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  1. Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research. We evaluated the usefulness of diffu...

    Authors: Shigeto Ueda, Noriko Nakamiya, Kazuo Matsuura, Takashi Shigekawa, Hiroshi Sano, Eiko Hirokawa, Hiroko Shimada, Hiroaki Suzuki, Motoki Oda, Yutaka Yamashita, Osamu Kishino, Ichiei Kuji, Akihiko Osaki and Toshiaki Saeki
    Citation: BMC Cancer 2013 13:514
    Content type: Research article Published on:

  2. Concurrent chemo-radiotherapy is demonstrately superior to sequential chemo-radiotherapy in the treatment of advanced Non-Small-Cell Lung Cancer not suitable for surgery. Docetaxel is considered to enhance the...

    Authors: Alessandra Bearz, Emilio Minatel, Imad Abu Rumeileh, Eugenio Borsatti, Renato Talamini, Giovanni Franchin, Carlo Gobitti, Alessandro Del Conte, Marco Trovò and Tanja Baresic
    Citation: BMC Cancer 2013 13:513
    Content type: Research article Published on:

  3. Different molecular subtypes of breast cancer have been identified based on gene expression profiling. Treatment suggestions based on an approximation of these subtypes by immunohistochemical criteria have bee...

    Authors: Wenjing Zhou, Karin Jirström, Rose-Marie Amini, Marie-Louise Fjällskog, Thomas Sollie, Henrik Lindman, Therese Sørlie, Carl Blomqvist and Fredrik Wärnberg
    Citation: BMC Cancer 2013 13:512
    Content type: Research article Published on:

  4. Cyclooxygenase (COX) and epidermal growth factor receptor (EGFR) activities promote progression of colorectal cancer. Combined treatment against these targets has not been more effective than single treatments...

    Authors: Annika Gustafsson Asting, Ava Farivar, Britt-Marie Iresjö, Helena Svensson, Bengt Gustavsson and Kent Lundholm
    Citation: BMC Cancer 2013 13:511
    Content type: Research article Published on:

  5. Breast cancer is the most common type of cancer and the second leading cause of cancer-death among women in Poland. The known high-risk mutations account for 25% of familial aggregation cases and 5% of total b...

    Authors: Joanna K Ledwoń, Ewa E Hennig, Natalia Maryan, Krzysztof Goryca, Dorota Nowakowska, Anna Niwińska and Jerzy Ostrowski
    Citation: BMC Cancer 2013 13:510
    Content type: Research article Published on:

  6. The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expres...

    Authors: Hironori Betsunoh, Takehiko Fukuda, Naohiko Anzai, Daisaku Nishihara, Tomoya Mizuno, Hideo Yuki, Akinori Masuda, Yoshiyuki Yamaguchi, Hideyuki Abe, Masahiro Yashi, Yoshitatsu Fukabori, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2013 13:509
    Content type: Research article Published on:

  7. One in eight women will develop breast cancer in her lifetime. The best-known awareness event is breast cancer awareness month (BCAM). BCAM month outreach efforts have been associated with increased media cove...

    Authors: Rosemary Thackeray, Scott H Burton, Christophe Giraud-Carrier, Stephen Rollins and Catherine R Draper
    Citation: BMC Cancer 2013 13:508
    Content type: Research article Published on:

  8. Genetic aberrations are required for the progression of HPV-induced cervical precancers. A prerequisite for clonal expansion of cancer cells is unlimited proliferative capacity. In a cell culture model for cer...

    Authors: Melanie Liesenfeld, Sandy Mosig, Harald Funke, Lars Jansen, Ingo B Runnebaum, Matthias Dürst and Claudia Backsch
    Citation: BMC Cancer 2013 13:507
    Content type: Research article Published on:

  9. Increased vascularity is a crucial event in the tumor progression and has prognostic significance in various cancers. However, the ultimate role of angiogenesis in the pathogenesis and clinical outcome of vulv...

