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  1. Alternate transcripts from a single gene locus greatly enhance the combinatorial flexibility of the human transcriptome. Different patterns of exon usage have been observed when comparing normal tissue to canc...

    Authors: Sunniva Stordal Bjørklund, Vessela N. Kristensen, Michael Seiler, Surendra Kumar, Grethe I. Grenaker Alnæs, Yao Ming, John Kerrigan, Bjørn Naume, Ravi Sachidanandam, Gyan Bhanot, Anne-Lise Børresen-Dale and Shridar Ganesan
    Citation: BMC Cancer 2015 15:524
    Content type: Research article Published on:

  2. About 3885 women are diagnosed with breast cancer and 1285 die from the disease each year in Bulgaria. However no genetic testing to identify the mutations in high-risk families has been provided so far.

    Authors: Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova - Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky…
    Citation: BMC Cancer 2015 15:523
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:195

  3. The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknow...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano and Kosei Hirakawa
    Citation: BMC Cancer 2015 15:521
    Content type: Research article Published on:

  4. Despite the large number of published papers analyzing the prognostic role of Ki-67 in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis su...

    Authors: Song Wen, Wei Zhou, Chun-ming Li, Juan Hu, Xiao-ming Hu, Ping Chen, Guo-liang Shao and Wu-hua Guo
    Citation: BMC Cancer 2015 15:520
    Content type: Research article Published on:

  5. Aim of this prospective study was to predict response to neoadjuvant therapy in breast cancer patients using an in vitro breast cancer spheroid model.

    Authors: Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin and Barbara Mayer
    Citation: BMC Cancer 2015 15:519
    Content type: Research article Published on:

  6. VHL inactivation is the most established molecular characteristic of clear cell renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of this kidney tumor. In recently published...

    Authors: Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen and Joanna Wesoly
    Citation: BMC Cancer 2015 15:518
    Content type: Research article Published on:

  7. Liver metastases from breast cancer (LMBC) are typically considered to indicate systemic disease spread and patients are most often offered systemic palliative treatment only. However, retrospective studies su...

    Authors: Max Seidensticker, Benjamin Garlipp, Sophia Scholz, Konrad Mohnike, Felix Popp, Ingo Steffen, Ricarda Seidensticker, Patrick Stübs, Maciej Pech, Maciej PowerskI, Peter Hass, Serban-Dan Costa, Holger Amthauer, Christiane Bruns and Jens Ricke
    Citation: BMC Cancer 2015 15:517
    Content type: Research article Published on:

  9. Decisions on head and neck squamous cell carcinoma (HNSCC) treatment are widely recognized as being difficult, due to high morbidity, often involving vital functions. Some patients may therefore decline standa...

    Authors: Emilie A. C. Dronkers, Steven W. Mes, Marjan H. Wieringa, Marc P. van der Schroeff and Robert J. Baatenburg de Jong
    Citation: BMC Cancer 2015 15:515
    Content type: Research article Published on:

  10. Determining the driving factors and molecular flow-through that define the switch from favorable to aggressive high-risk disease is critical to the betterment of neuroblastoma cure.

    Authors: Faizan H. Khan, Vijayabaskar Pandian, Satishkumar Ramraj, Mohan Natarajan, Sheeja Aravindan, Terence S. Herman and Natarajan Aravindan
    Citation: BMC Cancer 2015 15:514
    Content type: Research article Published on:

  11. Activating mutations in RAS are present in the majority of pancreatic cancer cases and represent an ideal therapeutic target. Reolysin is a proprietary formulation of oncolytic reovirus that is currently being...

    Authors: Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey and Steffan T. Nawrocki
    Citation: BMC Cancer 2015 15:513
    Content type: Case report Published on:

  12. Bone is the most common site of breast cancer distant metastasis, affecting 50–70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and...

    Authors: Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook, Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco and Christine M. Friedenreich
    Citation: BMC Cancer 2015 15:512
    Content type: Study protocol Published on:

  13. In patients with high risk stage II and stage III colon cancer (CC), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 20 to 30 % of these patients, the ...

