night over the past week. The items of each respective measure are scored on an 1–4 scale, with total transformed scores ranging from 0 to 100 (higher scores represent worse severity) [25]. Several studies provide evidence supporting the reliability and validity of the QLQ C-30 for use in individuals with cancer [24, 30, 31].


The QLQ-CIPN20 is comprised of three subscales that measure CIPN symptoms and associated functional deficits specific to each subscale [32]. Only responses to the sensory and motor subscales were evaluated in this study because recent studies indicate that the autonomic subscale has suboptimal reliability and/or validity [33]. The items of the sensory and motor subscales are scored on an 1–4 scale, with total transformed scores ranging from 0 to 100 (higher scores represent worse neuropathy). Studies have reported high reliability, discriminant validity, and responsiveness to change of the sensory and motor subscales [33]. To further explore the effect of the ESRA-C intervention on sensory and motor CIPN, we categorized participants based on the amount of neurotoxic chemotherapy received during the study. The categories (low, moderate, or high dose) were created based on cumulative dose ranges associated with increased CIPN severity [34,35,36,37]. The footnote of Table 1 further describes the dose ranges for paclitaxel, docetaxel, cisplatin, and oxaliplatin that constituted the low, moderate, and high dose categories.

Patient health questionnaire 9 (PHQ-9)

The PHQ-9 measures patient’s perceptions of their mood (e.g., feeling tired, lack of interest in doing things) over the past two weeks. Each item is scored from 0 to 3, with total scores ranging from 0 to 27 (higher scores represent worse depression) [38]. The PHQ-9 has demonstrated sufficient internal consistency reliability [39] and construct validity (strong associations between PHQ-9 scores and functional status) [39].

0–10 current pain intensity numerical scale (PINS)

Participants rated current pain on a scale of 0–10, with a score of “0” representing “no pain,” and a score of “10” representing the “worst pain you can imagine.” The use of a 0–10 numerical rating scale of pain intensity is recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials [40] and the scale’s strong psychometric properties are well documented [41, 42].


The primary randomized-controlled trial was fully reported elsewhere [23]. Briefly, following informed consent, participants completed the baseline assessments (e.g., QLQ-C30, QLQ-CIPN20, PHQ-9) via home computer or computer tablet before beginning their new chemotherapy regimen (T1). Participants were then randomized (via computer application) in an 1:1 ratio to the intervention or control group (blocks of four based on self-identification as a home or clinic user). Participants in both groups used the ESRA-C program to self-report symptoms and quality of life measures at each clinic visit and the intervention group could access the program at home (at their discretion) in between clinic visits. When an intervention group participant reported a specific symptom as moderate to severe (see Table 3 for cut points associated with each measure), the software prompted the participants to view three self-care messages: 1) education about why the symptom occurs, 2) how the symptom can be managed (e.g., links to local content and from national cancer organizations), and 3) how to talk to providers about the symptom. Intervention group participants also could use the ESRA-C to track symptom patterns at home by viewing graphs that displayed symptom severity scores over time and documenting self-care activities in a journal. CIPN-related self-care information focused on how to stay safe with neuropathy symptoms (e.g., wear gloves when outside in cold temperatures, using hot water, or handling sharp objects; use non-slip rugs in the house, ensure house is well lit when walking at night) [19]. Intervention group participants could access all self-care messages at any time during the study regardless if they scored above the pre-defined symptom threshold. Control group participants did not receive self-care messages for problematic symptoms or have the ability to track symptoms over time. Within 24 h of each clinic visit, the ESRA-C was to be completed, and participants in both groups received usual education (e.g., clinician assessment and symptom management education) and the clinicians received a graphical summary of symptom severity scores. All participants completed the assessment measures via the ESRA-C three to six weeks after beginning a new chemotherapy regimen (T2), two four weeks after the second-time point (T3), and two to four weeks after treatment completion (T4). If a participant finished treatment before T3, the T4 assessment was not administered. Information pertaining to enrolled participants’ cancer diagnosis, neurotoxic chemotherapy type, and neurotoxic chemotherapy dose was abstracted from the electronic medical record during the study.

