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  1. In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is...

    Authors: Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Teresa Mele, Sandra R Ramírez-Clavijo, Giorgio Scagliotti, Caterina Marchiò and Anna Sapino
    Citation: BMC Cancer 2014 14:922
    Content type: Research article Published on:

  2. There is evidence that calcium (Ca2+) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation betwee...

    Authors: Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Sonia Liberati, Claudio Cardinali, Valerio Farfariello, Daniele Tomassoni, Wilma Quaglia, Alessandro Piergentili, Alessandro Bonifazi, Fabio Del Bello, Matteo Santoni, Gabriele Mammana, Lucilla Servi, Alessandra Filosa, Angela Gismondi…
    Citation: BMC Cancer 2014 14:921
    Content type: Research article Published on:

  3. Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) is a truly novel protein, defining a new class of secreted factors. We have previously reported that ectopic overexpression of hHSS1 has a negative...

    Authors: Katiana S Junes-Gill, Chris E Lawrence, Christopher J Wheeler, Ryan Cordner, Tristan G Gill, Vernon Mar, Liron Shiri and Lena A Basile
    Citation: BMC Cancer 2014 14:920
    Content type: Research article Published on:

  4. Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically ex...

    Authors: Christine M Friedenreich, Sarah MacLaughlin, Heather K Neilson, Frank Z Stanczyk, Yutaka Yasui, Aalo Duha, Brigid M Lynch, Ciara Kallal and Kerry S Courneya
    Citation: BMC Cancer 2014 14:919
    Content type: Study protocol Published on:

  5. Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2014 14:918
    Content type: Research article Published on:

  6. MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer. The aberrant expression of miRNAs may contribute t...

    Authors: Rui Yang, Yongjun Chen, Cong Tang, Hongbo Li, Bing Wang, Qun Yan, Junbo Hu and Shengquan Zou
    Citation: BMC Cancer 2014 14:917
    Content type: Research article Published on:

  7. The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes
    Citation: BMC Cancer 2014 14:916
    Content type: Research article Published on:

  8. Carfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been repor...

    Authors: Ajai Chari and Daher Hajje
    Citation: BMC Cancer 2014 14:915
    Content type: Research article Published on:

  9. Papillary thyroid cancer (PTC) often presents as multifocal. However, the association of multifocality with poor prognosis remains controversial. The aim of this retrospective study was to identify the charact...

    Authors: Ning Qu, Ling Zhang, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Qiang Shen, Yu Wang and Duan-shu Li
    Citation: BMC Cancer 2014 14:914
    Content type: Research article Published on:

  10. The constituents of stable multiprotein complexes are known to dissociate from the complex to play independent regulatory roles. The components of translation elongation complex eEF1H (eEF1A, eEF1Bα, eEF1Bβ, e...

    Authors: Maryna Veremieva, Liudmyla Kapustian, Antonina Khoruzhenko, Valery Zakharychev, Boris Negrutskii and Anna El’skaya
    Citation: BMC Cancer 2014 14:913
    Content type: Research article Published on:

  11. Chronic inflammation is a key feature of colorectal cancer (CRC), meaning that inflammatory biomarkers may be useful for its diagnosis. In particular, high neutrophil gelatinase-associated lipocalin (NGAL) exp...

    Authors: Laurence Duvillard, Pablo Ortega-Deballon, Abderrahmane Bourredjem, Marie-Lorraine Scherrer, Georges Mantion, Jean-Baptiste Delhorme, Sophie Deguelte-Lardière, Jean-Michel Petit and Claire Bonithon-Kopp
    Citation: BMC Cancer 2014 14:912
    Content type: Research article Published on:

  12. Sphingosine-1-phosphate receptor-1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) play important roles in immune responses with potential oncogenic roles.

    Authors: Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim and Yoon Kyung Jeon
    Citation: BMC Cancer 2014 14:911
    Content type: Research article Published on:

  13. Accumulating evidences suggest that tumors are driven by a small population of cells, termed “cancer stem cells” (CSCs), which may be resistant to current therapeutic approaches. In breast carcinoma, the CSCs ...

    Authors: Refael Peleg, Marianna Romzova, Inga Kogan-Zviagin, Ron N Apte and Esther Priel
    Citation: BMC Cancer 2014 14:910
    Content type: Research article Published on:

  14. Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related mortality in the world. MicroRNAs (miRNAs) are small, noncoding RNAs that play essential roles in vario...

