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  1. Members of the urokinase-type plasminogen activator (uPA) system are up-regulated in various solid malignant tumors. High antigen levels of uPA, its inhibitor PAI-1 and its receptor uPAR have recently been sho...

    Authors: Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl and Helge Taubert
    Citation: BMC Cancer 2011 11:273
    Content type: Research article Published on:

  2. Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the re...

    Authors: Qing Wang, Ye-xiong Tan, Yi-bin Ren, Li-wei Dong, Zhi-fang Xie, Liang Tang, Dan Cao, Wei-ping Zhang, He-ping Hu and Hong-yang Wang
    Citation: BMC Cancer 2011 11:271
    Content type: Research article Published on:

  3. Flaxseed (FS) is a dietary supplement known for its antioxidant and anti-inflammatory properties. Radiation exposure of lung tissues occurs either when given therapeutically to treat intrathoracic malignancies...

    Authors: Melpo Christofidou-Solomidou, Sonia Tyagi, Kay-See Tan, Sarah Hagan, Ralph Pietrofesa, Floyd Dukes, Evguenia Arguiri, Daniel F Heitjan, Charalambos C Solomides and Keith A Cengel
    Citation: BMC Cancer 2011 11:269
    Content type: Research article Published on:

  4. Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia. However, other molecular targets of JSI-124 beyond the ...

    Authors: Ganchimeg Ishdorj, James B Johnston and Spencer B Gibson
    Citation: BMC Cancer 2011 11:268
    Content type: Research article Published on:

  5. Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility an...

    Authors: Marta Bonet Beltrán, Arnaud D Roth, Gilles Mentha and Abdelkarim S Allal
    Citation: BMC Cancer 2011 11:267
    Content type: Research article Published on:

  6. 18-Fluorodeoxyglucose-PET (18F-FDG-PET) can be used for early response assessment in patients with locally advanced adenocarcinomas of the oesophagogastric junction (AEG) undergoing neoadjuvant chemotherapy. It h...

    Authors: Sylvie Lorenzen, Carl von Gall, Annika Stange, Georg M Haag, Jürgen Weitz, Uwe Haberkorn, Florian Lordick, Wilko Weichert, Ulrich Abel, Jürgen Debus, Dirk Jäger and Marc W Münter
    Citation: BMC Cancer 2011 11:266
    Content type: Study protocol Published on:

  7. Detection of mutations by DNA sequencing can be facilitated by scanning methods to identify amplicons which may have mutations. Current scanning methods used for the detection of germline sequence variants are...

    Authors: Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong and Alexander Dobrovic
    Citation: BMC Cancer 2011 11:265
    Content type: Technical advance Published on:

  8. Although FOXO transcription factors may have an anti-angiogenic role, little is known about their role in tumor angiogenesis. The present study was performed to investigate the correlation between the constitu...

    Authors: Sue Youn Kim, Jiyeon Yoon, Young San Ko, Mee Soo Chang, Jong-Wan Park, Hee Eun Lee, Min A Kim, Ji Hun Kim, Woo Ho Kim and Byung Lan Lee
    Citation: BMC Cancer 2011 11:264
    Content type: Research article Published on:

  9. Cervical cancer continues to be an important worldwide health problem for women. Up to 35% of patients who are diagnosed with and appropriately treated for cervical cancer will recur and treatment results are ...

    Authors: Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Michelle Glasgow, Marta Bellone, Paola Todeschini, Luisa Carrara, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Thomas J Rutherford, Sergio Pecorelli, Charles J Lockwood and Alessandro D Santin
    Citation: BMC Cancer 2011 11:263
    Content type: Research article Published on:

  10. Triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC) are breast cancer subtypes with an especially poor prognosis. 8-Hydroxydeoxyguanosine (8-OHdG) is a widely used marker of oxidative stre...

    Authors: Peeter Karihtala, Saila Kauppila, Ylermi Soini and Arja-Jukkola-Vuorinen
    Citation: BMC Cancer 2011 11:262
    Content type: Research article Published on:

  12. Our objective was to measure myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) risk associated with radiation and/or chemotherapy breast cancer (BC) treatment.

    Authors: Henry G Kaplan, Judith A Malmgren and Mary K Atwood
    Citation: BMC Cancer 2011 11:260
    Content type: Research article Published on:

  13. Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C...