Statistical analysis

Descriptive statistics are calculated for all measures at each time point. Boxplots are used to graphically show the changes over time. Due to the low amount of missing data for the primary and secondary outcomes (< 5%), mean imputation is used to handle missing data. Baseline characteristics are compared using Wilcoxon rank-sum test and Fisher’s exact test for continuous and categorical variables, respectively.

In the analysis, a mixed effects model allowing for subject specific intercept and slopes is used to evaluate if there are significant differences in the changes in physical function, fatigue, insomnia, depression, sensory CIPN, motor CIPN, and pain intensity scores over time between the two groups. This model adjusted for age at baseline (T1). All data are analyzed using R version 3.3.2 [43]. The lme function of the nlme package of the R language is used for linear mixed models [44]. Results with p-values ≤0.05 are considered statistically significant. No adjustment for multiple outcome comparisons is performed for the secondary measures. The interpretation of the time by treatment interaction coefficient from the mixed model depend on the direction of the time effect. For example, if the scores are decreasing over time and the interaction coefficient is negative (positive), this means the intervention group scores decrease at a higher (lower) rate than the control group. Alternatively, if the scores are increasing over time and the interaction coefficient is negative (positive), this means the intervention group scores increase at a lower (higher) rate than the control group scores.

To provide information on how often intervention group participants were prompted to view the ESRA-C self-care messages, we report the frequency of intervention group participants’ symptom severity scores that were high enough to prompt the receipt of the self-care messages.


Sample characteristics

Of the 752 (374 intervention; 378 control) enrolled participants in the primary, randomized-controlled trial, 220 (29.2%) (108 intervention; 112 control) are eligible for this analysis. We initially excluded 482 participants from this analysis because these participants were not receiving neurotoxic chemotherapy (i.e., oxaliplatin, docetaxel, paclitaxel, or cisplatin). Next, of the 270 (140 intervention; 130 control) participants receiving neurotoxic chemotherapy, 50 participants were excluded from this analysis because they did not complete the T3/4 outcome assessments (i.e., 42% lost to follow up, 36% voluntary withdrawal, 22% other reasons such as death). The subjects at T1 were a median age of 54 (Range = 22–87) years old, mainly female, Caucasian, and employed/working. In terms of cancer treatment characteristics, most subjects: 1) received care in the medical oncology service, 2) had a diagnosis of breast cancer, 3) received taxane-based chemotherapy, and 4) had Stage III or IV cancer severity. There were no statistically significant between-group differences in demographic or cancer treatment-related characteristics at baseline (Table 1, p > 0.05). Baseline scores for the primary or secondary outcomes were not significantly different by treatment group for any of the measures (Table 2, p > 0.05 via two-sample t-test).

Table 1 Demographic and Cancer Treatment-Related Characteristics (N = 220)
Table 2 Scores for Primary and Secondary Outcomes Over Time (N = 220)

Physical function

Intervention group participants reported decreases in QLQ-C30 Physical Functioning Scale scores from 87.4 (SD = 15.6) at baseline to 84.5 (SD = 16.1) at T3/4, whereas control group participants reported decreases in QLQ-C30 Physical Functioning Scale scores from 90.2 (SD = 12.7) at baseline to 81.8 (SD = 17.0) at T3/4 (Fig. 1). The difference in physical function between groups over time was statistically significant (interaction coefficient = 2.75, p = 0.011) (Table 2). Since the physical scores are decreasing over time and the interaction coefficient is positive, the intervention group scores decrease at a lower rate than the control group.

Fig. 1

Physical Function Scores Across Time by Treatment (N = 220). a Baseline Physical Function Scores; Note: Higher scores represent greater physical function at baseline. b Mean Change in T2 and End of Study (T3/4) Physical Function Scores from Baseline. Note: Negative scores represent decreased physical function from baseline

