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  1. BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation ph...

    Authors: Sérgia Velho, Cátia Moutinho, Luís Cirnes, Cristina Albuquerque, Richard Hamelin, Fernando Schmitt, Fátima Carneiro, Carla Oliveira and Raquel Seruca
    Citation: BMC Cancer 2008 8:255
    Content type: Research article Published on:

  2. It is of great significance to find better markers to correctly distinguish between high-risk and low-risk breast cancer patients since the majority of breast cancer cases are at present being overtreated.

    Authors: Elin Karlsson, Ulla Delle, Anna Danielsson, Björn Olsson, Frida Abel, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2008 8:254
    Content type: Research article Published on:

  3. Nasopharyngeal carcinoma (NPC) is a head and neck malignancy with high occurrence in South-East Asia and Southern China. Recent findings suggest that epigenetic inactivation of multiple tumor suppressor genes ...

    Authors: Huaying Liu, Liming Zhang, Zhaoxia Niu, Ming Zhou, Cong Peng, Xiayu Li, Tan Deng, Lei Shi, Yixin Tan and Guiyuan Li
    Citation: BMC Cancer 2008 8:253
    Content type: Research article Published on:

  4. Mucinous ovarian carcinoma have a poorer prognosis compared with other histological subtypes. The aim of this study was to evaluate, retrospectively, the activity of chemotherapy in patients with platinum sens...

    Authors: Sandro Pignata, Gabriella Ferrandina, Giovanna Scarfone, Paolo Scollo, Franco Odicino, Gennaro Cormio, Dionyssios Katsaros, Antonella Villa, Liliana Mereu, Fabio Ghezzi, Luigi Manzione, Rossella Lauria, Enrico Breda, Desiderio Gueli Alletti, Michela Ballardini, Alessandra Vernaglia Lombardi…
    Citation: BMC Cancer 2008 8:252
    Content type: Research article Published on:

  5. The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological subtype – more so than th...

    Authors: Peter Schirmacher and Markus W Büchler
    Citation: BMC Cancer 2008 8:251
    Content type: Commentary Published on:

  6. In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. Th...

    Authors: Ali H Zarzour, Mohie Selim, Alaa A Abd-Elsayed, Diaa A Hameed and Mohammad A AbdelAziz
    Citation: BMC Cancer 2008 8:250
    Content type: Research article Published on:

  7. Bioelectrical impedance analysis (BIA) is an easy-to-use, non-invasive, and reproducible technique to evaluate changes in body composition and nutritional status. Phase angle, determined by bioelectrical imped...

    Authors: Digant Gupta, Carolyn A Lammersfeld, Pankaj G Vashi, Jessica King, Sadie L Dahlk, James F Grutsch and Christopher G Lis
    Citation: BMC Cancer 2008 8:249
    Content type: Research article Published on:

  8. We have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer specific from cancer patients. To facilitate this work we previously develope...

    Authors: Sergei Rudchenko, Matthew Scanlan, Gavreel Kalantarov, Victoria Yavelsky, Chen Levy, Alison Estabrook, Lloyd Old, Gerald L Chan, Leslie Lobel and Ilya Trakht
    Citation: BMC Cancer 2008 8:248
    Content type: Research article Published on:

  9. We have been studying the native humoral immune response to cancer and have isolated a library of fully human autoantibodies to a variety of malignancies. We previously described the isolation and characteriza...

    Authors: Victoria Yavelsky, Sarit Rohkin, Ruthy Shaco-Levy, Alina Tzikinovsky, Tamar Amir, Hila Kohn, Berta Delgado, Alex Rabinovich, Benjamin Piura, Gerald Chan, Gavreel Kalantarov, Ilya Trakht and Leslie Lobel
    Citation: BMC Cancer 2008 8:247
    Content type: Research article Published on:

  10. Persistent infection with oncogenic types of human papillomavirus (HPV) is the major risk factor for invasive cervical cancer (ICC), and non-European variants of HPV-16 are associated with an increased risk of...

    Authors: Patricia S de Araujo Souza, Paulo C Maciag, Karina B Ribeiro, Maria Luiza Petzl-Erler, Eduardo L Franco and Luisa L Villa
    Citation: BMC Cancer 2008 8:246
    Content type: Research article Published on:

  13. Glioblastoma is the most lethal primary malignant brain tumor. Although considerable progress has been made in the treatment of this aggressive tumor, the clinical outcome for patients remains poor. Histone de...

    Authors: Agda KB Lucio-Eterovic, Maria AA Cortez, Elvis T Valera, Fabio JN Motta, Rosane GP Queiroz, Helio R Machado, Carlos G Carlotti Jr, Luciano Neder, Carlos A Scrideli and Luiz G Tone
    Citation: BMC Cancer 2008 8:243
    Content type: Research article Published on:

  14. Honokiol is a major bioactive compound extracted from Magnolia. The present study was designed to determine whether liposomal honokiol has the antitumor activity against human lung cancer as well as potentiate...

