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  1. The quantitative analysis of microRNA (miRNA) gene expression in archived formalin-fixed, paraffin embedded (FFPE) tissues has been instrumental to identifying their potential roles in cancer biology, diagnosi...

    Authors: Sarah B. Peskoe, John R. Barber, Qizhi Zheng, Alan K. Meeker, Angelo M. De Marzo, Elizabeth A. Platz and Shawn E. Lupold
    Citation: BMC Cancer 2017 17:32
    Content type: Research article Published on:

  2. Multiple studies have reported evidence of an inverse association between parity and bladder cancer risk. However, a comprehensive and quantitative assessment of this association has never been conducted. We c...

    Authors: Yunjin Bai, Xiaoming Wang, Yubo Yang, Yin Tang, Jia Wang and Ping Han
    Citation: BMC Cancer 2017 17:31
    Content type: Research article Published on:

  3. This matched-pair study was initiated to validate the results of a retrospective study of 186 patients published in 2007 that compared whole-brain irradiation (WBI) alone and radiosurgery (RS) alone for up to ...

    Authors: Dirk Rades, Stefan Janssen, Liesa Dziggel, Oliver Blanck, Amira Bajrovic, Theo Veninga and Steven E. Schild
    Citation: BMC Cancer 2017 17:30
    Content type: Research article Published on:

  4. This study evaluated the distribution pattern of the Ki67-labeling index (LI) among patients at a Chinese breast cancer center, and analyzed its prognostic significance in the 2015 St Gallen consensus breast c...

    Authors: Yue Hu, Ran Gu, Jinghua Zhao, Yaping Yang, Fengtao Liu, Liang Jin, Kai Chen, Haixia Jia, Hongli Wang, Qiang Liu, Fengxi Su and Weijuan Jia
    Citation: BMC Cancer 2017 17:28
    Content type: Research article Published on:

  5. Metabolic toxicities of mTOR inhibitors (mTORi) are well characterized. The purpose of the study was to investigate the relationship between these metabolic toxicities and mTORi efficacy.

    Authors: M. Jebali, R. Elaidi, M. Brizard, J. Fouque, C. Takouchop, B. Sabatier, S. Oudard and J. Medioni
    Citation: BMC Cancer 2017 17:27
    Content type: Research article Published on:

  6. The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed ...

    Authors: Yuanyuan Xiao, Wen Chen, Zhihui Xie, Zhenyi Shao, Hua Xie, Guoyou Qin and Naiqing Zhao
    Citation: BMC Cancer 2017 17:25
    Content type: Research article Published on:

  7. Human chromosomes are capped and stabilized by telomeres. Telomere length regulates a ‘cellular mitotic clock’ that defines the number of cell divisions and hence, cellular life span. This study aimed to synth...

    Authors: Cho Naing, Kyan Aung, Pei Kuan Lai and Joon Wah Mak
    Citation: BMC Cancer 2017 17:24
    Content type: Research article Published on:

  8. The clinical prognosis of gastric cancer with peritoneal dissemination is poor because of its chemoresistance and rich fibrosis. While several gastric cancer cell lines have been used to establish models of pe...

    Authors: Mitsuyoshi Okazaki, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Itasu Ninomiya and Tetsuo Ohta
    Citation: BMC Cancer 2017 17:23
    Content type: Research article Published on:

  9. Receptor for advanced glycation end-products (RAGE), a receptor for amyloids, is constitutively expressed in lungs and generally observed to be downregulated in lung cancer tissues. However, increasing levels ...

    Authors: Shouichi Okamoto, Shinsaku Togo, Ichiro Nagata, Kazue Shimizu, Yoshika Koinuma, Yukiko Namba, Jun Ito, Toshimasa Uekusa and Kazuhisa Takahashi
    Citation: BMC Cancer 2017 17:22
    Content type: Case report Published on:

  10. CD105 was postulated as a renal cell carcinoma (RCC) stem cell marker, and CD133 as a putative RCC progenitor. Hypoxia, a natural microenvironment that prevails in tumors, was also incorporated into the study,...

