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  1. Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer...

    Authors: Christiana Charalambous, Chara A Pitta and Andreas I Constantinou
    Citation: BMC Cancer 2013 13:238
    Content type: Research article Published on:

  2. Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this ph...

    Authors: Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya and Takashi Joh
    Citation: BMC Cancer 2013 13:237
    Content type: Research article Published on:

  3. Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnorm...

    Authors: Tianbo Jin, Xiaolan Li, Jiayi Zhang, Hong Wang, Tingting Geng, Gang Li, Guodong Gao and Chao Chen
    Citation: BMC Cancer 2013 13:236
    Content type: Research article Published on:

  4. Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of ...

    Authors: Emelie Karnevi, Katarzyna Said, Roland Andersson and Ann H Rosendahl
    Citation: BMC Cancer 2013 13:235
    Content type: Research article Published on:

  5. Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual’s susceptibility to cancer. We studied whether polymorphisms in DNA ...

    Authors: Peng Zhao, Peng Zou, Lin Zhao, Wei Yan, Chunsheng Kang, Tao Jiang and Yongping You
    Citation: BMC Cancer 2013 13:234
    Content type: Research article Published on:

  6. The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor protein is a central negative regulator of the PI3K/AKT signaling cascade and suppresses cell survival as well as cell prolif...

    Authors: Mohan Singh, Parvesh Chaudhry, Francois Fabi and Eric Asselin
    Citation: BMC Cancer 2013 13:233
    Content type: Research article Published on:

  7. The aim of this sub-study is to explore the incidence of skin rash among advanced breast cancer(ABC) patients in a phase II trial treated with weekly nab-paclitaxel and cisplatin combination.

    Authors: Li Chen Tang, Bi Yun Wang, Si Sun, Jian Zhang, Zhen Jia, Yun Hua Lu, Geng Hong Di, Zhi Ming Shao and Xi Chun Hu
    Citation: BMC Cancer 2013 13:232
    Content type: Research article Published on:

  8. Aggressive neuroblastoma remains a significant cause of childhood cancer death despite current intensive multimodal treatment protocols. The purpose of the present work was to characterize the genetic and clin...

    Authors: Cihan Cetinkaya, Tommy Martinsson, Johanna Sandgren, Catarina Träger, Per Kogner, Jan Dumanski, Teresita Díaz de Ståhl and Fredrik Hedborg
    Citation: BMC Cancer 2013 13:231
    Content type: Research article Published on:

  9. To identify predictive factors of radiation-induced skin toxicity in breast cancer patients by the analysis of dosimetric and clinical factors.

    Authors: Grazia Tortorelli, Luana Di Murro, Rosaria Barbarino, Sara Cicchetti, Daniela di Cristino, Maria Daniela Falco, Dahlia Fedele, Gianluca Ingrosso, Dania Janniello, Pasquale Morelli, Alessandra Murgia, Elisabetta Ponti, Sara Terenzi, Barbara Tolu and Riccardo Santoni
    Citation: BMC Cancer 2013 13:230
    Content type: Research article Published on:

  10. Vascular endothelial growth factor-a (VEGF)-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, how...

    Authors: Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa and Kazuhito Rokutan
    Citation: BMC Cancer 2013 13:229
    Content type: Research article Published on:

  11. The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in t...

    Authors: Pablo Conesa-Zamora, Javier Ruiz-Cosano, Daniel Torres-Moreno, Ignacio Español, María D Gutiérrez-Meca, Javier Trujillo-Santos, Elena Pérez-Ceballos, Rocío González-Conejero, Javier Corral, Vicente Vicente and Miguel Pérez-Guillermo
    Citation: BMC Cancer 2013 13:228
    Content type: Research article Published on:

  12. The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast c...

    Authors: James S Foster, Lindsay M Fish, Jonathan E Phipps, Charles T Bruker, James M Lewis, John L Bell, Alan Solomon and Daniel P Kestler
    Citation: BMC Cancer 2013 13:227
    Content type: Research article Published on:

  14. Black women are more likely than white women to have an aggressive subtype of breast cancer that is associated with higher mortality and this may contribute to the observed black-white difference in mortality....

