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  1. Costimulatory signaling has been implicated as a potential regulator of antitumor immunity in various human cancers. In contrast to the negative prognostic value of aberrant B7-H1 expression by pancreatic canc...

    Authors: Martin Loos, Dennis M Hedderich, Malte Ottenhausen, Nathalia A Giese, Melanie Laschinger, Irene Esposito, Jörg Kleeff and Helmut Friess
    Citation: BMC Cancer 2009 9:463
  2. Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed and correlates with poor prognosis in many c...

    Authors: Li-Ru He, Meng-Zhong Liu, Bin-Kui Li, Hui-Lan Rao, Yi-Ji Liao, Xin-Yuan Guan, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2009 9:461
  3. To date, there is no consensus on the utility of screening procedures for the early detection of endometrial cancer. The value of transvaginal ultrasound for screening of asymptomatic endometrial cancer has be...

    Authors: Veronika Seebacher, Maximilian Schmid, Stephan Polterauer, Katrin Hefler-Frischmuth, Heinz Leipold, Nicole Concin, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:460
  4. The purpose of this study was to compare plasma levels of antioxidants and oxidative stress biomarkers in head and neck squamous cell carcinoma (HNSCC) patients with healthy controls. Furthermore, the effect o...

    Authors: Amrit K Sakhi, Kjell M Russnes, Magne Thoresen, Nasser E Bastani, Anette Karlsen, Sigbjørn Smeland and Rune Blomhoff
    Citation: BMC Cancer 2009 9:458
  5. About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in ...

    Authors: Maria Haanpää, Mervi Reiman, Jenni Nikkilä, Hannele Erkko, Katri Pylkäs and Robert Winqvist
    Citation: BMC Cancer 2009 9:457
  6. Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secre...

    Authors: Hong Shi, Jie Wang, Fusheng Dong, Xu Wang, Hexiang Li and Yali Hou
    Citation: BMC Cancer 2009 9:456
  7. Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL dif...

    Authors: Julia Richter, Ole Ammerpohl, José I Martín-Subero, Manuel Montesinos-Rongen, Marina Bibikova, Eliza Wickham-Garcia, Otmar D Wiestler, Martina Deckert and Reiner Siebert
    Citation: BMC Cancer 2009 9:455
  8. Alterations of mitochondrial DNA (mtDNA) have been implicated in carcinogenesis. We developed an accurate multiplex quantitative real-time PCR for synchronized determination of mtDNA and nuclear DNA (nDNA). We...

    Authors: Peng Xia, Han-Xiang An, Cheng-Xue Dang, Ramin Radpour, Corina Kohler, Emmanouil Fokas, Rita Engenhart-Cabillic, Wolfgang Holzgreve and Xiao Yan Zhong
    Citation: BMC Cancer 2009 9:454
  9. The High Resolution Melting (HRM) technology has recently been introduced as a rapid and robust analysis tool for the detection of DNA methylation. The methylation status of multiple tumor suppressor genes may...

    Authors: Lasse S Kristensen, Tomasz K Wojdacz, Britta B Thestrup, Carsten Wiuf, Henrik Hager and Lise Lotte Hansen
    Citation: BMC Cancer 2009 9:453
  10. Prostate cancer cells in primary tumors have been typed CD10-/CD13-/CD24hi/CD26+/CD38lo/CD44-/CD104-. This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of...

    Authors: Laura E Pascal, Ricardo ZN Vêncio, Laura S Page, Emily S Liebeskind, Christina P Shadle, Pamela Troisch, Bruz Marzolf, Lawrence D True, Leroy E Hood and Alvin Y Liu
    Citation: BMC Cancer 2009 9:452
  11. We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the resul...

    Authors: Chul-Kee Park, Se-Hoon Lee, Jung Ho Han, Chae-Yong Kim, Dong-Wan Kim, Sun Ha Paek, Dong Gyu Kim, Dae Seog Heo, Il Han Kim and Hee-Won Jung
    Citation: BMC Cancer 2009 9:450
  12. Compound K [20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol], a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer, has been reported to possess anti-tumor properties to inhibit angiogene...

