Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 2013, 63 (1): 11-30. 10.3322/caac.21166.
Article
PubMed
Google Scholar
López-Beltrán A, Scarpelli M, Montironi R, Kirkali Z: 2004 WHO classification of the renal tumors of the adults. Eur Urol. 2006, 49 (5): 798-805. 10.1016/j.eururo.2005.11.035.
Article
PubMed
Google Scholar
Schuetz NA, Yin-Goen Q, Amin MB, Moreno CS, Cohen C, Hornsby CD, Yang WL, Petros JA, Issa MM, Pattaras JG, Ogan K, Marshall FF, Young AN: Molecular classification of renal tumors by gene expression profiling. J Mol Diagn. 2005, 7 (2): 206-208. 10.1016/S1525-1578(10)60547-8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lam JS, Shvarts O, Leppert JT, Figlin RA, Belldegrun AS: Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol. 2005, 173 (6): 1853-1862. 10.1097/01.ju.0000165693.68449.c3.
Article
PubMed
Google Scholar
Jin JS, Hsieh DS, Lin YF, Wang JY, Sheu LF, Lee WH: Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. Int J Urol. 2006, 13 (5): 573-580. 10.1111/j.1442-2042.2006.01353.x.
Article
CAS
PubMed
Google Scholar
Patraki E, Cardillo MR: Quantitative immunohistochemical analysis of matrilysin 1 (MMP-7) in various renal cell carcinoma subtypes. Int J Immunopathol Pharmacol. 2007, 20 (4): 697-705.
CAS
PubMed
Google Scholar
Catania JM, Chen G, Parrish AR: Role of matrix metalloproteases in renal pathophysiologies. Am J Physiol Renal Physiol. 2007, 292 (3): 905-911.
Article
Google Scholar
Göhring B, Holzhausen HJ, Meye A, Heynemann H, Rebmann U, Langner J, Riemann D: Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer. Int J Mol Med. 1998, 2 (4): 409-414.
PubMed
Google Scholar
Nanus DM, Bogenrieder T, Papandreou CN, Finstad CL, Lee A, Vlamis V: Aminopeptidase A expression and enzymatic activity in primary human renal cancers. Int J Oncolology. 1998, 13 (2): 261-267.
CAS
Google Scholar
Varona A, Blanco L, López JI, Gil J, Agirregoitia E, Irazusta J, Larrinaga G: Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. Am J Physiol Renal Physiol. 2007, 292 (2): 780-788.
Article
Google Scholar
Blanco L, Larrinaga G, Pérez I, López JI, Gil J, Agirregoitia E, Varona A: Acid, basic and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma. Am J Physiol Renal Physiol. 2008, 294 (4): 850-858. 10.1152/ajprenal.00469.2007.
Article
Google Scholar
Varona A, Blanco L, Perez I, Gil J, Irazusta I, Lopez JI, Candenas ML, Pinto FM, Larrinaga G: Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent. BMC Cancer. 2010, 10: 193-10.1186/1471-2407-10-193.
Article
PubMed
PubMed Central
Google Scholar
Wolf G, Mentzel S, Assmann KJ: Aminopeptidase A: a key enzyme in the intrarenal degradation of angiotensin II. Experimental Nephrolology. 1997, 5 (5): 364-369.
CAS
Google Scholar
Dijkman HB, Assmann KJ, Steenbergen EJ, Weltzels JF: Expression and effect of inhibition of aminopeptidase-A during nephrogenesis. J Histochemestry and Cytochemestry. 2006, 54 (2): 253-262. 10.1369/jhc.5A6815.2005.
Article
CAS
Google Scholar
Bander NH, Cordon-Cardo C, Finstad CL, Whitmore WF, Vaughan ED, Oettgen HF, Melamed M, Old LJ: Immunohistologic dissection of the human kidney using monoclonal antibodies. J Urol. 1985, 133 (3): 502-505.
