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  1. For nearly two decades now, various studies have reported detecting the Epstein-Barr virus (EBV) in breast cancer (BC) cases. Yet the results are unconvincing, and their interpretation has remained a matter of...

    Authors: Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira and Emmanuel Drouet
    Citation: BMC Cancer 2014 14:665
    Content type: Research article Published on:

  2. Ribonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2 (RRM2) might be a novel prognostic and predictive biomarker for estrogen receptor (ER)-negative b...

    Authors: Hang Zhang, Xiyong Liu, Charles D Warden, Yasheng Huang, Sofia Loera, Lijun Xue, Suzhan Zhang, Peiguo Chu, Shu Zheng and Yun Yen
    Citation: BMC Cancer 2014 14:664
    Content type: Research article Published on:

  3. Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 ...

    Authors: Giovanna Forte, Valentina Grossi, Valentina Celestini, Giuseppe Lucisano, Marco Scardapane, Dora Varvara, Margherita Patruno, Rosanna Bagnulo, Daria Loconte, Laura Giunti, Antonio Petracca, Sabrina Giglio, Maurizio Genuardi, Fabio Pellegrini, Nicoletta Resta and Cristiano Simone
    Citation: BMC Cancer 2014 14:661
    Content type: Research article Published on:

  4. The nonreceptor tyrosine kinase Src regulates multiple pathways critical to tumor proliferation, chemoresistance, and epithelial-to-mesenchymal transition. It is robustly activated after acute oxaliplatin expo...

    Authors: Scott Kopetz, Van K Morris, Nila Parikh, Michael J Overman, Zhi-Qin Jiang, Dipen Maru, Paul Elvin and Gary Gallick
    Citation: BMC Cancer 2014 14:660
    Content type: Research article Published on:

  5. A large body of genetic research has focused on the potential role that mitochondrial DNA (mtDNA) variants might play on the predisposition to common and complex (multi-factorial) diseases. It has been argued ...

    Authors: Antonio Salas, Manuel García-Magariños, Ian Logan and Hans-Jürgen Bandelt
    Citation: BMC Cancer 2014 14:659
    Content type: Research article Published on:

  6. Despite recently implemented access to care programs, Mexican breast cancer (BC) mortality rates remain substantially above those in the US. We conducted a survey among Mexican Oncologists to determine whether...

    Authors: Yanin Chavarri-Guerra, Jessica St Louis, Pedro ER Liedke, Heather Symecko, Cynthia Villarreal-Garza, Alejandro Mohar, Dianne M Finkelstein and Paul E Goss
    Citation: BMC Cancer 2014 14:658
    Content type: Research article Published on:

  8. MicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC). The aim of our study was to evaluate the ability of miRNA expression patterns to predict che...

    Authors: Sonia Molina-Pinelo, Amancio Carnero, Fernando Rivera, Purificacion Estevez-Garcia, Juan Manuel Bozada, Maria Luisa Limon, Marta Benavent, Javier Gomez, Maria Dolores Pastor, Manuel Chaves, Rocio Suarez, Luis Paz-Ares, Fernando de la Portilla, Andres Carranza-Carranza, Isabel Sevilla, Luis Vicioso…
    Citation: BMC Cancer 2014 14:656
    Content type: Research article Published on:

  9. Prostate cancer has a variable clinical behaviour with frequently unpredictable outcome. DNA methylation plays an important role in determining the biology of cancer but prognostic information is scanty. We as...

    Authors: Nataša Vasiljević, Amar S Ahmad, Mangesh A Thorat, Gabrielle Fisher, Daniel M Berney, Henrik Møller, Christopher S Foster, Jack Cuzick and Attila T Lorincz
    Citation: BMC Cancer 2014 14:655
    Content type: Research article Published on:

  11. The aim of this study was to investigate the prognostic significance and various classifications for anatomic masticator space involvement (MSI) in patients with nasopharyngeal carcinoma (NPC).

