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  1. Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therap...

    Authors: Ten-i Godai, Tetsuji Suda, Nobuhiro Sugano, Kazuhito Tsuchida, Manabu Shiozawa, Hironobu Sekiguchi, Akiko Sekiyama, Mitsuyo Yoshihara, Shoichi Matsukuma, Yuji Sakuma, Eiju Tsuchiya, Yoichi Kameda, Makoto Akaike and Yohei Miyagi
    Citation: BMC Cancer 2009 9:420
    Content type: Research article Published on:

  2. Androgen deprivation therapy leads to a number of adverse effects including deterioration of the musculoskeletal system and increased risk factors for cardiovascular and metabolic complications. The purpose of...

    Authors: Daniel A Galvão, Nigel Spry, Dennis R Taaffe, James Denham, David Joseph, David S Lamb, Greg Levin, Gillian Duchesne and Robert U Newton
    Citation: BMC Cancer 2009 9:419
    Content type: Study protocol Published on:

  3. Despite well-studied tumor hypoxia in laboratory, little is known about the association with other pathophysiological events in the clinical view. We investigated the prognostic value of hypoxia-inducible fact...

    Authors: Chen-Xin Dai, Qiang Gao, Shuang-Jian Qiu, Min-Jie Ju, Ming-Yan Cai, Yong-Feng Xu, Jian Zhou, Bo-Heng Zhang and Jia Fan
    Citation: BMC Cancer 2009 9:418
    Content type: Research article Published on:

  4. TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis. We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a ther...

    Authors: Eleanor B Carson-Walter, Bethany N Winans, Melissa C Whiteman, Yang Liu, Sally Jarvela, Hannu Haapasalo, Betty M Tyler, David L Huso, Mahlon D Johnson and Kevin A Walter
    Citation: BMC Cancer 2009 9:417
    Content type: Research article Published on:

  5. Tumor-specific cytotoxic T cells and infiltrating lymphocytes are frequently found in tumor tissues in patients with nasopharyngeal carcinoma (NPC). Most patients with NPC, however, especially those with advan...

    Authors: Peng Liu, Bai-Lu Xie, Shao-Hui Cai, Yun-Wen He, Ge Zhang, Yan-Mei Yi and Jun Du
    Citation: BMC Cancer 2009 9:416
    Content type: Research article Published on:

  7. Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance t...

    Authors: Rizky Abdulah, Ahmad Faried, Kenji Kobayashi, Chiho Yamazaki, Eka W Suradji, Kazuto Ito, Kazuhiro Suzuki, Masami Murakami, Hiroyuki Kuwano and Hiroshi Koyama
    Citation: BMC Cancer 2009 9:414
    Content type: Research article Published on:

  8. Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase fami...

    Authors: Jerzy Ostrowski, Marcin Polkowski, Agnieszka Paziewska, Magdalena Skrzypczak, Krzysztof Goryca, Tymon Rubel, Katarzyna Kokoszyñska, Piotr Rutkowski, Zbigniew I Nowecki, Anna Jerzak Vel Dobosz, Dorota Jarosz, Wlodzimierz Ruka and Lucjan S Wyrwicz
    Citation: BMC Cancer 2009 9:413
    Content type: Research article Published on:

  9. Pancreatic cancer is an extremely aggressive malignancy. Subjects are afflicted with a variety of disconcerting symptoms, including profound cachexia. Recent data indicate that the outcome of oncological patie...

    Authors: Angela Märten, Moritz N Wente, Jennifer Ose, Markus W Büchler, Ingeborg Rötzer, Christiane Decker-Baumann, Irini Karapanagiotou-Schenkel, Sabine Harig, Jan Schmidt and Dirk Jäger
    Citation: BMC Cancer 2009 9:412
    Content type: Study protocol Published on:

  10. c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), and both c-Met and its ligand are expressed in a variety of tissues. C-Met/HGF/SF signaling is essential for normal emb...

    Authors: Hal E Crosswell, Anindya Dasgupta, Carlos S Alvarado, Tanya Watt, James G Christensen, Pradip De, Donald L Durden and Harry W Findley
    Citation: BMC Cancer 2009 9:411
    Content type: Research article Published on:

  11. Y-box binding protein-1 (YB-1) is the prototypic member of the cold shock protein family that fulfills numerous cellular functions. In the nucleus YB-1 protein orchestrates transcription of proliferation-relat...

