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  1. Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Ther...

    Authors: Shigeru Iida, Reiko Kuni-Kamochi, Katsuhiro Mori, Hirofumi Misaka, Miho Inoue, Akira Okazaki, Kenya Shitara and Mitsuo Satoh
    Citation: BMC Cancer 2009 9:58
    Content type: Research article Published on:

  2. The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activi...

    Authors: Miikka Korja, Anne Jokilammi, Toivo T Salmi, Hannu Kalimo, Tarja-Terttu Pelliniemi, Jorma Isola, Immo Rantala, Hannu Haapasalo and Jukka Finne
    Citation: BMC Cancer 2009 9:57
    Content type: Research article Published on:

  3. The proteasome inhibitor bortezomib has shown impressive clinical activity alone and in combination with conventional and other novel agents for the treatment of multiple myeloma (MM) and some solid cancers. A...

    Authors: Zhen-Xian Du, Hai-Yan Zhang, Xin Meng, Yifu Guan and Hua-Qin Wang
    Citation: BMC Cancer 2009 9:56
    Content type: Research article Published on:

  4. We previously found that r-hu-IFNγ exerts a potent anti-tumor effect on human nasopharyngeal carcinoma xenografts in vivo. Considering the fact that the clinical use of recombinant IFNγ is limited by its short ha...

    Authors: Jiangxue Wu, Xia Xiao, Hongyun Jia, Jiemin Chen, Yinghui Zhu, Peng Zhao, Huanxin Lin and Wenlin Huang
    Citation: BMC Cancer 2009 9:55
    Content type: Research article Published on:

  5. Although features of variable differentiation in glioblastoma cell cultures have been reported, a comparative analysis of differentiation properties of normal neural GFAP positive progenitors, and those shown ...

    Authors: Piotr Rieske, Ewa Golanska, Magdalena Zakrzewska, Sylwester Piaskowski, Krystyna Hulas-Bigoszewska, Magdalena Wolańczyk, Malgorzata Szybka, Monika Witusik-Perkowska, Dariusz J Jaskolski, Krzysztof Zakrzewski, Wojciech Biernat, Barbara Krynska and Pawel P Liberski
    Citation: BMC Cancer 2009 9:54
    Content type: Research article Published on:

  6. Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL). However, most advanced-phase CML and Ph+...

    Authors: Patricia Mambou Gwanmesia, Annette Romanski, Kerstin Schwarz, Biserka Bacic, Martin Ruthardt and Oliver G Ottmann
    Citation: BMC Cancer 2009 9:53
    Content type: Research article Published on:

  8. Oncoprotein HCCR-1 functions as a negative regulator of the p53 and contributes breast tumorigenesis. The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast ...

    Authors: Seon-Ah Ha, Youn Soo Lee, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Sang Seol Jung and Jin Woo Kim
    Citation: BMC Cancer 2009 9:51
    Content type: Research article Published on:

  9. The additional use of radiotherapy has changed the treatment of locally advanced rectal cancer (LARC) dramatically. But a major achievement has been the development of total mesorectal excision (TME) as a surg...

    Authors: Robert Siegel, Susen Burock, Klaus-Dieter Wernecke, Albrecht Kretzschmar, Manfred Dietel, Volker Loy, Stephan Koswig, Volker Budach and Peter M Schlag
    Citation: BMC Cancer 2009 9:50
    Content type: Study protocol Published on:

  10. Housekeeping genes are routinely used as endogenous references to account for experimental differences in gene expression assays. However, recent reports show that they could be de-regulated in different disea...

    Authors: Li-Yun Fu, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Cai Wu, Yue Zhao, Hai-Jun Zhou, Ning Ren, Qin-Hai Ye and Lun-Xiu Qin
    Citation: BMC Cancer 2009 9:49
    Content type: Research article Published on:

  11. The development of breast cancer is multifactorial. Hormonal, environmental factors and genetic predisposition, among others, could interact in the presentation of breast carcinoma. Human leukocyte antigen (HL...

    Authors: David Cantú de León, Delia Pérez-Montiel, Verónica Villavicencio, Alejandro García Carranca, Alejandro Mohar Betancourt, Victor Acuña-Alonzo, Alberto López-Tello, Gilberto Vargas-Alarcón, Rodrigo Barquera, Neng Yu, Edmond J Yunis and Julio Granados
    Citation: BMC Cancer 2009 9:48
    Content type: Research article Published on:

  12. Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the fac...

