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  1. Better breast cancer prognostication may improve selection of patients for adjuvant therapy. We conducted a retrospective follow-up study in which we investigated sera of high-risk primary breast cancer patien...

    Authors: Marie-Christine W Gast, Harm van Tinteren, Marijke Bontenbal, René QGCM van Hoesel, Marianne A Nooij, Sjoerd Rodenhuis, Paul N Span, Vivianne CG Tjan-Heijnen, Elisabeth GE de Vries, Nathan Harris, Jos WR Twisk, Jan HM Schellens and Jos H Beijnen
    Citation: BMC Cancer 2008 8:389
  2. Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression of ERCC1 correlates with insens...

    Authors: Kazumi Uchida, Peter V Danenberg, Kathleen D Danenberg and Jean L Grem
    Citation: BMC Cancer 2008 8:386
  3. Vitamin D serum levels have been found to be related to sun exposure and diet, together with cell differentiation, growth control and consequently, cancer risk. Vitamin D receptor (VDR) genotypes may influence ca...

    Authors: Eva Barroso, Lara P Fernandez, Roger L Milne, Guillermo Pita, Elena Sendagorta, Uxua Floristan, Marta Feito, Jose A Aviles, Manuel Martin-Gonzalez, Jose I Arias, Pilar Zamora, Monserrat Blanco, Pablo Lazaro, Javier Benitez and Gloria Ribas
    Citation: BMC Cancer 2008 8:385
  4. Higher standardized uptake value (SUV) detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) correlates with proliferation of primary breast cancer. The purpose of th...

    Authors: Shigeto Ueda, Nobuo Kondoh, Hitoshi Tsuda, Souhei Yamamoto, Hideki Asakawa, Kazuhiko Fukatsu, Takayuki Kobayashi, Junji Yamamoto, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe, Mikio Yamamoto and Hidetaka Mochizuki
    Citation: BMC Cancer 2008 8:384
  5. Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.

    Authors: Jie Yang, Lu Wang, Zhaoli Chen, Zhi-Qiang Shen, Min Jin, Xin-Wei Wang, Yufei Zheng, Zhi-Gang Qiu, Jing-feng Wang and Jun-Wen Li
    Citation: BMC Cancer 2008 8:383
  6. Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic ...

    Authors: Pablo Sáenz-López, Rafael Carretero, José Manuel Cózar, José Maria Romero, Julia Canton, José Ramón Vilchez, Miguel Tallada, Federico Garrido and Francisco Ruiz-Cabello
    Citation: BMC Cancer 2008 8:382
  7. Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known funct...

    Authors: Florian R Fritzsche, Wilko Weichert, Annika Röske, Volker Gekeler, Thomas Beckers, Carsten Stephan, Klaus Jung, Katharina Scholman, Carsten Denkert, Manfred Dietel and Glen Kristiansen
    Citation: BMC Cancer 2008 8:381
  8. Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membra...

    Authors: Patricia González-Arriaga, M Felicitas López-Cima, Ana Fernández-Somoano, Teresa Pascual, Manuel G Marrón, Xose S Puente and Adonina Tardón
    Citation: BMC Cancer 2008 8:378
  9. The effects of the olive oil-rich Mediterranean diet on breast cancer risk might be underestimated when HER2 (ERBB2) oncogene-positive and HER2-negative breast carcinomas are considered together. We here investig...

    Authors: Javier A Menendez, Alejandro Vazquez-Martin, Rocio Garcia-Villalba, Alegria Carrasco-Pancorbo, Cristina Oliveras-Ferraros, Alberto Fernandez-Gutierrez and Antonio Segura-Carretero
    Citation: BMC Cancer 2008 8:377
  10. Cimetidine, a histamine type-2 receptor antagonist, has been reported to inhibit the growth of glandular tumors such as colorectal cancer, however the mechanism of action underlying this effect is unknown. Ade...

    Authors: Masakatsu Fukuda, Kaoru Kusama and Hideaki Sakashita
    Citation: BMC Cancer 2008 8:376
  11. Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development ...

    Authors: Xianling Guo, Nannan Ma, Jin Wang, Jianrui Song, Xinxin Bu, Yue Cheng, Kai Sun, Haiyan Xiong, Guocheng Jiang, Baihe Zhang, Mengchao Wu and Lixin Wei
    Citation: BMC Cancer 2008 8:375
  12. There is no standard palliative chemotherapy regimen in biliary tract cancers (BTC). Fluoropyrimidine or gemcitabine, with or without platinum, are most frequently used. We conducted this study to clarify the ...