    Authors: Edgar Dahl, Abdelaziz En-Nia, Frank Wiesmann, Renate Krings, Sonja Djudjaj, Elisabeth Breuer, Thomas Fuchs, Peter J Wild, Arndt Hartmann, Sandra E Dunn and Peter R Mertens
    Citation: BMC Cancer 2009 9:410
    Content type: Research article Published on:

  13. Protracted low-dose concurrent chemotherapy combined with radiation has been proposed for enhanced treatment results for esophageal cancer. We evaluated the efficacy and the toxicity of a novel regimen of dail...

    Authors: Satoshi Osawa, Takahisa Furuta, Ken Sugimoto, Takashi Kosugi, Tomohiro Terai, Mihoko Yamade, Yasuhiro Takayanagi, Masafumi Nishino, Yasushi Hamaya, Chise Kodaira, Takanori Yamada, Moriya Iwaizumi, Kosuke Takagaki, Ken-ichi Yoshida, Shigeru Kanaoka and Mutsuhiro Ikuma
    Citation: BMC Cancer 2009 9:408
    Content type: Research article Published on:

  14. The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) an...

    Authors: Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland and Ulla Vogel
    Citation: BMC Cancer 2009 9:407
    Content type: Research article Published on:

  15. The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has ...

    Authors: Adela Castillejo, Trinidad Mata-Balaguer, Carla Guarinos, María-Isabel Castillejo, Ana Martínez-Cantó, Víctor-Manuel Barberá, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Carmen Guillén-Ponce, Alfredo Carrato and José-Luís Soto
    Citation: BMC Cancer 2009 9:406
    Content type: Research article Published on:

  16. Depending on the population studied, large genomic rearrangements (LGRs) of the mismatch repair (MMR) genes constitute various proportions of the germline mutations that predispose to hereditary non-polyposis col...

    Authors: Katarina Zavodna, Tomas Krivulcik, Maria Gerykova Bujalkova, Tomas Slamka, David Martinicky, Denisa Ilencikova and Zdena Bartosova
    Citation: BMC Cancer 2009 9:405
    Content type: Research article Published on:

  17. It has been speculated that the biostimulatory effect of Low Level Laser Therapy could cause undesirable enhancement of tumor growth in neoplastic diseases. The aim of the present study is to analyze the behav...

    Authors: Lúcio Frigo, Juliana SS Luppi, Giovani M Favero, Durnavei A Maria, Sócrates C Penna, Jan M Bjordal, Rene J Bensadoun and Rodrigo AB Lopes-Martins
    Citation: BMC Cancer 2009 9:404
    Content type: Research article Published on:

  18. The seroprevalence of IgG antibodies of Streptococcus gallolyticus subspecies gallolyticus, CIP 105428, was evaluated to investigate the controversial association of S. gallolyticus with colorectal carcinoma and ...

    Authors: Ahmed S Abdulamir, Rand R Hafidh, Layla K Mahdi, Tarik Al-jeboori and Fatimah Abubaker
    Citation: BMC Cancer 2009 9:403
    Content type: Research article Published on:

  19. Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is frequently over-expressed in simple epithelia, progenitors, embryonic and tissue stem cells, carcinoma and cancer-initiating ce...

    Authors: Sabine Denzel, Dorothea Maetzel, Brigitte Mack, Carola Eggert, Gabriele Bärr and Olivier Gires
    Citation: BMC Cancer 2009 9:402
    Content type: Research article Published on:

  20. Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate ...

    Authors: Aaron L Sarver, Amy J French, Pedro M Borralho, Venugopal Thayanithy, Ann L Oberg, Kevin AT Silverstein, Bruce W Morlan, Shaun M Riska, Lisa A Boardman, Julie M Cunningham, Subbaya Subramanian, Liang Wang, Tom C Smyrk, Cecilia MP Rodrigues, Stephen N Thibodeau and Clifford J Steer
    Citation: BMC Cancer 2009 9:401
    Content type: Research article Published on:

  21. Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of hepatocellular carcinoma (HCC) related to the exposure of aflatoxin B1 ...