    Authors: Mehdi Karoui, Anne Rullier, Alain Luciani, Franck Bonnetain, Marie-Luce Auriault, Antony Sarran, Geneviève Monges, Hervé Trillaud, Karine Le Malicot, Karen Leroy, Iradj Sobhani, Armelle Bardier, Marie Moreau, Isabelle Brindel, Jean François Seitz and Julien Taieb
    Citation: BMC Cancer 2015 15:511
    Content type: Study protocol Published on:

  14. We aimed to evaluate the efficiency and safety of cis/carboplatin plus gemcitabine, which was previously used for mesothelioma but with no recorded proof of its efficiency, compared with cis/carboplatin plus p...

    Authors: Guntulu Ak, Selma Metintas, Muhittin Akarsu and Muzaffer Metintas
    Citation: BMC Cancer 2015 15:510
    Content type: Research article Published on:

  15. Drug resistance is still one of the key causes of death in epithelial ovarian carcinoma (EOC) patients, however there are very few strategies to reverse chemoresistance. Here we try to clarify whether and how ...

    Authors: Xiao Li, Qianqian Pan, Xiaoyun Wan, Yuyan Mao, Weiguo Lu, Xing Xie and Xiaodong Cheng
    Citation: BMC Cancer 2015 15:509
    Content type: Research article Published on:

  16. Lenalidomide has been approved for the treatment of lower-risk myelodysplastic syndrome (MDS) with 5q deletion (del(5q)). We present for the first time a retrospective analysis of low-risk MDS with isolated de...

    Authors: Aleksandra Butrym, Ewa Lech-Maranda, Elżbieta Patkowska, Beata Kumiega, Maria Bieniaszewska, Andrzej Mital, Krzysztof Madry, Tigran Torosian, Ryszard Wichary, Justyna Rybka, Krzysztof Warzocha and Grzegorz Mazur
    Citation: BMC Cancer 2015 15:508
    Content type: Research article Published on:

  17. Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen ...

    Authors: Aline Hempen, Eleftherios P Samartzis, Jivko Kamarachev, Daniel Fink and Konstantin J Dedes
    Citation: BMC Cancer 2015 15:507
    Content type: Case report Published on:

  18. While a number of studies have examined miRNA profiles across the molecular subtypes of breast cancer, it is unclear whether BRCA1 basal-like cancers have a specific miRNA profile. This study aims to compare g...

    Authors: Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv and Stephen B Fox
    Citation: BMC Cancer 2015 15:506
    Content type: Research article Published on:

  19. Little is known about colorectal adenoma patients’ ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention pr...

    Authors: Deborah McCahon, Amanda J. Daley, Janet Jones, Richard Haslop, Arjun Shajpal, Aliki Taylor, Sue Wilson and George Dowswell
    Citation: BMC Cancer 2015 15:505
    Content type: Research article Published on:

  20. Photodynamic therapy (PDT) contains a photosensitizing process, which includes cellular uptake of photosensitizer and delivery of light to the target. ATP-binding cassette subfamily G2 (ABCG2) regulates endoge...

    Authors: Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan and Myung-Gyu Choi
    Citation: BMC Cancer 2015 15:504
    Content type: Research article Published on:

  21. Communication skills training has proven to be an effective means to enhance communication of health care professionals in oncology. These effects are well studied in standardized settings. The question of tra...

    Authors: Marcelo Niglio de Figueiredo, Bärbel Rodolph, Carma L Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche and Alexander Wuensch
    Citation: BMC Cancer 2015 15:503
    Content type: Study protocol Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:596

  22. Aldehyde dehydrogenase 1 (ALDH1) is widely used as a specific cancer stem cell marker in a variety of cancers, and may become a promising target for cancer therapy. However, the role of its expression in tumor...

    Authors: Ruixia Huang, Xiaoran Li, Ruth Holm, Claes G. Trope, Jahn M. Nesland and Zhenhe Suo
    Citation: BMC Cancer 2015 15:502
    Content type: Research article Published on:

  23. Performance status (PS) assessment is an integral part of the decision-making process in cancer care. Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group (ECOG) PS are the most widely use...

