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  1. The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydr...

    Authors: Jennifer Gjerde, Jürgen Geisler, Steinar Lundgren, Dagfinn Ekse, Jan Erik Varhaug, Gunnar Mellgren, Vidar M Steen and Ernst A Lien
    Citation: BMC Cancer 2010 10:313
    Content type: Research article Published on:

  2. Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively consi...

    Authors: Takahisa Nakayama, Zhi-Qiang Ling, Ken-ichi Mukaisho, Takanori Hattori and Hiroyuki Sugihara
    Citation: BMC Cancer 2010 10:311
    Content type: Research article Published on:

  3. The role of peri-operative chemotherapy in patients with resected stage IV colorectal cancer (CRC) remains to be defined. This study was aimed at evaluating the effectiveness of peri-operative chemotherapy in ...

    Authors: Martina Wieser, Stefan Sauerland, Dirk Arnold, Wolff Schmiegel and Anke Reinacher-Schick
    Citation: BMC Cancer 2010 10:309
    Content type: Research article Published on:

  4. We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery.

    Authors: Hao Zhang, Caigang Liu, Di Wu, Yi Meng, Ruonan Song, Ping Lu and Shubao Wang
    Citation: BMC Cancer 2010 10:308
    Content type: Research article Published on:

  5. Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27kip1, which is generally reduced in e...

    Authors: Laura MS Seeber, Nicole Horrée, Petra van der Groep, Elsken van der Wall, René HM Verheijen and Paul J van Diest
    Citation: BMC Cancer 2010 10:307
    Content type: Research article Published on:

  6. 14-3-3epsilon regulates a wide range of biological processes, including cell cycle control, proliferation, and apoptosis, and plays a significant role in neurogenesis and the formation of malignant tumours. Ho...

    Authors: Xing-Hua Che, Hong Chen, Zhen-Ming Xu, Chao Shang, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2010 10:306
    Content type: Research article Published on:

  7. Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.

    Authors: Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Wei Lin, Yong-qiang Zhang, Wei-ping Liu, Jian-ning Zhang, Hong Lin, Rui Wang and Hong Yin
    Citation: BMC Cancer 2010 10:305
    Content type: Research article Published on:

  9. Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (...

    Authors: Masakazu Yashiro, Kosei Hirakawa and C Richard Boland
    Citation: BMC Cancer 2010 10:303
    Content type: Research article Published on:

  10. Cholangiocarcinoma (CC) is a malignant neoplasm of the bile ducts or the gallbladder. Targeting of growth factor receptors showed therapeutic potential in palliative settings for many solid tumors. The aim of ...

    Authors: Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel, Elisabeth Lippert, Frank Klebl and Gerhard Rogler
    Citation: BMC Cancer 2010 10:302
    Content type: Research article Published on:

  11. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known.

    Authors: Hong Wei Yang, Lata G Menon, Peter M Black, Rona S Carroll and Mark D Johnson
    Citation: BMC Cancer 2010 10:301
    Content type: Research article Published on:

  12. The development and progression of colorectal cancer has been extensively studied and the genes responsible have been well characterized. However the correlation between the SMAD4 gene mutations with KRAS mutant ...

    Authors: A Syed Sameer, Nissar A Chowdri, Nidda Syeed, Mujeeb Z Banday, Zaffar A Shah and Mushtaq A Siddiqi
    Citation: BMC Cancer 2010 10:300
    Content type: Research article Published on:

  13. Patients with gastric cancer in China have worse outcome and poorer prognosis. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. The intratumoral and peritumoral lymphat...

    Authors: Xiao-Lei Wang, Jian-Ping Fang, Ru-Yong Tang and Xi-Mei Chen
    Citation: BMC Cancer 2010 10:299
    Content type: Research article Published on:

  14. The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast ...

    Authors: Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body and Fabrice Journé
    Citation: BMC Cancer 2010 10:298
    Content type: Research article Published on:

  15. The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts ...

    Authors: Imke Müller, Frank Wischnewski, Klaus Pantel and Heidi Schwarzenbach
    Citation: BMC Cancer 2010 10:297
    Content type: Research article Published on:

  16. Previous studies have shown that the ADIPOR1, ADORA1, BTG2 and CD46 genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy nu...

    Authors: Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2010 10:296
    Content type: Research article Published on:

  17. Pancreatic cancer is still associated with devastating prognosis. Real progress in treatment options has still not been achieved. Therefore new models are urgently needed to investigate this deadly disease. As...

    Authors: Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Maria Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki…
    Citation: BMC Cancer 2010 10:295
    Content type: Research article Published on:

  18. Metastasis is a multi-step process that is responsible for the majority of deaths in cancer patients. Current treatments are not effective in targeting metastasis. The molecular chaperone hsp90α is secreted fr...

    Authors: Jessica McCready, Jessica D Sims, Doug Chan and Daniel G Jay
    Citation: BMC Cancer 2010 10:294
    Content type: Research article Published on:

  19. Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We h...

    Authors: Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari and Caroline A Lamb
    Citation: BMC Cancer 2010 10:293
    Content type: Research article Published on:

  20. Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression...

    Authors: Brooke M Winzer, Jennifer D Paratz, Marina M Reeves and David C Whiteman
    Citation: BMC Cancer 2010 10:292
    Content type: Study protocol Published on:

  21. Molecularly targeted drugs inhibit aberrant signaling within oncogenic pathways. Identifying the predominant pathways at work within a tumor is a key step towards tailoring therapies to the patient. Clinical s...