    Authors: Mi-Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2008 8:374
  13. In a previous report we have demonstrated that the chymotryptic-like serine protease kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic cancer. In normal skin, hK7 is thought to participate in skin desquamati...

    Authors: Vishnu C Ramani, Leah Hennings and Randy S Haun
    Citation: BMC Cancer 2008 8:373
  14. Chemotherapy resistance remains a major obstacle for the treatment of small cell lung cancer (SCLC). Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, plays a critical role in chemother...

    Authors: Yingyan Wang, Wei Wang, Siyan Wang, Jiarui Wang, Shujuan Shao and Qi Wang
    Citation: BMC Cancer 2008 8:372
  15. Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinom...

    Authors: Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha and Manuel Rodrigues Teixeira
    Citation: BMC Cancer 2008 8:371
  16. Rejection of transplanted tumors by the immune system is a rare event in syngeneic hosts, and is considered to be dependent on the local interaction of defensive immune reactions and tumor tolerance mechanisms...

    Authors: Alexander Y Wagner, Eric Holle, Lori Holle, Xianzhong Yu and Günter Schwamberger
    Citation: BMC Cancer 2008 8:370
  17. The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncoge...

    Authors: Achim Weber, Ilka Kristiansen, Manfred Johannsen, Beibei Oelrich, Katharina Scholmann, Sven Gunia, Matthias May, Hellmuth-Alexander Meyer, Silvia Behnke, Holger Moch and Glen Kristiansen
    Citation: BMC Cancer 2008 8:369
  18. From 1968 to 2002, Singapore experienced an almost four-fold increase in prostate cancer incidence. This paper examines the incidence, mortality and survival patterns for prostate cancer among all residents in...

    Authors: Sin Eng Chia, Chuen Seng Tan, Gek Hsiang Lim, Xueling Sim, Yudi Pawitan, Marie Reilly, Safiyya Mohamed Ali, Weber Lau and Kee Seng Chia
    Citation: BMC Cancer 2008 8:368
  19. Several evidences suggested that ovarian cancer (OC) patients showing isolated lymph node recurrence (ILNR) have an indolent evolution. The aim of the study was to retrospectively review ILNR observed in our I...

    Authors: Francesco Legge, Marco Petrillo, Vincenzo Adamo, Salvatore Pisconti, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2008 8:367
  20. The effects of vegetable preference and leisure-time physical activity (LPA) on cancer have been inconsistent. We examined the effects of dietary preference and physical activity, as well as their combined eff...

    Authors: Young Ho Yun, Min Kyung Lim, Young-Joo Won, Sang Min Park, Yoon Jung Chang, Sang Woo Oh and Soon Ae Shin
    Citation: BMC Cancer 2008 8:366
  21. Carcinoma-associated fibroblasts (CAFs) can promote carcinogenesis and tumor progression. Only limited data on the response of CAFs to chemotherapy and their potential impact on therapy outcome are available. ...

    Authors: Maike Sonnenberg, Heiko van der Kuip, Silke Haubeiß, Peter Fritz, Werner Schroth, Godehard Friedel, Wolfgang Simon, Thomas E Mürdter and Walter E Aulitzky
    Citation: BMC Cancer 2008 8:364
  22. The EGFR and HER2 genes are located on chromosomes 7 and 17, respectively. They are therapeutic targets in some tumors. The TOP2A gene, which is located near HER2 on chromosome 17, is the target of many chemot...

    Authors: Zhiyong Liang, Xuan Zeng, Jie Gao, Shafei Wu, Peng Wang, Xiaohua Shi, Jing Zhang and Tonghua Liu
    Citation: BMC Cancer 2008 8:363
  23. Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ...

    Authors: Ingeborg M Bachmann, Rita G Ladstein, Oddbjørn Straume, George N Naumov and Lars A Akslen
    Citation: BMC Cancer 2008 8:362
  24. Advanced pancreatic cancer, in addition to its high mortality, is characterized by one of the highest rates of venous thromboembolic events (VTE) as compared to other types of cancer. Enoxaparin, a low molecul...