    Authors: Carlos Eduardo Paiva, Felipe Augusto Ferreira Siquelli, Henrique Amorim Santos, Marina Moreira Costa, Daniella Ramone Massaro, Domício Carvalho Lacerda, João Soares Nunes, Cristiano de Pádua Souza and Bianca Sakamoto Ribeiro Paiva
    Citation: BMC Cancer 2015 15:501
    Content type: Research article Published on:

  24. Survival from cancer is worse in England than in some European countries. To improve survival, strategies in England have focused on early presentation (reducing delay to improve stage at diagnosis), improving...

    Authors: Rebecca Maclean, Mona Jeffreys, Alex Ives, Tim Jones, Julia Verne and Yoav Ben-Shlomo
    Citation: BMC Cancer 2015 15:500
    Content type: Research article Published on:

  25. MicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles. Numerous microarray studies reported different expression patterns of miRNAs i...

    Authors: Geraldine Cizeron-Clairac, François Lallemand, Sophie Vacher, Rosette Lidereau, Ivan Bieche and Celine Callens
    Citation: BMC Cancer 2015 15:499
    Content type: Research article Published on:

  26. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD)...

    Authors: Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim and Jae-Ho Cheong
    Citation: BMC Cancer 2015 15:498
    Content type: Research article Published on:

  27. BRAF mutations are present in 40 % of human skin melanomas. Mutated tumors with an increased percentage of BRAF mutant alleles (BRAF-M%) may have a better response to RAF/MEK inhibitors. We evaluated the BRAF-M% ...

    Authors: Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Laure Baudoux, Chan Kwon Jung, Ute Zimmermann, Cristi Marin, Thierry Clerici, Catherine Le Gall, Frédérique Peschaud, Valérie Taly, Philippe Saiag and Jean-François Emile
    Citation: BMC Cancer 2015 15:497
    Content type: Research article Published on:

  28. The management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides ...

    Authors: Benoist Chibaudel, Franck Bonnetain, Christophe Tournigand, Marine Hug de Larauze, Armand de Gramont, Pierre Laurent-Puig, Jérôme Paget, Alexandra Hadengue, Dominique Notelet, Magdalena Benetkiewicz, Thierry André and Aimery de Gramont
    Citation: BMC Cancer 2015 15:496
    Content type: Study protocol Published on:

  29. Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours...

    Authors: Jaume Capdevila, Isabel Sevilla, Vicente Alonso, Luís Antón Aparicio, Paula Jiménez Fonseca, Enrique Grande, Juan José Reina, José Luís Manzano, Juan Domingo Alonso Lájara, Jorge Barriuso, Daniel Castellano, Javier Medina, Carlos López, Ángel Segura, Sergio Carrera, Guillermo Crespo…
    Citation: BMC Cancer 2015 15:495
    Content type: Research article Published on:

  31. Oxidative stress is a widely seen phenomenon in several carcinomas. Increasing evidence also suggests that it has a significant role in the development of epithelial ovarian carcinoma (EOC). 8-Hydroxydeoxyguan...

    Authors: Marjo Pylväs-Eerola, Peeter Karihtala and Ulla Puistola
    Citation: BMC Cancer 2015 15:493
    Content type: Research article Published on:

  32. Platinum-based combination therapy is the standard first-line treatment for women with advanced serous epithelial ovarian carcinoma (EOC). However, about 20 % will not respond and are considered clinically res...

    Authors: Denis Lane, Isabelle Matte, Perrine Garde-Granger, Claude Laplante, Alex Carignan, Claudine Rancourt and Alain Piché
    Citation: BMC Cancer 2015 15:492
    Content type: Research article Published on:

  33. It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related ...

    Authors: Peng Cao, Fan Feng, Guofu Dong, Chunyong Yu, Sizhe Feng, Erlin Song, Guobing Shi, Yong Liang and Guobiao Liang
    Citation: BMC Cancer 2015 15:491
    Content type: Research article Published on:

  34. Despite smoking cessation can largely improve cancer prognosis and quality of life, many patients continued smoking after the diagnosis of cancer. This study aims to test the effectiveness of a smoking cessati...

