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  1. The 5-year survival of patients with resected pancreatic adenocarcinoma is still unsatisfying. The ESPAC-1 and the CONKO 001 trial proofed that adjuvant chemotherapy improves 5-year survival significantly from...

    Authors: Angela Märten, Jan Schmidt, Jennifer Ose, Sabine Harig, Ulrich Abel, Marc W Münter, Dirk Jäger, Helmut Friess, Julia Mayerle, Guido Adler, Thomas Seufferlein, Thomas Gress, Roland Schmid and Markus W Büchler
    Citation: BMC Cancer 2009 9:160
    Content type: Study protocol Published on:

  3. Colorectal cancer is the third most common cancer in the western world. Chemotherapy is often ineffective to treat the advanced colorectal cancers due to the chemo-resistance. A major contributor to chemo-resi...

    Authors: Shi Yu Yang, Capucine Bolvin, Kevin M Sales, Barry Fuller, Alexander M Seifalian and Marc C Winslet
    Citation: BMC Cancer 2009 9:158
    Content type: Research article Published on:

  4. Thymidylate synthase (TS) is known to have a unique 28 bp tandemly repeated sequence in the promoter region, and the majorities of subjects have a heterozygous double repeat/triple repeat genotype in their non-c...

    Authors: Hidekazu Kuramochi, Kazumi Uchida, Jeffery H Peters, Daisuke Shimizu, Daniel Vallbohmer, Sylke Schneider, Kathleen D Danenberg and Peter V Danenberg
    Citation: BMC Cancer 2009 9:157
    Content type: Research article Published on:

  5. Chemotherapy may improve survival in patients undergoing resection of colorectal liver metastases (CLM). Neoadjuvant chemotherapy may help identify patients with occult extrahepatic disease (averting unnecessa...

    Authors: Oliver F Bathe, Scott Ernst, Francis R Sutherland, Elijah Dixon, Charles Butts, David Bigam, David Holland, Geoffrey A Porter, Jennifer Koppel and Scot Dowden
    Citation: BMC Cancer 2009 9:156
    Content type: Research article Published on:

  6. The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis to malignancy. Because the C-reactive protein (CRP) is a representative marker for inflammation, CRP has recent...

    Authors: Do-Kyong Kim, Sung Yong Oh, Hyuk-Chan Kwon, Suee Lee, Kyung A Kwon, Byung Geun Kim, Seong-Geun Kim, Sung-Hyun Kim, Jin Seok Jang, Min Chan Kim, Kyeong Hee Kim, Jin-Yeong Han and Hyo-Jin Kim
    Citation: BMC Cancer 2009 9:155
    Content type: Research article Published on:

  7. This retrospective study evaluated, according to hormone receptor status, the antitumor effects of bisphosphonate especially on survival and disease progression in breast cancer patients with metastatic bone d...

    Authors: In Hae Park, Jungsil Ro, Byung Ho Nam, Youngmi Kwon and Keun Seok Lee
    Citation: BMC Cancer 2009 9:154
    Content type: Research article Published on:

  8. Toxicity from chemotherapy is highly variable, unpredictable and results in substantial morbidity and increased healthcare costs. New predictors of toxicity are required to improve the safety and efficacy of c...

    Authors: Rohini Sharma, David Cunningham, Paul Smith, Graham Robertson, Owen Dent and Stephen J Clarke
    Citation: BMC Cancer 2009 9:153
    Content type: Research article Published on:

  9. The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases.

    Authors: Maria V Yusenko, Roland P Kuiper, Tamas Boethe, Börje Ljungberg, Ad Geurts van Kessel and Gyula Kovacs
    Citation: BMC Cancer 2009 9:152
    Content type: Research article Published on:

  11. SELDI-TOF-MS (Surface Enhanced Laser Desorption/Ionization-Time of Flight-Mass Spectrometry) has become an attractive approach for cancer biomarker discovery due to its ability to resolve low mass proteins and...

    Authors: Guodong Li, Wenjuan Zhang, Huazong Zeng, Lei Chen, Wenjing Wang, Jilong Liu, Zhiyu Zhang and Zhengdong Cai
    Citation: BMC Cancer 2009 9:150
    Content type: Research article Published on:

  12. Non-muscle invasive bladder neoplasms with invasion of the lamina propria (stage T1) or high grade of dysplasia are at "high risk" of progression to life-threatening cancer. However, the individual course is diff...