    Authors: Huiyan Ma, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Dennis M Deapen, Robert Spirtas, Ronald T Burkman, Brian L Strom, Jill A McDonald, Suzanne G Folger, Michael S Simon, Jane Sullivan-Halley, Michael F Press and Leslie Bernstein
    Citation: BMC Cancer 2013 13:225
    Content type: Research article Published on:

  15. Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive and associated with poor prognosis. Basic research to develop new treatment regimens is critically needed.

    Authors: Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita and Hiroshi Iwasaki
    Citation: BMC Cancer 2013 13:224
    Content type: Research article Published on:

  16. High levels of circulating C-reactive protein (CRP) have recently been linked to poor clinical outcome in various malignancies. The aim of this study was to evaluate the prognostic significance of the preopera...

    Authors: Sandra Steffens, Andreas Al Ghazal, Julie Steinestel, Rieke Lehmann, Gerd Wegener, Thomas J Schnoeller, Marcus V Cronauer, Florian Jentzmik, Mark Schrader, Markus A Kuczyk and Andres J Schrader
    Citation: BMC Cancer 2013 13:223
    Content type: Research article Published on:

  17. Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide...

    Authors: Jia-Jia Huang, Ya-Jun Li, Yi Xia, Yu Wang, Wen-Xiao Wei, Ying-Jie Zhu, Tong-Yu Lin, Hui-Qiang Huang, Wen-Qi Jiang and Zhi-Ming Li
    Citation: BMC Cancer 2013 13:222
    Content type: Research article Published on:

  18. The intestinal crypt homeostasis is maintained by a combination of growth factors including Wnt, R-Spondin1, Noggin and the epidermal growth factor (EGF). In human colorectal cancer, the Wnt pathway is constit...

    Authors: Kirsten Ludwig, Edison S Tse and Jean YJ Wang
    Citation: BMC Cancer 2013 13:221
    Content type: Research article Published on:

  19. The incidence of Human Papillomavirus (HPV) associated oropharyngeal cancer (OPC) is increasing. HPV-associated OPC appear to have better prognosis than HPV-negative OPC. The aim of this study was to robustly ...

    Authors: Mererid Evans, Robert Newcombe, Alison Fiander, James Powell, Martin Rolles, Selvam Thavaraj, Max Robinson and Ned Powell
    Citation: BMC Cancer 2013 13:220
    Content type: Research article Published on:

  21. Human and feline head and neck squamous cell carcinoma (HNSCC) share histology, certain molecular features, as well as locally aggressive and highly recurrent clinical behavior. In human HNSCC, the presence of...

    Authors: Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew and Elizabeth A McNiel
    Citation: BMC Cancer 2013 13:218
    Content type: Research article Published on:

  22. Aurora A kinase, a centrosomal serine/threonine kinase which plays an essential role in chromosome segregation during cell division, is commonly amplified and/or over expressed in human malignancies. Aurora A ...

    Authors: Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Saori Fujiwara and Hirotaka Iwase
    Citation: BMC Cancer 2013 13:217
    Content type: Research article Published on:

  24. In breast cancer, the role of epigenetic alterations including modifications of the acetylation status of histones in carcinogenesis has been an important research focus during the last years. An increased dea...

    Authors: Berit Maria Müller, Lisa Jana, Atsuko Kasajima, Annika Lehmann, Judith Prinzler, Jan Budczies, Klaus-Jürgen Winzer, Manfred Dietel, Wilko Weichert and Carsten Denkert
    Citation: BMC Cancer 2013 13:215
    Content type: Research article Published on:

  25. Selenium has attracted attention because of its antioxidant properties. Antioxidants protects cells from damage. Certain breakdown products of selenium are believed to prevent tumor growth by enhancing the imm...

    Authors: Marcin R Lener, Satish Gupta, Rodney J Scott, Martin Tootsi, Maria Kulp, Mari-Liis Tammesoo, Anu Viitak, Anders Metspalu, Pablo Serrano-Fernández, Józef Kładny, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Anna Jakubowska and Jan Lubiński
    Citation: BMC Cancer 2013 13:214
    Content type: Research article Published on:

  26. VEGF is one of the key drivers of physiological or pathological angiogenesis hence several VEGF inhibitors are in different stages of clinical development. To further dissect the role of VEGF in different stag...