    Authors: Hari Prasad Dhakal, Jahn M Nesland, Mette Førsund, Claes G Trope and Ruth Holm
    Citation: BMC Cancer 2013 13:506
    Content type: Research article Published on:

  10. Small intestinal neuroendocrine tumors (SI-NETs) are typically slow-growing tumors that have metastasized already at the time of diagnosis. The purpose of the present study was to further refine and define reg...

    Authors: Jamileh Hashemi, Omid Fotouhi, Luqman Sulaiman, Magnus Kjellman, Anders Höög, Jan Zedenius and Catharina Larsson
    Citation: BMC Cancer 2013 13:505
    Content type: Research article Published on:

  11. Heat Shock Transcription Factor 1 (HSF1) is activated under stress conditions. In turn, it induces expression of Heat Shock Proteins (HSPs), which are well-known regulators of protein homeostasis. Elevated lev...

    Authors: Natalia Vydra, Agnieszka Toma, Magdalena Glowala-Kosinska, Agnieszka Gogler-Piglowska and Wieslawa Widlak
    Citation: BMC Cancer 2013 13:504
    Content type: Research article Published on:

  12. The prognostic role of serum estrogen level in breast cancer patients is unclear. We investigated the prognostic importance of preoperative serum estradiol (E2) level in postmenopausal women according to their...

    Authors: Ju-Yeon Kim, Wonshik Han, Hyeong-Gon Moon, Soo Kyung Ahn, Jisun Kim, Jun Woo Lee, Min Kyoon Kim, Taeryung Kim and Dong-Young Noh
    Citation: BMC Cancer 2013 13:503
    Content type: Research article Published on:

  13. MTO1 and MRPL41 are nuclear-encoded mitochondrial genes encoding a mitochondrial tRNA-modifying enzyme and a mitochondrial ribosomal protein, respectively. Although both genes have been known to have potential...

    Authors: Tae Woo Kim, Byungtak Kim, Ju Hee Kim, Seongeun Kang, Sung-Bin Park, Gookjoo Jeong, Han-Sung Kang and Sun Jung Kim
    Citation: BMC Cancer 2013 13:502
    Content type: Research article Published on:

  14. Various pathways impinge on the actin-myosin pathway to facilitate cell migration and invasion including members of the Rho family of small GTPases and MAPK. However, the signaling components that are consider...

    Authors: Susan MW Harrison, Teresa Knifley, Min Chen and Kathleen L O’Connor
    Citation: BMC Cancer 2013 13:501
    Content type: Research article Published on:

  15. Autophagy induction can increase or decrease anticancer drug efficacy. Anticancer drug-induced autophagy induction is poorly characterized in osteosarcoma (OS). In this study, we investigated the impact of aut...

    Authors: Mario G Hollomon, Nancy Gordon, Janice M Santiago-O’Farrill and Eugenie S Kleinerman
    Citation: BMC Cancer 2013 13:500
    Content type: Research article Published on:

  16. There have been sporadic reports about synchronous as well as metachronous gastric adenocarcinoma and primary gastric lymphoma. Many reports have dealt with metachronous gastric adenocarcinoma in mucosa-associ...

    Authors: Koji Inaba, Ryoji Kushima, Naoya Murakami, Yuuki Kuroda, Ken Harada, Mayuka Kitaguchi, Kotaro Yoshio, Shuhei Sekii, Kana Takahashi, Madoka Morota, Hiroshi Mayahara, Yoshinori Ito, Minako Sumi, Takashi Uno and Jun Itami
    Citation: BMC Cancer 2013 13:499
    Content type: Research article Published on:

  17. The circadian clock and cell cycle are two global regulatory systems that have pervasive behavioral and physiological effects on eukaryotic cells, and both play a role in cancer development. Recent studies hav...

    Authors: Yingying Mao, Alan Fu, Derek Leaderer, Tongzhang Zheng, Kun Chen and Yong Zhu
    Citation: BMC Cancer 2013 13:498
    Content type: Research article Published on:

  18. Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (...