    Authors: Xi Dai Long, Yun Ma, Yun Feng Zhou, Jin Guang Yao, Fu Zhi Ban, Yong Zhi Huang and Bing Cheng Huang
    Citation: BMC Cancer 2009 9:400
    Content type: Research article Published on:

  22. Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although chemotherapy has improved the prognosis of osteosarcoma patients dramatically after introduction of neo-...

    Authors: Michiro Susa, Arun K Iyer, Keinosuke Ryu, Francis J Hornicek, Henry Mankin, Mansoor M Amiji and Zhenfeng Duan
    Citation: BMC Cancer 2009 9:399
    Content type: Research article Published on:

  23. Etoposide is currently one of the most commonly used antitumor drugs. The mechanisms of action proposed for its antitumor activity are based mainly on its interaction with topoisomerase II. Etoposide effects i...

    Authors: Emilio Rojas, Patricia Mussali, Efrain Tovar and Mahara Valverde
    Citation: BMC Cancer 2009 9:398
    Content type: Research article Published on:

  24. Polymorphisms in glutathione S-transferase (GST) genes may influence response to oxidative stress and modify prostate cancer (PCA) susceptibility. These enzymes generally detoxify endogenous and exogenous agents,...

    Authors: Nicole A Lavender, Marnita L Benford, Tiva T VanCleave, Guy N Brock, Rick A Kittles, Jason H Moore, David W Hein and La Creis R Kidd
    Citation: BMC Cancer 2009 9:397
    Content type: Research article Published on:

  25. The Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer neoplasm virtual biorepository is a bioinformatics-supported system to incorporate data from various clinical, pathological, and m...

    Authors: Waqas Amin, Hyunseok P Kang, Ann Marie Egloff, Harpreet Singh, Kerry Trent, Jennifer Ridge-Hetrick, Raja R Seethala, Jennifer Grandis and Anil V Parwani
    Citation: BMC Cancer 2009 9:396
    Content type: Technical advance Published on:

  26. The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeut...

    Authors: Annika Lehmann, Carsten Denkert, Jan Budczies, Ann-Christin Buckendahl, Silvia Darb-Esfahani, Aurelia Noske, Berit Maria Müller, Marcus Bahra, Peter Neuhaus, Manfred Dietel, Glen Kristiansen and Wilko Weichert
    Citation: BMC Cancer 2009 9:395
    Content type: Research article Published on:

  27. B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal...

    Authors: Jie Zhang, Mingyan Zhang, Wei Jiang, Lihong Wang, Zhenkun Fu, Dalin Li, Da Pang and Dianjun Li
    Citation: BMC Cancer 2009 9:394
    Content type: Research article Published on:

  28. Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed. Methods: We i...

    Authors: Salvatore Romeo, Karoly Szuhai, Isao Nishimori, Marije Ijszenga, Pauline Wijers-Koster, Antonie HM Taminiau and Pancras CW Hogendoorn
    Citation: BMC Cancer 2009 9:393
    Content type: Research article Published on:

  29. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis (X...

    Authors: Yao Dai, Meilan Liu, Wenhua Tang, Yongming Li, Jiqin Lian, Theodore S Lawrence and Liang Xu
    Citation: BMC Cancer 2009 9:392
    Content type: Research article Published on:

  30. Information on the biology of metastasis development in salivary gland tumors is scarce. Since angiogenesis seems associated with this phenomenon in other tumors, we sought to compare salivary gland tumors wit...

    Authors: Sergio V Cardoso, Kelen Christine N Souza, Paulo R Faria, Ana Lucia A Eisenberg, Fernando L Dias and Adriano M Loyola
    Citation: BMC Cancer 2009 9:391
    Content type: Research article Published on:

  31. Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9) is co...

    Authors: Xeni Provatopoulou, Antonia Gounaris, Eleni Kalogera, Flora Zagouri, Ioannis Flessas, Evgenios Goussetis, Afroditi Nonni, Ioannis Papassotiriou and George Zografos
    Citation: BMC Cancer 2009 9:390
    Content type: Research article Published on:

  32. Surgical resection is one important curative treatment for hepatocellular carcinoma (HCC), but the prognosis following surgery differs substantially and such large variation is mainly unexplained. A review of ...