    Authors: Sara Huerta-Yepez, Nam K Yoon, Angeles Hernandez-Cueto, Vei Mah, Clara M Rivera-Pazos, Devasis Chatterjee, Mario I Vega, Erin L Maresh, Steve Horvath, David Chia, Benjamin Bonavida and Lee Goodglick
    Citation: BMC Cancer 2011 11:259
    Content type: Research article Published on:

  14. Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the h...

    Authors: Hongxia Ma, Li-E Wang, Zhensheng Liu, Erich M Sturgis and Qingyi Wei
    Citation: BMC Cancer 2011 11:258
    Content type: Research article Published on:

  15. Cancer screening rates in Korea for five cancer types have increased steadily since 2002. With regard to the life-time cancer screening rates in 2009 according to cancer sites, the second highest was breast ca...

    Authors: Mi Jin Park, Eun-Cheol Park, Kui Son Choi, Jae Kwan Jun and Hoo-Yeon Lee
    Citation: BMC Cancer 2011 11:257
    Content type: Research article Published on:

  16. Recently we reported that activation of Epac1, an exchange protein activated by cAMP, increases melanoma cell migration via Ca 2+ release from the endoplasmic reticulum (ER). G-protein βγ subunits (Gβγ) are known...

    Authors: Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos and Kousaku Iwatsubo
    Citation: BMC Cancer 2011 11:256
    Content type: Research article Published on:

  17. Cladribine or 2-chlorodeoxyadenosine (2-CDA) is a well-known purine nucleoside analog with particular activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL). Its benefits in multiple...

    Authors: Jian Ma, Shuiliang Wang, Ming Zhao, Xin-Sheng Deng, Choon-Kee Lee, Xiao-Dan Yu and Bolin Liu
    Citation: BMC Cancer 2011 11:255
    Content type: Research article Published on:

  18. Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human mal...

    Authors: Martin Grundy, Claire Seedhouse, Nigel H Russell and Monica Pallis
    Citation: BMC Cancer 2011 11:254
    Content type: Research article Published on:

  19. The ability of gene profiling to predict treatment response and prognosis in breast cancers has been demonstrated in many studies using DNA microarray analyses on RNA from fresh frozen tumor specimens. In cert...

    Authors: Al Muktafi Sadi, Dong-Yu Wang, Bruce J Youngson, Naomi Miller, Scott Boerner, Susan J Done and Wey L Leong
    Citation: BMC Cancer 2011 11:253
    Content type: Research article Published on:

  20. The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation t...

    Authors: Montserrat Solá, Mireia Margelí, Eva Castellá, Juan F Julian, Miquel Rull, Josep M Gubern, Antonio Mariscal, Agustí Barnadas and Manuel Fraile
    Citation: BMC Cancer 2011 11:252
    Content type: Research article Published on:

  21. The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The r...

    Authors: Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao and Wenchao Liu
    Citation: BMC Cancer 2011 11:251
    Content type: Research article Published on:

  22. The economic costs of treating patients with metastatic breast cancer have been examined in several studies, but available estimates of economic burden are at least a decade old. In this study, we characterize...

    Authors: Montserrat Vera-Llonch, Derek Weycker, Andrew Glass, Sue Gao, Rohit Borker, Angie Qin and Gerry Oster
    Citation: BMC Cancer 2011 11:250
    Content type: Research article Published on:

  23. Radiation therapy is an essential modality in the treatment of breast cancer. Addition of radiotherapy to surgery has significantly increased local control and survival rates of the disease. However, radiother...

    Authors: Vasileios Askoxylakis, Alexandra D Jensen, Matthias F Häfner, Leonie Fetzner, Florian Sterzing, Joerg Heil, Christof Sohn, Johannes Hüsing, Uta Tiefenbacher, Frederik Wenz, Jürgen Debus and Holger Hof
    Citation: BMC Cancer 2011 11:249
    Content type: Study protocol Published on:

  24. Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB receptor tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or "...

    Authors: Leiping Wang, Qunling Zhang, Jian Zhang, Si Sun, Haiyi Guo, Zhen Jia, Biyun Wang, Zhimin Shao, Zhonghua Wang and Xichun Hu
    Citation: BMC Cancer 2011 11:248
    Content type: Research article Published on:

  25. Molecular predictors of bevacizumab efficacy in colorectal cancer have not been identified yet. Specific VEGF polymorphisms may affect gene transcription and therefore indirectly influence the efficacy of bevaciz...

