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Early pneumothorax as a feature of response to crizotinib therapy in a patient with ALK rearranged lung adenocarcinoma
© Gennatas et al.; licensee BioMed Central Ltd. 2013
Received: 19 September 2012
Accepted: 16 April 2013
Published: 26 April 2013
Single arm phase 1 and 2 studies on Crizotinib in ALK-positive patients so far have shown rapid and durable responses. Spontaneous pneumothoraces as a result of response to anti-cancer therapy are rare in oncology but have been documented in a number of tumour types including lung cancer. This includes cytotoxic chemotherapy as well as molecular targeted agents such as gefitinib and Bevacizumab. These often require chest drain insertion or surgical intervention with associated morbidity and mortality. They have also been associated with response to treatment. This is the first report we are aware of documenting pneumothorax as response to crizotinib therapy.
A 48-year-old Caucasian male presented with a Stage IV, TTF1 positive, EGFR wild-type adenocarcinoma of the lung. He received first line chemotherapy with three cycles of cisplatin-pemetrexed chemotherapy with a differential response, and then second-line erlotinib for two months before further radiological evidence of disease progression. Further analysis of his diagnostic specimen identified an ALK rearrangement by fluorescence in situ hybridization (FISH). He was commenced on crizotinib therapy 250 mg orally twice daily. At his 4-week assessment he had a chest radiograph that identified a large left-sided pneumothorax with disease response evident on the right. Chest CT confirmed a 50% left-sided pneumothorax on a background of overall disease response. A chest tube was inserted with complete resolution of the pneumothorax that did not recur following its removal.
Our case demonstrates this potential complication of crizotinib therapy and we therefore recommend that pneumothorax be considered in patients on crizotinib presenting with high lung metastatic burden and with worsening dyspnoea.
Crizotinib is approved for ALK rearranged relapsed non-small cell lung cancer with most patients treated in the initial expanded cohort phase 1b study acquiring durable responses. The overall response rate was 57% (CI 46-68) and the disease-control rate was 87% . A retrospective study on the same population by Shaw et al. suggested that overall survival for patients with advanced ALK-positive NSCLC was significantly longer in patients given Crizotinib second- or third-line compared to Crizotinib-naïve patients, whose prognosis was very similar to the general NSCLC population. This evidence indicates Crizotinib might prolong overall survival in ALK-positive NSCLC patients . Regarding the timing of responses, in both the phase I and phase II trials, the majority were achieved within 8 weeks of treatment initiation. The duration of response was 48.1 and 41.9 weeks respectively indicating a very rapid and prolonged response. Treatment was generally well tolerated with gastrointestinal (Grade 1/2) and visual disorders (Grade 1) being the commonest [3, 4].
Case reports of remarkable responses to Crizotinib are emerging. Kim et al., reported a case of a 14-year old girl with extensive Stage IV (multiple lymph nodes and lymphangitic lung metastasis), ALK-positive lung adenocarcinoma, who was treated with first-line Crizotinib. An FDG-PET at Day 21 revealed an impressive partial response across all disease sites. A 9-week CT revealed a 76.3% decrease in tumour bulk and at 64 weeks the patient remained at confirmed partial response .
Spontaneous pneumothoraces as a result of response to anti-cancer therapy are rare in oncology and typically occur in cases of metastatic osteosarcoma or germ cell tumours, with case reports in other histologies eg. breast cancer . Although, spontaneous pneumothoraces have also been described in primary lung cancer (including small cell and NSCLC) as initial presentation or as complication, more commonly, of chest radiotherapy, they have been very rarely associated with cytotoxic chemotherapy [8, 9]. A retrospective evaluation at a single centre from Maniwa et al, demonstrated that patients with pneumothorax as a result of treatment for pulmonary malignancy (primary or metastatic) often require prolonged chest tube drainage and sometimes surgical drainage, which is associated with increased peri-operative morbidity and mortality, highlighting the significance of early diagnosis and prompt expert management of such cases .
Molecular targeted therapies have also been linked with the development of spontaneous pneumothoraces. Mori et al., reported a case of bilateral spontaneous pneumothoraces within four weeks of initiation of gefitinib treatment in a patient with multiple bilateral pulmonary metastases. These were only small and resolved spontaneously. Interestingly there was associated treatment response in both lungs within the same time period as seen on CT . Yang et al., reported a case of Bevacizumab-induced pneumothorax in a patient treated for metastatic colorectal cancer, including multiple lung metastases. This required chest tube drainage for 5 days with complete resolution of the pneumothorax, highlighting the importance of considering this diagnosis in patients with acute chest discomfort while on Bevacizumab . This is the first report we are aware of documenting pneumothorax as response to crizotinib therapy. Proposed mechanisms include rapid tumour lysis and tissue necrosis in response to cytotoxics leading to rupture into the pleural cavity or bronchopleural fistula development . In our case, imaging did not suggest obvious macroscopic pleural disease with no pleural nodularity evident, although several of his lung metastases did abut the pleura.
Our case demonstrates that spontaneous pneumothoraces are a potential complication of crizotinib therapy and we therefore recommend that pneumothorax is considered in patients on crizotinib presenting with high lung metastatic burden and with worsening dyspnoea.
Verbal informed consent was obtained from the patient on the 24th of April 2012 for publication of this case report and any accompanying images. His family were present at the time. The patient is unfortunately now deceased.
SP is in receipt of a Clinical Senior Lectureship Award from the Higher Education Funding Council for England. All authors also acknowledge NHS funding to the Royal Marsden Hospital/Institute of Cancer Research NIHR Biomedical Research Centre.
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