    Authors: Harue Tada, Satoshi Teramukai, Masanori Fukushima and Hiroshi Sasaki
    Citation: BMC Cancer 2009 9:47
    Content type: Research article Published on:

  14. The bone-tumor microenvironment encompasses unique interactions between the normal cells of the bone and marrow cavity and the malignant cells from a primary or metastasized cancer. A multitude of paracrine fa...

    Authors: Katherine R Schiller, Marion R Zillhardt, Jeremy Alley, Dori L Borjesson, Alvin J Beitz and Laura J Mauro
    Citation: BMC Cancer 2009 9:45
    Content type: Research article Published on:

  15. Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficul...

    Authors: Cinzia Lavarino, Nai-Kong V Cheung, Idoia Garcia, Gema Domenech, Carmen de Torres, Miguel Alaminos, Jose Rios, William L Gerald, Brian Kushner, Mike LaQuaglia and Jaume Mora
    Citation: BMC Cancer 2009 9:44
    Content type: Research article Published on:

  16. Only a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer, we hypothesized tha...

    Authors: Christopher A Haiman, Rachel R Garcia, Chris Hsu, Lucy Xia, Helen Ha, Xin Sheng, Loic Le Marchand, Laurence N Kolonel, Brian E Henderson, Michael R Stallcup, Geoffrey L Greene and Michael F Press
    Citation: BMC Cancer 2009 9:43
    Content type: Research article Published on:

  18. Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeut...

    Authors: Srinivas Koduru, Srinivasan Sowmyalakshmi, Raj Kumar, Rohini Gomathinayagam, Jürgen Rohr and Chendil Damodaran
    Citation: BMC Cancer 2009 9:41
    Content type: Research article Published on:

  20. Evidence suggests that truth telling and honest disclosure of cancer diagnosis could lead to improved outcomes in cancer patients. To examine such findings in Iran, this trial aimed to study the various dimens...

    Authors: Ali Montazeri, Azadeh Tavoli, Mohammad Ali Mohagheghi, Rasool Roshan and Zahra Tavoli
    Citation: BMC Cancer 2009 9:39
    Content type: Research article Published on:

  21. Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patie...

    Authors: Louise A Knight, Christian M Kurbacher, Sharon Glaysher, Augusta Fernando, Ralf Reichelt, Susanne Dexel, Uwe Reinhold and Ian A Cree
    Citation: BMC Cancer 2009 9:38
    Content type: Research article Published on:

  22. A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient outcomes. Bioelectrical impedance analysis (BIA) is an easy-to-use an...

    Authors: Digant Gupta, Carolyn A Lammersfeld, Pankaj G Vashi, Jessica King, Sadie L Dahlk, James F Grutsch and Christopher G Lis
    Citation: BMC Cancer 2009 9:37
    Content type: Research article Published on:

  23. Bowel cancer is common and a major cause of death. The NHS is currently rolling out a national bowel cancer screening programme that aims to cover the entire population by 2010. The programme will be based on ...

    Authors: Sue Wilson, Taina Taskila, Tariq Ismail, Deborah D Stocken, Ashley Martin, Val Redman, Michael Wakelam, Ian Perry and Richard Hobbs
    Citation: BMC Cancer 2009 9:36
    Content type: Study protocol Published on:

  24. The purpose of this study has been to establish the level of RCAS1 – a membrane protein expressed in various cancer cells and able to induce apoptosis of CTLs and NK cells in pharyngeal and laryngeal cancer an...

    Authors: Magdalena Dutsch-Wicherek, Romana Tomaszewska, Agata Lazar, Lukasz Wicherek and Jacek Skladzien
    Citation: BMC Cancer 2009 9:35
    Content type: Research article Published on:

  26. A consensus on the most reliable staging system for hepatocellular carcinoma (HCC) is still lacking but the most used is a revised Barcelona Clinic Liver Cancer (BCLC) system, adopted by the American Associati...

    Authors: Fabio Farinati, Adriana Sergio, Anna Baldan, Anna Giacomin, Maria Anna Di Nolfo, Paolo Del Poggio, Luisa Benvegnu, Gianludovico Rapaccini, Marco Zoli, Franco Borzio, Edoardo G Giannini, Eugenio Caturelli and Franco Trevisani
    Citation: BMC Cancer 2009 9:33
    Content type: Research article Published on:

  27. Clinical characterization of bladder carcinomas is still inadequate using the standard clinico-pathological prognostic markers. We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the cli...