    Authors: Stephanie M George, Anne McTiernan, Adriana Villaseñor, Catherine M Alfano, Melinda L Irwin, Marian L Neuhouser, Richard N Baumgartner, Kathy B Baumgartner, Leslie Bernstein, Ashley W Smith and Rachel Ballard-Barbash
    Citation: BMC Cancer 2013 13:497
    Content type: Research article Published on:

  19. Pancreatic cancer is one of the most lethal cancers worldwide. The aim of this study was to determine the expression pattern, clinical significance, and biological functions of Wnt5a in pancreatic cancer.

    Authors: Haiji Bo, Shuhui Zhang, Li Gao, Ying Chen, Jing Zhang, Xuejiao Chang and Minghua Zhu
    Citation: BMC Cancer 2013 13:496
    Content type: Research article Published on:

  20. Calcium and magnesium (Ca/Mg) infusions have been suggested as an effective intervention for preventing oxaliplatin-induced neurotoxicity, but the effects of Ca/Mg infusions on oxaliplatin pharmacokinetics, mo...

    Authors: Catherine H Han, Prashannata Khwaounjoo, Dean H Kilfoyle, Andrew Hill and Mark J McKeage
    Citation: BMC Cancer 2013 13:495
    Content type: Research article Published on:

  21. Recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. Pharmacological interventions that effectively enhance tumor cell death through activating ER stress h...

    Authors: Zhiguo Liu, Yusheng Sun, Luqing Ren, Yi Huang, Yuepiao Cai, Qiaoyou Weng, Xueqian Shen, Xiaokun Li, Guang Liang and Yi Wang
    Citation: BMC Cancer 2013 13:494
    Content type: Research article Published on:

  23. Dietary selenium has the potential to reduce growth of mammary tumors. Increasing the Se content of cows’ milk proteins is a potentially effective means to increase Se intake in humans. We investigate the effe...

    Authors: Jenny M Warrington, Julie JM Kim, Priska Stahel, Scott RL Cieslar, Roger A Moorehead, Brenda L Coomber, Milena Corredig and John P Cant
    Citation: BMC Cancer 2013 13:492
    Content type: Research article Published on:

  24. Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiologica...

    Authors: Filip YFL De Vos, Sasja F Mulder, Joost PH Drenth, Iris D Nagtegaal, Jurgen J Fütterer and Winette TA van der Graaf
    Citation: BMC Cancer 2013 13:491
    Content type: Case report Published on:

  25. Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic sali...

    Authors: Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff and Alireza Mirmohammadsadegh
    Citation: BMC Cancer 2013 13:490
    Content type: Research article Published on:

  26. Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been...

    Authors: David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Bo Markussen, Sven Müller, Hans Jørgen Nielsen, Nils Brünner and Kirsten Vang Nielsen
    Citation: BMC Cancer 2013 13:489
    Content type: Research article Published on:

  27. Chicken Anemia Virus (CAV) VP3 protein (also known as Apoptin), a basic and proline-rich protein has a unique capability in inducing apoptosis in cancer cells but not in normal cells. Five truncated Apoptin pr...

    Authors: Lim Shen Ni, Zeenathul Nazariah bt Allaudin, Mohd Azmi b Mohd Lila, Abas Mazni b Othman and Fauziah bt Othman
    Citation: BMC Cancer 2013 13:488
    Content type: Research article Published on:

  28. Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluat...

    Authors: Lukas Schwentner, Achim Wöckel, Jochem König, Wolfgang Janni, Florian Ebner, Maria Blettner, Rolf Kreienberg and Reyn Van Ewijk
    Citation: BMC Cancer 2013 13:487
    Content type: Research article Published on:

  29. Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed ...

    Authors: Bilal O Al-Jiffry, Yasir AlNemary, Samah H Khayat, Moutaz Haiba and Mohammed Hatem
    Citation: BMC Cancer 2013 13:486
    Content type: Case report Published on:

  31. Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified ...