    Authors: Ke Hao, John M Luk, Nikki PY Lee, Mao Mao, Chunsheng Zhang, Mark D Ferguson, John Lamb, Hongyue Dai, Irene O Ng, Pak C Sham and Ronnie TP Poon
    Citation: BMC Cancer 2009 9:389
    Content type: Research article Published on:

  33. Well-differentiated neuroendocrine carcinomas are highly vascularized and may be sensitive to drugs administered on a metronomic schedule that has shown antiangiogenic properties. A phase II study was designed...

    Authors: Maria P Brizzi, Alfredo Berruti, Anna Ferrero, Enrica Milanesi, Marco Volante, Federico Castiglione, Nadia Birocco, Sebastiano Bombaci, Davide Perroni, Benedetta Ferretti, Oscar Alabiso, Libero Ciuffreda, Oscar Bertetto, Mauro Papotti and Luigi Dogliotti
    Citation: BMC Cancer 2009 9:388
    Content type: Research article Published on:

  34. Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. The possibility of using inhibitors on the BRAF pathway as b...

    Authors: Ana Preto, Joana Gonçalves, Ana P Rebocho, Joana Figueiredo, Ana M Meireles, Ana S Rocha, Helena M Vasconcelos, Hugo Seca, Raquel Seruca, Paula Soares and Manuel Sobrinho-Simões
    Citation: BMC Cancer 2009 9:387
    Content type: Research article Published on:

  35. Her2/neu is overexpressed in various human cancers of epithelial origin and is associated with increased metastatic potential and poor prognosis. Several attempts have been made using the extracellular domain ...

    Authors: Alexios Dimitriadis, Chrysanthi Gontinou, Constantin N Baxevanis and Avgi Mamalaki
    Citation: BMC Cancer 2009 9:386
    Content type: Research article Published on:

  36. Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer h...

    Authors: Frederikke Lihme Egerod, Annette Bartels, Niels Fristrup, Michael Borre, Torben F Ørntoft, Martin B Oleksiewicz, Nils Brünner and Lars Dyrskjøt
    Citation: BMC Cancer 2009 9:385
    Content type: Research article Published on:

  37. Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages o...

    Authors: Ling-Juan Gao, Shu-Yu Guo, You-Qun Cai, Ping-Qing Gu, Ya-Juan Su, Hui Gong, Yun Liu and Chen Chen
    Citation: BMC Cancer 2009 9:384
    Content type: Research article Published on:

  38. Testicular germ cell tumors (TGCTs) are classified as seminonas or non-seminomas of which a major subset is embryonal carcinoma (EC) that can differentiate into diverse tissues. The pluripotent nature of human...

    Authors: Grace E Snow, Allison C Kasper, Alexander M Busch, Elisabeth Schwarz, Katherine E Ewings, Thomas Bee, Michael J Spinella, Ethan Dmitrovsky and Sarah J Freemantle
    Citation: BMC Cancer 2009 9:383
    Content type: Research article Published on:

  39. Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all MLH1 alterations result in loss of MMR funct...

    Authors: Matjaz Vogelsang, Aleksandra Comino, Neja Zupanec, Petra Hudler and Radovan Komel
    Citation: BMC Cancer 2009 9:382
    Content type: Research article Published on:

  40. Patterns in survival can provide information about the burden and severity of cancer, help uncover gaps in systemic policy and program delivery, and support the planning of enhanced cancer control systems. The...

    Authors: Alireza Sadjadi, T Gregory Hislop, Chris Bajdik, Morteza Bashash, Anahita Ghorbani, Mehdi Nouraie, Masoud Babaei, Reza Malekzadeh and Parvin Yavari
    Citation: BMC Cancer 2009 9:381
    Content type: Research article Published on:

  41. The transient receptor potential, subfamily V, member 6 (TRPV6) is a Ca2+ selective cation channel. Several studies have shown that TRPV6 transcripts are expressed in locally advanced prostatic adenocarcinoma, me...

    Authors: Thorsten Kessler, Ulrich Wissenbach, Rainer Grobholz and Veit Flockerzi
    Citation: BMC Cancer 2009 9:380
    Content type: Research article Published on:

  42. A genome-wide association study (GWAS), which assessed multiple ethnicities, reported an association between single nucleotide polymorphisms in the 8q24 region and colorectal cancer risk. Although the associat...

