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  1. Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourab...

    Authors: Donal J Brennan, Jenny Brändstedt, Elton Rexhepaj, Michael Foley, Fredrik Pontén, Mathias Uhlén, William M Gallagher, Darran P O'Connor, Colm O'Herlihy and Karin Jirstrom
    Citation: BMC Cancer 2010 10:125
    Content type: Research article Published on:

  2. Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis...

    Authors: Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura and Yan Li
    Citation: BMC Cancer 2010 10:124
    Content type: Research article Published on:

  3. Since hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, it is still important to understand hepatocarcinogenesis mechanisms and identify effective markers for tumor progres...

    Authors: Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi and Yeun-Jun Chung
    Citation: BMC Cancer 2010 10:122
    Content type: Research article Published on:

  4. Spontaneous Regression/Complete Resistant (SR/CR) mice are a colony of cancer-resistant mice that can detect and rapidly destroy malignant cells with innate cellular immunity, predominately mediated by granulo...

    Authors: Anne M Sanders, John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Arta M Monjazeb, Jonathan M Adams, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:121
    Content type: Research article Published on:

  5. Mollicutes contamination is recognized to be a critical issue for the cultivation of continuous cell lines. In this work we characterized the effect of Mycoplasma hyorhinis contamination on CD133 expression in h...

    Authors: Elisabetta Mariotti, Marica Gemei, Peppino Mirabelli, Francesca D'Alessio, Rosa Di Noto, Giuliana Fortunato and Luigi Del Vecchio
    Citation: BMC Cancer 2010 10:120
    Content type: Research article Published on:

  6. There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer d...

    Authors: Sivasai Balivada, Raja Shekar Rachakatla, Hongwang Wang, Thilani N Samarakoon, Raj Kumar Dani, Marla Pyle, Franklin O Kroh, Brandon Walker, Xiaoxuan Leaym, Olga B Koper, Masaaki Tamura, Viktor Chikan, Stefan H Bossmann and Deryl L Troyer
    Citation: BMC Cancer 2010 10:119
    Content type: Research article Published on:

  7. The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular p...

    Authors: Tsuyoshi Mitsuishi, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Takehiko Kaneko, Kuniaki Ohara, Ikuroh Ohsawa, Fumino Oda, Yuko Yamada, Seiji Kawana, Kohji Ozaki, Mayuka Nakatake and Osamu Yamada
    Citation: BMC Cancer 2010 10:118
    Content type: Research article Published on:

  8. Based on the well-recognized etiological role of human papillomavirus (HPV) in cervical, anogenital and oropharyngeal carcinogenesis, a potential role of HPV in colorectal carcinogenesis has been suggested. Fo...

    Authors: Vanessa Deschoolmeester, Veerle Van Marck, Marc Baay, Christine Weyn, Peter Vermeulen, Eric Van Marck, Filip Lardon, Veronique Fontaine and Jan B Vermorken
    Citation: BMC Cancer 2010 10:117
    Content type: Research article Published on:

  9. Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a s...

    Authors: Xiaohua Jiang, Ynnez Gwye, Darren Russell, Christine Cao, Dorothea Douglas, Long Hung, Heinrich Kovar, Timothy J Triche and Elizabeth R Lawlor
    Citation: BMC Cancer 2010 10:116
    Content type: Research article Published on:

  10. Birth size, and particularly birth length, is positively associated with breast cancer risk in adulthood. The objective of this study was to examine whether birth size is associated with survival among breast ...

    Authors: Bjørn O Mæhle, Lars J Vatten and Steinar Tretli
    Citation: BMC Cancer 2010 10:115
    Content type: Research article Published on:

  11. Breast cancer is one of the leading causes of women's death worldwide. It is important to discover a reliable biomarker for the detection of breast cancer. Plasma is the most ideal source for cancer biomarker ...

    Authors: Un-Beom Kang, Younghee Ahn, Jong Won Lee, Yong-Hak Kim, Joon Kim, Myeong-Hee Yu, Dong-Young Noh and Cheolju Lee
    Citation: BMC Cancer 2010 10:114
    Content type: Research article Published on:

  12. Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous...

    Authors: Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi and Edvaldo S Trindade
    Citation: BMC Cancer 2010 10:113
    Content type: Research article Published on:

  13. Tumor-associated macrophages (TAMs) play an important role in growth, progression and metastasis of tumors. In non-small cell lung cancer (NSCLC), TAMs' anti-tumor or pro-tumor role is not determined. Macropha...

    Authors: Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai and Zongbing You
    Citation: BMC Cancer 2010 10:112
    Content type: Research article Published on:

  14. In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-positive women compared to LBC followed by ...

    Authors: Gina S Ogilvie, Dirk J van Niekerk, Mel Krajden, Ruth E Martin, Thomas G Ehlen, Kathy Ceballos, Stuart J Peacock, Laurie W Smith, Lisa Kan, Darrel A Cook, Wendy Mei, Gavin CE Stuart, Eduardo L Franco and Andrew J Coldman
    Citation: BMC Cancer 2010 10:111
    Content type: Study protocol Published on:

  15. Circadian genes continue to gain attention as important transcriptional regulators with the potential to influence a variety of biological pathways, including many cancer-related processes. The core circadian ...