    Authors: William H.C. Li, Sophia S.C. Chan, Kelvin M. P. Wang and T.H. Lam
    Citation: BMC Cancer 2015 15:490
    Content type: Study protocol Published on:

  35. An enduring challenge in personalized medicine is to select right drug for individual patients. Testing drugs on patients in large clinical trials is one way to assess their efficacy and toxicity, but it is im...

    Authors: Zuoli Dong, Naiqian Zhang, Chun Li, Haiyun Wang, Yun Fang, Jun Wang and Xiaoqi Zheng
    Citation: BMC Cancer 2015 15:489
    Content type: Research article Published on:

  36. The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative funct...

    Authors: Maria Thomas, Christine Bayha, Kathrin Klein, Simon Müller, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger
    Citation: BMC Cancer 2015 15:488
    Content type: Research article Published on:

  37. Endometrial carcinoma is the most common gynaecologic malignancy in industrialised countries and the incidence is still rising. Primary treatment is based on preoperative risk classification and consists in mo...

    Authors: Nicole C. M. Visser, Johan Bulten, Anneke A. M. van der Wurff, Erik A. Boss, Carolien M. Bronkhorst, Harrie W. H. Feijen, Joke E. Haartsen, Hilde A. D. M. van Herk, Ineke M. de Kievit, Paul J. J. M. Klinkhamer, Brenda M. Pijlman, Marc P. M. L. Snijders, Ingrid Vandenput, M. Caroline Vos, Peter E. J. de Wit, Lonneke V. van de Poll-Franse…
    Citation: BMC Cancer 2015 15:487
    Content type: Study protocol Published on:

  38. Long-term local control in Glioblastoma is rarely achieved and nearly all patients relapse. In this study we evaluated the clinical effect of different treatment approaches in recurrent patients.

    Authors: Marta Scorsetti, Pierina Navarria, Federico Pessina, Anna Maria Ascolese, Giuseppe D’Agostino, Stefano Tomatis, Fiorenza De Rose, Elisa Villa, Giulia Maggi, Matteo Simonelli, Elena Clerici, Riccardo Soffietti, Armando Santoro, Luca Cozzi and Lorenzo Bello
    Citation: BMC Cancer 2015 15:486
    Content type: Research article Published on:

  39. Controversy remains whether a pattern of cervical intraepithelial neoplasia exists on the cervix. Our study aims at determining if the prevalence of histologically proven lesions differs by cervical four-quadr...

    Authors: Yu-qian Zhao, Irene J. Chang, Fang-hui Zhao, Shang-ying Hu, Jennifer S. Smith, Xun Zhang, Shu-min Li, Ping Bai, Wen-hua Zhang and You-lin Qiao
    Citation: BMC Cancer 2015 15:485
    Content type: Research article Published on:

  40. Mutations in genes that are part of the splicing machinery for myelodysplastic syndromes (MDS), including MDS without ring sideroblasts (RS), have been widely investigated. The effects of these mutations on cl...

    Authors: Min-Gu Kang, Hye-Ran Kim, Bo-Young Seo, Jun Hyung Lee, Seok-Yong Choi, Soo-Hyun Kim, Jong-Hee Shin, Soon-Pal Suh, Jae-Sook Ahn and Myung-Geun Shin
    Citation: BMC Cancer 2015 15:484
    Content type: Research article Published on:

  41. Menacalc is an immunofluorescence-based, quantitative method in which expression of the non-invasive Mena protein isoform (Mena11a) is subtracted from total Mena protein expression. Previous work has found a sign...

    Authors: Catherine L. Forse, Seema Agarwal, Dushanthi Pinnaduwage, Frank Gertler, John S. Condeelis, Juan Lin, Xiaonan Xue, Kimberly Johung, Anna Marie Mulligan, Thomas E. Rohan, Shelley B. Bull and Irene L. Andrulis
    Citation: BMC Cancer 2015 15:483
    Content type: Research article Published on:

  42. Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary ope...

