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  1. Despite evidence that breast cancer screening reduces morbidity and mortality, until recently most women have not undergone regular mammogram examinations in Korea. We aimed to identify factors associated with...

    Authors: Kiheon Lee, Hyung Taek Lim and Sang Min Park
    Citation: BMC Cancer 2010 10:144
    Content type: Research article Published on:

  2. Emerging reports suggest resistance, increased tumor invasiveness and metastasis arising from treatment with drugs targeting vascular endothelial growth factor (VEGF). It is believed that increased tumoral hyp...

    Authors: Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky and David L Morris
    Citation: BMC Cancer 2010 10:143
    Content type: Research article Published on:

  3. Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulat...

    Authors: Gregory B Lesinski, Jason M Zimmerer, Melanie Kreiner, John Trefry, Matthew A Bill, Gregory S Young, Brian Becknell and William E Carson III
    Citation: BMC Cancer 2010 10:142
    Content type: Research article Published on:

  4. Previous studies showed a differential distribution of the four regulatory subunits of cAMP-dependent protein kinases inside the brain, that changed in rodent gliomas: therefore, the distribution of these prot...

    Authors: Carla Mucignat-Caretta, Luca Denaro, Marco Redaelli, Domenico D'Avella and Antonio Caretta
    Citation: BMC Cancer 2010 10:141
    Content type: Research article Published on:

  5. Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ...

    Authors: Rita G Ladstein, Ingeborg M Bachmann, Oddbjørn Straume and Lars A Akslen
    Citation: BMC Cancer 2010 10:140
    Content type: Research article Published on:

  6. Angiogenesis appears to play an important role in ovarian cancer. Vascular endothelial growth factor (VEGF) has recently been implicated as a therapeutic target in ovarian cancer. The tissue inhibitor of metal...

    Authors: Sven Mahner, Linn Woelber, Christine Eulenburg, Joerg Schwarz, Walter Carney, Fritz Jaenicke, Karin Milde-Langosch and Volkmar Mueller
    Citation: BMC Cancer 2010 10:139
    Content type: Research article Published on:

  7. Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the ab...

    Authors: Noushin Taghavi, Firouzeh Biramijamal, Masoud Sotoudeh, Hooman Khademi, Reza Malekzadeh, Omeed Moaven, Bahram Memar, Azadeh A'rabi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:138
    Content type: Research article Published on:

  8. The aim of our study was to analyze the effect of taxane-based chemotherapy on tumor angiogenesis in patients with advanced epithelial ovarian cancer.

    Authors: Martin Pölcher, Christian Rudlowski, Nicolaus Friedrichs, Marieke Mielich, Tobias Höller, Mathias Wolfgarten, Kirsten Kübler, Reinhard Büttner, Walther Kuhn and Michael Braun
    Citation: BMC Cancer 2010 10:137
    Content type: Research article Published on:

  9. Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal gr...

    Authors: Alfonso Sánchez-Muñoz, Elena Gallego, Vanessa de Luque, Luís G Pérez-Rivas, Luís Vicioso, Nuria Ribelles, José Lozano and Emilio Alba
    Citation: BMC Cancer 2010 10:136
    Content type: Research article Published on:

  10. Microtubules are considered major therapeutic targets in patients with breast cancer. In spite of their essential role in biological functions including cell motility, cell division and intracellular transport...

    Authors: Rouba Hage-Sleiman, Stéphanie Herveau, Eva-Laure Matera, Jean-Fabien Laurier and Charles Dumontet
    Citation: BMC Cancer 2010 10:135
    Content type: Research article Published on:

  11. Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model. In this work we defined the expr...

    Authors: Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath and Christopher Christophi
    Citation: BMC Cancer 2010 10:134
    Content type: Research article Published on:

  12. It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression i...

    Authors: Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2010 10:133
    Content type: Research article Published on:

  13. Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet.

    Authors: Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter Würl, Helge Taubert and Dirk Vordermark
    Citation: BMC Cancer 2010 10:132
    Content type: Research article Published on:

  14. The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for...

    Authors: Ying Gao, Zi Liu, Fei Gao and Xiao-yu Meng
    Citation: BMC Cancer 2010 10:131
    Content type: Research article Published on:

  15. Moxibustion is a traditional Chinese method that uses the heat generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points. Considering moxibustion is closely related to...

