Human papillomavirus-positive oropharyngeal squamous cell carcinoma is increasing in incidence worldwide. Current treatments are associated with high survival rates but often result in significant long-term toxicities. In particular, long-term dysphagia has a negative impact on patient quality of life and health. The aim of PATHOS is to determine whether reducing the intensity of adjuvant treatment after minimally invasive transoral surgery in this favourable prognosis disease will result in better long-term swallowing function whilst maintaining excellent disease-specific survival outcomes.
The study is a multicentre phase II/III randomised controlled trial for patients with biopsy-proven Human papillomavirus-positive oropharyngeal squamous cell cancer staged T1-T3 N0-N2b with a primary tumour that is resectable via a transoral approach. Following transoral surgery and neck dissection, patients are allocated into three groups based on pathological risk factors for recurrence. Patients in the low-risk pathology group will receive no adjuvant treatment, as in standard practice. Patients in the intermediate-risk pathology group will be randomised to receive either standard dose post-operative radiotherapy (control) or reduced dose radiotherapy. Patients in the high-risk pathology group will be randomised to receive either post-operative chemoradiotherapy (control) or radiotherapy alone. The primary outcome of the phase II study is patient reported swallowing function measured using the MD Anderson Dysphagia Inventory score at 12 months post-treatment. If the phase II study is successful, PATHOS will proceed to a phase III non-inferiority trial with overall survival as the primary endpoint.
PATHOS is a prospective, randomised trial for Human papillomavirus-positive oropharyngeal cancer, which represents a different disease entity compared with other head and neck cancers. The trial aims to demonstrate that long-term dysphagia can be lessened by reducing the intensity of adjuvant treatment without having a negative impact on clinical outcome. The study will standardise transoral surgery and post-operative intensity-modulated radiotherapy protocols in the UK and develop a gold-standard swallowing assessment panel. An associated planned translational research programme, underpinned by tumour specimens and sequential blood collected as part of PATHOS, will facilitate further empirical understanding of this new disease and its response to treatment.
This study is registered with ClinicalTrials.gov identifier NCT02215265.
Oropharyngeal squamous cell carcinoma (OPSCC) is a rapidly increasing disease in the UK and other developed countries as a result of Human papillomavirus (HPV) genotype 16 infection. Currently, over 70 % of OPSCC in Europe is HPV 16 positive . HPV status is a strong and independent prognostic factor for survival, and HPV-positive OPSCC has a 58 % reduction in the risk of death compared to HPV-negative OPSCC . Other factors known to influence prognosis in HPV-positive OPSCC include smoking, particularly current smoking, nodal stage and patient comorbidities [2–4].
Currently, the management of OPSCC is based on the stage of disease as well as clinician and patient preference, irrespective of HPV status. Early stage disease is treated with either surgery or radiotherapy (RT) alone, whilst locally advanced disease requires multimodality treatment with primary chemoradiotherapy (CRT) +/- neck dissection or primary surgical resection followed by post-operative RT/CRT. Severe late toxicities after multimodality treatment are reported in up to 43 % of patients and may be permanent . Patients and their carers report dysphagia to be a primary cause for distress, and patient reported dysphagia independently predicts for poor long-term quality of life (QOL) [6, 7]. Patients with HPV-positive OPSCC tend to be young (mean age 54 years) and fit at presentation . Reducing the adverse impact of treatment on function and maintaining good QOL are therefore of paramount importance in these patients who have good prognosis disease.
Role of transoral surgery
With the advent of minimally invasive techniques, such as Transoral Laser Microsurgery (TLM) and Transoral Robotic Surgery (TORS), there has been renewed interest in primary surgical treatment for OPSCC as these techniques result in less morbidity when compared to open surgery. There are as yet no prospective randomised data on TLM/TORS for OPSCC but retrospective studies have demonstrated excellent outcomes. A US study of 204 patients with stage III-IV OPSCC treated with TLM and neck dissection found rates of local control (LC), overall survival (OS) and disease-free survival (DFS) to be 97, 86 and 82 % respectively at 3 years, with HPV-positive OPSCC having even better outcomes . Most patients had adjuvant treatment (RT/CRT), which increased toxicity. Single centre data on TLM in the UK is also encouraging. Data from Liverpool on 153 patients with T1-T3 OPSCC (66 % HPV positive) treated with TLM and neck dissection demonstrate 3 year OS of 84.5 %, disease specific survival (DSS) of 91.7 % and DFS of 78.2 %. Patients with HPV-positive OPSCC had a 71 % reduction in the risk of death. 83.6 % of patients received adjuvant treatment. (TMJ, manuscript submitted). Single institution data also show a functional advantage with upfront transoral surgery compared to primary CRT . A UK study compared swallowing function between 23 patients with locally advanced OPSCC treated with TLM +/- adjuvant therapy and 33 matched patients treated with CRT from a historical cohort and reported improved early swallowing function at 3 months in the upfront surgery group, using 3 different swallowing measures, including the MD Anderson Dysphagia Inventory (MDADI) score .