    Authors: Sung-Hee Cho, Kyung-Sook Chung, Jung-Hye Choi, Dong-Hyun Kim and Kyung-Tae Lee
    Citation: BMC Cancer 2009 9:449
  13. Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, al...

    Authors: Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller and Sonja Sievers
    Citation: BMC Cancer 2009 9:447
  14. Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and th...

    Authors: Ingrid Moen, Karl J Tronstad, Odd Kolmannskog, Gerd S Salvesen, Rolf K Reed and Linda EB Stuhr
    Citation: BMC Cancer 2009 9:446
  15. The MYCN gene is transcribed into two major mRNAs: one full-length (MYCN) and one exon 1b-spliced (MYCN Δ1b ) mRNA. But nothing is known about their respective ability to translate the MYCN protein.

    Authors: Roger Besançon, Sandrine Valsesia-Wittmann, Clara Locher, Céline Delloye-Bourgeois, Lydie Furhman, Giovani Tutrone, Christophe Bertrand, Anne-Catherine Jallas, Elisabeth Garin and Alain Puisieux
    Citation: BMC Cancer 2009 9:445
  16. The relevance of angiogenesis inhibition in the treatment of glioblastoma multiforme (GBM) should be considered in the unique context of malignant brain tumours. Although patients benefit greatly from reduced ...

    Authors: Joost JC Verhoeff, Olaf van Tellingen, An Claes, Lukas JA Stalpers, Myra E van Linde, Dirk J Richel, William PJ Leenders and Wouter R van Furth
    Citation: BMC Cancer 2009 9:444
  17. Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-ter...

    Authors: Paola Scaruffi, Sara Stigliani, Stefano Moretti, Simona Coco, Carla De Vecchi, Francesca Valdora, Alberto Garaventa, Stefano Bonassi and Gian Paolo Tonini
    Citation: BMC Cancer 2009 9:441
  18. Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, H...

    Authors: David M Winder, Siolian LR Ball, Katie Vaughan, Nashat Hanna, Yin Ling Woo, Jürgen-Theodor Fränzer, Jane C Sterling, Margaret A Stanley, Holger Sudhoff and Peter KC Goon
    Citation: BMC Cancer 2009 9:440
  19. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) proteins play important roles in the repair of DNA damage and adducts. Single nucle...

    Authors: Zhihua Yin, Baosen Zhou, Qincheng He, Mingchuan Li, Peng Guan, Xuelian Li, Zeshi Cui, Xiaoxia Xue, Meng Su, Rui Ma, Weijun Bai, Shuyue Xia, Yanduo Jiang, Shun Xu, Yi Lv and Xun Li
    Citation: BMC Cancer 2009 9:439
  20. Coregulator proteins are "master regulators", directing transcriptional and posttranscriptional regulation of many target genes, and are critical in many normal physiological processes, but also in hormone dri...

    Authors: Ryan J Hartmaier, Sandrine Tchatchou, Alexandra S Richter, Jay Wang, Sean E McGuire, Todd C Skaar, Jimmy M Rae, Kari Hemminki, Christian Sutter, Nina Ditsch, Peter Bugert, Bernhard HF Weber, Dieter Niederacher, Norbert Arnold, Raymonda Varon-Mateeva, Barbara Wappenschmidt…
    Citation: BMC Cancer 2009 9:438
  21. TrkA (encoded by NTRK1 gene), the high-affinity tyrosine kinase receptor for neurotrophins, is involved in neural crest cell differentiation. Its expression has been reported to be associated with a favourable pr...