    Authors: Damian Matak, Klaudia K. Brodaczewska, Cezary Szczylik, Irena Koch, Adam Myszczyszyn, Monika Lipiec, Slawomir Lewicki, Lukasz Szymanski, Robert Zdanowski and Anna M. Czarnecka
    Citation: BMC Cancer 2017 17:21
    Content type: Research article Published on:

  12. One of the hallmarks of cancer is an altered energy metabolism, and here, mitochondria play a central role. Previous studies have indicated that some mitochondrial ribosomal proteins change their expression pa...

    Authors: Karen Marie Juul Sørensen, Theresa Meldgaard, Connie Jenning Melchjorsen, Agla J. Fridriksdottir, Henrik Pedersen, Ole William Petersen and Peter Kristensen
    Citation: BMC Cancer 2017 17:19
    Content type: Research article Published on:

  13. In endemic area, nasopharyngeal carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and a...

    Authors: Mei-Chun Lin, Yong-Chong Lin, Syue-Ting Chen, Tai-Horng Young and Pei-Jen Lou
    Citation: BMC Cancer 2017 17:18
    Content type: Research article Published on:

  14. Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many time...

    Authors: Leah Zhrebker, Irene Cherni, Lara M. Gross, Margaret M. Hinshelwood, Merrick Reese, Jessica Aldrich, Joseph M. Guileyardo, William C. Roberts, David Craig, Daniel D. Von Hoff, Robert G. Mennel and John D. Carpten
    Citation: BMC Cancer 2017 17:17
    Content type: Case report Published on:

  15. To compare the efficacy of sorafenib and sunitinib with regard to overall survival (OS) and progression free survival (PFS) in Chinese patients with metastatic renal cell carcinoma (mRCC).

    Authors: Hai-Liang Zhang, Xi-Nan Sheng, Xue-Song Li, Hong-Kai Wang, Zhi-Hong Chi, Zhi-Song He, Ding-Wei Ye and Jun Guo
    Citation: BMC Cancer 2017 17:16
    Content type: Research article Published on:

  16. Primary natural killer (NK)/T cell lymphoma of adrenal glands is an extremely rare tumor with aggressive clinical behavior. There have only been a few cases reported worldwide and the highest reported survival...

    Authors: Liu Hu, Weimin Xu, Mingwei Wang, Pan Wang, Guang Han and Chi Lin
    Citation: BMC Cancer 2017 17:15
    Content type: Case report Published on:

  17. The Hangzhou criteria expand the Milan criteria safely and effectively in selecting hepatocellular carcinoma (HCC) candidates for liver transplantation (LT), but some patients exceeding the Milan but fulfillin...

    Authors: Weiliang Xia, Qinghong Ke, Hua Guo, Weilin Wang, Min Zhang, Yan Shen, Jian Wu, Xiao Xu, Sheng Yan, Jun Yu, Mangli Zhang and Shusen Zheng
    Citation: BMC Cancer 2017 17:14
    Content type: Research article Published on:

  18. Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population s...

    Authors: Nishitha Thumallapally, Ahmed Meshref, Mohammed Mousa and Terenig Terjanian
    Citation: BMC Cancer 2017 17:13
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:443

  19. Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and...

    Authors: Messaouda Merzoug-Larabi, Caroline Spasojevic, Marianne Eymard, Caroline Hugonin, Christian Auclair and Manale Karam
    Citation: BMC Cancer 2017 17:12
    Content type: Research article Published on:

  20. Lymphatic metastasis, facilitated by lymphangiogenesis is a common occurrence in breast cancer, the molecular mechanisms remaining incompletely understood. We had earlier shown that cyclooxygenase (COX)-2 expr...