    Authors: Xue-Wei Yang, Guan-Zhu Shen, Liang-Qi Cao, Xiao-Feng Jiang, He-Ping Peng, Gang Shen, De Chen and Ping Xue
    Citation: BMC Cancer 2014 14:909
    Content type: Research article Published on:

  15. PREDICT (http://​www.​predict.​nhs.​uk) is a prognostication and treatment benefit tool for early breast cancer (EBC). The aim of this study was to incorporate t...

    Authors: Gordon C Wishart, Emad Rakha, Andrew Green, Ian Ellis, Hamid Raza Ali, Elena Provenzano, Fiona M Blows, Carlos Caldas and Paul DP Pharoah
    Citation: BMC Cancer 2014 14:908
    Content type: Research article Published on:

  16. Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer...

    Authors: Niamh Lynam-Lennon, Ruth Connaughton, Eibhlin Carr, Ann-Marie Mongan, Naoimh J O’Farrell, Richard K Porter, Lorraine Brennan, Graham P Pidgeon, Joanne Lysaght, John V Reynolds and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:907
    Content type: Research article Published on:

  17. Everolimus was recently introduced as a second-line treatment for renal cell carcinoma (RCC) and many other cancers. Several prospective studies have shown that serum creatinine levels are increased in a signi...

    Authors: Sung Hae Ha, Ji Hyeon Park, Hye Ryoun Jang, Wooseong Huh, Ho-Yeong Lim, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee
    Citation: BMC Cancer 2014 14:906
    Content type: Research article Published on:

  18. Persistent infection with high-risk (HR) human papillomavirus (HPV) causes cervical cancer, the fourth most frequent cancer in the Kingdom of Bahrain, with an annual incidence of four per 100,000 women. The ai...

    Authors: Khairya Moosa, Adel Salman Alsayyad, Wim Quint, Kusuma Gopala and Rodrigo DeAntonio
    Citation: BMC Cancer 2014 14:905
    Content type: Research article Published on:

  19. Routine chemotherapy often cannot achieve good therapeutic effects because of multidrug resistance (MDR). MDR is frequently caused by the elevated expression of the MDR1 gene encoding P-glycoprotein (P-gp). E2...

    Authors: Lin-Hai Yan, Wei-Yuan Wei, Wen-Long Cao, Xiao-Shi Zhang, Yu-Bo Xie and Qiang Xiao
    Citation: BMC Cancer 2014 14:904
    Content type: Research article Published on:

  21. The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour mode...

    Authors: Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen and Michael R Horsman
    Citation: BMC Cancer 2014 14:903
    Content type: Research article Published on:

  23. Posttranslational protein modifications are known to modulate key biological processes like proliferation and apoptosis. Accumulating evidence shows that ST6GAL1, an enzyme that catalyzes the transfer of siali...

    Authors: Pia Antony, Michael Rose, Axel Heidenreich, Ruth Knüchel, Nadine T Gaisa and Edgar Dahl
    Citation: BMC Cancer 2014 14:901
    Content type: Research article Published on:

  24. Malignant bone lymphoma can be classified as primary (PBL) or secondary (SBL) bone lymphoma. However, the clinico-pathological characteristics and prognostic factors of PBL versus SBL have not yet been well de...

    Authors: Huanwen Wu, Marilyn M Bui, Douglas G Leston, Haipeng Shao, Lubomir Sokol, Eduardo M Sotomayor and Ling Zhang
    Citation: BMC Cancer 2014 14:900
    Content type: Research article Published on:

  25. Thyroid carcinoma is the leading cause of death among endocrine cancers second to carcinoma of the ovary. Now a day, the incidence of thyroid malignancy is increasing more rapidly than any other malignancy. Bu...

    Authors: Tadele Melak, Biniam Mathewos, Bamlaku Enawgaw and Debasu Damtie
    Citation: BMC Cancer 2014 14:899
    Content type: Research article Published on:

  26. Recent studies have suggested that adenosine generated by ecto-5′-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulati...

    Authors: Sandra Burghoff, Xuan Gong, Claudia Viethen, Christoph Jacoby, Ulrich Flögel, Sabine Bongardt, Anne Schorr, Andreas Hippe, Bernhard Homey and Jürgen Schrader
    Citation: BMC Cancer 2014 14:898
    Content type: Research article Published on:

  27. In colorectal cancer (CRC), unresectable liver metastases are linked to poor prognosis. Systemic chemotherapy with regimens such as FOLFOX (combination of infusional 5-fluorouracil, leucovorin and oxaliplatin)...