    Authors: Bharat K Majeti, Joseph H Lee, Brett H Simmons and Farbod Shojaei
    Citation: BMC Cancer 2013 13:213
    Content type: Research article Published on:

  28. New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signalin...

    Authors: Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky and Sarah J Freemantle
    Citation: BMC Cancer 2013 13:211
    Content type: Research article Published on:

  29. Epidermal growth factor receptor (EGFR) gene mutations identify patients withnon-small cell lung cancer (NSCLC) who have a high likelihood of benefitingfrom treatment with anti-EGFR tyrosine kinase inhibitors....

    Authors: Patrick O’Donnell, Jane Ferguson, Johnny Shyu, Robert Current, Taraneh Rehage, Julie Tsai, Mari Christensen, Ha Bich Tran, Sean Shih-Chang Chien, Felice Shieh, Wen Wei, H Jeffrey Lawrence, Lin Wu, Robert Schilling, Kenneth Bloom, Warren Maltzman…
    Citation: BMC Cancer 2013 13:210
    Content type: Technical advance Published on:

  30. Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. The extent of venous thromboembolic co-morbid...

    Authors: Alexandra Connelly-Frost, Sumitra Shantakumar, Monica G Kobayashi, Haojie Li and Li Li
    Citation: BMC Cancer 2013 13:209
    Content type: Research article Published on:

  31. In an ongoing study of racial/ethnic disparities in breast cancer stage atdiagnosis, we consented patients to allow us to review their mammogramimages, in order to examine the potential role of mammogram image...

    Authors: Garth H Rauscher, Emily F Conant, Jenna A Khan and Michael L Berbaum
    Citation: BMC Cancer 2013 13:208
    Content type: Research article Published on:

  32. Single arm phase 1 and 2 studies on Crizotinib in ALK-positive patients so far have shown rapid and durable responses. Spontaneous pneumothoraces as a result of response to anti-cancer therapy are rare in onco...

    Authors: Spyridon Gennatas, Susana J Stanway, Robert Thomas, Toon Min, Riyaz Shah, Mary ER O’Brien and Sanjay Popat
    Citation: BMC Cancer 2013 13:207
    Content type: Case report Published on:

  33. The JAK2 V617F mutation is the most frequent somatic change in myeloproliferative neoplasms, making it an important tumour-specific marker for diagnostic purposes and for the detection of minimal residual disease...

    Authors: Giada V Zapparoli, Robert N Jorissen, Chelsee A Hewitt, Michelle McBean, David A Westerman and Alexander Dobrovic
    Citation: BMC Cancer 2013 13:206
    Content type: Technical advance Published on:

  34. Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very ...

    Authors: Chiharu Tabata, Eisuke Shibata, Rie Tabata, Shingo Kanemura, Koji Mikami, Yoshitaka Nogi, Eriko Masachika, Tomoyuki Nishizaki and Takashi Nakano
    Citation: BMC Cancer 2013 13:205
    Content type: Research article Published on:

  35. Previously, we showed that M3 muscarinic receptor (M3R; gene name Chrm3) deficiency attenuates murine intestinal neoplasia, supporting the hypothesis that muscarinic receptors play an important role in intestinal...

    Authors: Zhongsheng Peng, Jonathon Heath, Cinthia Drachenberg, Jean-Pierre Raufman and Guofeng Xie
    Citation: BMC Cancer 2013 13:204
    Content type: Research article Published on:

  36. To develop a Consumer Quality Index (CQI) Cancer Care questionnaire for measuring experiences with hospital care of patients with different types of cancer.

    Authors: Judith C Booij, Marieke Zegers, Pauline MPJ Evers, Michelle Hendriks, Diana MJ Delnoij and Jany JDJM Rademakers
    Citation: BMC Cancer 2013 13:203
    Content type: Research article Published on:

  37. This study was initiated to investigate the prognostic significance of circulating tumor cell (CTC) enumeration and the predictive value of CTC HER2 expression for efficient anti-HER2 therapy in HER2-positive ...

    Authors: Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, Haixu Hu, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu and Zefei Jiang
    Citation: BMC Cancer 2013 13:202
    Content type: Research article Published on:

  38. Up to 70% of cancer survivors report clinically significant levels of fear of cancer recurrence (FCR). Despite the known negative impact of FCR on psychological wellbeing and quality of life, little research h...