Secondary measures

Intervention group participants experienced significantly less depression in comparison to control group participants (interaction coefficient = − 0.72, p = 0.005) (Fig. 2). Since the depression scores are higher at post baseline assessments relative to baseline and the interaction coefficient is negative, the intervention group scores increase at a lower rate than the control group. Differences in fatigue severity over time were marginally significant (p = 0.053) and in favor of the intervention group (Fig. 3). There were no significant differences in mean scores over time between groups for the variables of sensory CIPN (p = 0.141), motor CIPN (p = 0.122), pain intensity (p = 0.500), or insomnia (p = 0.760) (Table 2). Results from an exploratory subgroup analysis (n = 84) revealed that within individuals who were receiving high cumulative neurotoxic chemotherapy dosages [34,35,36,37], intervention group participants reported less severe sensory CIPN symptoms with maximum change of 9.8 as compared to 21.2 for control participants (p = 0.007) as well as less severe motor CIPN symptoms with maximum change of 4.4 as compared to 11.3 for control participants (p = 0.039) (Table 2; Figs. 4 and 5).

Fig. 2

Mean Change in T2 and End of Study (T3/4) Depression Scores from Baseline (N = 220). Note: Positive scores represent increased depression severity from baseline

Fig. 3

Mean Change in T2 and End of Study (T3/4) Fatigue Scores from Baseline (N = 220). Note: Positive scores represent increased fatigue severity from baseline

Fig. 4

Mean Change in T2 and End of Study (T3/4) Sensory CIPN Scores from Baseline in Participants Receiving High Cumulative Neurotoxic Chemotherapy Dosages (N = 84). Note: Positive scores represent increased sensory CIPN severity from baseline

Fig. 5

Mean Change in T2 and End of Study (T3/4) Motor CIPN Scores from Baseline in Participants Receiving High Cumulative Neurotoxic Chemotherapy Dosages (N = 84). Note: Positive scores represent increased motor CIPN severity from baseline

Prompted ESRA-C intervention messages

Table 3 describes the number of times that intervention group participants scored above the pre-specified severity threshold associated with each symptom questionnaire to prompt the receipt of symptom specific ESRA-C self-care messages. Overall, the frequency of prompted self-care messages across the three time points for physical function (Range = 2–5%), sensory CIPN (Range = 1–3%), motor CIPN (Range = 2–4%), and depression (Range = 9–14%) were low, while the frequency of prompted self-care messages for fatigue (Range = 28–44%), insomnia (Range = 17–31%), and current pain intensity (Range = 17–21%) were higher.

Table 3 Frequency of Intervention Group Participants Scoring Above the Pre-Specified Symptom Severity Thresholds to Prompt Receipt of ESRA-C Self-Care Messages (N = 108)


The findings from this secondary analysis revealed that intervention group participants reported less reduction in physical function in comparison to control group participants following use of the ESRA-C. Control group participants’, but not intervention group participants’, mean physical function score at the end of treatment met the threshold for clinical importance (≤ 83/100) [45] and mean change in physical function score from baseline to posttest approached the minimal clinically meaningful difference for deterioration ( -9) [46]. However, our results should be interpreted with caution as there were no differences in sensory or motor CIPN severity between groups. To our knowledge, this analysis is among the first to explore the efficacy of a web-based symptom assessment and management platform to preserve physical function in a large sample of individuals receiving neurotoxic chemotherapy. Previous studies have examined the implementation of electronic assessment and management platforms in practice on outcomes such as technology usability [20], patient activation [21], and provider documentation of CIPN assessment and management [47] in individuals receiving neurotoxic chemotherapy. Additionally, Tofthagen and colleagues developed an algorithm to guide nursing management of CIPN symptoms and associated functional impairment [48] that was later incorporated into a web-based psychoeducational intervention for individuals with acute CIPN symptoms. Results of the intervention study revealed that use of the web-based psychoeducational program led to improvements in pain-related interference (d = 0.39, N = 14) [49]. Finally, the authors of a secondary analysis evaluated an automated telephone symptom reporting system for chemotherapy-related neuropathic pain management in patients receiving taxane or platnium-based chemotherapy agents. During chemotherapy, intervention and control group participants (N = 252) called the telephone system every day to self-report chemotherapy-related symptoms, but intervention group participants received automated self-management information and nurse practitioner follow up phone calls for more severe symptoms. Participants in the intervention group reported less days with moderate (p < 0.001) and severe CIPN symptoms (p = 0.006) and decreased activity interference due to CIPN (p = 0.08) in comparison to control group participants [22].