    Authors: Karsten Zieger, Carsten Wiuf, Klaus Møller-Ernst Jensen, Torben Falck Ørntoft and Lars Dyrskjøt
    Citation: BMC Cancer 2009 9:149
    Content type: Research article Published on:

  13. Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of significance is the finding that BRCA1...

    Authors: Ashwini L Chand, Evan R Simpson and Colin D Clyne
    Citation: BMC Cancer 2009 9:148
    Content type: Research article Published on:

  14. A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL-related leukemia. Recently, we have established the MLL-SEPT2 gene fusion as the molecular abnormalit...

    Authors: Nuno Cerveira, Joana Santos, Susana Bizarro, Vera Costa, Franclim R Ribeiro, Susana Lisboa, Cecília Correia, Lurdes Torres, Joana Vieira, Simone Snijder, José M Mariz, Lucília Norton, Clemens H Mellink, Arjan Buijs and Manuel R Teixeira
    Citation: BMC Cancer 2009 9:147
    Content type: Research article Published on:

  15. Cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. Similarly, high grade squamous intr...

    Authors: Ana M Solares, Agueda Santana, Idania Baladrón, Carmen Valenzuela, Carlos A González, Alina Díaz, Dagnelia Castillo, Thelvia Ramos, Roberto Gómez, Daniel F Alonso, Luis Herrera, Hugo Sigman, Silvio E Perea, Boris E Acevedo and Pedro López-Saura
    Citation: BMC Cancer 2009 9:146
    Content type: Research article Published on:

  16. The anti-EGFR monoclonal antibody cetuximab is used in metastatic colorectal cancer (CRC), and predicting responsive patients garners great interest, due to the high cost of therapy. Mutations in the KRAS gene...

    Authors: Justin M Balko and Esther P Black
    Citation: BMC Cancer 2009 9:145
    Content type: Research article Published on:

  17. Kinase insert domain-containing receptor (KDR) plays a critical role in the metastasis of cancer and is used as a molecular target in cancer therapy. We investigated the characteristics of the -271 G>A polymor...

    Authors: She-Juan An, Zhi-Hong Chen, Qiu-Xiong Lin, Jian Su, Hua-Jun Chen, Jia-Ying Lin and Yi-Long Wu
    Citation: BMC Cancer 2009 9:144
    Content type: Research article Published on:

  18. Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis. To explore possible contributors to the accu...

    Authors: Timo K Nykopp, Kirsi Rilla, Reijo Sironen, Markku I Tammi, Raija H Tammi, Kirsi Hämäläinen, Anna-Mari Heikkinen, Marja Komulainen, Veli-Matti Kosma and Maarit Anttila
    Citation: BMC Cancer 2009 9:143
    Content type: Research article Published on:

  19. Prostate cancer is a common disease in men and at present there is no effective therapy available due to its recurrence despite androgen deprivation therapy. The epidermal growth factor receptor family (EGFR/H...

    Authors: Wenqing Qi, Larry S Cooke, Amy Stejskal, Christopher Riley, Kimiko Della Croce, Jose W Saldanha, David Bearss and Daruka Mahadevan
    Citation: BMC Cancer 2009 9:142
    Content type: Research article Published on:

  20. Research has shown that ethnicity is a significant predictor of Hodgkin lymphoma (HL). Variations in cancer incidence among ethnic groups in the same country can lead to important information in the search for...

    Authors: Punam Pahwa, Chandima P Karunanayake, John J Spinelli, James A Dosman and Helen H McDuffie
    Citation: BMC Cancer 2009 9:141
    Content type: Research article Published on:

  21. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with BLM, such as TOP3A and RMI1, migh...

    Authors: Karin Broberg, Elizabeth Huynh, Karin Schläwicke Engström, Jonas Björk, Maria Albin, Christian Ingvar, Håkan Olsson and Mattias Höglund
    Citation: BMC Cancer 2009 9:140
    Content type: Research article Published on:

  22. Previous studies showed that at the individual level, positron emission tomography (PET) has some benefits for patients and physicians in terms of cancer management and staging. We aimed to describe the benefi...

    Authors: Irawati Lemonnier, Cédric Baumann, Nicolas Jay, Kazem Alzahouri, Patrick Arveux, Damien Jolly, Catherine Lejeune, Michel Velten, Fabien Vitry, Marie-Christine Woronoff-Lemsi and Francis Guillemin
    Citation: BMC Cancer 2009 9:139
    Content type: Research article Published on:

  23. Bone marrow transplantation (BMT) is often used in the treatment of various diseases. Before BMT, patients are submitted to a conditioning regimen (CR), which consists of the administration of high doses of ch...