    Authors: Lisa Golmard, Virginie Caux-Moncoutier, Grégoire Davy, Essam Al Ageeli, Brigitte Poirot, Carole Tirapo, Dorothée Michaux, Catherine Barbaroux, Catherine Dubois d’Enghien, André Nicolas, Laurent Castéra, Xavier Sastre-Garau, Marc-Henri Stern, Claude Houdayer and Dominique Stoppa-Lyonnet
    Citation: BMC Cancer 2013 13:484
    Content type: Research article Published on:

  32. Patients diagnosed for a serous ovarian borderline tumor (s-BOT) typically present with an excellent clinical outcome. However there have been controversies concerning the prognostic impact of so-called implan...

    Authors: Sabine Heublein, Katinka Grasse, Harald Hessel, Alexander Burges, Miriam Lenhard, Jutta Engel, Thomas Kirchner, Udo Jeschke and Doris Mayr
    Citation: BMC Cancer 2013 13:483
    Content type: Research article Published on:

  33. The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in tumor cell growth and survival. However, it remains unclear about the clinicopathological significance of ...

    Authors: Kyoichi Kaira, Yutaka Sunose, Yasuhiro Ohshima, Noriko S Ishioka, Kazuhisa Arakawa, Tetsushi Ogawa, Noriaki Sunaga, Kimihiro Shimizu, Hideyuki Tominaga, Noboru Oriuchi, Hideaki Itoh, Shushi Nagamori, Yoshikatsu Kanai, Aiko Yamaguchi, Atsuki Segawa, Munenori Ide…
    Citation: BMC Cancer 2013 13:482
    Content type: Research article Published on:

  34. TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potent...

    Authors: Shanique K E Edwards, Carissa R Moore, Yan Liu, Sukhdeep Grewal, Lori R Covey and Ping Xie
    Citation: BMC Cancer 2013 13:481
    Content type: Research article Published on:

  35. The presence of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients is associated with reduced clinical outcome. Bisphosphonate treatment was shown to eradicate DTC from BM in several ...

    Authors: Malgorzata Banys, Erich-Franz Solomayer, Gerhard Gebauer, Wolfgang Janni, Natalia Krawczyk, Hans-Joachim Lueck, Sven Becker, Jens Huober, Bernhard Kraemer, Birgit Wackwitz, Peter Hirnle, Diethelm Wallwiener and Tanja Fehm
    Citation: BMC Cancer 2013 13:480
    Content type: Research article Published on:

  36. Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targe...

    Authors: Wen-guo Jiang, Xin-an Lu, Bo-yang Shang, Yan Fu, Sheng-hua Zhang, Daifu Zhou, Liang Li, Yi Li, Yongzhang Luo and Yong-su Zhen
    Citation: BMC Cancer 2013 13:479
    Content type: Research article Published on:

  37. MiR-106a is frequently down-regulated in various types of human cancer. However the underlying mechanism of miR-106a involved in glioma remains elusive.

    Authors: Dong-Wei Dai, Qiong Lu, Lai-Xing Wang, Wen-Yuan Zhao, Yi-Qun Cao, Ya-Nan Li, Guo-Sheng Han, Jian-Min Liu and Zhi-Jian Yue
    Citation: BMC Cancer 2013 13:478
    Content type: Research article Published on:

  38. Lung cancer is the leading cause of cancer death in North America and Western Europe. Patients with lung cancer in general have reduced physical capacity, functional capacity, poor quality of life and increase...

    Authors: Morten Quist, Seppo W Langer, Mikael Rørth, Karl Bang Christensen and Lis Adamsen
    Citation: BMC Cancer 2013 13:477
    Content type: Study protocol Published on:

  39. Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This...

    Authors: Carmela Ricciardelli, Miranda P Ween, Noor A Lokman, Izza A Tan, Carmen E Pyragius and Martin K Oehler
    Citation: BMC Cancer 2013 13:476
    Content type: Research article Published on:

  40. Obesity has been shown to be inversely associated with breast cancer risk in premenopausal women, while increasing risk in postmenopausal women. However, the current evidence is largely based on studies in Cau...