    Authors: Qi-qi Jiang, Lin-yu Fan, Guang-li Yang, Wen-Hao Guo, Wen-li Hou, Li-juan Chen and Yu-quan Wei
    Citation: BMC Cancer 2008 8:242
    Content type: Research article Published on:

  15. There is an urgent need to discover more sensitive and specific biomarkers to improve early diagnosis and screen high-risk patients for pancreatic ductal adenocarcinoma (PDAC). Pancreatic juice is an ideal spe...

    Authors: Mei Tian, Ya-Zhou Cui, Guan-Hua Song, Mei-Juan Zong, Xiao-Yan Zhou, Yu Chen and Jin-Xiang Han
    Citation: BMC Cancer 2008 8:241
    Content type: Research article Published on:

  16. Prostate cancer is a frequent finding in man. In dogs, malignant disease of the prostate is also of clinical relevance, although it is a less common diagnosis. Even though there are numerous differences in ori...

    Authors: Melani AM Fork, Hugo Murua Escobar, Jan T Soller, Katharina A Sterenczak, Saskia Willenbrock, Susanne Winkler, Martina Dorsch, Nicola Reimann-Berg, Hans J Hedrich, Jörn Bullerdiek and Ingo Nolte
    Citation: BMC Cancer 2008 8:240
    Content type: Research article Published on:

  17. BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an imp...

    Authors: David J Novak, Long Qi Chen, Parviz Ghadirian, Nancy Hamel, Phil Zhang, Vanessa Rossiny, Guy Cardinal, André Robidoux, Patricia N Tonin, Francois Rousseau, Steven A Narod and William D Foulkes
    Citation: BMC Cancer 2008 8:239
    Content type: Research article Published on:

  18. Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence.

    Authors: Priscilla D Negraes, Francine P Favaro, João Lauro V Camargo, Maria Luiza CS Oliveira, José Goldberg, Cláudia A Rainho and Daisy MF Salvadori
    Citation: BMC Cancer 2008 8:238
    Content type: Research article Published on:

  19. Epidemiologic and laboratory investigations suggest that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon cancer perhaps due at least in part to their ...

    Authors: Randall E Harris, Joanne Beebe-Donk and Galal A Alshafie
    Citation: BMC Cancer 2008 8:237
    Content type: Research article Published on:

  20. Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to h...

    Authors: Waqas Amin, Anil V Parwani, Linda Schmandt, Sambit K Mohanty, Ghada Farhat, Andrew K Pople, Sharon B Winters, Nancy B Whelan, Althea M Schneider, John T Milnes, Federico A Valdivieso, Michael Feldman, Harvey I Pass, Rajiv Dhir, Jonathan Melamed and Michael J Becich
    Citation: BMC Cancer 2008 8:236
    Content type: Research article Published on:

  22. The epidermal growth factor receptor (EGFR) is over-expressed in 70–75% of colorectal adenocarcinomas (CRC). The anti-EGFR monoclonal antibody cetuximab has been approved for the treatment of metastatic CRC, h...

    Authors: Evangelia Razis, Evangelos Briasoulis, Eleni Vrettou, Dimosthenis V Skarlos, Dimitrios Papamichael, Ioannis Kostopoulos, Epaminontas Samantas, Ioannis Xanthakis, Mattheos Bobos, Eleni Galanidi, Maria Bai, Ioanna Gikonti, Alona Koukouma, Georgia Kafiri, Pavlos Papakostas, Konstantine T Kalogeras…
    Citation: BMC Cancer 2008 8:234
    Content type: Research article Published on:

  23. Many kinetochore proteins have been shown to be associated with human cancers. The aim of the present study was to clarify the expression of Centromere protein H (CENP-H), one of the fundamental components of ...

    Authors: Xian-Zhi Guo, Ge Zhang, Jun-Ye Wang, Wan-Li Liu, Fang Wang, Ju-Qin Dong, Li-Hua Xu, Jing-Yan Cao, Li-Bing Song and Mu-Sheng Zeng
    Citation: BMC Cancer 2008 8:233
    Content type: Research article Published on:

  24. Proteins overexpressed on the surface of tumor cells can be selectively targeted. Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are among the most often targeted p...

    Authors: Li Shen, Yongjie Shui, Xiaojia Wang, Liming Sheng, Zhengyan Yang, Danfeng Xue and Qichun Wei
    Citation: BMC Cancer 2008 8:232
    Content type: Research article Published on:

  26. The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer. These associations suggest the hy...

    Authors: Liesel M FitzGerald, Ilir Agalliu, Karynn Johnson, Melinda A Miller, Erika M Kwon, Antonio Hurtado-Coll, Ladan Fazli, Ashish B Rajput, Martin E Gleave, Michael E Cox, Elaine A Ostrander, Janet L Stanford and David G Huntsman
    Citation: BMC Cancer 2008 8:230
    Content type: Research article Published on:

  27. Although lung cancer is among the few malignancies for which we know the primary etiological agent (i.e., cigarette smoke), a precise understanding of the temporal sequence of events that drive tumor progressi...