    Authors: Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti, Andressa V Frediani and João Batista T Rocha
    Citation: BMC Cancer 2009 9:138
    Content type: Research article Published on:

  24. The purpose of this study is to analyze the combined effects of selected p53 and p73 polymorphisms and their interaction with lifestyle habits on squamous cell carcinoma of the head and neck (SCCHN) risk and prog...

    Authors: Paola Gallì, Gabriella Cadoni, Mariangela Volante, Emma De Feo, Rosarita Amore, Arianna Giorgio, Dario Arzani, Gaetano Paludetti, Gualtiero Ricciardi and Stefania Boccia
    Citation: BMC Cancer 2009 9:137
    Content type: Research article Published on:

  25. Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes. Type VII collagen is...

    Authors: Hanne Skovbjerg, Dorit Anthonsen, Inger MB Lothe, Kjell M Tveit, Elin H Kure and Lotte K Vogel
    Citation: BMC Cancer 2009 9:136
    Content type: Research article Published on:

  26. Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify n...

    Authors: Ming-Szu Hung, Zhidong Xu, Yu-Ching Lin, Jian-Hua Mao, Cheng-Ta Yang, Pey-Jium Chang, David M Jablons and Liang You
    Citation: BMC Cancer 2009 9:135
    Content type: Research article Published on:

  27. Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and p...

    Authors: Xiu-Feng Zhang, Ying Zhang, Xiao-Hua Zhang, Su-Mei Zhou, Guan-Gen Yang, Ou-Chen Wang, Gui-Long Guo, Gao-Yi Yang and Xiao-Qu Hu
    Citation: BMC Cancer 2009 9:134
    Content type: Research article Published on:

  28. Doxorubicin is an effective breast cancer drug but is hampered by a severe, dose-dependent toxicity. Concomitant administration of doxorubicin and another cancer drug may be able to sensitize tumor cells to th...

    Authors: Xuejun Dong, Anding Liu, Cindy Zer, Jianguo Feng, Zhuan Zhen, Mingfeng Yang and Li Zhong
    Citation: BMC Cancer 2009 9:133
    Content type: Research article Published on:

  29. Aberrant activation NF-kappaB has been proposed as a mechanism of drug resistance in pancreatic cancer. Recently, inhibition of glycogen synthase kinase-3 has been shown to exert anti-tumor effects on pancreat...

    Authors: Shadi Mamaghani, Satish Patel and David W Hedley
    Citation: BMC Cancer 2009 9:132
    Content type: Research article Published on:

  30. Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatm...

    Authors: Daniel TT Chua, Kwan-Ngai Hung, Victor Lee, Sherry CY Ng and Janice Tsang
    Citation: BMC Cancer 2009 9:131
    Content type: Research article Published on:

  31. Evidence that chemotherapy improves survival and quality of life in patients with stage IIIB & IV non small cell lung cancer (NSCLC) is based on large randomized controlled trials. The purpose of this study wa...

    Authors: Janette Vardy, Ryan Dadasovich, Philip Beale, Michael Boyer and Stephen J Clarke
    Citation: BMC Cancer 2009 9:130
    Content type: Research article Published on:

  32. In the American region, Puerto Rico (PR) has the highest incidence of oral and pharyngeal cancer (OPC), but racial/ethnic differences have never been assessed and compared with other groups in the United State...

    Authors: Erick Suárez, William A Calo, Eduardo Y Hernández, Elba C Diaz, Nayda R Figueroa and Ana P Ortiz
    Citation: BMC Cancer 2009 9:129
    Content type: Research article Published on:

  33. Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cum...

    Authors: Ines J Marques, Frank Ulrich Weiss, Danielle H Vlecken, Claudia Nitsche, Jeroen Bakkers, Anne K Lagendijk, Lars Ivo Partecke, Claus-Dieter Heidecke, Markus M Lerch and Christoph P Bagowski
    Citation: BMC Cancer 2009 9:128
    Content type: Research article Published on:

  34. Our purpose was to collect preliminary data on newly diagnosed breast cancer patient knowledge of prognosis before and after oncology visits. Many oncologists use a validated prognostic software model, Adjuvan...

    Authors: Jeffrey K Belkora, Hope S Rugo, Dan H Moore, David W Hutton, Daniel F Chen and Laura J Esserman
    Citation: BMC Cancer 2009 9:127
    Content type: Research article Published on:

  35. Compared with viral vectors, nonviral vectors are less immunogenic, more stable, safer and easier to replication for application in cancer gene therapy. However, nonviral gene delivery system has not been exte...