    Authors: Myeong Soo Lee, Tae-Young Choi, Ji-Eun Park, Song-Shil Lee and Edzard Ernst
    Citation: BMC Cancer 2010 10:130
    Content type: Research article Published on:

  16. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analy...

    Authors: Emanuele Marra, Paolo Uva, Valentina Viti, Valeria Simonelli, Eugenia Dogliotti, Emanuele De Rinaldis, Armin Lahm, Nicola La Monica, Alfredo Nicosia, Gennaro Ciliberto and Fabio Palombo
    Citation: BMC Cancer 2010 10:129
    Content type: Research article Published on:

  17. Steroid receptors play major roles in the development, differentiation, and homeostasis of normal and malignant tissue. STAMP is a novel coregulator that not only enhances the ability of p160 coactivator famil...

    Authors: Yuanzheng He, John A Blackford Jr, Elise C Kohn and S Stoney Simons Jr
    Citation: BMC Cancer 2010 10:128
    Content type: Research article Published on:

  18. To evaluate the safety of focal dose escalation to regions with standardized uptake value (SUV) >2.0 using intensity-modulated radiation therapy (IMRT) by comparison of radiotherapy plans using dose-volume his...

    Authors: Keiichi Jingu, Hisanori Ariga, Tomohiro Kaneta, Yoshihiro Takai, Ken Takeda, Lindel Katja, Kakutaro Narazaki, Takahiro Metoki, Keisuke Fujimoto, Rei Umezawa, Yoshihiro Ogawa, Kenji Nemoto, Masashi Koto, Masatoshi Mitsuya, Naruhiro Matsufuji, Shoki Takahashi…
    Citation: BMC Cancer 2010 10:127
    Content type: Research article Published on:

  19. The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and translation. Traditional methods of genome wide micro...

    Authors: Robert Calaluce, Matthew M Gubin, J Wade Davis, Joseph D Magee, Jing Chen, Yuki Kuwano, Myriam Gorospe and Ulus Atasoy
    Citation: BMC Cancer 2010 10:126
    Content type: Research article Published on:

  20. Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourab...

    Authors: Donal J Brennan, Jenny Brändstedt, Elton Rexhepaj, Michael Foley, Fredrik Pontén, Mathias Uhlén, William M Gallagher, Darran P O'Connor, Colm O'Herlihy and Karin Jirstrom
    Citation: BMC Cancer 2010 10:125
    Content type: Research article Published on:

  21. Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis...

    Authors: Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura and Yan Li
    Citation: BMC Cancer 2010 10:124
    Content type: Research article Published on:

  22. The post-translational modification of proteins, including glycosylation, differs between normal and tumor cells. The UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferases (GalNAc-Tases) ...

    Authors: Chen Wu, Xiaodan Guo, Weina Wang, Yun Wang, Yaojun Shan, Bo Zhang, Wenqian Song, Sisi Ma, Jianfeng Ge, Hao Deng and Mingsheng Zhu
    Citation: BMC Cancer 2010 10:123
    Content type: Research article Published on:

  23. Since hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, it is still important to understand hepatocarcinogenesis mechanisms and identify effective markers for tumor progres...

    Authors: Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi and Yeun-Jun Chung
    Citation: BMC Cancer 2010 10:122
    Content type: Research article Published on:

  24. Spontaneous Regression/Complete Resistant (SR/CR) mice are a colony of cancer-resistant mice that can detect and rapidly destroy malignant cells with innate cellular immunity, predominately mediated by granulo...

    Authors: Anne M Sanders, John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Arta M Monjazeb, Jonathan M Adams, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:121
    Content type: Research article Published on:

  25. Mollicutes contamination is recognized to be a critical issue for the cultivation of continuous cell lines. In this work we characterized the effect of Mycoplasma hyorhinis contamination on CD133 expression in h...