    Authors: Beata S Lipska, Elżbieta Drożynska, Paola Scaruffi, Gian Paolo Tonini, Ewa Iżycka-Świeszewska, Szymon Ziętkiewicz, Anna Balcerska, Danuta Perek, Alicja Chybicka, Wojciech Biernat and Janusz Limon
    Citation: BMC Cancer 2009 9:436
  22. Overexpression of Aurora-A and mutant Ras (RasV12) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between...

    Authors: Ya-Shih Tseng, Jenq-Chang Lee, Chi-Ying F Huang and Hsiao-Sheng Liu
    Citation: BMC Cancer 2009 9:435
  23. 5-Fluorouracil(5FU) and oral analogues, such as capecitabine, remain one of the most useful agents for the treatment of colorectal adenocarcinoma. Low toxicity and convenience of administration facilitate use,...

    Authors: Russell D Petty, Leslie M Samuel, Graeme I Murray, Graham MacDonald, Terrence O'Kelly, Malcolm Loudon, Norman Binnie, Emad Aly, Aileen McKinlay, Weiguang Wang, Fiona Gilbert, Scot Semple and Elaina SR Collie-Duguid
    Citation: BMC Cancer 2009 9:434
  24. The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is low, prompting interest in targeted molecular therapies. We investigated HER2 expression and amplification, and the potential for t...

    Authors: Jessica N McAlpine, Kimberly C Wiegand, Russell Vang, Brigitte M Ronnett, Anna Adamiak, Martin Köbel, Steve E Kalloger, Kenneth D Swenerton, David G Huntsman, C Blake Gilks and Dianne M Miller
    Citation: BMC Cancer 2009 9:433
  25. Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are frequently overexpressed in numerous types of cancers and are known to be important regulators of angiogenesis. Until...

    Authors: Dan Cao, Mei Hou, Yong-song Guan, Ming Jiang, Yu Yang and Hong-feng Gou
    Citation: BMC Cancer 2009 9:432
  26. Increased ST6Gal I activity has been associated with the α(2,6)sialylation enhancement of membrane glycoconjugates observed in metastatic colorectal carcinomas (CRC). Siaα(2,6)Galβ(1,4)GlcNAc sequence, known a...

    Authors: Clotilde Costa-Nogueira, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín and Almudena Fernández-Briera
    Citation: BMC Cancer 2009 9:431
  27. Studies on the association between prostate cancer and cadmium exposure have yielded conflicting results. This study explored cadmium burden on the risk and phenotype of prostate cancer in men with no evident ...

    Authors: Yi-Chun Chen, Yeong S Pu, Hsi-Chin Wu, Tony T Wu, Ming Kuen Lai, Chun Y Yang and Fung-Chang Sung
    Citation: BMC Cancer 2009 9:429
  28. Ameloblastoma is a frequent odontogenic benign tumor characterized by local invasiveness, high risk of recurrence and occasional metastasis and malignant transformation. Matrix metalloproteinase-2 (MMP-2) prom...

    Authors: Bin Zhang, Jin Zhang, Zhi-Ying Xu and Hong-Liang Xie
    Citation: BMC Cancer 2009 9:427
  29. HIWI, the human homologue of Piwi family, is present in CD34+ hematopoietic stem cells and germ cells, but not in well-differentiated cell populations, indicating that HIWI may play an impotent role in determinin...

    Authors: Wei He, Zhihui Wang, Qi Wang, Qingxia Fan, Chengcao Shou, Junsheng Wang, Karl-Erik Giercksky, Jahn M Nesland and Zhenhe Suo
    Citation: BMC Cancer 2009 9:426
  30. Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected b...

    Authors: Ove Bruland, Øystein Fluge, Lars A Akslen, Hans G Eiken, Johan R Lillehaug, Jan E Varhaug and Per M Knappskog
    Citation: BMC Cancer 2009 9:425
  31. Techniques for detecting circulating tumor cells in the peripheral blood of patients with head and neck cancers may identify individuals likely to benefit from early systemic treatment.