    Authors: Hanno Riess, Uwe Pelzer, Andreas Hilbig, Jens Stieler, Bernhard Opitz, Theo Scholten, Dörte Kauschat-Brüning, Peter Bramlage, Bernd Dörken and Helmut Oettle
    Citation: BMC Cancer 2008 8:361
  25. Human cancer vaccines incorporating autologous tumor cells carry a risk of implantation and subsequent metastasis of viable tumor cells into the patient who is being treated. Despite the fact that the melanoma...

    Authors: Donna H Deacon, Kevin T Hogan, Erin M Swanson, Kimberly A Chianese-Bullock, Chadrick E Denlinger, Andrea R Czarkowski, Randy S Schrecengost, James W Patterson, Mark W Teague and Craig L Slingluff Jr
    Citation: BMC Cancer 2008 8:360
  26. Human Epidermal Growth Factor Receptor 2 (HER-2; also known as erbB-2 or neu), a proto-oncogene of the receptor tyrosine kinase superfamily, has been associated with carcinogenesis and prognosis of human cance...

    Authors: Uk Hyun Jo, Sle Gi Lo Han, Jae Hong Seo, Kyong Hwa Park, Jae Won Lee, Hyo Jung Lee, Jeong Seon Ryu and Yeul Hong Kim
    Citation: BMC Cancer 2008 8:359
  27. The main study objectives were: to establish a nationwide voluntary collaborative network of breast centres with independent data analysis; to define suitable quality indicators (QIs) for benchmarking the qual...

    Authors: Sara Y Brucker, Claudia Schumacher, Christoph Sohn, Mahdi Rezai, Michael Bamberg and Diethelm Wallwiener
    Citation: BMC Cancer 2008 8:358
  28. The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not as...

    Authors: Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellaro, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise and José Andres Yunes
    Citation: BMC Cancer 2008 8:357
  29. Recent reviews claiming smokeless tobacco increases pancreatic cancer risk appear not to have considered all available epidemiological evidence; nor were meta-analyses included. We present a systematic review ...

    Authors: Zheng Sponsiello-Wang, Rolf Weitkunat and Peter N Lee
    Citation: BMC Cancer 2008 8:356
  30. Little is known about the effect of migrant status on childhood cancer survival. We studied cancer survival among children of Turkish descent in the German Cancer Childhood Registry, one of the largest childho...

    Authors: Claudia Spix, Jacob Spallek, Peter Kaatsch, Oliver Razum and Hajo Zeeb
    Citation: BMC Cancer 2008 8:355
  31. Recepteur d'origine nantais (RON) is a receptor tyrosine kinase that is activated by a serum-derived, macrophage stimulating protein (MSP) growth factor and is expressed in many malignant tumors. The aim of th...

    Authors: Donghui Zhou, Gang Pan, Chen Zheng, Jingjing Zheng, Liping Yian and Xiaodong Teng
    Citation: BMC Cancer 2008 8:353
  32. Pancreatic cancer continues to have a 5-year survival of less than 5%. Therefore, more effective therapies are necessary to improve prognosis in this disease. Angiogenesis is required for tumor growth, and sub...

    Authors: Sean P Dineen, Laura A Sullivan, Adam W Beck, Andrew F Miller, Juliet G Carbon, Roni Mamluk, Henry Wong and Rolf A Brekken
    Citation: BMC Cancer 2008 8:352
  33. The objectives of this retrospective study was to evaluate the efficacy of stereotactic body radiation therapy (SBRT) for small non-resectable hepatocellular carcinoma (HCC) and SBRT combined with transarteria...

    Authors: Byung Ock Choi, Ihl Bohng Choi, Hong Seok Jang, Young Nam Kang, Ji Sun Jang, Si Hyun Bae, Seung Kew Yoon, Gyu Young Chai and Ki Mun Kang
    Citation: BMC Cancer 2008 8:351
  34. Reference genes, which are often referred to as housekeeping genes are frequently used to normalize mRNA levels between different samples in quantitative reverse transcription polymerase chain reaction (qRT-PC...

    Authors: Vito R Cicinnati, Qingli Shen, Georgios C Sotiropoulos, Arnold Radtke, Guido Gerken and Susanne Beckebaum
    Citation: BMC Cancer 2008 8:350
  35. Disease progression of hepatocellular cancer (HCC) in patients eligible for liver transplantation (LTx) occurs in up to 50% of patients, resulting in withdrawal from the LTx waiting list. Transarterial chemoem...