    Authors: Dong-Hua Luo, Jing Yang, Hui-Zhi Qiu, Ting Shen, Qiu-Yan Chen, Pei-Yu Huang, Rui Sun, Chao-Nan Qian, Hai-Qiang Mai, Xiang Guo and Hao-Yuan Mo
    Citation: BMC Cancer 2014 14:653
    Content type: Research article Published on:

  12. Preoperative jaundice is frequent in gallbladder cancer (GBC) and indicates advanced disease. Resection is rarely recommended to treat advanced GBC. An aggressive surgical approach for advanced GBC remains lac...

    Authors: Xin-wei Yang, Jian-mao Yuan, Jun-yi Chen, Jue Yang, Quan-gen Gao, Xing-zhou Yan, Bao-hua Zhang, Shen Feng and Meng-chao Wu
    Citation: BMC Cancer 2014 14:652
    Content type: Research article Published on:

  13. The detection of circulating tumor cells (CTCs) in peripheral blood (PB) of patients with breast cancer predicts poor clinical outcome. Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT)...

    Authors: Maria A Papadaki, Galatea Kallergi, Zafeiris Zafeiriou, Lefteris Manouras, Panayiotis A Theodoropoulos, Dimitris Mavroudis, Vassilis Georgoulias and Sofia Agelaki
    Citation: BMC Cancer 2014 14:651
    Content type: Research article Published on:

  14. P21-activated protein kinase 1 (PAK1), a main downstream effector of small Rho GTPases, is overexpressed in many malignancies. PAK1 overexpression is associated with poor prognosis in some tumor types, includi...

    Authors: Juan Han, Feng Wang, Shu-qiang Yuan, Ying Guo, Zhao-lei Zeng, Li-ren Li, Jing Yang, De-sen Wang, Mei-yuan Liu, Han Zhao, Kai-yan Liu, Jian-wei Liao, Qing-feng Zou and Rui-hua Xu
    Citation: BMC Cancer 2014 14:650
    Content type: Research article Published on:

  15. The Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition, there is increasing data to suggest direct tumor promoting effec...

    Authors: Tilman D Rachner, Stefanie Thiele, Andy Göbel, Andrew Browne, Susanne Fuessel, Kati Erdmann, Manfred P Wirth, Michael Fröhner, Tilman Todenhöfer, Michael H Muders, Matthias Kieslinger, Martina Rauner and Lorenz C Hofbauer
    Citation: BMC Cancer 2014 14:649
    Content type: Research article Published on:

  16. Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this co...

    Authors: Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin and Johan Wennerberg
    Citation: BMC Cancer 2014 14:648
    Content type: Research article Published on:

  17. Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new ant...

    Authors: Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu and SaeGwang Park
    Citation: BMC Cancer 2014 14:647
    Content type: Research article Published on:

  18. The existence of two distinct groups of tumors with different clinical characteristic is a remarkable feature of transitional cell carcinomas (TCCs) of the bladder. More than 70% are low-grade (LG) non-infiltr...

    Authors: Donatella Conconi, Elena Panzeri, Serena Redaelli, Giorgio Bovo, Paolo Viganò, Guido Strada, Leda Dalprà and Angela Bentivegna
    Citation: BMC Cancer 2014 14:646
    Content type: Research article Published on:

  19. Large genomic rearrangements (LGRs) in the BRCA1/2 genes are frequently observed in breast cancer patients who are negative for BRCA1/2 small mutations. Here, we examined 221 familial breast cancer patients from ...

    Authors: Moon-Woo Seong, Sung Im Cho, Kyu Hyung Kim, Il Yong Chung, Eunyoung Kang, Jong Won Lee, Sue K Park, Min Hyuk Lee, Doo Ho Choi, Cha Kyong Yom, Woo-Chul Noh, Myung Chul Chang, Sung Sup Park and Sung-Won Kim
    Citation: BMC Cancer 2014 14:645
    Content type: Research article Published on:

  20. microRNAs have recently succeeded in grabbing the center stage in cancer research for their potential to regulate vital cellular process like cell cycle, stem cell renewal and epithelial mesenchymal transition...