    Authors: Phyllis N Butow, Melanie L Bell, Allan B Smith, Joanna E Fardell, Belinda Thewes, Jane Turner, Jemma Gilchrist, Jane Beith, Afaf Girgis, Louise Sharpe, Sophy Shih and Cathrine Mihalopoulos
    Citation: BMC Cancer 2013 13:201
    Content type: Study protocol Published on:

  39. Conventional treatment for locally advanced rectal cancer usually combines neoadjuvant radiochemotherapy and surgery. Until recently, there have been limited predictive factors (clinical or biological) for rec...

    Authors: Olfa Derbel, Qing Wang, Françoise Desseigne, Michel Rivoire, Pierre Meeus, Patrice Peyrat, Mattia Stella, Isabelle Martel-Lafay, Anne-Isabelle Lemaistre and Christelle de La Fouchardière
    Citation: BMC Cancer 2013 13:200
    Content type: Research article Published on:

  40. Significance of Urocortin (Ucn or UcnI), Ucn2, Ucn3 and their receptors, Corticotropin Releasing Factor Receptor 1 and 2 (CRFR1 and CRFR2), and the binding protein, Corticotropin-Releasing Hormone-Binding Prot...

    Authors: Hossein Tezval, Faranaz Atschekzei, Inga Peters, Sandra Waalkes, Jörg Hennenlotter, Arnulf Stenzl, Jan U Becker, Axel S Merseburger, Markus A Kuczyk and Jürgen Serth
    Citation: BMC Cancer 2013 13:199
    Content type: Research article Published on:

  41. Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and ...

    Authors: Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy and Fuyuhiko Tamanoi
    Citation: BMC Cancer 2013 13:198
    Content type: Research article Published on:

  42. Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating fac...

    Authors: Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev and Axel Ullrich
    Citation: BMC Cancer 2013 13:197
    Content type: Research article Published on:

  43. The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, ...

    Authors: Bilal Alaiyan, Nadia Ilyayev, Alexander Stojadinovic, Mina Izadjoo, Marina Roistacher, Vera Pavlov, Victoria Tzivin, David Halle, Honguang Pan, Barry Trink, Ali O Gure and Aviram Nissan
    Citation: BMC Cancer 2013 13:196
    Content type: Research article Published on:

  44. Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a ...

    Authors: Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus and Manuel L Penichet
    Citation: BMC Cancer 2013 13:195
    Content type: Research article Published on:

  45. Pancreatic cancer remains one of the deadliest cancers due to lack of early detection and absence of effective treatments. Gemcitabine, the current standard-of-care chemotherapy for pancreatic cancer, has limi...

    Authors: Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks and C Max Schmidt
    Citation: BMC Cancer 2013 13:194
    Content type: Research article Published on:

  47. Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma...

    Authors: Zhihua Shen, Xiaofan Jiang, Chao Zeng, Shaojiang Zheng, Botao Luo, Yumei Zeng, Ranran Ding, Hanguo Jiang, Qiyi He, Junli Guo and Wei Jie
    Citation: BMC Cancer 2013 13:192
    Content type: Research article Published on:

  48. The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little...

    Authors: Masao Honda, Taro Yamashita, Tatsuya Yamashita, Kuniaki Arai, Yoshio Sakai, Akito Sakai, Mikiko Nakamura, Eishiro Mizukoshi and Shuichi Kaneko
    Citation: BMC Cancer 2013 13:191
    Content type: Research article Published on:

  49. Surgery is a curative treatment for patients with locally advanced colon cancer, but recurrences are frequent for those with stage III disease. FOLFOX adjuvant chemotherapy has been shown to improve recurrence...

    Authors: Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart…
    Citation: BMC Cancer 2013 13:190
    Content type: Study protocol Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:173

  50. Communication about prognosis and treatment choices is essential for informed decision making in advanced cancer. This article describes an investigation designed to facilitate communication and decision makin...

    Authors: Michael Hoerger, Ronald M Epstein, Paul C Winters, Kevin Fiscella, Paul R Duberstein, Robert Gramling, Phyllis N Butow, Supriya G Mohile, Paul R Kaesberg, Wan Tang, Sandy Plumb, Adam Walczak, Anthony L Back, Daniel Tancredi, Alison Venuti, Camille Cipri…
    Citation: BMC Cancer 2013 13:188
    Content type: Study protocol Published on:

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