    Authors: Pinki Nandi, Gannareddy V. Girish, Mousumi Majumder, Xiping Xin, Elena Tutunea-Fatan and Peeyush K. Lala
    Citation: BMC Cancer 2017 17:11
    Content type: Research article Published on:

  21. The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is inevitable for many cancer patients, despite many impro...

    Authors: Ian A. Cree and Peter Charlton
    Citation: BMC Cancer 2017 17:10
    Content type: Review Published on:

  22. There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).

    Authors: Gabriela Gremel, Dijana Djureinovic, Marjut Niinivirta, Alexander Laird, Oscar Ljungqvist, Henrik Johannesson, Julia Bergman, Per-Henrik Edqvist, Sanjay Navani, Naila Khan, Tushar Patil, Åsa Sivertsson, Mathias Uhlén, David J. Harrison, Gustav J. Ullenhag, Grant D. Stewart…
    Citation: BMC Cancer 2017 17:9
    Content type: Research article Published on:

  23. Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular carcinoma (HCC), but no data existed for early-stage ...

    Authors: Leung Li, Frankie KF Mo, Stephen L Chan, Edwin P Hui, Nelson SL Tang, Jane Koh, Linda KS Leung, Annette NY Poon, Joyce Hui, Cheuk M Chu, Kit F Lee, Brigette BY Ma, Paul BS Lai, Anthony TC Chan, Simon CH Yu and Winnie Yeo
    Citation: BMC Cancer 2017 17:8
    Content type: Research article Published on:

  24. Discordance in hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) status between primary tumors and metastatic sites for breast cancer is well established. However, it is uncertain whic...

    Authors: Shlomit Strulov Shachar, Tanya Mashiach, Georgeta Fried, Karen Drumea, Noa Shafran, Hyman B. Muss and Gil Bar-Sela
    Citation: BMC Cancer 2017 17:7
    Content type: Research article Published on:

  25. In head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery.

    Authors: Bülent Polat, Philipp Kaiser, Gisela Wohlleben, Thomas Gehrke, Agmal Scherzad, Matthias Scheich, Uwe Malzahn, Thomas Fischer, Dirk Vordermark and Michael Flentje
    Citation: BMC Cancer 2017 17:6
    Content type: Research article Published on:

  26. The incidence of melanoma is rising. Early detection is associated with a more favourable outcome. The factors that influence the timing of a patient’s presentation for medical assessment are not fully underst...

    Authors: Sally Jane O’Shea, Zoe Rogers, Fiona Warburton, Amanda J. Ramirez, Julia A. Newton-Bishop and Lindsay J. L. Forbes
    Citation: BMC Cancer 2017 17:5
    Content type: Research article Published on:

  27. Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. New anti-cancer agents are needed for treating late stage colorectal cancer as most of the deaths occur due to cancer metastasis. A recentl...

    Authors: Khayal Al-Khayal, Ahmed Alafeefy, Mansoor-Ali Vaali-Mohammed, Amer Mahmood, Ahmed Zubaidi, Omar Al-Obeed, Zahid Khan, Maha Abdulla and Rehan Ahmad
    Citation: BMC Cancer 2017 17:4
    Content type: Research article Published on:

  28. The Special AT-rich Sequence Binding Protein 1 (SATB1) regulates the expression of many genes by acting as a global chromatin organizer. While in many tumor entities SATB1 overexpression has been observed and ...

    Authors: Anja Frömberg, Michael Rabe, Henry Oppermann, Frank Gaunitz and Achim Aigner
    Citation: BMC Cancer 2017 17:3
    Content type: Research article Published on:

  29. Except for overall survival, whether or not waiting time for treatment could influences other domains of cancer patients’ overall well-being is to a large extent unknown. Therefore, we performed this study to ...

    Authors: Huan Song, Fang Fang, Unnur Valdimarsdóttir, Donghao Lu, Therese M.-L. Andersson, Christina Hultman, Weimin Ye, Lars Lundell, Jan Johansson, Magnus Nilsson and Mats Lindblad
    Citation: BMC Cancer 2017 17:2
    Content type: Research article Published on:

  30. Cancer-related fatigue is one of the most prevalent, prolonged and distressing side effects of prostate cancer treatment with androgen deprivation therapy. Preliminary evidence suggests natural therapies such ...