    Authors: Ellen Jorgensen, Andy Stinson, Lin Shan, Jin Yang, Diana Gietl and Anthony P Albino
    Citation: BMC Cancer 2008 8:229
    Content type: Research article Published on:

  28. The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modifi...

    Authors: Kai Tao, Min Fang, Joseph Alroy and G Gary Sahagian
    Citation: BMC Cancer 2008 8:228
    Content type: Research article Published on:

  29. EGFR is frequently overexpressed in colon cancer. We characterized HT-29 and Caco-2, human colon cancer cell lines, untreated and treated with cetuximab or gefitinib alone and in combination with EGF.

    Authors: Rossella Solmi, Mattia Lauriola, Mirko Francesconi, Désirée Martini, Manuela Voltattorni, Claudio Ceccarelli, Giampaolo Ugolini, Giancarlo Rosati, Simone Zanotti, Isacco Montroni, Gabriella Mattei, Mario Taffurelli, Donatella Santini, Furio Pezzetti, Alessandro Ruggeri, Gastone Castellani…
    Citation: BMC Cancer 2008 8:227
    Content type: Research article Published on:

  30. Prostate cancer is the most common male cancer in the Western world. The most substantial long term morbidity from this cancer is sexual dysfunction with consequent adverse changes in couple and intimate relat...

    Authors: Suzanne K Chambers, Leslie Schover, Kim Halford, Samantha Clutton, Megan Ferguson, Louisa Gordon, RA Gardiner, Stefano Occhipinti and Jeff Dunn
    Citation: BMC Cancer 2008 8:226
    Content type: Study protocol Published on:

  31. Primary central nervous system lymphoma (PCNSL) is a frequent complication in acquired immunodeficiency syndrome (AIDS). The objective of this survey was to investigate incidence, clinical features, radiologic...

    Authors: Ingfrid S Haldorsen, Jostein Kråkenes, Anne K Goplen, Oona Dunlop, Olav Mella and Ansgar Espeland
    Citation: BMC Cancer 2008 8:225
    Content type: Research article Published on:

  32. The purpose of this study was to evaluate the role of osteoprotegerin gene (OPG) polymorphisms as genetic modifiers in the etiology of prostate cancer (PCa) and disease progression.

    Authors: Naofumi Narita, Takeshi Yuasa, Norihiko Tsuchiya, Teruaki Kumazawa, Shintaro Narita, Takamitsu Inoue, Zhiyong Ma, Mitsuru Saito, Yohei Horikawa, Shigeru Satoh, Osamu Ogawa and Tomonori Habuchi
    Citation: BMC Cancer 2008 8:224
    Content type: Research article Published on:

  33. The invasive potential of cancer cells is usually assessed in vitro using Matrigel as a surrogate basement membrane. Yet cancer cell interaction with collagen I matrices is critical, particularly for the peritone...

    Authors: Katharine L Sodek, Theodore J Brown and Maurice J Ringuette
    Citation: BMC Cancer 2008 8:223
    Content type: Research article Published on:

  34. Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment a...

    Authors: Anthony Anisowicz, Hui Huang, Karen I Braunschweiger, Ziying Liu, Heidi Giese, Huajun Wang, Sergey Mamaev, Jerzy Olejnik, Pierre P Massion and Richard G Del Mastro
    Citation: BMC Cancer 2008 8:222
    Content type: Technical advance Published on:

  35. The effect of tobacco smoking and alcohol drinking on esophageal cancer (EC) has never been explored in Spain where black tobacco and wine consumptions are quite prevalent. We estimated the independent effect ...

    Authors: Jesus Vioque, Xavier Barber, Francisco Bolumar, Miquel Porta, Miguel Santibáñez, Manuela García de la Hera and Eduardo Moreno-Osset
    Citation: BMC Cancer 2008 8:221
    Content type: Research article Published on:

  36. Oral squamous cell carcinoma (OSCC) represents the most common oral malignancy. Despite recent advances in therapy, up to 50% of the cases have relapse and/or metastasis. There is therefore a strong need for t...