While intervention group participants reported less reduction in physical function in comparison to control group participants, little is known about the possible mechanisms by which physical function was preserved. The principles of causal mediation state that the intervention must significantly affect the hypothesized mediator in comparison to the control for mediation to occur [50]. Depression was the only symptom where significant differences were observed between treatment groups. While it is possible that depression was a significant mediator of physical function preservation, it is unlikely that improvements in depression alone mediated physical function preservation as the change in mean depression severity score between groups was not clinically significant [51]. Further, our original hypothesis was that interventions like the ESRA-C may work to prevent reductions in physical function in individuals receiving neurotoxic chemotherapy by increasing the early identification and management of CIPN (e.g., referral to specialty services such as neurology or physical therapy, chemotherapy dose modification). As there were no formal clinical practice guidelines for CIPN management when the original trial was conducted (2009–2011), chemotherapy-dose reduction would have been one of the primary treatments for patients with CIPN [19]. Thus, our results provide evidence against our initial hypothesis as there were no differences in sensory or motor CIPN severity between treatment groups and there were no differences in the frequency of neurotoxic chemotherapy dose reduction due to CIPN. We may not have observed differences in many of the secondary outcomes because symptom severity scores were low, and few participants scored high enough on the associated measures to prompt the receipt of symptom specific self-care messages. As such, it is puzzling that in individuals receiving cumulative neurotoxic chemotherapy dosages that were associated with more severe CIPN, intervention group participants reported less severe sensory and motor CIPN than control group participants. A replication study in the future may be warranted as more is currently known about evidence-based treatments for CIPN (i.e., duloxetine 60 mg/day) [15, 16].

It is possible that intervention group participants reported better physical function at posttest in comparison to control group participants because they experienced small improvements in all symptoms. This hypothesis may be partially explained using the Theory of Unpleasant Symptoms (TOUS) as a guiding framework [52]. Per the TOUS, it is hypothesized that physical and psychological influencing factors (i.e., depression, insomnia, fatigue), symptoms (i.e., sensory/motor CIPN, pain intensity), and performance outcomes (i.e., physical function) all influence one another. Intervention group participants may have been able to experience small improvements in multiple symptoms because while few scored high enough on the study specific scales associated with each outcome measure to prompt the receipt of self-care messages, previous research suggests that a majority (233/374, 62.3%) of intervention group participants in the original trial were exposed to the ESRA-C intervention (e.g., clicked on self-care messages or symptom reports at least twice) [53]. Many intervention group participants may still have been able to use the strategies (e.g., patient-provider communication strategies) and self-care information to increase patient activation in cancer treatment-related symptom management [21]. In sum, our findings highlight the need for further research to determine variables that mediate physical function preservation following the implementation of web-based symptom assessment and management interventions to tailor such interventions in the future to variables known to positively influence physical function.

Due to the lack of differences in sensory or motor CIPN between groups, the ESRA-C intervention may be modified in the future to further bolster strategies for the self-management of CIPN and associated symptoms to ultimately preserve physical function. Recent evidence has revealed that increased BMI and low participation in moderate-vigorous physical activity are associated with the development of CIPN [54]. Thus, self-management programs that encourage daily physical activity may be a promising treatment approach. Two recent prospective trials provide evidence supporting the efficacy of exercise interventions in reducing CIPN symptoms and/or improving function in patients receiving chemotherapy [55, 56]. Further, cognitive behavioral pain management strategies (e.g., sleep hygiene, relaxation, activity pacing) [57] have been shown to have a positive effect on common cancer treatment-related symptoms (e.g., pain, anxiety, fatigue, insomnia) [58,59,60]. Specifically, the authors of a recent randomized controlled trial demonstrated that the delivery of cognitive behavioral pain management strategies via the internet may significantly improve worst CIPN pain severity in individuals with chronic painful CIPN [60]. Taken together, incorporating exercise and cognitive behavioral strategies into web-based symptom assessment and management platforms like the ESRA-C, may provide patients with additional efficacious self-management strategies to improve CIPN symptoms and preserve physical function during neurotoxic chemotherapy treatment.