    Authors: Brenton J. Baguley, Tina L. Skinner, Michael D. Leveritt and Olivia R. L. Wright
    Citation: BMC Cancer 2017 17:1
    Content type: Study protocol Published on:

  31. Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inh...

    Authors: Nofar Yedid, Yael Kalma, Mira Malcov, Ami Amit, Revital Kariv, Michal Caspi, Rina Rosin-Arbesfeld and Dalit Ben-Yosef
    Citation: BMC Cancer 2016 16:952
    Content type: Research article Published on:

  32. Estrogen receptor β (ERβ) is expressed in the majority of invasive breast cancer cases, irrespective of their subtype, including triple-negative breast cancer (TNBC). Thus, ERβ might be a potential target for ...

    Authors: Susanne Schüler-Toprak, Julia Häring, Elisabeth C. Inwald, Christoph Moehle, Olaf Ortmann and Oliver Treeck
    Citation: BMC Cancer 2016 16:951
    Content type: Research article Published on:

  33. Oral cancer is a significant public health problem world-wide and exerts high economic, social, psychological, and physical burdens on patients, their families, and on their primary care providers. We set out ...

    Authors: Hala Ali, Sarah-Jo Sinnott, Paul Corcoran, Sandra Deady, Linda Sharp and Zubair Kabir
    Citation: BMC Cancer 2016 16:950
    Content type: Research article Published on:

  34. Sialyltransferase I (ST6Gal-I) is an enzyme involved in tumor metastasis that processes sialic acid precursors into their mature form, enabling them to regulate gene expression. However, the effect of ST6Gal-I...

    Authors: Xiaopeng Zhang, Chunchen Pan, Lei Zhou, Zhaogen Cai, Shufang Zhao and Donghong Yu
    Citation: BMC Cancer 2016 16:949
    Content type: Research article Published on:

  35. Advanced age has been shown to be a factor predicting poor survival in patients with brain metastases (BM). There have been only a few studies focusing on stereotactic radiosurgery (SRS) for elderly BM patient...

    Authors: Shoji Yomo and Motohiro Hayashi
    Citation: BMC Cancer 2016 16:948
    Content type: Research article Published on:

  36. Primary pancreatic leiomyosarcoma is a rare pancreatic malignancy; the clinical presentation and treatment is not well-characterized. Further, the molecular mechanisms underlying its pathogenesis are not known...

    Authors: Chao Lin, Liping Wang, Jiyao Sheng, Dan Zhang, Lianyue Guan, Kai Zhao and Xuewen Zhang
    Citation: BMC Cancer 2016 16:947
    Content type: Case report Published on:

  37. To compare efficacy and toxicity of nimotuzumab versus cisplatin (CDDP) concurrent with intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).

    Authors: H. M. Li, P. Li, Y. J. Qian, X. Wu, L. Xie, F. Wang, H. Zhang and L. Liu
    Citation: BMC Cancer 2016 16:946
    Content type: Research article Published on:

  38. Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known about the relevance of this marker for the prognosis a...

    Authors: Mami Kaneko, Masanori Kotake, Hiroyuki Bando, Tetsuji Yamada, Hirofumi Takemura and Toshinari Minamoto
    Citation: BMC Cancer 2016 16:945
    Content type: Research article Published on:

  39. To investigate the impact of biological gender on operative parameters, especially operative time, in laparoscopic partial nephrectomy (LPN) for T1 renal tumor.