    Authors: Peter Gibbs, Val Gebski, Mark Van Buskirk, Kenneth Thurston, David N Cade and Guy A Van Hazel
    Citation: BMC Cancer 2014 14:897
    Content type: Study protocol Published on:

  28. The aim of the present study was to evaluate the predictive value of a novel quantitative measure for the spatial heterogeneity of FDG uptake, the asphericity (ASP) in patients with non-small cell lung cancer ...

    Authors: Ivayla Apostolova, Julian Rogasch, Ralph Buchert, Heinz Wertzel, H Jost Achenbach, Jens Schreiber, Sandra Riedel, Christian Furth, Alexandr Lougovski, Georg Schramm, Frank Hofheinz, Holger Amthauer and Ingo G Steffen
    Citation: BMC Cancer 2014 14:896
    Content type: Research article Published on:

  29. In contrast with breast cancers (BCs) in other parts of the world, most previous studies reported that the majority of BCs in sub-Saharan Africa are estrogen-receptor (ER) negative. However, a recent study usi...

    Authors: Eva Johanna Kantelhardt, Assefa Mathewos, Abreha Aynalem, Tigeneh Wondemagegnehu, Ahmedin Jemal, Martina Vetter, Erdme Knauf, Anne Reeler, Solomon Bogale, Christoph Thomssen, Andreas Stang, Tufa Gemechu, Pietro Trocchi and Bekuretsion Yonas
    Citation: BMC Cancer 2014 14:895
    Content type: Research article Published on:

  30. Two-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guide...

    Authors: YuFeng Ren, QuanCheng Zhao, Hui Liu, YingJuan Huang, ZhenYu Wang, XinPing Cao, Bin S Teh and BiXiu Wen
    Citation: BMC Cancer 2014 14:894
    Content type: Research article Published on:

  31. The reasons for the worldwide sex disparity in the incidence of hepatocellular carcinoma (HCC) remain elusive. We investigated the role of multiple pregnancies on the associations between viral hepatitis C (HC...

    Authors: Sania Amr, Emily A Iarocci, Ghada R Nasr, Doa’a Saleh, Jan Blancato, Kirti Shetty and Christopher A Loffredo
    Citation: BMC Cancer 2014 14:893
    Content type: Research article Published on:

  32. There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage....

    Authors: Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz and Ashraf EK Ibrahim
    Citation: BMC Cancer 2014 14:891
    Content type: Research article Published on:

  34. A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan
    Citation: BMC Cancer 2014 14:889
    Content type: Research article Published on:

  35. There is no general agreement about whether patients who have already received neoadjuvant chemoradiotherapy need further postoperative chemotherapy based on 5-fluorouracil(5-FU) or 5-FU plus oxaliplatin.

    Authors: Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Ying-ying Xu, Jun-hua Zhao, Xuan-zhang Huang, Hui-mian Xu and Zhen-ning Wang
    Citation: BMC Cancer 2014 14:888
    Content type: Research article Published on:

  36. Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatment. The ai...

    Authors: Petra Martin, Sinead Noonan, Michael P Mullen, Caitriona Scaife, Miriam Tosetto, Blathnaid Nolan, Kieran Wynne, John Hyland, Kieran Sheahan, Giuliano Elia, Diarmuid O’Donoghue, David Fennelly and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:887
    Content type: Research article Published on:

  37. We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In thi...

    Authors: Shaolei Zang, Na Liu, Hongchun Wang, David N Wald, Na Shao, Jingru Zhang, Daoxin Ma, Chunyan Ji and William Tse
    Citation: BMC Cancer 2014 14:886
    Content type: Research article Published on:

  38. Upregulator of cell proliferation 4 (URG4) has been implicated in the oncogenesis of certain cancers. However, the correlation between URG4 expression and clinicopathological significance in human cancer remai...

    Authors: Lan Zhang, He Huang, Longjuan Zhang, Teng Hou, Shu Wu, Qidan Huang, Libing Song and Jihong Liu
    Citation: BMC Cancer 2014 14:885
    Content type: Research article Published on:

  39. Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clini...

    Authors: Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino and Daphne W Bell
    Citation: BMC Cancer 2014 14:884
    Content type: Research article Published on:

  40. We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment...

    Authors: Seung Tae Kim, Yong Sang Hong, Ho Yeong Lim, Jeeyun Lee, Tae Won Kim, Kyu-Pyo Kim, Sun Young Kim, Ji Yeon Baek, Jee Hyun Kim, Keun-Wook Lee, Ik-Joo Chung, Sang-Hee Cho, Kyung Hee Lee, Sang Joon Shin, Hye Jin Kang, Dong Bok Shin…
    Citation: BMC Cancer 2014 14:883
    Content type: Research article Published on:

  41. Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell in...