    Authors: Elisabetta Mariotti, Marica Gemei, Peppino Mirabelli, Francesca D'Alessio, Rosa Di Noto, Giuliana Fortunato and Luigi Del Vecchio
    Citation: BMC Cancer 2010 10:120
    Content type: Research article Published on:

  26. There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer d...

    Authors: Sivasai Balivada, Raja Shekar Rachakatla, Hongwang Wang, Thilani N Samarakoon, Raj Kumar Dani, Marla Pyle, Franklin O Kroh, Brandon Walker, Xiaoxuan Leaym, Olga B Koper, Masaaki Tamura, Viktor Chikan, Stefan H Bossmann and Deryl L Troyer
    Citation: BMC Cancer 2010 10:119
    Content type: Research article Published on:

  27. The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular p...

    Authors: Tsuyoshi Mitsuishi, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Takehiko Kaneko, Kuniaki Ohara, Ikuroh Ohsawa, Fumino Oda, Yuko Yamada, Seiji Kawana, Kohji Ozaki, Mayuka Nakatake and Osamu Yamada
    Citation: BMC Cancer 2010 10:118
    Content type: Research article Published on:

  28. Based on the well-recognized etiological role of human papillomavirus (HPV) in cervical, anogenital and oropharyngeal carcinogenesis, a potential role of HPV in colorectal carcinogenesis has been suggested. Fo...

    Authors: Vanessa Deschoolmeester, Veerle Van Marck, Marc Baay, Christine Weyn, Peter Vermeulen, Eric Van Marck, Filip Lardon, Veronique Fontaine and Jan B Vermorken
    Citation: BMC Cancer 2010 10:117
    Content type: Research article Published on:

  29. Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a s...

    Authors: Xiaohua Jiang, Ynnez Gwye, Darren Russell, Christine Cao, Dorothea Douglas, Long Hung, Heinrich Kovar, Timothy J Triche and Elizabeth R Lawlor
    Citation: BMC Cancer 2010 10:116
    Content type: Research article Published on:

  30. Birth size, and particularly birth length, is positively associated with breast cancer risk in adulthood. The objective of this study was to examine whether birth size is associated with survival among breast ...

    Authors: Bjørn O Mæhle, Lars J Vatten and Steinar Tretli
    Citation: BMC Cancer 2010 10:115
    Content type: Research article Published on:

  31. Breast cancer is one of the leading causes of women's death worldwide. It is important to discover a reliable biomarker for the detection of breast cancer. Plasma is the most ideal source for cancer biomarker ...

    Authors: Un-Beom Kang, Younghee Ahn, Jong Won Lee, Yong-Hak Kim, Joon Kim, Myeong-Hee Yu, Dong-Young Noh and Cheolju Lee
    Citation: BMC Cancer 2010 10:114
    Content type: Research article Published on:

  32. Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous...

    Authors: Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi and Edvaldo S Trindade
    Citation: BMC Cancer 2010 10:113
    Content type: Research article Published on:

  33. Tumor-associated macrophages (TAMs) play an important role in growth, progression and metastasis of tumors. In non-small cell lung cancer (NSCLC), TAMs' anti-tumor or pro-tumor role is not determined. Macropha...

    Authors: Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai and Zongbing You
    Citation: BMC Cancer 2010 10:112
    Content type: Research article Published on:

  34. In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-positive women compared to LBC followed by ...

    Authors: Gina S Ogilvie, Dirk J van Niekerk, Mel Krajden, Ruth E Martin, Thomas G Ehlen, Kathy Ceballos, Stuart J Peacock, Laurie W Smith, Lisa Kan, Darrel A Cook, Wendy Mei, Gavin CE Stuart, Eduardo L Franco and Andrew J Coldman
    Citation: BMC Cancer 2010 10:111
    Content type: Study protocol Published on:

  35. Circadian genes continue to gain attention as important transcriptional regulators with the potential to influence a variety of biological pathways, including many cancer-related processes. The core circadian ...

    Authors: Aaron E Hoffman, Tongzhang Zheng, Yue Ba, Richard G Stevens, Chun-Hui Yi, Derek Leaderer and Yong Zhu
    Citation: BMC Cancer 2010 10:110
    Content type: Research article Published on:

  36. The discovery of small non-coding RNAs and the subsequent analysis of microRNA expression patterns in human cancer specimens have provided completely new insights into cancer biology. Genetic and epigenetic da...