Adjuvant therapy: risk factors, RT dose and use of chemotherapy
Currently, decisions about adjuvant therapy after surgery are based on the presence of pathological risk factors established more than 20 years ago in studies that included squamous cancers from multiple head and neck anatomical subsites and that did not test for tumour HPV status . These risk factors include surgical margin status, presence of perineural and vascular invasion, number of lymph node metastases and presence of extracapsular spread (ECS) of nodal disease. The relevance of these risk factors in HPV-positive disease has been questioned and the optimum adjuvant treatment protocols for HPV-positive OPSCC are yet to be determined .
Adjuvant RT after surgery for advanced head and neck cancers improved LC in the RTOG 73-03 trial . Subsequent studies recommended a minimum dose of 57.6Gy to the primary site and involved nodal areas and doses of up to 63Gy to areas of ECS . However, lower doses of adjuvant RT may be sufficient for HPV-positive OPSCC based on the following: (i) observations that HPV-positive cell lines show increased radiosensitivity compared to HPV-negative cell lines in vitro [15, 16]; (ii) phase II data (ECOG 1308) showing equivalent LC rates at 2 years with reduced dose RT (54Gy in 27 × 2Gy fractions) in patients with HPV-positive OPSCC who achieved a complete response after 3 cycles of induction chemotherapy ; (iii) use of lower doses of prophylactic RT (50Gy in 35 × 1.4Gy fractions, equivalent to 43Gy in 2Gy fractions) with no increase in recurrences .
The EORTC 22931 and RTOG 9501 Randomised Controlled Trials (RCTs) showed that adjuvant CRT improved LC and DFS compared with adjuvant RT alone in some patients with advanced head and neck cancer [19, 20]. When the results of both studies were pooled, adjuvant CRT significantly improved OS in patients with positive (or ‘involved’) surgical margins and/or presence of nodal ECS . These pathological features are now widely used criteria for adjuvant CRT. There is variation in practice however, particularly around the issue of surgical margins with positive (<1 mm) and close (1-5 mm) margins being grouped together in some studies. A survey of clinical oncologists from 17 UK centres reported that all would recommend adjuvant CRT for positive surgical margins (<1 mm) whilst only 30 % would advocate its use for close margins (1–5 mm) and 88 % for ECS . The relevance of the EORTC 22931 and RTOG 9501 study results should be questioned in the context of HPV-positive OPSCC. Patients in these studies had tumours from multiple head and neck anatomical subsites and the prevalence rate of HPV-positive OPSCC would have been significantly lower than the current rate . Evidence for using adjuvant CRT after transoral surgery for OPSCC is also lacking. A retrospective study of TLM for advanced OPSCC showed that the addition of chemotherapy to adjuvant RT did not improve outcomes even in the presence of ECS, possibly because a high proportion of patients in that study had HPV-positive tumours with already excellent outcomes [8, 12].
Dysphagia after treatment
There are several factors that may contribute to dysphagia after treatment. Dysphagia after RT has been shown to correlate with increased mean doses of radiation to swallowing-related organs, with a higher mean dose to superior pharyngeal constrictor muscle region and larynx being particularly associated with worse long-term swallowing outcomes [23, 24]. The sigmoidal shape of the normal tissue complication probability curve indicates that increasing mean dose to pharyngeal musculature between 50Gy and 60Gy is a critical point at which risk of long-term dysphagia begins to inflect upwards, suggesting that reducing radiation dose from 60Gy to 50Gy could impart a clinically significant improvement in long-term swallowing outcomes . Adding concurrent chemotherapy to primary or adjuvant RT increases the risk of dysphagia: a systematic review of TORS for OPSCC showed clear demarcation in swallowing outcomes across a variety of outcome measures in patients who received adjuvant RT alone compared to adjuvant CRT .