    Authors: Elisa V Bandera, Urmila Chandran, Gary Zirpoli, Zhihong Gong, Susan E McCann, Chi-Chen Hong, Gregory Ciupak, Karen Pawlish and Christine B Ambrosone
    Citation: BMC Cancer 2013 13:475
    Content type: Research article Published on:

  41. The role of chemotherapy given concurrently with thoracic three-dimensional radiotherapy for stage IV non-small cell lung cancer (NSCLC) is not well defined. We performed this study to investigate overall surv...

    Authors: Sheng-Fa Su, Yin-Xiang Hu, Wei-Wei Ouyang, Bing Lu, Zhu Ma, Qing-Song Li, Hui-Qin Li and Yi-Chao Geng
    Citation: BMC Cancer 2013 13:474
    Content type: Research article Published on:

  42. Long-term estrogen deprivation models are widely employed in an in vitro setting to recapitulate the hormonal milieu of breast cancer patients treated with endocrine therapy. Despite the wealth information we hav...

    Authors: Jelena Milosevic, Johanna Klinge, Anna-Lena Borg, Theodoros Foukakis, Jonas Bergh and Nicholas P Tobin
    Citation: BMC Cancer 2013 13:473
    Content type: Research article Published on:

  43. Knowledge about tumour gene mutation status is essential for the treatment of increasing numbers of cancer patients, and testing quality has a major impact on treatment response and cost. In 2012, 4,629 tests ...

    Authors: Jean-François Emile, Julie Tisserand, Loic Bergougnoux, Frédérique Nowak, Gladwys Faucher, Sylvie Surel, Aude Lamy, Delphine Lecorre, Zofia Helias-Rodzewicz, Paul Hofman, Jean-Christophe Sabourin and Pierre Laurent-Puig
    Citation: BMC Cancer 2013 13:472
    Content type: Research article Published on:

  44. Activation of the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway has been demonstrated to be involved in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated tumorigenesis in anaplast...

    Authors: Ju Gao, Minzhi Yin, Yiping Zhu, Ling Gu, Yanle Zhang, Qiang Li, Cangsong Jia and Zhigui Ma
    Citation: BMC Cancer 2013 13:471
    Content type: Research article Published on:

  45. Follow-up rate after a fecal occult blood test (FOBT) is low worldwide. In order to increase the follow-up rate, segmentation of the target population has been proposed as a promising strategy, because an inte...

    Authors: Yoshiki Ishikawa, Ying-Fang Zheng, Hiromu Nishiuchi, Takeo Suda, Tadahiko Hasumi and Hiroshi Saito
    Citation: BMC Cancer 2013 13:470
    Content type: Research article Published on:

  46. microRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC b...

    Authors: Guangxian Xu, Yilin Zhang, Jun Wei, Wei Jia, Zhaohui Ge, Zhaobo Zhang and Xiaoming Liu
    Citation: BMC Cancer 2013 13:469
    Content type: Research article Published on:

  47. Accumulating evidence has suggested the importance of glutamate signaling in cancer growth, yet the signaling pathway has not been fully elucidated. N-methyl-D-aspartic acid (NMDA) receptor activates intracell...

    Authors: Fuminori Yamaguchi, Yuko Hirata, Hossain Akram, Kazuyo Kamitori, Youyi Dong, Li Sui and Masaaki Tokuda
    Citation: BMC Cancer 2013 13:468
    Content type: Research article Published on:

  48. Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that ind...

    Authors: Cheng Shen, Huan Xu, Lunxu Liu, Yubin Zhou, Dali Chen, Heng Du, Zhaojie Han and Guowei Che
    Citation: BMC Cancer 2013 13:467
    Content type: Research article Published on:

  49. The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel
    Citation: BMC Cancer 2013 13:466
    Content type: Research article Published on:

  50. A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibi...

    Authors: Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick and Devasis Chatterjee
    Citation: BMC Cancer 2013 13:463
    Content type: Research article Published on:

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