    Authors: Aaron E Hoffman, Tongzhang Zheng, Yue Ba, Richard G Stevens, Chun-Hui Yi, Derek Leaderer and Yong Zhu
    Citation: BMC Cancer 2010 10:110
    Content type: Research article Published on:

  16. The discovery of small non-coding RNAs and the subsequent analysis of microRNA expression patterns in human cancer specimens have provided completely new insights into cancer biology. Genetic and epigenetic da...

    Authors: Ulrich Lehmann, Thomas Streichert, Benjamin Otto, Cord Albat, Britta Hasemeier, Henriette Christgen, Elisa Schipper, Ursula Hille, Hans H Kreipe and Florian Länger
    Citation: BMC Cancer 2010 10:109
    Content type: Research article Published on:

  17. Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ pa...

    Authors: David G Hicks, Bagi R Janarthanan, Ramya Vardarajan, Swati A Kulkarni, Thaer Khoury, Daniel Dim, G Thomas Budd, Brian J Yoder, Raymond Tubbs, Marshall T Schreeder, Noel C Estopinal, Rodney A Beck, Yanling Wang, Brian Z Ring, Robert S Seitz and Douglas T Ross
    Citation: BMC Cancer 2010 10:108
    Content type: Research article Published on:

  18. Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that is associated with cell death h...

    Authors: Louise Flanagan, Lorna Whyte, Namita Chatterjee and Martin Tenniswood
    Citation: BMC Cancer 2010 10:107
    Content type: Research article Published on:

  19. Multicellular tumour sphere models have been shown to closely mimic phenotype characteristics of in vivo solid tumours, or to allow in vitro propagation of cancer stem cells (CSCs). CSCs are usually characterized...

    Authors: Louis-Bastien Weiswald, Jean-Marc Guinebretière, Sophie Richon, Dominique Bellet, Bruno Saubaméa and Virginie Dangles-Marie
    Citation: BMC Cancer 2010 10:106
    Content type: Technical advance Published on:

  20. Cancer, heart failure and stroke are among the most common causes of death worldwide. Investigation of the prognostic impact of each disease is important, especially for a better understanding of competing ris...

    Authors: Vasileios Askoxylakis, Christian Thieke, Sven T Pleger, Patrick Most, Judith Tanner, Katja Lindel, Hugo A Katus, Jürgen Debus and Marc Bischof
    Citation: BMC Cancer 2010 10:105
    Content type: Research article Published on:

  22. Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatm...

    Authors: Anna Martirosyan, James W Clendening, Carolyn A Goard and Linda Z Penn
    Citation: BMC Cancer 2010 10:103
    Content type: Research article Published on:

  23. The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with...

    Authors: Wen-Shan Liu, Chung-Han Hsin, Ying-Hsiang Chou, Jung-Tung Liu, Ming-Fang Wu, Szu-Wen Tseng, Jong-Kang Lee, Hsien-Chun Tseng, Tzu-Hwei Wang, Mao-Chang Su and Huei Lee
    Citation: BMC Cancer 2010 10:102
    Content type: Research article Published on:

  24. An increasing number of studies show that genetic markers can aid in refining prognostic information and predicting the benefit from systemic therapy. Our goal was to develop a high throughput, cost-effective ...

    Authors: Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik and Katherine L Pogue-Geile
    Citation: BMC Cancer 2010 10:101
    Content type: Research article Published on:

  25. Previous population-based studies showed differences in international and within country colorectal cancer survival estimates, but few investigated the role of prognostic factors. Using a "high resolution appr...

    Authors: Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy and Hermann Brenner
    Citation: BMC Cancer 2010 10:100
    Content type: Research article Published on:

  26. BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clini...

    Authors: Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends and Sheila A Rodwell
    Citation: BMC Cancer 2010 10:99
    Content type: Research article Published on:

  28. In the present study, we determined the gene hypermethylation profiles of normal tissues adjacent to invasive breast carcinomas and investigated whether these are associated with the gene hypermethylation prof...

    Authors: Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix and Peter B Vermeulen
    Citation: BMC Cancer 2010 10:97
    Content type: Research article Published on:

  29. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. For effective treatment, local control of the tumor is absolutely critical, because the chances of long term survival a...

    Authors: Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik and Jürgen Debus
    Citation: BMC Cancer 2010 10:96
    Content type: Study protocol Published on:

  30. Invasiveness and metastasis are the most common characteristics of non small cell lung cancer (NSCLC) and causes of tumour-related morbidity and mortality. Mitogen-activated protein kinases (MAPKs) signalling ...

    Authors: Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee and Win-Ping Deng
    Citation: BMC Cancer 2010 10:95
    Content type: Research article Published on:

  31. Remodeling of the extracellular matrix (ECM) has been implicated in ovarian cancer, and we hypothesize that these alterations may provide a better optical marker of early disease than currently available imagi...