    Authors: Evelyne MJ Meys, Iris JG Rutten, Roy FPM Kruitwagen, Brigitte F Slangen, Martin GM Bergmans, Helen JMM Mertens, Ernst Nolting, Dieuwke Boskamp, Regina GH Beets-Tan and Toon van Gorp
    Citation: BMC Cancer 2015 15:482
    Content type: Study protocol Published on:

  43. Gliomas account for more than 60 % of all primary central nervous system neoplasms. Low-grade gliomas display a tendency to progress to more malignant phenotypes and the most frequent and malignant gliomas are...

    Authors: Marcela Gimenez, Suely Kazue Nagahashi Marie, Sueli Oba-Shinjo, Miyuki Uno, Clarice Izumi, João Bosco Oliveira and Jose Cesar Rosa
    Citation: BMC Cancer 2015 15:481
    Content type: Research article Published on:

  44. Nasal NK/T-cell lymphoma is a rare type of lymphoma in Caucasian individuals, but is relatively common in Asian populations. Genetic variants in immune and inflammatory response genes may thus be associated wi...

    Authors: Sensen Cheng, Jianzhong Li, Wenjian Liu, Chengxiang Liu, Lei Su, Xiuchun Liu, Liangjun Guo, Yuan Ma, Bao Song and Jie Liu
    Citation: BMC Cancer 2015 15:480
    Content type: Research article Published on:

  45. Valosin containing protein (VCP) is a critical mediator of protein homeostasis and may represent a valuable therapeutic target for several forms of cancer. Overexpression of VCP occurs in many cancers, and oft...

    Authors: Marie-Ève Nadeau, Charlène Rico, Mayra Tsoi, Mélanie Vivancos, Sabin Filimon, Marilène Paquet and Derek Boerboom
    Citation: BMC Cancer 2015 15:479
    Content type: Research article Published on:

  46. In Brazil, the rate of cervical cancer remains high despite the availability of screening programs. With ongoing vaccine development and implementation, information on the prevalence of specific HPV types is n...

    Authors: Jessica L. Castilho, José Eduardo Levi, Paula M. Luz, Mary Catherine Cambou, Tazio Vanni, Angela de Andrade, Mônica Derrico, Valdiléa G. Veloso, Beatriz Grinsztejn and Ruth K. Friedman
    Citation: BMC Cancer 2015 15:478
    Content type: Research article Published on:

  47. Neuroblastoma (NB) is an aggressive childhood malignancy in children up to 5 years of age. High-stage tumors frequently relapse even after aggressive multimodal treatment, and then show therapy resistance, typ...

    Authors: Lisette P. Yco, Dirk Geerts, Gabor Mocz, Jan Koster and André S. Bachmann
    Citation: BMC Cancer 2015 15:477
    Content type: Research article Published on:

  48. Bcl-2 (B cell lymphoma/leukemia gene-2) is the first proto-oncogene recognized to function by inhibiting programmed cell death/apoptosis. Although much is known about the anti-apoptotic ability of Bcl-2, littl...

    Authors: Juan An, Jin Lv, Aimin Li, Junxiao Qiao, Liang Fang, Zhihua Li, Bo Li, Wei Zhao, Huoming Chen and Liying Wang
    Citation: BMC Cancer 2015 15:476
    Content type: Research article Published on:

  49. Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans, often demonstrating resistance to multimodal therapeutic approaches. The median survival of ATC patients after initial diag...

    Authors: Naoyoshi Onoda, Iwao Sugitani, Takuya Higashiyama, Hisato Hara, Ken-ichi Ito, Makoto Kammori, Kiminori Sugino, Shinichi Suzuki, Kazuhisa Toda, Akira Yoshida and Akira Miyauchi
    Citation: BMC Cancer 2015 15:475
    Content type: Study protocol Published on:

  50. Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic s...

    Authors: Nipin SP, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Dong Young Kang, Don Nam Kim, Tae Sook Hwang, Sang Yoon Kim, Wan Seop Kim, Hak Kyo Lee, Byung Wook Cho, Heui Soo Kim, Kyung Do Park, Jong Hwan Park, Soung Hoon Chang and Young Mok Yang
    Citation: BMC Cancer 2015 15:474
    Content type: Research article Published on:

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