    Authors: Ulrich Lehmann, Thomas Streichert, Benjamin Otto, Cord Albat, Britta Hasemeier, Henriette Christgen, Elisa Schipper, Ursula Hille, Hans H Kreipe and Florian Länger
    Citation: BMC Cancer 2010 10:109
    Content type: Research article Published on:

  37. Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ pa...

    Authors: David G Hicks, Bagi R Janarthanan, Ramya Vardarajan, Swati A Kulkarni, Thaer Khoury, Daniel Dim, G Thomas Budd, Brian J Yoder, Raymond Tubbs, Marshall T Schreeder, Noel C Estopinal, Rodney A Beck, Yanling Wang, Brian Z Ring, Robert S Seitz and Douglas T Ross
    Citation: BMC Cancer 2010 10:108
    Content type: Research article Published on:

  38. Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that is associated with cell death h...

    Authors: Louise Flanagan, Lorna Whyte, Namita Chatterjee and Martin Tenniswood
    Citation: BMC Cancer 2010 10:107
    Content type: Research article Published on:

  39. Multicellular tumour sphere models have been shown to closely mimic phenotype characteristics of in vivo solid tumours, or to allow in vitro propagation of cancer stem cells (CSCs). CSCs are usually characterized...

    Authors: Louis-Bastien Weiswald, Jean-Marc Guinebretière, Sophie Richon, Dominique Bellet, Bruno Saubaméa and Virginie Dangles-Marie
    Citation: BMC Cancer 2010 10:106
    Content type: Technical advance Published on:

  40. Cancer, heart failure and stroke are among the most common causes of death worldwide. Investigation of the prognostic impact of each disease is important, especially for a better understanding of competing ris...

    Authors: Vasileios Askoxylakis, Christian Thieke, Sven T Pleger, Patrick Most, Judith Tanner, Katja Lindel, Hugo A Katus, Jürgen Debus and Marc Bischof
    Citation: BMC Cancer 2010 10:105
    Content type: Research article Published on:

  42. Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatm...

    Authors: Anna Martirosyan, James W Clendening, Carolyn A Goard and Linda Z Penn
    Citation: BMC Cancer 2010 10:103
    Content type: Research article Published on:

  43. The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with...

    Authors: Wen-Shan Liu, Chung-Han Hsin, Ying-Hsiang Chou, Jung-Tung Liu, Ming-Fang Wu, Szu-Wen Tseng, Jong-Kang Lee, Hsien-Chun Tseng, Tzu-Hwei Wang, Mao-Chang Su and Huei Lee
    Citation: BMC Cancer 2010 10:102
    Content type: Research article Published on:

  44. An increasing number of studies show that genetic markers can aid in refining prognostic information and predicting the benefit from systemic therapy. Our goal was to develop a high throughput, cost-effective ...

    Authors: Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik and Katherine L Pogue-Geile
    Citation: BMC Cancer 2010 10:101
    Content type: Research article Published on:

  45. Previous population-based studies showed differences in international and within country colorectal cancer survival estimates, but few investigated the role of prognostic factors. Using a "high resolution appr...

    Authors: Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy and Hermann Brenner
    Citation: BMC Cancer 2010 10:100
    Content type: Research article Published on:

  46. BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clini...

    Authors: Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends and Sheila A Rodwell
    Citation: BMC Cancer 2010 10:99
    Content type: Research article Published on:

  48. In the present study, we determined the gene hypermethylation profiles of normal tissues adjacent to invasive breast carcinomas and investigated whether these are associated with the gene hypermethylation prof...

    Authors: Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix and Peter B Vermeulen
    Citation: BMC Cancer 2010 10:97
    Content type: Research article Published on:

  49. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. For effective treatment, local control of the tumor is absolutely critical, because the chances of long term survival a...

    Authors: Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik and Jürgen Debus
    Citation: BMC Cancer 2010 10:96
    Content type: Study protocol Published on:

  50. Invasiveness and metastasis are the most common characteristics of non small cell lung cancer (NSCLC) and causes of tumour-related morbidity and mortality. Mitogen-activated protein kinases (MAPKs) signalling ...

    Authors: Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee and Win-Ping Deng
    Citation: BMC Cancer 2010 10:95
    Content type: Research article Published on:

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