    Authors: Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh and Takuya Matsunaga
    Citation: BMC Cancer 2014 14:882
    Content type: Research article Published on:

  42. Polymorphisms in angiogenesis-related genes and metabolic syndrome (MetS) risk factors play important roles in cancer development. Moreover, recent studies have reported associations between a number of 3′-UTR...

    Authors: Young Joo Jeon, Jong Woo Kim, Hye Mi Park, Hyo Geun Jang, Jung O Kim, Jisu Oh, So Young Chong, Sung Won Kwon, Eo Jin Kim, Doyeun Oh and Nam Keun Kim
    Citation: BMC Cancer 2014 14:881
    Content type: Research article Published on:

  43. Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. MicroRNAs (miRNAs) represent a class of short, non-coding, regulatory RNAs which play a criti...

    Authors: Francesca Megiorni, Samantha Cialfi, Heather P McDowell, Armando Felsani, Simona Camero, Alessandro Guffanti, Barry Pizer, Anna Clerico, Alessandra De Grazia, Antonio Pizzuti, Anna Moles and Carlo Dominici
    Citation: BMC Cancer 2014 14:880
    Content type: Research article Published on:

  44. Hepatocyte nuclear factor-3β (HNF-3β) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but the molecular...

    Authors: Li Lin, Hongwei Liang, Yanbo Wang, Xiaomao Yin, Yanwei Hu, Jinlan Huang, Tingyu Ren, Hui Xu, Lei Zheng and Xi Chen
    Citation: BMC Cancer 2014 14:879
    Content type: Research article Published on:

  45. The optimal treatment for adrenal metastases from hepatocellular carcinoma (HCC) has not been established. This study analyzed the effects of radiation therapy (RT) for such metastases and identified clinical ...

    Authors: Le-Yuan Zhou, Zhao-Chong Zeng, Jia Fan, Bing Chen, Sheng-xiang Rao, Jian He, Ping Yang, Jia-zhou Hou, Zhi-feng Wu, Jian-ying Zhang and Yong Hu
    Citation: BMC Cancer 2014 14:878
    Content type: Research article Published on:

  46. Glycemic index (GI) and glycemic load (GL) have been investigated as etiologic factors for some cancers, but epidemiological data on possible associations between dietary carbohydrate intake and esophageal can...

    Authors: Petra H Lahmann, Torukiri I Ibiebele, Penelope M Webb, Christina M Nagle and David C Whiteman
    Citation: BMC Cancer 2014 14:877
    Content type: Research article Published on:

  47. The clinical behaviour of colon cancer is heterogeneous. Five-year overall survival is 50-65% with all stages included. Recurring somatic chromosomal alterations have been identified and some have shown potent...

    Authors: Markus Mayrhofer, Hanna Göransson Kultima, Helgi Birgisson, Magnus Sundström, Lucy Mathot, Karolina Edlund, Björn Viklund, Tobias Sjöblom, Johan Botling, Patrick Micke, Lars Påhlman, Bengt Glimelius and Anders Isaksson
    Citation: BMC Cancer 2014 14:872
    Content type: Research article Published on:

  49. Few targeted therapies (TTs) are registered for sarcoma treatment despite numerous phase II studies and yet there are potential treatment options for patients after standard treatment escape. The French Sarcom...

    Authors: Lauriane Eberst, Claire Cropet, Axel Le Cesne, Patricia Pautier, Nicolas Penel, Antoine Adenis, Christine Chevreau, Jacques-Olivier Bay, Olivier Collard, Didier Cupissol, Florence Duffaud, Jean-Claude Gentet, Sophie Piperno-Neumann, Perrine Marec-Berard, Emmanuelle Bompas, Antoine Thyss…
    Citation: BMC Cancer 2014 14:870
    Content type: Research article Published on:

  50. We wished to estimate the proportion of patients with breast cancer eligible for an exclusive targeted intraoperative radiotherapy (TARGIT) and to evaluate their survival without local recurrence.

    Authors: Amira Ziouèche-Mottet, Gilles Houvenaeghel, Jean Marc Classe, Jean Rémi Garbay, Sylvia Giard, Hélène Charitansky, Monique Cohen, Catherine Belichard, Christelle Faure, Elisabeth Chéreau Ewald, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet…
    Citation: BMC Cancer 2014 14:868
    Content type: Research article Published on:

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