    Authors: Sushmita Bose Nandy, Ramadevi Subramani, Venkatesh Rajamanickam, Rebecca Lopez-Valdez, Arunkumar Arumugam, Thiyagarajan Boopalan and Rajkumar Lakshmanaswamy
    Citation: BMC Cancer 2014 14:644
    Content type: Research article Published on:

  21. Although several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconc...

    Authors: Jia-Hui Qi, Jin Wang, Jinyun Chen, Fan Shen, Jing-Tao Huang, Subrata Sen, Xin Zhou and Song-Mei Liu
    Citation: BMC Cancer 2014 14:643
    Content type: Research article Published on:

  22. Colorectal cancer survival in the UK is lower than in other developed countries, but the association of time interval between diagnosis and treatment on excess mortality remains unclear.

    Authors: Maria Theresa Redaniel, Richard M Martin, Jane M Blazeby, Julia Wade and Mona Jeffreys
    Citation: BMC Cancer 2014 14:642
    Content type: Research article Published on:

  23. O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is reported to be a prognostic and predictive factor of alkylating chemotherapy for glioblastoma patients. Methylation specific PCR (MSP) has bee...

    Authors: Manabu Kanemoto, Mitsuaki Shirahata, Akiyo Nakauma, Katsumi Nakanishi, Kazuya Taniguchi, Yoji Kukita, Yoshiki Arakawa, Susumu Miyamoto and Kikuya Kato
    Citation: BMC Cancer 2014 14:641
    Content type: Research article Published on:

  24. Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal fe...

    Authors: Nicolás Tobar, Marcela Toyos, Carla Urra, Nicolás Méndez, Rodrigo Arancibia, Patricio C Smith and Jorge Martínez
    Citation: BMC Cancer 2014 14:640
    Content type: Research article Published on:

  25. The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR and heat shock proteins HSP70 and MRJ (DNAJB6) have been im...

    Authors: Yuli Lin, Nana Peng, Hongqin Zhuang, Di Zhang, Yao Wang and Zi-Chun Hua
    Citation: BMC Cancer 2014 14:639
    Content type: Research article Published on:

  26. The standard treatment for non-metastatic muscle-invasive bladder cancer (stages T2–T4a) is radical cystectomy with lymphadenectomy. However, patients undergoing cystectomy show metastatic spread in 25% of cas...

    Authors: Jens Reumert Laurberg, Jørgen Bjerggaard Jensen, Troels Schepeler, Michael Borre, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Cancer 2014 14:638
    Content type: Research article Published on:

  27. Incidence rates of various cancers are increasing in Arab countries and are expected to reach those of industrialized ones in few decades. This paper aimed to describe the incidence rates of most common cancer...

    Authors: Mokhtar Hamdi Cherif, Diego Serraino, Abbes Mahnane, Slimane Laouamri, Zoubida Zaidi, Hafida Boukharouba, Dahbia Cherka, Manel Rakeb, Lamia Kara, Asma Ayat, Silvia Birri, Saverio Virdone, Paolo De Paoli and Ettore Bidoli
    Citation: BMC Cancer 2014 14:637
    Content type: Research article Published on:

  28. Many countries have implemented standardised cancer patient pathways (CPPs) to ensure fast diagnosis of patients suspected of having cancer. Yet, studies are sparse on the impact of such CPPs, and few have dis...

    Authors: Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard and Peter Vedsted
    Citation: BMC Cancer 2014 14:636
    Content type: Research article Published on:

  29. Lymphoceles are a common complication after pelvic lymphadenectomy in women with gynecologic malignancies. Although typically asymptomatic, lymphoceles can superinfect requiring medical or surgical interventio...

    Authors: Christoph Grimm, Stephan Polterauer, Samir Helmy, David Cibula, Michal Zikan, Alexander Reinthaller and Clemens Tempfer
    Citation: BMC Cancer 2014 14:635
    Content type: Study protocol Published on:

  31. An increasing body of evidence indicates that miRNAs have a critical role in carcinogenesis and cancer progression; however, the role of miRNAs in the tumorigenesis of adencarcinoma of gastric esophageal junct...

    Authors: Xiaoshan Feng, Ying Wang, Zhikun Ma, Ruina Yang, Shuo Liang, Mengxi Zhang, Shiyuan Song, Shuoguo Li, Gang Liu, Daiming Fan and Shegan Gao
    Citation: BMC Cancer 2014 14:633
    Content type: Research article Published on:

  32. Aggressive fibromatosis (AF) is a rare fibroblastic proliferative disease with a locally aggressive behavior and no distant metastasis, characterized by driver mutations in CTNNB1 or the APC gene. When progressiv...