Current treatments for HPV-positive OPSCC are associated with high survival rates but often result in significant long-term toxicities, particularly affecting swallowing function, that have a negative effect on QOL. Patients recruited into PATHOS will undergo transoral surgery to resect their primary tumours as well as a neck dissection. Post-operatively, they will be stratified into risk groups according to the presence or absence of pathological risk factors for recurrence. The aim of PATHOS is to determine whether reducing the intensity of adjuvant treatment after minimally invasive surgery in HPV-positive OPSCC, either by lowering RT dose in intermediate-risk patients or omitting chemotherapy in high-risk patients will result in better swallowing function, whilst maintaining excellent clinical outcomes. The primary outcome of the PATHOS phase II study will be long-term patient reported swallowing function measured using the MDADI score at 12 months post-treatment. Secondary outcomes will include local control rates and survival as well as a panel of objective and self-reported swallowing assessments. If the phase II study is successful, PATHOS will continue to a phase III study. The primary outcome of the proposed phase III study will be overall survival.
PATHOS is a multicentre, open label, parallel group phase II/III RCT funded by Cancer Research UK (CRUK). Patients must have biopsy proven OPSCC and should be clinically staged T1–T3 N0-N2b M0. Their primary tumour must be considered resectable via a transoral approach as determined by the local Multidisciplinary Team (MDT). HPV-positivity will be confirmed by central testing of diagnostic biopsy specimens by p16 immunohistochemistry and high risk HPV in-situ hybridisation. Synchronous neck dissection will be undertaken as per standard protocols depending upon the volume of regional metastatic disease. Following surgery, patients will be allocated into study groups based on histological findings (Fig. 1):
Group A: Patients whose tumours have no adverse histological features will not receive any adjuvant treatment as per standard of care.
Group B: Patients with T3 tumours (or T1–T2 tumours with additional risk factors), N2a (metastasis in single ipsilateral node 31–60 mm diameter) or N2b (metastasis in multiple ipsilateral nodes <61 mm diameter), tumours with evidence of perineural and/or vascular invasion, or close margins (1–5 mm) around the primary tumour specimen but with negative marginal biopsies and no evidence of cervical lymph node ECS. Patients in this group will be randomised to either post-operative RT 60Gy in 30 fractions over 6 weeks (Control Arm B1) or post-operative RT 50Gy in 25 fractions over 5 weeks (Test Arm B2).
Group C: Patients with tumours of any T or any N stage with the following high risk pathological features: positive (<1 mm) margins around the primary tumour (but with negative marginal biopsies) and/or evidence of cervical lymph node ECS. Patients in this group will be randomised to either post-operative CRT 60Gy in 30 fractions over 6 weeks with concurrent cisplatin (Control Arm C1) or post-operative RT 60Gy in 30 fractions over 6 weeks without chemotherapy (Test Arm C2).
The phase II trial will recruit at over approximately 20 sites in the UK. Participating sites will be required to complete a registration form to confirm that they have adequate resources and experience to conduct the trial. The planned phase III trial will recruit across Europe.
Participants are eligible to enter the trial pre-operatively if they meet all of the inclusion criteria and none of the exclusion criteria (Table 1). Post-operatively, patients allocated to Groups B and C on the basis of their pathology must re-confirm their consent for the study and will be assessed for their suitability for adjuvant treatment. Patients in Group B must be fit to undergo RT. Patients in Group C must be fit to undergo CRT and meet additional criteria as per Table 2.
Method of randomisation
Patients in Groups B and C will be randomised to a trial arm using the method of minimisation with a random element. Randomisation will be performed centrally by the Wales Cancer Trials Unit (WCTU). Participants will be stratified prior to randomisation by T stage, N stage, smoking history and treating centre.
Surgery to the primary site will be carried out by TLM or TORS, while a standard open approach will be used for neck dissection. These can be carried out as a single or staged procedure. Surgery should take place within 4 weeks (maximum 6 weeks) of study registration.
Transoral Laser Microsurgery (TLM) and marginal biopsies
TLM will be conducted according to the principles outlined by Steiner and Ambrosch . Tumours will be removed in several (at least two) planned pieces following trans-tumoural resection. It is mandatory that representative marginal biopsies are taken from the tumour bed in all cases of TLM to ensure complete surgical removal of the tumour. Re-resection is allowed when initial marginal biopsies are found to be positive for microscopic disease. If positive marginal biopsies are obtained on re-resection, the patient is withdrawn from the trial.
