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Table 3 Functional outcomes panel for multidimensional assessment of swallowing function

From: PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer

Study Description Domain Endpoint
MDADI MDADI is a patient reported swallowing outcome measure, specifically designed and psychometrically validated for the head and neck cancer population Swallowing-related QOL Total/Composite, Global, Subscale Scores (continuous scores: 20 to 100)
WST 100mls WST is a timed swallowing test. Swallow performance Swallow capacity (mls per swallow)
Swallow volume (mls per swallow)
VF VF is the gold standard radiographic measure of swallowing function. It allows quantification of more objective endpoints of swallowing function including pathophysiology, swallowing efficiency and airway protection. Swallow physiology MBSImpairment profile (MBSImp) (continuous scores: oral impairment 0 to 22; pharyngeal impairment 0 to 29) [33]
Airway protection Penetration-aspiration scale (PAS) (ordinal score: 1 to 8)
Aspiration, yes/no (binary) [34]
Pharyngeal dysphagia grade Videofluoroscopic Swallow Grade-Head & Neck (VSG-HN) (ordinal grade: 0 to 4)
PSS-HN PSS-HN is a 3-item scale designed to evaluate functional performance of head and neck cancer patients according to normalcy of diet, eating in public and understandability of speech Functional performance status Normalcy of diet subscale, public eating subscale, understandability of speech scores (ordinal: 0 to 100)
EORTC QLQ C30 H&N35 QOL questionnaires Health related QOL Raw scores from scales and single item measures are transformed to a standardised 0–100 final scale score.