    Authors: Keitaro Matsuo, Takeshi Suzuki, Hidemi Ito, Satoyo Hosono, Takakazu Kawase, Miki Watanabe, Kohei Shitara, Koji Komori, Yukihide Kanemitsu, Takashi Hirai, Yasushi Yatabe, Hideo Tanaka and Kazuo Tajima
    Citation: BMC Cancer 2009 9:379
    Content type: Research article Published on:

  43. The malignant potential of serous ovarian tumors, the most common ovarian tumor subtype, varies from benign to low malignant potential (LMP) tumors to frankly invasive cancers. Given the uncertainty about the ...

    Authors: Melissa A Merritt, Peter G Parsons, Tanya R Newton, Adam C Martyn, Penelope M Webb, Adèle C Green, David J Papadimos and Glen M Boyle
    Citation: BMC Cancer 2009 9:378
    Content type: Research article Published on:

  44. The glycosylphosphatidylinositol (GPI)-anchored epithelial extracellular membrane serine protease prostasin (PRSS8) is expressed abundantly in normal epithelia and essential for terminal epithelial differentia...

    Authors: Li-Mei Chen, Nicole J Verity and Karl X Chai
    Citation: BMC Cancer 2009 9:377
    Content type: Research article Published on:

  45. Colorectal cancer (CRC) is one of the leading causes of malignant death worldwide. Because young age of onset is often considered a poor prognostic factor for CRC, it is important to identify the poor outcomes...

    Authors: Chun-Chao Chang, Shung-Haur Yang, Chih-Cheng Chien, Shu-Hung Chen, Shiann Pan, Chia-Long Lee, Chih-Ming Lin, Hsiao-Lun Sun, Chi-Cheng Huang, Yih-Yiing Wu, Ruey-Neng Yang and Chi-Jung Huang
    Citation: BMC Cancer 2009 9:376
    Content type: Research article Published on:

  46. This study is a retrospective evaluation of the efficacy of neoadjuvant chemotherapy (NC) with a vinorelbine (V) and epirubicin (E) intravenous combination regimen and is aimed at identification of predictive ...

    Authors: Ou Huang, CanMing Chen, JiaYi Wu, ShuJie Chen, XiaoSong Chen, GuangYu Liu, Zhen Hu, JingSong Lu, Jiong Wu, ZhiMin Shao, ZhenZhou Shen and KunWei Shen
    Citation: BMC Cancer 2009 9:375
    Content type: Research article Published on:

  47. MicroRNAs (MiRNAs) are short non-coding RNAs that control protein expression through various mechanisms. Their altered expression has been shown to be associated with various cancers. The aim of this study was...

    Authors: Greg M Arndt, Lesley Dossey, Lara M Cullen, Angela Lai, Riki Druker, Michael Eisbacher, Chunyan Zhang, Nham Tran, Hongtao Fan, Kathy Retzlaff, Anton Bittner and Mitch Raponi
    Citation: BMC Cancer 2009 9:374
    Content type: Research article Published on:

  48. The incidence of oral and pharyngeal (including oral cavity, oropharynx and hypopharynx) carcinoma increases rapidly in Asia and South Pacific because of betel quid chewing. Thus far, large-scale epidemiologic...

    Authors: Kuan-Der Lee, Chang-Hsien Lu, Ping-Tsung Chen, Chunghuang Hubert Chan, Jen-Tsun Lin, Cih-En Huang, Chih-Cheng Chen and Min-Chi Chen
    Citation: BMC Cancer 2009 9:373
    Content type: Research article Published on:

  49. Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant gliomas. As it presents an excellent safety profile,...

    Authors: Pierre A Robe, Didier H Martin, Minh T Nguyen-Khac, Maria Artesi, Manuel Deprez, Adelin Albert, Sophie Vanbelle, Stephane Califice, Markus Bredel and Vincent Bours
    Citation: BMC Cancer 2009 9:372
    Content type: Research article Published on:

  50. Homeodomain proteins control fundamental cellular processes in development and in cancer if deregulated. Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated i...

    Authors: Stefan Nagel, Letizia Venturini, Grzegorz K Przybylski, Piotr Grabarczyk, Corinna Meyer, Maren Kaufmann, Karin Battmer, Christian A Schmidt, Hans G Drexler, Michaela Scherr and Roderick AF MacLeod
    Citation: BMC Cancer 2009 9:371
    Content type: Research article Published on:

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