The results of this study have several implications for practice. Nurses may consider implementing common components of web-based technology such as the ESRA-C to facilitate patient-nurse communication about cancer treatment-related symptoms during neurotoxic chemotherapy administration. Components of the ESRA-C that nurses may translate to their practice include: 1) using standardized patient-reported outcome measures to help patients identify cancer treatment-related symptoms and 2) providing self-care instruction for cancer treatment-related symptoms. Increased patient-nurse communication about cancer treatment-related symptoms may lead to earlier identification and management of symptoms, thereby preventing reductions in physical function in individuals receiving neurotoxic chemotherapy.


This study has several limitations. First, symptom severity scores for all secondary outcomes were fairly low, and therefore, we may not have observed any statistically significant differences between groups in some outcomes due to a floor effect. Similarly, there were many cases in which individuals in the intervention arm did not score high enough on the associated symptom measures to trigger the receipt of the additional ESRA-C self-care messages. This limitation is a potential threat to internal validity because in these cases, the content of the intervention and control arms were not significantly different. Second, the effect of the ESRA-C intervention on physical function was evaluated soon after the completion of chemotherapy treatment or late within the treatment course. It is important to evaluate long term outcomes in individuals with CIPN because CIPN symptoms may persist or worsen after the completion of treatment, especially following platinum-based chemotherapy [35]. Third, this study was conducted in a homogenous patient population (Caucasian, middle aged, receiving care at comprehensive cancer centers) and subsequently, our results may not be widely generalizable. Fourth, this analysis used a subset of the full sample from the primary study and may be underpowered for all outcome comparisons. Finally, patients and clinicians were not blinded to treatment assignment in the original randomized-controlled trial.


CIPN is a common toxicity of neurotoxic chemotherapy treatment that can impair physical function during and months to years after the completion of treatment. The findings of this analysis suggest that use of a web-based symptom assessment and management platform (ESRA-C) may positively affect physical functioning during neurotoxic chemotherapy treatment. Yet, our results must be interpreted cautiously as this was an exploratory analysis, little is known as to how the ESRA-C intervention worked to prevent reductions in physical function, and there were no differences in sensory or motor CIPN severity between treatments. Overall, based on the positive results of this secondary analysis, and dearth of prospective studies, future research is needed to test interventions that improve the assessment and management of CIPN in clinical practice to prevent reductions in physical function related to unmanaged CIPN symptoms.

Change history

  • 13 May 2019




Chemotherapy-induced peripheral neuropathy


European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire 30


European Organisation for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy twenty-item scale


Electronic Symptom Assessment – Cancer


Patient Health Questionnaire 9


0–10 Current Pain Intensity Numerical Scale


Theory of Unpleasant Symptoms


  1. 1.

    Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30.

  2. 2.

    Argyriou AA, Bruna J, Marmiroli P, Cavaletti G. Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit Rev Oncol Hematol. 2012;82:51–77.

  3. 3.

    Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Pain. 2014;155:2461–70.

  4. 4.

    Fukuda Y, Li Y, Segal RA. A mechanistic understanding of axon degeneration in chemotherapy-induced peripheral neuropathy. Front Neurosci. 2017;11:481.

  5. 5.

    Ewertz M, Qvortrup C, Eckhoff L. Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncol (Madr). 2015;54:587–91.

  6. 6.

    Kolb NA, Smith AG, Singleton JR, Beck SL, Stoddard GJ, Brown S, et al. The association of chemotherapy-induced peripheral neuropathy symptoms and the risk of falling. JAMA Neurol. 2016;73:860.

  7. 7.

    Monfort SM, Pan X, Patrick R, Ramaswamy B, Wesolowski R, Naughton MJ, et al. Gait, balance, and patient-reported outcomes during taxane-based chemotherapy in early-stage breast cancer patients. Breast Cancer Res Treat. 2017;164:69–77.

  8. 8.

    Simon NB, Danso MA, Alberico TA, Basch E, Bennett A V. The prevalence and pattern of chemotherapy-induced peripheral neuropathy among women with breast cancer receiving care in a large community oncology practice. Qual Life Res. 2017;1–10. doi:

  9. 9.

    Winters-Stone KM, Horak F, Jacobs PG, Trubowitz P, Dieckmann NF, Stoyles S, et al. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J Clin Oncol. 2017;35:2604–12.