    Authors: Hussein M Khaled, Abeer A Bahnassy, Amira A Raafat, Abdel-Rahman N Zekri, Maha S Madboul and Nadia M Mokhtar
    Citation: BMC Cancer 2009 9:32
    Content type: Research article Published on:

  28. Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands...

    Authors: Huining Tan, Yili Zhong and Zhongzong Pan
    Citation: BMC Cancer 2009 9:31
    Content type: Research article Published on:

  29. Prostate cancer is the second most frequently diagnosed cancer in men. Animal models that closely mimic clinical disease in humans are invaluable tools in the fight against prostate cancer. Recently, a Simian ...

    Authors: Curt E Harper, Brijesh B Patel, Leah M Cook, Jun Wang, Tomoyuki Shirai, Isam A Eltoum and Coral A Lamartiniere
    Citation: BMC Cancer 2009 9:30
    Content type: Research article Published on:

  30. The development of new therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models that generate both reproducible metastasis and the dis...

    Authors: Andreas Thalheimer, Christoph Otto, Marco Bueter, Bertram Illert, Stefan Gattenlohner, Martin Gasser, Detlef Meyer, Martin Fein, Christoph T Germer and Ana M Waaga-Gasser
    Citation: BMC Cancer 2009 9:29
    Content type: Research article Published on:

  31. Mesothelioma is a highly fatal cancer that is caused by exposure to asbestos fibres. In many populations, the occurrence of mesothelioma is monitored with the use of mortality data from death certification. We...

    Authors: Catherine Okello, Tom Treasure, Andrew G Nicholson, Julian Peto and Henrik Møller
    Citation: BMC Cancer 2009 9:28
    Content type: Research article Published on:

  33. Breast cancer is one of the main health problems in developed countries, occupying first place in mortality in women. It is well-known that there are risk factors associated with breast cancer development. Non...

    Authors: David Cantu de León, Delia Pérez Montiel, Jana Nemcova, Iva Mykyskova, Elmer Turcios, Verónica Villavicencio, Lucely Cetina, Alberto Coronel and Ondraj Hes
    Citation: BMC Cancer 2009 9:26
    Content type: Research article Published on:

  34. Microsatellite instability (MSI) refers to mutations in short motifs of tandemly repeated nucleotides resulting from replication errors and deficient mismatch repair (MMR). Colorectal cancer with MSI has chara...

    Authors: Søren A Jensen, Ben Vainer, Mogens Kruhøffer and Jens B Sørensen
    Citation: BMC Cancer 2009 9:25
    Content type: Research article Published on:

  35. Squamous cell carcinoma of esophagus (SCCE) occurs at a high incidence rate in certain parts of the world. This feature necessitates that different aspects of the disease and in particular genetic characterist...

    Authors: Maryam Zare, Ferdous Rastgar Jazii, Mohammad Reza Alivand, Negin Karimi Nasseri, Reza Malekzadeh and Mansour Yazdanbod
    Citation: BMC Cancer 2009 9:24
    Content type: Research article Published on:

  36. Traditionally standard treatment for patients with early stage endometrial cancer (EC) is total abdominal hysterectomy and bilateral salpingo oophorectomy (TAH+BSO) with or without lymph node dissection throug...

    Authors: Claudia BM Bijen, Justine M Briët, Geertruida H de Bock, Henriëtte JG Arts, Johanna A Bergsma-Kadijk and Marian JE Mourits
    Citation: BMC Cancer 2009 9:23
    Content type: Study protocol Published on:

  37. Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults. In an attempt to gain insight into the pathobiology of this eni...

    Authors: Luke H Stockwin, David T Vistica, Susan Kenney, David S Schrump, Donna O Butcher, Mark Raffeld and Robert H Shoemaker
    Citation: BMC Cancer 2009 9:22
    Content type: Research article Published on:

  38. Lumbar punctures (LPs) are common in children with cancer. Although pain management during the lumbar puncture has been well standardized, dealing with stress and anxiety is not well addressed yet. Our objecti...

    Authors: Perrine Marec-Bérard, Alvine Bissery, Kamila Kebaïli, Matthias Schell, Françoise Aubert, Ségolène Gaillard, Muriel Rabilloud, Behrouz Kassaï and Catherine Cornu
    Citation: BMC Cancer 2009 9:21
    Content type: Research article Published on:

  39. The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer. The role of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMP...