    Authors: Armelle Dufresne, Laurent Alberti, Mehdi Brahmi, Sarah Kabani, Héloïse Philippon, David Pérol and Jean Yves Blay
    Citation: BMC Cancer 2014 14:632
    Content type: Research article Published on:

  33. Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis...

    Authors: Marina Curado Valsechi, Ana Beatriz Bortolozo Oliveira, André Luis Giacometti Conceição, Bruna Stuqui, Natalia Maria Candido, Paola Jocelan Scarin Provazzi, Luiza Ferreira de Araújo, Wilson Araújo Silva Jr, Marilia de Freitas Calmon and Paula Rahal
    Citation: BMC Cancer 2014 14:631
    Content type: Research article Published on:

  34. Macrophage migration inhibitory factor (MIF) is a widely expressed cytokine involved in a variety of cellular processes including cell cycle regulation and the control of proliferation. Overexpression of MIF h...

    Authors: Camila S Oliveira, Charles E de Bock, Timothy J Molloy, Elham Sadeqzadeh, Xin Yan Geng, Peter Hersey, Xu Dong Zhang and Rick F Thorne
    Citation: BMC Cancer 2014 14:630
    Content type: Research article Published on:

  35. The 90-kDa heat shock protein HSP90AA1 is critical for the stability of several proteins that are important for tumor progression and thus, is a promising target for cancer therapy. Selenosemicarbazone metal c...

    Authors: Hongtao Shen, Haichuan Zhu, Mowei Song, Yonglu Tian, Yafei Huang, Hui Zheng, Ruiyuan Cao, Jian Lin, Zhenggang Bi and Wu Zhong
    Citation: BMC Cancer 2014 14:629
    Content type: Research article Published on:

  36. Notch signalling regulates cell fate in most tissues, promoting precursor cell proliferation in some, but differentiation in others. Accordingly, downregulation or overactivity variously contributes to cancer ...

    Authors: Annemarie Greife, Silvia Jankowiak, Jochen Steinbring, Parvaneh Nikpour, Günter Niegisch, Michèle J Hoffmann and Wolfgang A Schulz
    Citation: BMC Cancer 2014 14:628
    Content type: Research article Published on:

  37. Cancer metastasis is the main contributor to breast cancer fatalities as women with the metastatic disease have poorer survival outcomes than women with localised breast cancers. There is an urgent need to dev...

    Authors: Helen C Plant, Abhishek S Kashyap, Kerry J Manton, Brett G Hollier, Cameron P Hurst, Sandra R Stein, Glenn D Francis, Geoffrey F Beadle, Zee Upton and David I Leavesley
    Citation: BMC Cancer 2014 14:627
    Content type: Research article Published on:

  38. Colorectal cancer (CRC) is a disease that can be prevented through early detection. Through the use of effective educational tools, individuals can become better informed about CRC and understand the importanc...

    Authors: Janeth I Sanchez, Rebecca Palacios, Adrianna Cole and Mary A O’Connell
    Citation: BMC Cancer 2014 14:626
    Content type: Research article Published on:

  39. Dual anti-human epidermal growth factor receptor 2 (HER2) therapies have been shown to improve outcomes of HER2-positive breast cancer patients. We undertook a systematic review to compare treatment outcomes f...

    Authors: Xiao Zhang, Xin-Ji Zhang, Tian-Yi Zhang, Fei-Fei Yu, Xin Wei, Ye-Sheng Li and Jia He
    Citation: BMC Cancer 2014 14:625
    Content type: Research article Published on:

  40. The role of pERK, pAKT and p53 as biomarkers in patients with advanced pancreatic cancer has not yet been defined.

    Authors: Steffen Ormanns, Jens T Siveke, Volker Heinemann, Michael Haas, Bence Sipos, Anna Melissa Schlitter, Irene Esposito, Andreas Jung, Rüdiger P Laubender, Stephan Kruger, Ursula Vehling-Kaiser, Cornelia Winkelmann, Ludwig Fischer von Weikersthal, Michael R Clemens, Thomas C Gauler, Angela Märten…
    Citation: BMC Cancer 2014 14:624
    Content type: Research article Published on:

  41. The aim of the study was to assess the localization of Polysialic acid (polySia) and Neural cell adhesion molecule (NCAM) in grade I–IV astrocytomas by confocal microscopy, and also to clarify and compare thei...