    Authors: K Hoffmann, H Glimm, B Radeleff, G Richter, C Heining, I Schenkel, A Zahlten-Hinguranage, P Schirrmacher, J Schmidt, MW Büchler, D Jaeger, C von Kalle and P Schemmer
    Citation: BMC Cancer 2008 8:349
  36. Thymidylate synthase (TS) is an important target for chemotherapeutic treatment of cancer and high expression of TS has been associated with poor prognosis or refractory disease in several cancers including co...

    Authors: Takashi Shirasaki, Shin-ichiro Maruya, Hiroki Mizukami, Seiji Kakehata, Hidekachi Kurotaki, Soroku Yagihashi and Hideichi Shinkawa
    Citation: BMC Cancer 2008 8:348
  37. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. T...

    Authors: D Mendoza-Villanueva, J Diaz-Chavez, L Uribe-Figueroa, C Rangel-Escareão, A Hidalgo-Miranda, S March-Mifsut, G Jimenez-Sanchez, PF Lambert and P Gariglio
    Citation: BMC Cancer 2008 8:347
  38. Serous epithelial ovarian tumors can be subdivided into benign (BOV), low malignant potential (LMP) or borderline and invasive (TOV) tumors. Although the molecular characteristics of serous BOV, LMP and low gr...

    Authors: Véronique Ouellet, Tak Hay Ling, Karine Normandin, Jason Madore, Christian Lussier, Véronique Barrès, Dimcho Bachvarov, Claudine Rancourt, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:346
  39. Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity...

    Authors: S Yousuf Zafar, Amy P Abernethy, David H Abbott, Steven C Grambow, Jennifer E Marcello, James E Herndon II, Krista L Rowe, Jane T Kolimaga, Leah L Zullig, Meenal B Patwardhan and Dawn T Provenzale
    Citation: BMC Cancer 2008 8:345
  40. Spatial clustering of different diseases has received much less attention than single disease mapping. Besides chance or artifact, clustering of different cancers in a given area may depend on exposure to a sh...

    Authors: Tiziana Cassetti, Francesco La Rosa, Luca Rossi, Daniela D'Alò and Fabrizio Stracci
    Citation: BMC Cancer 2008 8:344
  41. Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate t...

    Authors: Martina Schobesberger, Anna Baltzer, Andrea Oberli, Andreas Kappeler, Mathias Gugger, Hana Burger and Rolf Jaggi
    Citation: BMC Cancer 2008 8:343
  42. Tripeptide tyroserleutide (YSL) is a novel small molecule anti-tumor polypeptide that has been shown to inhibit the growth of human liver cancer cells. In this study, we investigated the effects of YSL plus do...

    Authors: Zhi-feng Zhu, Li-juan Chen, Rong Lu, Jing Jia, Yu Liang, Qiong Xu, Chun-lei Zhou, Li Wang, Song Wang and Zhi Yao
    Citation: BMC Cancer 2008 8:342
  43. Different methods exist to estimate smoking attributable cancer mortality rates (Peto and Ezzati methods, as examples). However, the smoking attributable estimates using these methods cannot be generalized to ...

    Authors: Bruce N Leistikow, Zubair Kabir, Gregory N Connolly, Luke Clancy and Hillel R Alpert
    Citation: BMC Cancer 2008 8:341
  44. Lymph nodes constitute the first site of metastasis for most malignancies, and the extent of lymph node involvement is a major criterion for evaluating patient prognosis. The CXC chemokine receptor 4 (CXCR4) h...

    Authors: Hironao Yasuoka, Masahiko Tsujimoto, Katsuhide Yoshidome, Masaaki Nakahara, Rieko Kodama, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:340
  45. Given the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this stu...

    Authors: Andrew Tutt, Alice Wang, Charles Rowland, Cheryl Gillett, Kit Lau, Karen Chew, Hongyue Dai, Shirley Kwok, Kenneth Ryder, Henry Shu, Robert Springall, Paul Cane, Blair McCallie, Lauren Kam-Morgan, Steve Anderson, Horst Buerger…
    Citation: BMC Cancer 2008 8:339
  46. Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin rece...

    Authors: Michael N Okobia, Clareann H Bunker, Seymour J Garte, Joseph M Zmuda, Emmanuel R Ezeome, Stanley N Anyanwu, Emmanuel E Uche, Lewis H Kuller, Robert E Ferrell and Emanuela Taioli
    Citation: BMC Cancer 2008 8:338

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