  10. 10.

    Pike CT, Birnbaum HG, Muehlenbein CE, Pohl GM, Natale RB. Healthcare costs and workloss burden of patients with chemotherapy-associated peripheral neuropathy in breast, ovarian, head and neck, and nonsmall cell lung cancer. Chemother Res Pract. 2012;2012:913848.

  11. 11.

    Zanville NR, Nudelman KNH, Smith DJ, Von Ah D, McDonald BC, Champion VL, et al. Evaluating the impact of chemotherapy-induced peripheral neuropathy symptoms (CIPN-sx) on perceived ability to work in breast cancer survivors during the first year post-treatment. Support Care Cancer. 2016;24:4779–89.

  12. 12.

    Beijers A, Mols F, Dercksen W, Driessen C, Vreugdenhil G. Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy. J community Support Oncol. 2014;12:401–6.

  13. 13.

    Smith EML, Campbell G, Tofthagen C, Kottschade L, Collins ML, Warton C, et al. Nursing knowledge, practice patterns, and learning preferences regarding chemotherapy-induced peripheral neuropathy. Oncol Nurs Forum. 2014;41:669–79.

  14. 14.

    Alberti P, Rossi E, Cornblath DR, Merkies ISJ, Postma TJ, Frigeni B, et al. Physician-assessed and patient-reported outcome measures in chemotherapy-induced sensory peripheral neurotoxicity: two sides of the same coin. Ann Oncol. 2014;25:257–64.

  15. 15.

    Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309:1359–67.

  16. 16.

    Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32:1941–67.

  17. 17.

    Schwenk M, Grewal GS, Holloway D, Muchna A, Garland L, Najafi B. Interactive sensor-based balance training in older cancer patients with chemotherapy-induced peripheral neuropathy: a randomized controlled trial. Gerontology. 2016;62:553–63.

  18. 18.

    Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, et al. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2018;26:615–24.

  19. 19.

    Stubblefield MD, Burstein HJ, Burton AW, Custodio CM, Deng GE, Ho M, et al. National comprehensive cancer network task force report: management of neuropathy in cancer. J Natl Compr Cancer Netw. 2009;7(Suppl 5):S1–S26.

  20. 20.

    Knoerl R, Dudley WN, Smith G, Bridges C, Kanzawa-Lee G, Lavoie Smith EM. Pilot testing a web-based system for the assessment and management of chemotherapy-induced peripheral neuropathy. CIN Comput Informatics Nurs. 2016;1. doi:

  21. 21.

    Knoerl R, Lee D, Yang J, Bridges C, Kanzawa-Lee G, Lita Smith G, et al. Examining the impact of a web-based intervention to promote patient activation in chemotherapy-induced peripheral neuropathy assessment and management. J Cancer Educ. 2017;1–9. doi:

  22. 22.

    Kolb NA, Smith AG, Singleton JR, Beck SL, Howard D, Dittus K, et al. Chemotherapy-related neuropathic symptom management: a randomized trial of an automated symptom-monitoring system paired with nurse practitioner follow-up. Support Care Cancer. 2018;26:1607–15.

  23. 23.

    Berry DL, Hong F, Halpenny B, Partridge AH, Fann JR, Wolpin S, et al. Electronic self-report assessment for cancer and self-care support: results of a multicenter randomized trial. J Clin Oncol. 2014;32:199–205.

  24. 24.

    Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The european organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–76.

  25. 25.

    Fayers P, Aaronson N, Bjordal K, Groenvold M, Curran D, Bottomley A, et al. EORTC QLQ-C30 scoring manual. 3rd ed. Brussels; 2001.

  26. 26.

    Atkinson TM, Stover AM, Storfer DF, Saracino RM, D’Agostino TA, Pergolizzi D, et al. Patient-reported physical function measures in cancer clinical trials. Epidemiol Rev. 2017;39:59–70.

  27. 27.

    Miaskowski C, Barsevick A, Berger A, Casagrande R, Grady PA, Jacobsen P, et al. Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations. J Natl Cancer Inst. 2017;109:djw253.

  28. 28.