CAS
PubMed
Google Scholar
Nanus DM, Engelstein D, Gastl GA, Gluck L, Vidal MJ, Morrison M, Finstad C, Bander NH, Albino AP: Molecular cloning of the human kidney differentiation antigen gp160: Human aminopeptidase A. Proc Natl Acad Sci U S A. 1993, 90 (15): 7069-7073. 10.1073/pnas.90.15.7069.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kehlen A, Göhring B, Langer J, Riemann D: Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines ans cAMP-increasing mediators. Clin Exp Immunol. 1998, 111 (2): 435-441. 10.1046/j.1365-2249.1998.00513.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nanus DM, Pfeffer LM, Bander NH, Bahri S, Albino AP: Antiproliferative and antitumor effects of alpha interferon in renal cell carcinomas: correlation with the expression of a kidney associated differentiation glycoprotein. Cancer Res. 1990, 50 (14): 4190-4194.
CAS
PubMed
Google Scholar
Sobin LH, Wittekind C: TNM Classification of Malignant Tumors. 2002, New York: Wiley-Liss, 6
Google Scholar
Furhman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982, 6 (7): 655-663. 10.1097/00000478-198210000-00007.
Article
Google Scholar
Martínez JM, Prieto I, Ramírez MJ, Cueva C, Alba F, Ramírez M: Aminopeptidase activities in breast cancer tissue. Clin Chem. 1999, 45 (10): 1797-1802.
PubMed
Google Scholar
Ramírez-Expósito MJ, Martínez JM, Prieto I, Alba F, Ramírez M: Comparative distribution of glutamyl and aspartyl aminopeptidase activities in mouse organs. Horm Metab Res. 2000, 32 (5): 161-163. 10.1055/s-2007-978614.
Article
PubMed
Google Scholar
Ramírez M, Prieto M, Alba F, Vives F, Banegas I, de Gasparo M: Role of central and peripheral aminopeptidase activities in the control of blood pressure: a working hypothesis. Heart Fail Rev. 2008, 13 (3): 339-353. 10.1007/s10741-007-9066-6.
Article
PubMed
Google Scholar
Tobe H, Kojima F, Aoyagi T, Umezawa H: Purification using amastatin and properties of aminopeptidase A from pig kidney. Biochimica Biophysica Acta. 1980, 613 (2): 459-468. 10.1016/0005-2744(80)90100-X.
Article
CAS
Google Scholar
Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976, 72: 248-254. 10.1016/0003-2697(76)90527-3.
Article
CAS
PubMed
Google Scholar
Patak E, Candenas ML, Pennefather JN, Ziccone S, Lilley A, Martín JD, Flores C, Flores C, Mantecón AG, Story ME, Pinto FM: Tachykinins and tachykinin receptors in human uterus. Br J Pharmacol. 2003, 139 (3): 523-532. 10.1038/sj.bjp.0705279.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rozen S, Skaletsky H: Primers on the WWW for general users and for biologist programmers. Methods Mol Biol. 2000, 132: 365-368.
CAS
PubMed
Google Scholar
Jung M, Ramankulov A, Roigas J, Johannsen M, Ringsdorf M, Kristiansen G, Jung K: In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR. BMC Mol Biol. 2007, 8: 47-10.1186/1471-2199-8-47.
Article
PubMed
PubMed Central
Google Scholar
Radonic A, Thulke S, Mackay IM, Landt O, Siegert W, Nitsche A: Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun. 2004, 313 (4): 856-862. 10.1016/j.bbrc.2003.11.177.
Article
CAS
PubMed
Google Scholar
Pinto FM, Almeida TA, Hernandez M, Devillier P, Advenier C, Candenas ML: mRNA expression of tachykinins and tachykinin receptors in different human tissues. Eur J Pharmacol. 2004, 494 (2–3): 233-239.
Article
CAS
PubMed
Google Scholar
Antczak C, De Meester I, Bauvois B: Ectopeptidases in pathophysiology. Bioessays. 2001, 23 (3): 251-260. 10.1002/1521-1878(200103)23:3<251::AID-BIES1035>3.0.CO;2-O.
