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  1. Since targeting oxidative stress markers has been recently recognized as a novel therapeutic target in cancer, it is interesting to investigate whether genetic susceptibility may modify oxidative stress respon...

    Authors: Ewa Jablonska, Jolanta Gromadzinska, Beata Peplonska, Wojciech Fendler, Edyta Reszka, Magdalena B. Krol, Edyta Wieczorek, Agnieszka Bukowska, Peter Gresner, Michal Galicki, Oskar Zambrano Quispe, Zbigniew Morawiec and Wojciech Wasowicz
    Citation: BMC Cancer 2015 15:657
    Content type: Research article Published on:

  2. Fibulin-4, a member of the fibulin family of extracellular glycoproteins, is implicated in the progressions of some cancers. However, no information has been available to date regarding the function of fibulin...

    Authors: Jie Chen, Zhao Liu, Shuang Fang, Rui Fang, Xi Liu, Yueran Zhao, XiangXin Li, Lei Huang and Jie Zhang
    Citation: BMC Cancer 2015 15:91
    Content type: Research article Published on:

  3. Hepatocellular carcinoma (HCC) is a major cause of cancer deaths worldwide. However, current chemotherapeutic drugs for HCC are either poorly effective or expensive, and treatment with these drugs has not led ...

    Authors: Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen and Cheng-Da Hsu
    Citation: BMC Cancer 2015 15:134
    Content type: Research article Published on:

  4. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang
    Citation: BMC Cancer 2019 19:1085
    Content type: Research article Published on:

  5. Glioblastoma is the most frequent and most malignant brain tumor with the patients having a median survival of only 14.6 months. Although glioblastoma patients are treated with surgery, radiation and chemother...

    Authors: Stine S. Jensen, Stine A. Petterson, Bo Halle, Charlotte Aaberg-Jessen and Bjarne W. Kristensen
    Citation: BMC Cancer 2017 17:178
    Content type: Research article Published on:

  7. There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable pro...

    Authors: Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat and Andrey Bychkov
    Citation: BMC Cancer 2019 19:1050
    Content type: Research article Published on:

  8. Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of...

    Authors: Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich and Darren R. Brenner
    Citation: BMC Cancer 2018 18:71
    Content type: Research article Published on:

  9. Angiogenesis is important both in normal tissue function and disease and represents a key target in lung cancer (LC) therapy. Unfortunately, the two main subtypes of non-small-cell lung cancers (NSCLC) namely,...

    Authors: J. Rapp, E. Kiss, M. Meggyes, E. Szabo-Meleg, D. Feller, G. Smuk, T. Laszlo, V. Sarosi, T. F. Molnar, K. Kvell and J. E. Pongracz
    Citation: BMC Cancer 2016 16:915
    Content type: Research article Published on:

  10. AXL is a well-characterized, protumorigenic receptor tyrosine kinase that is highly expressed and activated in numerous human carcinomas and sarcomas, including aggressive subtypes of liposarcoma. However, the...

    Authors: Caitlin D. May, Jeannine Garnett, XiaoYan Ma, Sharon M. Landers, Davis R. Ingram, Elizabeth G. Demicco, Ghadah A. Al Sannaa, Tona Vu, Lixia Han, Yi Zhang, Christine M. Kivlin, Svetlana Bolshakov, Azad Abul Kalam, Juehui Liu, Fuguo Zhou, Dominique Broccoli…
    Citation: BMC Cancer 2015 15:901
    Content type: Research article Published on:

  11. Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can...

    Authors: Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto and Taisuke Mori
    Citation: BMC Cancer 2019 19:245
    Content type: Research article Published on:

  12. Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease. However, an un-met clinical need remains in B-Raf inhibitor resist...

    Authors: Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux and George S. Baillie
    Citation: BMC Cancer 2019 19:266
    Content type: Research article Published on:

  14. Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to h...

    Authors: Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet and Christelle Dufour
    Citation: BMC Cancer 2018 18:177
    Content type: Research article Published on:

  16. The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for ...

    Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho and Joseph Taube
    Citation: BMC Cancer 2020 20:141
    Content type: Research article Published on:

  17. Lung cancer is typically diagnosed at a late stage. Early presentation and detection of lung cancer symptoms is critical to improving survival but can be clinically complicated and as yet a robust screening me...

    Authors: Shemana Cassim, Lynne Chepulis, Rawiri Keenan, Jacquie Kidd, Melissa Firth and Ross Lawrenson
    Citation: BMC Cancer 2019 19:25
    Content type: Research article Published on:

  18. Multiple myeloma is a cancer in the bone marrow causing bone destruction. Patients experience various symptoms related to the disease and/or treatment, such as pain and fatigue, leading to poorer quality of li...