    Authors: Yu Kang, Xiaoyan Zhang, Wei Jiang, Chaoqun Wu, Chunmei Chen, Yufang Zheng, Jianren Gu and Congjian Xu
    Citation: BMC Cancer 2009 9:126
    Content type: Research article Published on:

  36. Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP famil...

    Authors: Claudia Augello, Luca Caruso, Marco Maggioni, Matteo Donadon, Marco Montorsi, Roberto Santambrogio, Guido Torzilli, Valentina Vaira, Caterina Pellegrini, Massimo Roncalli, Guido Coggi and Silvano Bosari
    Citation: BMC Cancer 2009 9:125
    Content type: Research article Published on:

  38. Methylation of DNA is a common mechanism for silencing genes, and aberrant methylation is increasingly being implicated in many diseases such as cancer. There is a need for robust, inexpensive methods to quant...

    Authors: Eric Smith, Michael E Jones and Paul A Drew
    Citation: BMC Cancer 2009 9:123
    Content type: Technical advance Published on:

  39. Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synt...

    Authors: Enbo Ma, Motoki Iwasaki, Ishihara Junko, Gerson Shigeaki Hamada, Ines Nobuko Nishimoto, Solange Maria Torchia Carvalho, Juvenal Motola Jr, Fábio Martins Laginha and Shoichiro Tsugane
    Citation: BMC Cancer 2009 9:122
    Content type: Research article Published on:

  40. A recent model for activation of the zymogen form of matrix metalloproteinase 2 (MMP-2, also known as gelatinase A) has suggested that interactions between the SIBLING protein bone sialoprotein (BSP) and MMP-2...

    Authors: Queena Hwang, Sela Cheifetz, Christopher M Overall, Christopher A McCulloch and Jaro Sodek
    Citation: BMC Cancer 2009 9:121
    Content type: Research article Published on:

  41. Phase II studies have shown that the combination of capecitabine and irinotecan (the XELIRI regimen) is active in metastatic colorectal cancer (MCRC). There are, however, no data about the use of the XELIRI re...

    Authors: Erik Skof, Martina Rebersek, Zvezdana Hlebanja and Janja Ocvirk
    Citation: BMC Cancer 2009 9:120
    Content type: Research article Published on:

  42. Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-patholo...

    Authors: Oscar Arrieta, David Saavedra-Perez, Roberto Kuri, Alejandro Aviles-Salas, Luis Martinez, Daniel Mendoza-Posada, Patricia Castillo, Alma Astorga, Enrique Guzman and Jaime De la Garza
    Citation: BMC Cancer 2009 9:119
    Content type: Research article Published on:

  45. Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbid...

    Authors: Diana Sarfati, Sarah Hill, Tony Blakely, Bridget Robson, Gordon Purdie, Elizabeth Dennett, Donna Cormack and Kevin Dew
    Citation: BMC Cancer 2009 9:116
    Content type: Research article Published on:

  46. Estrogens, environmental chemicals with carcinogenic potential, as well as oxidative and carbonyl stresses play a very important role in breast cancer (BC) genesis and progression. Therefore, polymorphisms of ...

    Authors: Cinzia Antognelli, Chiara Del Buono, Vienna Ludovini, Stefania Gori, Vincenzo N Talesa, Lucio Crinò, Francesco Barberini and Antonio Rulli
    Citation: BMC Cancer 2009 9:115
    Content type: Research article Published on:

  47. The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X7 receptor regulates growth of epithelial cells. T...

    Authors: Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim and George I Gorodeski
    Citation: BMC Cancer 2009 9:114
    Content type: Research article Published on:

  48. The study of somatic DNA instabilities constitutes a debatable topic because different causes can lead to seeming DNA alteration patterns between different cells or tissues from the same individual. Carcinogen...

    Authors: Hans-Jürgen Bandelt and Antonio Salas
    Citation: BMC Cancer 2009 9:113
    Content type: Correspondence Published on:

  49. This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusion...

    Authors: Jean-Luc Raoul, Jean-Luc Van Laethem, Marc Peeters, Catherine Brezault, Fares Husseini, Laurent Cals, Johannes Nippgen, Anja-Helena Loos and Philippe Rougier
    Citation: BMC Cancer 2009 9:112
    Content type: Research article Published on:

  50. Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. They are of renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies are being investi...

    Authors: Veronika Auner, Gernot Kriegshäuser, Dan Tong, Reinhard Horvat, Alexander Reinthaller, Alexander Mustea and Robert Zeillinger
    Citation: BMC Cancer 2009 9:111
    Content type: Research article Published on:

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