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Table 2 Scores for Primary and Secondary Outcomes Over Time (N = 220)

From: Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in individuals receiving neurotoxic chemotherapy

  Mean (SD) Mean Change from Baseline (SD) Model Estimate (95% CI, p)b
Outcomesa Intervention Control Intervention Control Interaction effect
Physical Function
 Baseline 87.4 (15.6) 90.2 (12.7)    2.75 (0.65, 4.86), p = 0.011
 Time 2 85.2 (17.5) 83.9 (16.7) −2.2 (15.2) −6.3 (14.1)
 Time 3/4 84.5 (16.1) 81.8 (17.0) −2.9 (15.0) −8.5 (16.8)
Depression
 Baseline 4.2 (4.4) 3.5 (3.4)    −0.72 (−1.23, − 0.22) p = 0.005
 Time 2 4.9 (4.0) 5.4 (3.3) 0.7 (3.5) 1.9 (3.2)
 Time 3/4 3.9 (3.6) 4.64 (4.3) −0.3 (3.4) 1.2 (4.2)
Fatigue
 Baseline 27.7 (20.5) 23.8 (18.9)    − 3.12 (−6.29, 0.04) p = 0.053
 Time 2 37.6 (23.5) 41.0 (22.8) 9.8 (21.0) 17.3 (22.7)
 Time 3/4 34.4 (21.8) 36.7 (21.0) 6.7 (21.4) 12.9 (23.8)
CIPN Sensory
 Baseline 3.9 (9.6) 3.3 (6.6)    −1.67 (−3.90, 0.55) p = 0.141
 Time 2 7.8 (11.9) 6.4 (10.3) 4.0 (9.7) 3.1 (9.1)
 Time 3/4 12.9 (14.3) 15.7 (18.2) 9.0 (14.2) 12.4 (19.0)
CIPN Motor
 Baseline 4.5 (10.1) 2.5 (4.0)    −1.3 (−2.95, 0.35) p = 0.122
 Time 2 5.7 (11.5) 5.3 (7.4) 1.2 (6.2) 2.8 (6.6)
 Time 3/4 8.9 (12.7) 9.6 (13.4) 4.5 (11.7) 7.1 (13.1)
Current Pain Intensity
 Baseline 1.7 (1.9) 1.5 (1.9)    −0.09 (−0.37, 0.18) p = 0.500
 Time 2 1.72 (1.9) 1.6 (1.9) 0.03 (2.3) 0.10 (2.2)
 Time 3/4 1.7 (1.9) 1.7 (1.8) 0.00 (1.8) 0.19 (2.2)
Insomnia
 Baseline 28.4 (24.9) 27.7 (26.8)    −0.62 (−4.58, 3.35) p = 0.760
 Time 2 31.2 (29.6) 33.6 (25.9) 2.8 (31.6) 6 (28.7)
 Time 3/4 28.3 (24.9) 28.9 (27.0) −0.05 (24.6) 1.19 (32.2)
High Cumulative Dose Category (n = 84)
 CIPN Sensory      
  Baseline 4.0 (12.3) 3.5 (6.2)    −5.70 (−9.89, −1.60) p = 0.007
  Time 2 8.1(12.7) 7.7 (13.0) 4.1 (10.8) 4.2 (12.7)
  Time 3/4 13.8 (14.3) 24.7 (22.4) 9.8 (14.0) 21.2 (23.9)
CIPN Motor
  Baseline 4.2 (10.7) 2.0 (3.4)    −3.45 (−6.70, −0.19) p = 0.039
  Time 2 4.9 (10.3) 5.1 (7.3) 0.7 (6.0) 3.2 (6.9)
  Time 3/4 8.6 (10.7) 13.3 (17.8) 4.4 (12.9) 11.3 (17.6)
  1. This table describes differences in mean scores for the primary and secondary outcomes over time between treatment groups. There were no statistically significant differences in baseline scores between groups for any outcome (p > 0.05)
  2. aOutcomes include the mean and standard deviation at each time point, the mean change from baseline and standard deviation of this change at the two follow-up time points, and the results from fitting a mixed model
  3. bThis effect represents interaction of time and treatment. For example, if the scores are decreasing over time and the interaction coefficient is negative (positive), this means the intervention group scores decrease at a higher (lower) rate than the control group scores. Alternatively, if the scores are increasing over time and the interaction coefficient is negative (positive), this means the intervention group scores increase at a lower (higher) rate than the control group scores. In this data, scores for all outcomes except for the physical assessment are increasing over time (main effects) and interaction coefficients are negative. Therefore, the interpretation for all outcomes except for physical function is that the intervention group scores increase at a lower rate than the control group scores. For physical function, the intervention group scores decrease at a lower rate as compared to the control group scores