    Dong ST, Costa DSJ, Butow PN, Lovell MR, Agar M, Velikova G, et al. Symptom clusters in advanced Cancer patients: an empirical comparison of statistical methods and the impact on quality of life. J Pain Symptom Manag. 2016;51:88–98.

  29. 29.

    Hwang K-H, Cho O-H, Yoo Y-S. Symptom clusters of ovarian cancer patients undergoing chemotherapy, and their emotional status and quality of life. Eur J Oncol Nurs. 2016;21:215–22.

  30. 30.

    Kaasa S, Bjordal K, Aaronson N, Moum T, Wist E, Hagen S, et al. The EORTC Core quality of life questionnaire (QLQ-C30): validity and reliability when analysed with patients treated with palliative radiotherapy. Eur J Cancer. 1995;31:2260–3.

  31. 31.

    Bjordal K, de Graeff A, Fayers P, Hammerlid E, van Pottelsberghe C, Curran D, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. Eur J Cancer. 2000;36:1796–807.

  32. 32.

    Postma TJ, Aaronson NK, Heimans JJ, Muller MJ, Hildebrand JG, Delattre JY, et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20. Eur J Cancer. 2005;41:1135–9.

  33. 33.

    Smith EML, Barton DL, Qin R, Steen PD, Aaronson NK, Loprinzi CL. Assessing patient-reported peripheral neuropathy: the reliability and validity of the european organization for research and treatment of cancer QLQ-CIPN20 questionnaire. Qual Life Res. 2013;22:2787–99.

  34. 34.

    Eckhoff L, Knoop AS, Jensen M-B, Ejlertsen B, Ewertz M. Risk of docetaxel-induced peripheral neuropathy among 1,725 danish patients with early stage breast cancer. Breast Cancer Res Treat. 2013;142:109–18.

  35. 35.

    Grisold W, Cavaletti G, Windebank AJ. Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol. 2012;14(Suppl 4):iv45–54.

  36. 36.

    Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8:86.

  37. 37.

    Pace A, Nisticò C, Cuppone F, Bria E, Galiè E, Graziano G, et al. Peripheral neurotoxicity of weekly paclitaxel chemotherapy: a schedule or a dose issue? Clin Breast Cancer. 2007;7:550–4.

  38. 38.

    Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire. JAMA. 1999;282:1737–44.

  39. 39.

    Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.

  40. 40.

    Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005;113:9–19.

  41. 41.

    Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manag. 2011;41:1073–93.

  42. 42.

    Li L, Liu X, Herr K. Postoperative pain intensity assessment: a comparison of four scales in Chinese adults. Pain Med. 2007;8:223–34.

  43. 43.

    R Development Core Team. R: A language and environment for statistical computing. 2017.

  44. 44.

    Pinheiro J, Bates D, DebRoy S, Sarkar D, R Development Core Team. nlme: Linear and Nonlinear Mixed Effects Models (R Package Version 3.1–137). 2018.

  45. 45.

    Giesinger JM, Kuijpers W, Young T, Tomaszewski KA, Friend E, Zabernigg A, et al. Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain. Health Qual Life Outcomes. 2016;14:87.

  46. 46.

    Maringwa J, Quinten C, King M, Ringash J, Osoba D, Coens C, et al. Minimal clinically meaningful differences for the EORTC QLQ-C30 and EORTC QLQ-BN20 scales in brain cancer patients. Ann Oncol. 2011;22:2107–12.

  47. 47.

    Knoerl R, Bridges C, Smith G, Yang J, Kanzawa-Lee G, Smith E. Chemotherapy-induced peripheral neuropathy: use of an electronic care planning system to improve adherence to recommended assessment and management practices. Clin J Oncol Nurs. 2018;22:E134–40.

  48. 48.

    Tofthagen C, Visovsky CM, Hopgood R. Chemotherapy-induced peripheral neuropathy: an algorithm to guide nursing management. Clin J Oncol Nurs. 2013;17:138–44.

  49. 49.

    Tofthagen C, Kip KE, Passmore D, Loy I, Berry DL. Usability and acceptability of a web-based program for chemotherapy-induced peripheral neuropathy. Comput Inform Nurs. 2016;34:322–9.

  50. 50.