    Authors: Rikke Faebo Larsen, Mary Jarden, Lisbeth Rosenbek Minet, Ulf Christian Frølund, Sören Möller and Niels Abildgaard
    Citation: BMC Cancer 2020 20:169
    Content type: Research article Published on:

  19. Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing o...

    Authors: Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske and Ewelina Stoczynska-Fidelus
    Citation: BMC Cancer 2019 19:923
    Content type: Research article Published on:

  20. The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) an...

    Authors: Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang and Jianfeng Li
    Citation: BMC Cancer 2015 15:13
    Content type: Research article Published on:

  22. Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-cateni...

    Authors: S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan and D. Velmurugan
    Citation: BMC Cancer 2018 18:1168
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2021 21:151

  23. In a previous paper, we had assumed that the risk of screen-detected breast cancer mostly reflects inherent risk, and the risk of whether a breast cancer is interval versus screen-detected mostly reflects risk...

    Authors: Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Catriona McLean, Melissa C. Southey, Dallas R. English, Graham G. Giles and John L. Hopper
    Citation: BMC Cancer 2017 17:859
    Content type: Research article Published on:

  24. Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear.

    Authors: Mehdi Brahmi, Laurent Alberti, Armelle Dufresne, Isabelle Ray-Coquard, Philippe Cassier, Pierre Meeus, Anne-Valérie Decouvelaere, Dominique Ranchère-Vince and Jean-Yves Blay
    Citation: BMC Cancer 2015 15:780
    Content type: Research article Published on:

  25. Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...

    Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc
    Citation: BMC Cancer 2019 19:137
    Content type: Research article Published on:

  26. Almost all of the extracellular matrix (ECM) components can be degraded by the endoproteinases matrix metalloproteinases (MMPs). Important regulators of MMPs, and thereby of the extracellular environment, are ...

    Authors: Camilla Böckelman, Ines Beilmann-Lehtonen, Tuomas Kaprio, Selja Koskensalo, Taina Tervahartiala, Harri Mustonen, Ulf-Håkan Stenman, Timo Sorsa and Caj Haglund
    Citation: BMC Cancer 2018 18:679
    Content type: Research article Published on:

  27. It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. ...

    Authors: Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang and Wai-Lun Law
    Citation: BMC Cancer 2018 18:621
    Content type: Research article Published on:

  28. Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need for understanding the molecular mechanism underlying the...

    Authors: Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo and Yiyan Lei
    Citation: BMC Cancer 2019 19:609
    Content type: Research article Published on:

  29. Improvement of transduction and augmentation of cytotoxicity are crucial for adenoviruses (Ad)-mediated gene therapy for cancer. Down-regulated expression of type 5 Ad (Ad5) receptors on human tumors hampered ...

    Authors: Shan Yang, Kiyoko Kawamura, Shinya Okamoto, Suguru Yamauchi, Masato Shingyoji, Ikuo Sekine, Hiroshi Kobayashi, Yuji Tada, Koichiro Tatsumi, Kenzo Hiroshima, Hideaki Shimada and Masatoshi Tagawa
    Citation: BMC Cancer 2015 15:464
    Content type: Research article Published on:

  30. Occult invasive cervical cancer (OICC) is sometimes incidentally found in surgical specimens after a simple hysterectomy (SH). This study was aimed at identifying a subset of patients with OICC who have a favo...

    Authors: Huimin Bai, Dongyan Cao, Fang Yuan, Huilan Wang, Jie Chen, Yue Wang, Keng Shen and Zhenyu Zhang
    Citation: BMC Cancer 2016 16:507
    Content type: Research article Published on:

  31. Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-β pathway is the most com...

    Authors: Jo-Anne de la Mare, Tamarin Jurgens and Adrienne L. Edkins
    Citation: BMC Cancer 2017 17:202
    Content type: Research article Published on:

  32. Of many specialized blood cells, monocytes are gaining increasing attention for their role in neoplastic disorders. The purpose of the present investigation was to determine the expression of selected peripher...

    Authors: Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik and Piotr Radziwon
    Citation: BMC Cancer 2015 15:129
    Content type: Research article Published on:

  33. Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann
    Citation: BMC Cancer 2019 19:812
    Content type: Research article Published on:

  34. Cancer treatment during pregnancy is a growing problem especially now that women delay childbearing. Systemic treatment of these malignancies during pregnancy centers mainly on the anticancer drugs anthracycli...

    Authors: Marialuisa Framarino-dei-Malatesta, Paolo Sammartino and Angela Napoli
    Citation: BMC Cancer 2017 17:777
    Content type: Debate Published on:

  35. The composition of the matrix molecules is important in in vitro cell culture experiments of e.g. human cancer invasion and vessel formation. Currently, the mouse Engelbreth-Holm-Swarm (EHS) sarcoma -derived prod...