Transoral Robotic Surgery (TORS)
TORS involves en bloc removal of the tumour as per the principles outlined in the da Vinci Transoral Surgery Procedure Guide:
Patients with clinically node negative (cN0) disease will undergo a selective neck dissection involving clearance of at least nodal levels II and III. Patients with clinically node positive (cN+) disease will undergo clearance of lymph node levels II and III and any additional involved lymph node levels. Patients with neck disease involving adjacent structures will undergo a modified radical neck dissection. In the case of non-lateralised primary tumours, as an alternative to non-surgical treatment (see below), some centres may undertake a selective neck dissection of the contralateral cN0 neck.
Patients should start RT within 5 weeks and no later than 6 weeks from surgery, so that combined treatment (surgery and RT) is completed within 11 weeks to avoid poor LC and survival rates that result from protracted treatment . Patients are managed as category 1 as per the Royal College of Radiologists Guidelines and RT should be completed within 6 weeks for patients having 60Gy in 30 fractions and within 5 weeks for those having 50Gy in 25 fractions .
The primary tumour should be categorised as lateralised or non-lateralised based on clinical and radiological assessments.
Lateralised tumour: Tonsillar tumour confined to the tonsillar fossa or extending onto or into the adjacent base of tongue and/or soft palate by less than 1 cm.
Non-lateralised tumour: Tonsillar tumour that involves the adjacent base of tongue and/or soft palate by more than 1 cm or a tumour that arises from a midline structure (base of tongue, soft palate, posterior pharyngeal wall).
Patients with lateralised tumours should undergo unilateral neck RT, regardless of the nodal stage of the ipsilateral neck. Patients with non-lateralised tumours should undergo bilateral neck RT, except in cases where they have undergone contralateral selective neck dissection and pN0 status is confirmed on that side (see above).
PATHOS uses a geometric approach to define target volumes. Pre-operative imaging, pan-endoscopy reports, operative findings and pathology information should be used to delineate target volumes. The Clinical Target Volume 1 (CTV1) includes the primary and nodal tumour beds with a margin (1–1.5 cm) and all pathologically involved nodal levels. Arms B1, C1, C2 receive 60Gy/30 fractions and Arm B2 receives 50Gy/25 fractions. The Clinical Target Volume 2 (CTV2) includes all at risk uninvolved nodal levels that require prophylactic RT. Arms B1, C1, C2 receive 54Gy/30 fractions and Arm B2 receives 50Gy/25fractions. Some centres may, a priori opt to boost high-risk sub-volume(s) for patients in Group C to 66Gy/30 fractions. Neck node levels for prophylactic RT should be outlined according to updated consensus guidelines and atlas . A margin (3–5 mm) will be added to each CTV to produce the respective Planning Target Volume.
Dose constraints to the following organs at risk will be used for treatment plan optimisation: spinal cord, brainstem, parotid glands. Investigators are also encouraged to contour swallowing-related structures. These include the pharyngeal constrictor muscles (superior, middle and inferior), supraglottic/glottic larynx, cricopharyngeus, oesophageal inlet, cervical oesophagus and oral cavity and should be outlined according to the PATHOS atlas of swallowing structures, itself based on previously published guidelines [24, 29]. The swallowing structures will not be used for treatment plan optimisation but swallowing outcomes will be correlated to the dose received by these structures. All patients will be planned using Intensity Modulated Radiotherapy (IMRT).
The following regimens can be used: Cisplatin 100 mg/m2 administered intravenously in a three weekly-cycle on days 1 and 22 of the RT schedule or Cisplatin 40 mg/m2 weekly for a maximum of 6 weeks. Carboplatin may be used instead of Cisplatin from cycle 2 onwards if the patient develops complications (ototoxicity, impaired renal function) related to Cisplatin.
Assessments and outcomes
Comprehensive assessment of swallowing function requires a multidimensional panel of measures that incorporates instrumental examination of swallowing along with clinician-rated and patient reported outcomes. A functional outcomes panel for assessing swallowing function has been developed for PATHOS (Table 3). The following assessments will be conducted prior to surgery, 4 weeks post surgery and at 4 weeks, 6, 12 and 24 months post treatment: (1) MD Anderson Dysphagia Inventory score (MDADI); (2) Water swallow test (WST); (3) Performance Status Scale-Head and Neck (PSS-HN); (4) Quality of Life questionnaires (EORTC QLQ-C30 and EORTC QLQ-H&N35). Patients will also undergo a videofluoroscopy (VF) assessment prior to surgery, at 4 weeks post surgery and at 12 months post treatment. CTCAE Toxicity (v4.03) will be assessed weekly during and at the end of RT and at 4 weeks, 6, 12 and 24 months.