Article
CAS
PubMed
Google Scholar
Carl-McGrath S, Lendeckel U, Ebert M, Röcken C: Ectopeptidases in tumour biology: a review. Histol Histopathol. 2006, 21 (12): 1339-1353.
CAS
PubMed
Google Scholar
Zhou M, Roma A, Magi-Galluzzi C: The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms. Clin Lab Med. 2005, 25 (2): 247-257. 10.1016/j.cll.2005.01.004.
Article
PubMed
Google Scholar
Larrinaga G, Perez I, Sanz B, Blanco L, López JI, Candenas ML, Pinto FM, Gil J, Irazusta J, Varona A: Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors. Regul Pept. 2010, 165 (2–3): 218-223.
Article
CAS
PubMed
Google Scholar
Blanco L, Perez I, Sanz B, Gil J, López JI, Ugalde A, Varona A, Larrinaga G: Changes in cell-surface peptidase activity in papillary renal cell carcinoma. Anticancer Res. 2010, 30 (4): 1137-1141.
CAS
PubMed
Google Scholar
Larrinaga G, López JI, Casis L, Blanco L, Gil J, Agirregoitia E, Varona A: Cystinyl aminopeptidase activity is decreased in renal cell carcinoma. Regul Pept. 2007, 144 (1–3): 56-61.
Article
CAS
PubMed
Google Scholar
Larrinaga G, Blanco L, Sanz B, Perez I, Gil J, Unda M, Andrés L, Casis L, López JI: The impact of peptidase activity on clear cell renal cell carcinoma survival. Am J Physiol Renal Physiol. 2012, 303 (12): 1584-1591. 10.1152/ajprenal.00477.2012.
Article
Google Scholar
Kasinath BS, Mariappan MM, Sataranatarajan K, Lee MJ, Feliers D: mRNA traslation: unexplored territory in renal science. J Am Soc Nephrol. 2006, 17 (12): 3281-3292. 10.1681/ASN.2006050488.
Article
CAS
PubMed
Google Scholar
Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Battle D: ACE and ACE2 activity in diabetic mice. Diabetes. 2006, 55 (77): 2132-2139.
Article
CAS
PubMed
Google Scholar
Ino K, Shibata K, Kajiyama H, Kikkawa F, Mizutani S: Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies. Biol Chem. 2004, 385 (8): 683-690.
Article
CAS
PubMed
Google Scholar
Deshayes F, Nahmias C: Angiotensin receptors: a new role in cancer?. Trends Endocrinol Metab. 2005, 16 (7): 293-299. 10.1016/j.tem.2005.07.009.
Article
CAS
PubMed
Google Scholar
George AJ, Thomas WG, Hannan RD: The renin-angiotensin system and cancer: old dog, new trick. Nat Rev Cancer. 2010, 10 (11): 745-759. 10.1038/nrc2945.
Article
CAS
PubMed
Google Scholar
Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HB, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W: Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell. 2004, 5 (2): 151-162. 10.1016/S1535-6108(04)00025-X.
Article
PubMed
Google Scholar
Re RN, Cook JL: The intracrine hypothesis: an update. Regul Pept. 2006, 133 (1–3): 1-9.
Article
CAS
PubMed
Google Scholar
Re RN, Cook JL: An intracrine view of angiogenesis. Bioessays. 2006, 28 (9): 943-953. 10.1002/bies.20459.
Article
CAS
PubMed
Google Scholar
Baker KM, Chernin MI, Schreiber T, Sanghi S, Heiderzaidi S, Booz GW, Dostal D, Kumar R: Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul Pept. 2004, 120 (1–3): 5-13.
Article
CAS
PubMed
Google Scholar
Zhuo JL, Li XC: New insights and perspectives on intrarenal renin-angiotensin system: fous on intracrine/intracellular angiotensin II. Peptides. 2011, 32 (7): 1551-1565. 10.1016/j.peptides.2011.05.012.
Article
CAS
PubMed
PubMed Central
Google Scholar