    Imai K, Keele L, Tingley D. A general approach to causal mediation analysis. Psychol Methods. 2010;15:309–34.

  51. 51.

    Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care. 2004;42:1194–201.

  52. 52.

    Lenz ER, Pugh LC, Milligan RA, Gift A, Suppe F. The middle-range theory of unpleasant symptoms: an update. ANS Adv Nurs Sci. 1997;19:14–27.

  53. 53.

    Berry DL, Blonquist TM, Patel RA, Halpenny B, McReynolds J. Exposure to a patient-centered, Web-based intervention for managing cancer symptom and quality of life issues: impact on symptom distress. J Med Internet Res. 2015;17:e136.

  54. 54.

    Greenlee H, Hershman DL, Shi Z, Kwan ML, Ergas IJ, Roh JM, et al. BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study. J Natl Cancer Inst. 2017;109:djw206.

  55. 55.

    Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, et al. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2017;1–10. doi:

  56. 56.

    Kleckner IR, Kamen C, Gewandter JS, Mohile NA, Heckler CE, Culakova E, et al. Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial. Support Care Cancer. 2017.

  57. 57.

    Kerns RD, Sellinger J, Goodin BR. Psychological treatment of chronic pain. Annu Rev Clin Psychol. 2011;7:411–34.

  58. 58.

    Kwekkeboom KL, Abbott-Anderson K, Cherwin C, Roiland R, Serlin RC, Ward SE. Pilot randomized controlled trial of a patient-controlled cognitive-behavioral intervention for the pain, fatigue, and sleep disturbance symptom cluster in Cancer. J Pain Symptom Manag. 2012;44:810–22.

  59. 59.

    Carlson LE, Zelinski E, Toivonen K, Flynn M, Qureshi M, Piedalue K-A, et al. Mind-body therapies in Cancer: what is the latest evidence? Curr Oncol Rep. 2017;19:67.

  60. 60.

    Knoerl R, Smith EML, Barton DL, Williams DA, Holden JE, Krauss JC, et al. Self-guided online cognitive behavioral strategies for chemotherapy-induced peripheral neuropathy: a multicenter, pilot, randomized, Wait-List Controlled, Trial. J Pain. 2018;19:382–94.

  61. 61.

    McCorkle R. The measurement of symptom distress. Semin Oncol Nurs. 1987;3:248–56.

Download references


The authors would like to acknowledge Fangxin Hong, PhD and Traci Blonquist, MS for statistical consultation. This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102) and financial contributions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic healthcare centers, or the National Institutes of Health.


Original data generated with support from R01 NR008726 (2008–2010); National Institute of Nursing Research, National Institutes of Health. The funding source had no role in the design of the study, data collection, data analysis, or manuscript writing.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

RK was primarily responsible for the writing of this manuscript and was involved in all aspects of data analysis pertinent to this secondary analysis. DB contributed to the design, conduct, and analysis of the primary randomized controlled trial (Principal Investigator). DB also contributed to manuscript writing in this current secondary analysis. BH contributed to the design, conduct, and analysis of the primary randomized controlled trial and was also involved in the writing of this current manuscript. EW conducted the statistical analyses of this secondary analysis and was involved in manuscript writing. All authors have read and approved the final manuscript.

Correspondence to Robert Knoerl.

Ethics declarations

Authors’ information

Not applicable

Ethics approval and consent to participate

The conduct of the primary randomized controlled study was reviewed and regulated by the Dana-Farber Cancer Institute Office for Human Research Studies (Protocol #08–284). All study participants provided written consent to participate in the trial.

Consent for publication

Not applicable

Competing interests

RK and DB are supported by the Mittelman Family Fund. DB reports grants from the National Institute of Nursing Research during the conduct of the study and RK reports a consulting honorarium from System Analytic, otherwise, the authors declare no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Knoerl, R., Weller, E., Halpenny, B. et al. Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in individuals receiving neurotoxic chemotherapy. BMC Cancer 18, 1203 (2018).

Download citation


  • Peripheral nervous system diseases/chemically-induced
  • Chemotherapy-induced peripheral neuropathy
  • Electronic symptom assessment
  • Technology assessment
  • Cancer symptom management