Primary outcome measures
The primary outcome of the phase II study will be swallowing function, measured using the 19-item composite MDADI score at 12 months post-treatment. The primary outcome of the planned phase III study will be overall survival (OS).
Secondary outcome measures
These will include data from: (1) functional outcomes panel (Table 3); (2) acute and late toxicity using CTCAE version 4.03; (3) QOL using EORTC QLQ C30 and H35 questionnaires; (4) overall survival (OS); (5) disease free survival (DFS); (6) locoregional control (LC); (7) distant metastases
Sample size calculation
Data show that a 10-point difference in mean MDADI score can differentiate aspirators from non-aspirators, tube-dependent from oral eaters and clinically distinct diet levels . For the study to have 80 % power to detect this difference (two sided 5 % alpha), a sample size of 148 patients is required (i.en = 74 in both randomisations). Given a 20 % loss to follow up as shown in previous studies, 186 patients will need to be randomised . Assuming that 15 % of patients recruited are not randomised post-operatively (10 % who do not require adjuvant treatment and 5 % who decline randomisation) and that 10 % who are consented to the study will not be HPV positive at central HPV testing, we estimate that 242 patients will need to be enrolled into the phase II study.
If the trial proceeds to phase III, then a sample size calculation for non-inferiority will be made. It is likely that around 800 patients will need to be recruited to prove that survival is maintained with de-intensified adjuvant therapy and European collaboration (through the EORTC) will be required for this.
Mean MDADI scores at 12 months will be compared between arms using either a t-test or nonparametric methods depending upon distributions. We will adjust for the randomisation stratification variables using regression techniques. This primary analysis will be conducted when the last patient has had their 12 month assessment. An Independent Data Monitoring Committee will review the accumulating data (survival, toxicities, recruitment) at 6 monthly intervals. Strict monitoring has been built in for recurrence. A formal interim analysis will be performed after 38 patients have been randomised in each randomisation (19 per arm), treated and followed up for 6 months. Within each randomisation, a stopping rule will be based on observing an absolute observed difference of 6 or more locoregional recurrences and/or deaths in either of the intervention arms. For swallowing endpoints, subgroup analysis by T stage and tumour subsite (tonsil, soft palate, tongue base) will be carried out, as the most likely relevant clinical co-variables affecting swallowing function.
Quality Assurance (QA)
All surgeons will need to demonstrate evidence of suitable training in the procedures employed and/or an established surgical practice in the relevant techniques (TLM/TORS). They should have undertaken a minimum of 5 previous transoral resections for OPSCC. It is expected that over the duration of the trial, positive marginal biopsy rates for an individual surgeon will not exceed 10 %.
The Radiotherapy Quality Assurance (RTQA) programme for the trial will be coordinated by the National Radiotherapy Trials Quality Assurance group. A comprehensive RTQA guidance document has been developed to accompany the main trial protocol. In brief, this will consist of pre-accrual and on-trial components. Each site must perform a pre-accrual outlining benchmark case on one lateralised and one non-lateralised case. Sites may need to complete a pre-accrual planning exercise of a benchmark case, depending on participation in other national head and neck trials. Real time review of the first lateralised and non-lateralised patients recruited by each centre will be carried out before treatment starts, both for outlining and planning.
All swallow assessments will be conducted by speech and language therapists with the required level of competency, or appropriately trained research nurses. DVDs of the VFs will be assessed centrally by members of the research team to QA the functional endpoint data.
The trial is associated with a CR-UK funded bioresource collection – PATHOS-T. Accordingly, up to five geographically distinct biopsies from the primary tumour will be harvested prior to surgical resection. In addition, up to two samples of involved cervical lymph node tissue will also be collected. Blood samples for research will also be taken before treatment and at 6 weeks, 6, 12, 18 and 24 months post treatment. Trial participants will be asked for additional optional consent to participate in this aspect of the study.