    Authors: Rita CS Figueira, Luciana R Gomes, João S Neto, Fabricio C Silva, Ismael DCG Silva and Mari C Sogayar
    Citation: BMC Cancer 2009 9:20
    Content type: Research article Published on:

  40. Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation indu...

    Authors: Michelle S Cotroneo, Jill D Haag, Nicholas R Stapel, Jordy L Waller, Stephan Woditschka and Michael N Gould
    Citation: BMC Cancer 2009 9:19
    Content type: Research article Published on:

  41. To define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from benign lesions, and to evaluate the ADC change of peri-tumor tissue in breast c...

    Authors: Zhang Yili, Huang Xiaoyan, Du Hongwen, Zhang Yun, Chen Xin, Wang Peng and Guo Youmin
    Citation: BMC Cancer 2009 9:18
    Content type: Research article Published on:

  42. Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known...

    Authors: Suvi Savola, Arto Klami, Abhishek Tripathi, Tarja Niini, Massimo Serra, Piero Picci, Samuel Kaski, Diana Zambelli, Katia Scotlandi and Sakari Knuutila
    Citation: BMC Cancer 2009 9:17
    Content type: Research article Published on:

  43. Antibody-based immuneotherapy has achieved some success for cancer. But the main problem is that only a few tumor-associated antigens or therapeutic targets have been known to us so far. It is essential to ide...

    Authors: Ze-jun Lu, Qi-fang Song, Sa-sa Jiang, Qi Song, Wei Wang, Gao-hua Zhang, Bin Kan, Lan-tu Gou, Li-juan Chen, Feng Luo, Zhi Yong Qian, Jin-liang Yang and Yu Quan Wei
    Citation: BMC Cancer 2009 9:16
    Content type: Research article Published on:

  44. Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary r...

    Authors: Chen-yu Liu, Yi-Hsiang Hsu, Ming-Tsang Wu, Pi-Chen Pan, Chi-Kung Ho, Li Su, Xin Xu, Yi Li and David C Christiani
    Citation: BMC Cancer 2009 9:15
    Content type: Research article Published on:

  45. We explored the heterogeneity of philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) in a study of the effect of early features on prognosis in children. Here we report the long-term result...

    Authors: Virginie Gandemer, Marie-Francoise Auclerc, Yves Perel, Jean-Pierre Vannier, Edouard Le Gall, Francois Demeocq, Claudine Schmitt, Christophe Piguet, Jean-Louis Stephan, Odile Lejars, Marianne Debre, Philippe Jonveaux, Jean-Michel Cayuela, Sylvie Chevret, Guy Leverger and Andre Baruchel
    Citation: BMC Cancer 2009 9:14
    Content type: Study protocol Published on:

  46. It has been suggested that the single nucleotide polymorphism 309 (SNP309, T -> G) in the promoter region of the MDM2 gene is important for tumor development; however, with regards to breast cancer, inconsiste...

    Authors: Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, I-Feng Lin and Yi-Jang Lee
    Citation: BMC Cancer 2009 9:13
    Content type: Research article Published on:

  47. Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, pr...

    Authors: Sanjay Sachdev, Yahao Bu and Irwin H Gelman
    Citation: BMC Cancer 2009 9:12
    Content type: Research article Published on:

  48. The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling.

    Authors: Cherry L Estilo, Pornchai O-charoenrat, Simon Talbot, Nicholas D Socci, Diane L Carlson, Ronald Ghossein, Tijaana Williams, Yoshihiro Yonekawa, Yegnanarayana Ramanathan, Jay O Boyle, Dennis H Kraus, Snehal Patel, Ashok R Shaha, Richard J Wong, Joseph M Huryn, Jatin P Shah…
    Citation: BMC Cancer 2009 9:11
    Content type: Research article Published on:

  49. With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulati...

    Authors: André O von Bueren, Tarek Shalaby, Christoph Oehler-Jänne, Lucia Arnold, Duncan Stearns, Charles G Eberhart, Alexandre Arcaro, Martin Pruschy and Michael A Grotzer
    Citation: BMC Cancer 2009 9:10
    Content type: Research article Published on:

  50. p75NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75NTR in esophageal squamous cell carcinoma (ESCC) and explored the biologica...

    Authors: Sheng-Dong Huang, Yang Yuan, Xiao-Hong Liu, De-Jun Gong, Chen-Guang Bai, Feng Wang, Jun-Hui Luo and Zhi-Yun Xu
    Citation: BMC Cancer 2009 9:9
    Content type: Research article Published on:

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