    Authors: Roberta Bacchiocchi, Corrado Rubini, Elisa Pierpaoli, Giulia Borghetti, Pasquale Procacci, Pier Francesco Nocini, Andrea Santarelli, Romina Rocchetti, Domenico Ciavarella, Lorenzo Lo Muzio and Francesca Fazioli
    Citation: BMC Cancer 2008 8:220
    Content type: Research article Published on:

  37. The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested ...

    Authors: Alfonso Urbanucci, Kati K Waltering, Hanna E Suikki, Merja A Helenius and Tapio Visakorpi
    Citation: BMC Cancer 2008 8:219
    Content type: Research article Published on:

  38. Cyclooxygenase (COX)-2 has been implicated in tumour progression, angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that inhibition of COX-2 activity might reduce expression of t...

    Authors: Yong Ming Zhu, Nor Saadah M Azahri, Danny CW Yu and Penella J Woll
    Citation: BMC Cancer 2008 8:218
    Content type: Research article Published on:

  41. Functional inactivation of the tumor suppressor Smad4 in colorectal and pancreatic carcinogenesis occurs coincident with the transition to invasive growth. Breaking the basement membrane (BM) barrier, a prereq...

    Authors: Dirk Zboralski, Miriam Böckmann, Marc Zapatka, Sabine Hoppe, Anna Schöneck, Stephan A Hahn, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2008 8:215
    Content type: Research article Published on:

  42. Breast Cancer is the most commonly diagnosed cancer among Sri Lankan women. Germline mutations in the susceptibility genes BRCA1 and BRCA2 in hereditary breast/ovarian cancer, though low in prevalence, are highly...

    Authors: Wasanthi De Silva, Eric H Karunanayake, Kamani H Tennekoon, Marie Allen, Indrani Amarasinghe, Preethika Angunawala and Mohamed H Ziard
    Citation: BMC Cancer 2008 8:214
    Content type: Research article Published on:

  43. After total mesorectal excision (TME) for rectal cancer around 10% of patients develops local recurrences within the pelvis. One reason for recurrence might be spillage of cancer cells during surgery. This pil...

    Authors: Annette Torgunrud Kristensen, Johan N Wiig, Stein G Larsen, Karl-Erik Giercksky and Per O Ekstrøm
    Citation: BMC Cancer 2008 8:213
    Content type: Research article Published on:

  44. PTX is one of the most widely used drug in oncology due to its high efficacy against solid tumors and several hematological cancers. PTX is administered in a formulation containing 1:1 Cremophor® EL (polyethoxyla...

    Authors: Luisa Vicari, Teresa Musumeci, Ignazio Giannone, Luana Adamo, Concetta Conticello, Ruggero De Maria, Rosario Pignatello, Giovanni Puglisi and Massimo Gulisano
    Citation: BMC Cancer 2008 8:212
    Content type: Research article Published on:

  45. In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytologica...

    Authors: Yasmin Adam, Cyril J van Gelderen, Guy de Bruyn, James A McIntyre, Diane A Turton and Neil A Martinson
    Citation: BMC Cancer 2008 8:211
    Content type: Research article Published on:

  46. Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity...

    Authors: Hiroshi Makino, Hiroyuki Uetake, Kathleen Danenberg, Peter V Danenberg and Kenichi Sugihara
    Citation: BMC Cancer 2008 8:210
    Content type: Research article Published on:

  47. The vinka-alkaloyd vinorelbine is a potentially valuable treatment in patients with HER2-positive, trastuzumab-resistant advanced breast cancer. We sought to document the clinical activity of vinorelbine-based...

    Authors: Filippo Montemurro, Stefania Redana, Franco Nolè, Michela Donadio, Maria Elena Jacomuzzzi, Giorgio Valabrega, Giuseppe Viale, Anna Sapino and Massimo Aglietta
    Citation: BMC Cancer 2008 8:209
    Content type: Research article Published on:

  48. Conjugated linoleic acid (CLA), a naturally occurring fatty acid found in ruminant products such as milk and beef, has been shown to possess anti-cancer activities in in vivo animal models and in vitro cell cultu...

    Authors: Li-Shu Wang, Yi-Wen Huang, Suling Liu, Pearlly Yan and Young C Lin
    Citation: BMC Cancer 2008 8:208
    Content type: Research article Published on:

  49. Prostate cancer is the most common male cancer in the Western world but is highly heterogeneous in disease progression and outcomes. Consequently, the most substantial morbidity may actually arise from the adv...

    Authors: Suzanne K Chambers, Megan Ferguson, RA Gardiner, David Nicol, Louisa Gordon, Stefano Occhipinti and Joanne Aitken
    Citation: BMC Cancer 2008 8:207
    Content type: Study protocol Published on:

  50. DLC2, a unique RhoGAP, has been recently identified as a tumor suppressor gene in hepatocellular carcinoma (HCC). However, the expression of DLC2 protein, and its relationship with RhoA in clinical hepatocellu...

    Authors: Li Xiaorong, Wu Wei, Qian Liyuan and Yang Kaiyan
    Citation: BMC Cancer 2008 8:205
    Content type: Research article Published on:

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