Regulatory approval, sponsorship and current status
PATHOS has ethical approval from the Wales Research Ethics Committee which is legally recognised by the UK Ethics Committee Authority for review and approval. It also has approval from the Medicines and Health Care Product Regulatory Agency to be conducted in the UK. The Wales Cancer Trials Unit, a CRUK core funded and UK Clinical Research Collaboration accredited Clinical Trials Unit, is coordinating the trial. Velindre NHS Trust is the sponsor for the trial. A Trial Steering Committee and an Independent Data Monitoring Committee has been set up to monitor the progress and safety of the study. The PATHOS Trial Management Group, including clinicians, clinical trial unit staff, patient representatives, nursing and pharmacy representatives carry out the day-to-day running of the trial. PATHOS is registered with ClinicalTrials.gov identifier: NCT02215265.
A systematic review and meta-analysis of more than 500 OPSCC patients treated with TORS in 17 retrospective studies concluded that minimally invasive surgical techniques had a positive effect on QOL and long-term function as well as good oncological control . The authors suggested that there was potential to reduce the intensity of treatment based on successful surgical control of disease in good prognosis HPV-positive patients. However, further validation through RCTs, like PATHOS, is needed prior to widespread shifts in practice. The RT dose of 50Gy in 25 fractions in the test arm (B2) of PATHOS was recommended by the National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting on transoral resection of pharyngeal cancer . This reduced dose is also currently being used in a parallel US study (ECOG 3311) for transorally resected HPV-positive OPSCC. Another ongoing US study (ADEPT) is investigating if concurrent chemotherapy can be withheld in patients with ECS in the adjuvant setting. PATHOS is the only study to investigate both the effects of lowering RT dose and omitting chemotherapy in the same study.
PATHOS will allow clinical and pathological correlations of outcomes for HPV-positive disease, such that predictive factors for disease behaviour can be determined specifically in the context of HPV-positive disease. The study also provides a unique opportunity in the UK to standardise transoral surgical approaches for the treatment of OPSCC. It is imperative that in light of the increased uptake of these new techniques that surgical QA be established. This will ensure the rigorous application of appropriate and consistent surgical standards to allow valid comparison whenever these techniques are used in surgical trials and more importantly whenever they are used to treat patients. A panel of objective and self-reported swallowing assessments has been developed for PATHOS to allow multidimensional assessment of swallowing function. This panel will be prospectively validated in the trial and represents a step change in the standardisation of swallowing assessment in head and neck trials. Equally important is the fact that PATHOS will be the first UK study of post-operative IMRT for head and neck cancer. A novel aspect of the study will be outlining of the swallowing structures by investigators in participating centres. Dose/volume data for swallowing structures will be correlated with long-term swallowing function, collected prospectively in this multicentre randomised trial.
PATHOS phase II will open to recruitment in the UK in June 2015, with a planned recruitment period of 3 years. If the phase II study is successful, we plan to proceed to a phase III study to establish survival non-inferiority in the de-intensified treatment arms, which will require European collaboration.
Post-operative adjuvant treatment for HPV-positive tumours
Cancer Research UK
Common terminology criteria for adverse events
Clinical target volume
Intensity modulated radiotherapy
MD Anderson dysphagia inventory
Oropharyngeal squamous cell carcinoma
Performance status scale – head and neck
Quality of life
Randomised controlled trial
Transoral laser microsurgery
Transoral robotic surgery
Wales Cancer trials unit
Water swallow test
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PATHOS is funded by the Clinical Trials Advisory and Awards Committee (CTAAC) on behalf of Cancer Research UK (CRUK/13/025) and is supported by CRUK core funding at the Wales Cancer Trials Unit (WCTU). The trial is sponsored by Velindre NHS Trust. WO was supported by the Velindre NHS Trust Charitable Board. The authors would like to thank Wendy Wade (Nursing Advisor), Clare Donnithorne (Pharmacy Advisor), Loys Richards (Safety Officer), David Robson (Consumer Representative), Stephen Bahari (Consumer Representative) for their collaboration.
Authors and Affiliations
Velindre NHS Trust, Velindre Road, Cardiff, CF14 2TL, UK
The authors declare that they have no competing interests.
ME, TMJ, JP, KH, CR, MB, NaP, NeP and CH are responsible for the research question, design of the trial and contributed to the writing of the study protocol. CH is the trial statistician and corresponding author. HT is the trial manager. EP is the radiotherapy QA advisor. ST is the research and development manager for the trial sponsor. WO is responsible for the manuscript. All authors have read and approved the final manuscript.
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Owadally, W., Hurt, C., Timmins, H. et al. PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer.
BMC Cancer15, 602 (2015). https://doi.org/10.1186/s12885-015-1598-x