    Authors: Stuart C Winter, Sally-Anne Stephenson, Selva K Subramaniam, Vinidh Paleri, Kien Ha, Conor Marnane, Suren Krishnan and Guy Rees
    Citation: BMC Cancer 2009 9:424
  32. Retinoid Receptors are involved in development and cell homeostasis. Alterations of their expressions have been observed in lung cancer. However, retinoid chemoprevention trials in populations at risk to devel...

    Authors: Stéphane Poulain, Stéphanie Lacomme, Shyue-Fang Battaglia-Hsu, Stanislas du Manoir, Lydia Brochin, Jean-Michel Vignaud and Nadine Martinet
    Citation: BMC Cancer 2009 9:423
  33. Neuroblastoma is a pediatric tumor of neural crest cells that is clinically characterized by its variable evolution, from spontaneous regression to malignancy. Despite many advances in neuroblastoma research, ...

    Authors: Carine Nyalendo, Hervé Sartelet, Stéphane Barrette, Shigeru Ohta, Denis Gingras and Richard Béliveau
    Citation: BMC Cancer 2009 9:422
  34. Along with the development of new cancer therapeutics, more effective tools for the estimation of response to therapy and prediction of disease progression are required for the better management of inoperable ...

    Authors: Sachin Kumar, Randeep Guleria, Vikas Singh, Alok C Bharti, Anant Mohan and Bhudev C Das
    Citation: BMC Cancer 2009 9:421
  35. Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients, biomarkers to predict those who may benefit from the therap...

    Authors: Ten-i Godai, Tetsuji Suda, Nobuhiro Sugano, Kazuhito Tsuchida, Manabu Shiozawa, Hironobu Sekiguchi, Akiko Sekiyama, Mitsuyo Yoshihara, Shoichi Matsukuma, Yuji Sakuma, Eiju Tsuchiya, Yoichi Kameda, Makoto Akaike and Yohei Miyagi
    Citation: BMC Cancer 2009 9:420
  36. Androgen deprivation therapy leads to a number of adverse effects including deterioration of the musculoskeletal system and increased risk factors for cardiovascular and metabolic complications. The purpose of...

    Authors: Daniel A Galvão, Nigel Spry, Dennis R Taaffe, James Denham, David Joseph, David S Lamb, Greg Levin, Gillian Duchesne and Robert U Newton
    Citation: BMC Cancer 2009 9:419
  37. Despite well-studied tumor hypoxia in laboratory, little is known about the association with other pathophysiological events in the clinical view. We investigated the prognostic value of hypoxia-inducible fact...

    Authors: Chen-Xin Dai, Qiang Gao, Shuang-Jian Qiu, Min-Jie Ju, Ming-Yan Cai, Yong-Feng Xu, Jian Zhou, Bo-Heng Zhang and Jia Fan
    Citation: BMC Cancer 2009 9:418
  38. TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis. We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a ther...

    Authors: Eleanor B Carson-Walter, Bethany N Winans, Melissa C Whiteman, Yang Liu, Sally Jarvela, Hannu Haapasalo, Betty M Tyler, David L Huso, Mahlon D Johnson and Kevin A Walter
    Citation: BMC Cancer 2009 9:417
  39. Tumor-specific cytotoxic T cells and infiltrating lymphocytes are frequently found in tumor tissues in patients with nasopharyngeal carcinoma (NPC). Most patients with NPC, however, especially those with advan...

    Authors: Peng Liu, Bai-Lu Xie, Shao-Hui Cai, Yun-Wen He, Ge Zhang, Yan-Mei Yi and Jun Du
    Citation: BMC Cancer 2009 9:416
  40. Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance t...

    Authors: Rizky Abdulah, Ahmad Faried, Kenji Kobayashi, Chiho Yamazaki, Eka W Suradji, Kazuto Ito, Kazuhiro Suzuki, Masami Murakami, Hiroyuki Kuwano and Hiroshi Koyama
    Citation: BMC Cancer 2009 9:414

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