    Authors: Hiroki Ito, Kazuhide Makiyama, Takashi Kawahara, Kimito Osaka, Koji Izumi, Yumiko Yokomizo, Noboru Nakaigawa and Masahiro Yao
    Citation: BMC Cancer 2016 16:944
    Content type: Research article Published on:

  40. Circulating cell-free DNA (ccf-DNA) in plasma may contain both specific and non-specific of tumor markers. The concentration and integrity of ccf-DNA may be clinical useful for detecting and predicting cancer ...

    Authors: Wang-Yang Pu, Rong Zhang, Li Xiao, Yong-You Wu, Wei Gong, Xiao-Dong Lv, Feng-Yun Zhong, Zhi-Xiang Zhuang, Xu-Ming Bai, Kai Li and Chun-Gen Xing
    Citation: BMC Cancer 2016 16:943
    Content type: Research article Published on:

  41. Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cance...

    Authors: Jeffrey Wimsatt, Meghan Villers, Laurel Thomas, Stacey Kamarec, Caitlin Montgomery, Leo W. Y. Yeung, Yanqing Hu and Kim Innes
    Citation: BMC Cancer 2016 16:942
    Content type: Research article Published on:

  42. Neuroendocrine cells (NECs) reside adjacent to colonic stem cells (SCs) in the crypt stem cell (SC) niche, but how NECs are involved in regulation of SCs is unclear. We investigated NECs expressing somatostati...

    Authors: Shirin R. Modarai, Lynn M. Opdenaker, Vignesh Viswanathan, Jeremy Z. Fields and Bruce M. Boman
    Citation: BMC Cancer 2016 16:941
    Content type: Research article Published on:

  43. Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to ...

    Authors: Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I. Wolf, Jindřich Chmelař, Jan Kopecký and Jan Ženka
    Citation: BMC Cancer 2016 16:940
    Content type: Research article Published on:

  45. Intracellular signaling through cyclic nucleotides, both cyclic AMP and cyclic GMP, is altered in colorectal cancer. Accordingly, it is hypothesized that an underlying mechanism for colorectal neoplasia involv...

    Authors: Badar Mahmood, Morten Matthiesen Bach Damm, Thorbjørn Søren Rønn Jensen, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Niels Bindslev and Mark Berner Hansen
    Citation: BMC Cancer 2016 16:938
    Content type: Research article Published on:

  46. Decisions on palliative chemotherapy (CT) for locally advanced or metastatic gastric cancer (mGC) require trade-offs between potential benefits and risks for patients. Healthcare providers and payers agree tha...

    Authors: R. Hofheinz, J. Clouth, J. Borchardt-Wagner, U. Wagner, E. Weidling, M. H. Jen and P. Brück
    Citation: BMC Cancer 2016 16:937
    Content type: Research article Published on:

  47. Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this s...

    Authors: Olaf Schoffer, Stefanie Schülein, Gerlinde Arand, Hans Arnholdt, Dieter Baaske, Ralf C. Bargou, Nikolaus Becker, Matthias W. Beckmann, Yves Bodack, Beatrix Böhme, Tayfun Bozkurt, Regine Breitsprecher, Andre Buchali, Elke Burger, Ulrike Burger, Klaus Dommisch…
    Citation: BMC Cancer 2016 16:936
    Content type: Research article Published on:

  49. Approximately 8–15% epithelial ovarian cancer patients are BRCA1 or BRCA2 germline mutation carriers. Brazilian inhabitants may have peculiar genetic characteristics associated with ethnic diversity, and studies ...

    Authors: Simone Maistro, Natalia Teixeira, Giselly Encinas, Maria Lucia Hirata Katayama, Vivian Dionisio Tavares Niewiadonski, Larissa Garcia Cabral, Roberto Marques Ribeiro, Nelson Gaburo Junior, Ana Carolina Ribeiro Chaves de Gouvêa, Dirce Maria Carraro, Ester Cerdeira Sabino, Maria del Pilar Estevez Diz, Roger Chammas, Geertruida Hendrika de Bock and Maria Aparecida Azevedo Koike Folgueira
    Citation: BMC Cancer 2016 16:934
    Content type: Research article Published on:

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