    Authors: Fotios Loupakis, Annamaria Ruzzo, Lisa Salvatore, Chiara Cremolini, Gianluca Masi, Paolo Frumento, Marta Schirripa, Vincenzo Catalano, Nadia Galluccio, Emanuele Canestrari, Bruno Vincenzi, Daniele Santini, Katia Bencardino, Vincenzo Ricci, Mariangela Manzoni, Marco Danova…
    Citation: BMC Cancer 2011 11:247
    Content type: Research article Published on:

  26. The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regu...

    Authors: Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo and Olufunmilayo I Olopade
    Citation: BMC Cancer 2011 11:246
    Content type: Research article Published on:

  27. Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively pr...

    Authors: Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman and Jonathan D Cheng
    Citation: BMC Cancer 2011 11:245
    Content type: Research article Published on:

  28. Clear cell renal cell carcinoma (ccRCC) is characterized by recurrent copy number alterations (CNAs) and loss of heterozygosity (LOH), which may have potential diagnostic and prognostic applications. Here, we ...

    Authors: Ingrid Cifola, Cristina Bianchi, Eleonora Mangano, Silvia Bombelli, Fabio Frascati, Ester Fasoli, Stefano Ferrero, Vitalba Di Stefano, Maria A Zipeto, Fulvio Magni, Stefano Signorini, Cristina Battaglia and Roberto A Perego
    Citation: BMC Cancer 2011 11:244
    Content type: Research article Published on:

  29. Heterozygosity of TP53 missense mutations is related to the phenomenon of the dominant-negative effect (DNE). To estimate the importance of the DNE of TP53 mutations, we analysed the percentage of cancer cases sh...

    Authors: Ewelina Stoczynska-Fidelus, Malgorzata Szybka, Sylwester Piaskowski, Michal Bienkowski, Krystyna Hulas-Bigoszewska, Mateusz Banaszczyk, Izabela Zawlik, Dorota Jesionek-Kupnicka, Radzislaw Kordek, Pawel P Liberski and Piotr Rieske
    Citation: BMC Cancer 2011 11:243
    Content type: Research article Published on:

  30. Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of prima...

    Authors: Nai-Yuan Wu, Hui-Cheng Cheng, James S Ko, Yu-Chen Cheng, Po-Wei Lin, Wei-Chan Lin, Cheng-Yen Chang and Der-Ming Liou
    Citation: BMC Cancer 2011 11:242
    Content type: Research article Published on:

  31. Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis. ...

    Authors: Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger and Martin Hagedorn
    Citation: BMC Cancer 2011 11:241
    Content type: Research article Published on:

  33. A new lower-cost rapid-throughput human papillomavirus (HPV) test (careHPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia.

    Authors: Ju-Fang Shi, Karen Canfell, Jie-Bin Lew, Fang-Hui Zhao, Rosa Legood, Yan Ning, Leonardo Simonella, Li Ma, Yoon-Jung Kang, Yong-Zhen Zhang, Megan A Smith, Jun-Feng Chen, Xiang-Xian Feng and You-Lin Qiao
    Citation: BMC Cancer 2011 11:239
    Content type: Research article Published on:

  34. Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and trans...

    Authors: Annika Gustafsson Asting, Helena Carén, Marianne Andersson, Christina Lönnroth, Kristina Lagerstedt and Kent Lundholm
    Citation: BMC Cancer 2011 11:238
    Content type: Research article Published on:

  35. Despite evidence that physical activity improves the health and well-being of prostate cancer survivors, many men do not engage in sufficient levels of activity. The primary aim of this study (ENGAGE) is to de...

    Authors: Patricia M Livingston, Jo Salmon, Kerry S Courneya, Cadeyrn J Gaskin, Melinda Craike, Mari Botti, Suzanne Broadbent and Bridie Kent
    Citation: BMC Cancer 2011 11:237
    Content type: Study protocol Published on:

  36. Uterine sarcomas are relatively rare tumors that account for approximately 1-3% of female genital tract malignancies and between 4-9% of uterine cancers. Less than 8% of all cases are Mullerian adenosarcoma, a...