    Authors: Oleg Nadiarnykh, Ronald B LaComb, Molly A Brewer and Paul J Campagnola
    Citation: BMC Cancer 2010 10:94
    Content type: Research article Published on:

  32. The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding...

    Authors: Manuela Eppenberger, Inti Zlobec, Daniel Baumhoer, Luigi Terracciano and Alessandro Lugli
    Citation: BMC Cancer 2010 10:93
    Content type: Research article Published on:

  33. Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulf...

    Authors: Pamela Zengel, Diana Ramp, Brigitte Mack, Stefan Zahler, Alexander Berghaus, Bernd Muehlenweg, Olivier Gires and Suna Schmitz
    Citation: BMC Cancer 2010 10:92
    Content type: Research article Published on:

  34. Glioblastoma multiforme (GBM) is the most aggressive and frequent brain tumor, albeit without cure. Although patient survival is limited to one year on average, significant variability in outcome is observed. ...

    Authors: Marie-Claude Amoureux, Béma Coulibaly, Olivier Chinot, Anderson Loundou, Philippe Metellus, Geneviève Rougon and Dominique Figarella-Branger
    Citation: BMC Cancer 2010 10:91
    Content type: Research article Published on:

  35. The purpose of our study was to compare differences in the prognosis of breast cancer (BC) patients at high (H) risk or intermediate slightly (IS) increased risk based on family history and those without a fam...

    Authors: Laura Cortesi, Cristina Masini, Claudia Cirilli, Veronica Medici, Isabella Marchi, Giovanna Cavazzini, Giuseppe Pasini, Daniela Turchetti and Massimo Federico
    Citation: BMC Cancer 2010 10:90
    Content type: Research article Published on:

  36. Ovarian cancer still has a relatively poor prognosis due to the frequent occurrence of drug resistance, making the identification of new therapeutic targets an important goal. We have studied the role of HOX gene...

    Authors: Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael and Hardev S Pandha
    Citation: BMC Cancer 2010 10:89
    Content type: Research article Published on:

  37. Single nucleotide polymorphism (SNP) 309 resulting in a T or G allele in the promoter of MDM2, the negative regulator of p53, has been suggested to affect cancer predisposition and age of onset, primarily in fema...

    Authors: Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy and Adeline Seow
    Citation: BMC Cancer 2010 10:88
    Content type: Research article Published on:

  38. Dendritic cells (DCs) isolated from tumor bearing animals or from individuals with solid tumors display functional abnormalities and the DC impairment has emerged as one mechanism for tumor evasion from the co...

    Authors: Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch and Marie Larsson
    Citation: BMC Cancer 2010 10:87
    Content type: Research article Published on:

  39. Cachexia is a common problem in patients (pts) suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to thei...

    Authors: Uwe Pelzer, Dirk Arnold, Mehmet Goevercin, Jens Stieler, Bernd Doerken, Hanno Riess and Helmut Oettle
    Citation: BMC Cancer 2010 10:86
    Content type: Research article Published on:

  40. To improve the efficacy of first-line therapy for advanced non-small cell lung cancer (NSCLC), additional maintenance chemotherapy may be given after initial induction chemotherapy in patients who did not prog...

    Authors: Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, Jesús Corral Jaime, Francesca Russo and Carla Visseren-Grul
    Citation: BMC Cancer 2010 10:85
    Content type: Study protocol Published on:

  41. Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated wit...

    Authors: Sunitha V Bachawal, Vikram B Wali and Paul W Sylvester
    Citation: BMC Cancer 2010 10:84
    Content type: Research article Published on:

  42. The hepaCAM gene encodes a new immunoglobulin-like cell adhesion molecule, and its expression is suppressed in a variety of human cancers. Additionally, hepaCAM possesses properties often observed in tumor sup...

    Authors: Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang and Jie Lin
    Citation: BMC Cancer 2010 10:83
    Content type: Research article Published on:

  43. The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that...

    Authors: Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser and Andreas Thalheimer
    Citation: BMC Cancer 2010 10:82
    Content type: Research article Published on:

  45. Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs ...

    Authors: Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands and Dileep N Lobo
    Citation: BMC Cancer 2010 10:80
    Content type: Research article Published on:

  46. Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular mark...

    Authors: Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka and Naoki Yokota
    Citation: BMC Cancer 2010 10:79
    Content type: Research article Published on:

  47. Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpo...

    Authors: Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger and Burkhard Brandt
    Citation: BMC Cancer 2010 10:78
    Content type: Research article Published on:

  48. Several different gene expression signatures have been proposed to predict response to therapy and clinical outcome in lung adenocarcinoma. Herein, we investigate if elements of published gene sets can be repr...

    Authors: Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner and Axel zur Hausen
    Citation: BMC Cancer 2010 10:77
    Content type: Research article Published on:

  49. HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexp...

    Authors: Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki and Ewa A Grzybowska
    Citation: BMC Cancer 2010 10:76
    Content type: Research article Published on:

  50. Multiple myeloma is an uncommon cancer with a poor prognosis. Its incidence is expected to increase due to ageing populations and better diagnosis, and new treatments have been developed to improve survival. O...

    Authors: Christine Renshaw, Nicolas Ketley, Henrik Møller and Elizabeth A Davies
    Citation: BMC Cancer 2010 10:74
    Content type: Research article Published on:

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