    Authors: Tuula Salo, Meeri Sutinen, Ehsanul Hoque Apu, Elias Sundquist, Nilva K. Cervigne, Carine Ervolino de Oliveira, Saad Ullah Akram, Steffen Ohlmeier, Fumi Suomi, Lauri Eklund, Pirjo Juusela, Pirjo Ã…ström, Carolina Cavalcante Bitu, Markku Santala, Kalle Savolainen, Johanna Korvala…
    Citation: BMC Cancer 2015 15:981
    Content type: Research article Published on:

  36. Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperat...

    Authors: Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink…
    Citation: BMC Cancer 2018 18:877
    Content type: Study protocol Published on:

  37. Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used...

    Authors: Kasia Matula, Elaina Collie-Duguid, Graeme Murray, Khyati Parikh, Heike Grabsch, Patrick Tan, Salina Lalwani, Roberta Garau, Yuhan Ong, Gillian Bain, Asa-Dahle Smith, Gordon Urquhart, Jacek Bielawski, Michael Finnegan and Russell Petty
    Citation: BMC Cancer 2015 15:762
    Content type: Research article Published on:

  38. The rates of thoracoscopic esophagectomy performed in the prone and left lateral decubitus positions are similar in Japan. We retrospectively reviewed short- and long-term outcomes of thoracoscopic esophagecto...

    Authors: Masahiko Murakami, Koji Otsuka, Satoru Goto, Tomotake Ariyoshi, Takeshi Yamashita and Takeshi Aoki
    Citation: BMC Cancer 2017 17:748
    Content type: Research article Published on:

  39. Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms of head and neck/oral cancer (HNOC), and is a complex disease with extensive genetic and epigenetic defects, including microRNA d...

    Authors: Qianting He, Zujian Chen, Qian Dong, Leitao Zhang, Dan Chen, Aditi Patel, Ajay Koya, Xianghong Luan, Robert J. Cabay, Yang Dai, Anxun Wang and Xiaofeng Zhou
    Citation: BMC Cancer 2016 16:685
    Content type: Research article Published on:

  41. Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of ca...

    Authors: Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson and Michael Ladomery
    Citation: BMC Cancer 2018 18:355
    Content type: Research article Published on:

  42. In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the cr...

    Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati and Sushanta K. Banerjee
    Citation: BMC Cancer 2018 18:99
    Content type: Research article Published on:

  43. Vascular endothelial growth factor (VEGF), tyrosine kinase (TK) and mechanistic target of rapamycin kinase (mTOR) inhibitors are common first-line (1 L) treatments for metastatic renal cell carcinoma (mRCC). D...

    Authors: Sumanta Pal, Jun Gong, Shivani K. Mhatre, Shih-Wen Lin, Andy Surinach, Sarika Ogale, Rini Vohra, Herschel Wallen and Daniel George
    Citation: BMC Cancer 2019 19:548
    Content type: Research article Published on:

  44. Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results.

    Authors: Danny V. Colombara, Lisa E. Manhart, Joseph J. Carter, Stephen E. Hawes, Noel S. Weiss, James P. Hughes, You-Lin Qiao, Philip R. Taylor, Jennifer S. Smith and Denise A. Galloway
    Citation: BMC Cancer 2016 16:342
    Content type: Research article Published on:

  45. Epidemiologic data indicates that Asian diets, which are high in soy protein, reduce a women’s risk of developing breast cancer. However, it has been difficult to dissociate the benefits of soy from other vari...

    Authors: Katrina L Watson, Leanne Stalker, Robert A Jones and Roger A Moorehead
    Citation: BMC Cancer 2015 15:37
    Content type: Research article Published on:

  46. Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is ...

    Authors: Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal and Hervé Sartelet
    Citation: BMC Cancer 2019 19:1018
    Content type: Research article Published on:

  48. Although the actin cytoskeleton is vital for carcinogenesis and subsequent pathology, no microfilament-directed agent has been approved for cancer chemotherapy. One of the most studied classes of microfilament...

    Authors: Matthew Trendowski, Timothy D. Christen, Christopher Acquafondata and Thomas P. Fondy
    Citation: BMC Cancer 2015 15:632
    Content type: Research article Published on:

  49. Clinical trials are necessary for the advancement of cancer treatment and care, however low rates of participation in such trials limit the generalisability of findings. The objective of this study was to exam...

    Authors: Mariko Carey, Allison W. Boyes, Rochelle Smits, Jamie Bryant, Amy Waller and Ian Olver
    Citation: BMC Cancer 2017 17:653
    Content type: Research article Published on:

  50. NF-kB can function as an oncogene or tumor suppressor depending on cancer types. The role of NF-kB in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the function of NF-...

    Authors: Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang and Jinsong Liu
    Citation: BMC Cancer 2016 16:582
    Content type: Research article Published on:

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