    Authors: Tito Silvio Patrelli, Salvatore Gizzo, Stefania Di Gangi, Giorgia Guidi, Mario Rondinelli and Giovanni Battista Nardelli
    Citation: BMC Cancer 2011 11:236
    Content type: Case report Published on:

  38. Bladder cancer is a significant healthcare problem in the United States of America with a high recurrence rate. Early detection of bladder cancer is essential for removing the tumor with preservation of the bl...

    Authors: Antara Datta, Martin E Adelson, Yakov Mogilevkin, Eli Mordechai, Abraham A Sidi and Jason P Trama
    Citation: BMC Cancer 2011 11:234
    Content type: Research article Published on:

  39. Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how...

    Authors: Cydney Urbanek, Steve Goodison, Myron Chang, Stacy Porvasnik, Noburo Sakamoto, Chen-zhong Li, Susan K Boehlein and Charles J Rosser
    Citation: BMC Cancer 2011 11:233
    Content type: Research article Published on:

  40. Long-term gene silencing throughout cell division is generally achieved by DNA methylation and other epigenetic processes. Aberrant DNA methylation is now widely recognized to be associated with cancer and oth...

    Authors: Mercedes Dávalos-Salas, Mayra Furlan-Magaril, Edgar González-Buendía, Christian Valdes-Quezada, Erandi Ayala-Ortega and Félix Recillas-Targa
    Citation: BMC Cancer 2011 11:232
    Content type: Research article Published on:

  41. Aromatase inhibitors (AI) that inhibit breast cancer cell growth by blocking estrogen synthesis have become the treatment of choice for post-menopausal women with estrogen receptor positive (ER+) breast cancer. H...

    Authors: Tesfom Abrhale, Angela Brodie, Gauri Sabnis, Luciana Macedo, Changsheng Tian, Binbin Yue and Ginette Serrero
    Citation: BMC Cancer 2011 11:231
    Content type: Research article Published on:

  42. Tissue microarray (TMA) data are commonly used to validate the prognostic accuracy of tumor markers. For example, breast cancer TMA data have led to the identification of several promising prognostic markers o...

    Authors: Angela P Presson, Nam K Yoon, Lora Bagryanova, Vei Mah, Mohammad Alavi, Erin L Maresh, Ayyappan K Rajasekaran, Lee Goodglick, David Chia and Steve Horvath
    Citation: BMC Cancer 2011 11:230
    Content type: Research article Published on:

  43. Tumor cells adapt to endoplasmic reticulum (ER) stress through a set of conserved intracellular pathways, as part of a process termed the unfolded protein response (UPR). The expression of UPR genes/proteins c...

    Authors: Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler and Maurizio Zanetti
    Citation: BMC Cancer 2011 11:229
    Content type: Research article Published on:

  44. Lung cancer is the leading cause of cancer death in the United States. Identifying factors associated with stage of diagnosis can improve our understanding of biologic and behavioral pathways of lung cancer de...

    Authors: Christopher G Slatore, Michael K Gould, David H Au, Mark E Deffebach and Emily White
    Citation: BMC Cancer 2011 11:228
    Content type: Research article Published on:

  45. LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non...

    Authors: Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu and Yongming Luo
    Citation: BMC Cancer 2011 11:227
    Content type: Research article Published on:

  46. Recent advances in lung cancer biology presuppose its inflammatory origin. In this regard, LTB-4 and IL-8 are recognized to play a crucial role in neutrophil recruitment into airways during lung cancer.

    Authors: Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando and Maria P Foschino-Barbaro
    Citation: BMC Cancer 2011 11:226
    Content type: Research article Published on:

  48. Cancer affects older adults disproportionately. The disease is often difficult to diagnose and treat due to co-morbidities and performance status, and patients tend to discontinue chemotherapy prematurely. The...

    Authors: Rong Hu, Yong Wu, Xiaoying Jiang, Wenteng Zhang and Le Xu
    Citation: BMC Cancer 2011 11:224
    Content type: Research article Published on:

  50. Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in com...

    Authors: Lucy Heinemann, Guy R Simpson, Angela Boxall, Timothy Kottke, Kate L Relph, Richard Vile, Alan Melcher, Robin Prestwich, Kevin J Harrington, Richard Morgan and Hardev S Pandha
    Citation: BMC Cancer 2011 11:221
    Content type: Research article Published on:

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