    Authors: Katri Mäkelä, Kristiina Nordfors, Jukka Finne, Anne Jokilammi, Timo Paavonen, Hannu Haapasalo, Miikka Korja and Joonas Haapasalo
    Citation: BMC Cancer 2014 14:623
    Content type: Research article Published on:

  42. Patients with Ewing sarcoma family of tumors (ESFT) who are resistant even to salvage chemotherapy, have dismal prognoses and few therapeutic options. Because the docetaxel/irinotecan (DI) combination has not ...

    Authors: Jong Hyung Yoon, Mi Mi Kwon, Hyeon Jin Park, Seog Yun Park, Kun Young Lim, Jungnam Joo and Byung-Kiu Park
    Citation: BMC Cancer 2014 14:622
    Content type: Research article Published on:

  43. Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis....

    Authors: Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles and James A Thomson
    Citation: BMC Cancer 2014 14:621
    Content type: Research article Published on:

  44. Ovarian tumors create a dynamic microenvironment that promotes angiogenesis and reduces immune responses. Our research has revealed that threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity...

    Authors: Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Sharon L Mount, Christopher S Francklyn and Karen M Lounsbury
    Citation: BMC Cancer 2014 14:620
    Content type: Research article Published on:

  45. To assess the safety and efficacy of Stereotactic Ablative Radiotherapy (SABR) in oligometastatic patients from colorectal cancer.

    Authors: Tiziana Comito, Luca Cozzi, Elena Clerici, Maria Concetta Campisi, Rocco Luca Emanuele Liardo, Pierina Navarria, AnnaMaria Ascolese, Angelo Tozzi, Cristina Iftode, Fiorenza De Rose, Elisa Villa, Nicola Personeni, Lorenza Rimassa, Armando Santoro, Antonella Fogliata, Pietro Mancosu…
    Citation: BMC Cancer 2014 14:619
    Content type: Research article Published on:

  47. To report an unplanned interim analysis of a prospective, one-armed, single center phase I/II trial (NCT01566123).

    Authors: Falk Roeder, Alexis Ulrich, Gregor Habl, Matthias Uhl, Ladan Saleh-Ebrahimi, Peter E Huber, Daniela Schulz-Ertner, Anna V Nikoghosyan, Ingo Alldinger, Robert Krempien, Gunhild Mechtersheimer, Frank W Hensley, Juergen Debus and Marc Bischof
    Citation: BMC Cancer 2014 14:617
    Content type: Research article Published on:

  48. The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression of hepatocarcinoma. miR-1246 expression in High invasive ability cell line than significantly...

    Authors: Zhao Sun, Changting Meng, Shihua Wang, Na Zhou, Mei Guan, Chunmei Bai, Shan Lu, Qin Han and Robert Chunhua Zhao
    Citation: BMC Cancer 2014 14:616
    Content type: Research article Published on:

  49. Pelvic lymph nodes removed during radical retropubic prostatectomy for prostatic cancer can be found on pathological examination to harbor various unexpected pathologies. Among these, hematologic neoplasms are...

    Authors: Antonio Di Meglio, Pier Vitale Nuzzo, Francesco Ricci, Bruno Spina and Francesco Boccardo
    Citation: BMC Cancer 2014 14:613
    Content type: Case report Published on:

  50. There is a lack of standardized definition for treatment-related mortality (TRM), which represents an important endpoint in cancer. Our objective was to describe TRM definitions used in studies of children, ad...

    Authors: Thai Hoa Tran, Michelle Lee, Sarah Alexander, Paul Gibson, Ute Bartels, Donna L Johnston, Carol Portwine, Marianna Silva, Jason D Pole and Lillian Sung
    Citation: BMC Cancer 2014 14:612
    Content type: Research article Published on:

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