    Authors: Yogesh M Kulkarni, Vivian Suarez and David J Klinke II
    Citation: BMC Cancer 2010 10:291
    Content type: Research article Published on:

  22. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Early diagnosis is critical for guiding the therapeutic management of ESCC. It is imperative to find more effective biomarkers ...

    Authors: Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan and Fu-Kun Zhao
    Citation: BMC Cancer 2010 10:290
    Content type: Research article Published on:

  23. Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a ...

    Authors: Chris E Holmes, Maria E Ramos-Nino and Benjamin Littenberg
    Citation: BMC Cancer 2010 10:289
    Content type: Research article Published on:

  24. Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression. The aim of this study was...

    Authors: Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber and Karin Welén
    Citation: BMC Cancer 2010 10:288
    Content type: Research article Published on:

  25. Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one ...

    Authors: Till Krech, Margarethe Thiede, Ellen Hilgenberg, Reinhold Schäfer and Karsten Jürchott
    Citation: BMC Cancer 2010 10:287
    Content type: Research article Published on:

  26. Epigenetic aberrations and a CpG island methylator phenotype have been shown to be associated with poor outcomes in children with neuroblastoma (NB). Seven cancer related genes (THBS-1, CASP8, HIN-1, TIG-1, BLU, ...

    Authors: Qiwei Yang, Yufeng Tian, Kelly R Ostler, Alexandre Chlenski, Lisa J Guerrero, Helen R Salwen, Lucy A Godley and Susan L Cohn
    Citation: BMC Cancer 2010 10:286
    Content type: Research article Published on:

  27. We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution...

    Authors: Darren R Brenner, Rayjean J Hung, Ming-Sound Tsao, Frances A Shepherd, Michael R Johnston, Steven Narod, Warren Rubenstein and John R McLaughlin
    Citation: BMC Cancer 2010 10:285
    Content type: Research article Published on:

  29. Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implica...

    Authors: Kaouther Snoussi, Wijden Mahfoudh, Noureddine Bouaouina, Meriem Fekih, Hedi Khairi, Ahmed N Helal and Lotfi Chouchane
    Citation: BMC Cancer 2010 10:283
    Content type: Research article Published on:

  30. The alkylating agent Dacarbazine (DTIC) has been used in the treatment of melanoma for decades, but when used as a monotherapy for cancer only moderate response rates are achieved. Recently, the clinical use o...

    Authors: Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand and Randy Burd
    Citation: BMC Cancer 2010 10:282
    Content type: Research article Published on:

  31. The rates of chemotherapy-induced amenorrhea (CIA) associated with docetaxel-based regimens reported by previous studies are discordant. For navelbine-based chemotherapies, rates of CIA have seldom been reported.

    Authors: Wen-Bin Zhou, Hong Yin, Xiao-An Liu, Xiao-Ming Zha, Lin Chen, Jun-Cheng Dai, Ai-di Tao, Ling Chen, Jing-Jing Ma, Li-Jun Ling and Shui Wang
    Citation: BMC Cancer 2010 10:281
    Content type: Research article Published on:

  32. Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tum...

    Authors: Javier del Rey, Esther Prat, Immaculada Ponsa, Josep Lloreta, Antoni Gelabert, Ferran Algaba, Jordi Camps and Rosa Miró
    Citation: BMC Cancer 2010 10:280
    Content type: Research article Published on:

  33. Genetic testing for hereditary colorectal cancer (HCRC) had significant psychological consequences for test recipients. This prospective longitudinal study investigated the factors that predict psychological r...

    Authors: Samuel MY Ho, Judy WC Ho, George A Bonanno, Annie TW Chu and Emily MS Chan
    Citation: BMC Cancer 2010 10:279
    Content type: Research article Published on:

  34. Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but onl...

    Authors: Koushik Chatterjee, Collet Dandara, Margaret Hoffman and Anna-Lise Williamson
    Citation: BMC Cancer 2010 10:278
    Content type: Research article Published on:

  35. Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration. To date, few surrogate endpoi...

    Authors: Nicolas Methy, Laurent Bedenne and Franck Bonnetain
    Citation: BMC Cancer 2010 10:277
    Content type: Research article Published on:

  36. Epigallocatechin-3-gallate (EGCG), one of the major catechins in green tea, is a potential chemopreventive agent for various cancers. The aim of this study was to examine the effect of EGCG on the expression o...

    Authors: Phan LCHB Tran, Soo-A Kim, Hong Seok Choi, Jung-Hoon Yoon and Sang-Gun Ahn
    Citation: BMC Cancer 2010 10:276
    Content type: Research article Published on:

  37. Fas (Apo-1/CD95) and its specific ligand (FasL) are key elements in apoptosis. They have been studied in different malignancies but there are few published studies about the soluble forms of these markers (i.e...

    Authors: Samaneh Boroumand-Noughabi, Hamid Reza Sima, Kamran Ghaffarzadehgan, Mostafa Jafarzadeh, Hamid Reza Raziee, Hanieh Hosseinnezhad, Omeed Moaven, Mohammad Taghi Rajabi-Mashhadi, Amir Abbas Azarian, Mojtaba Mashhadinejad and Jalil Tavakkol-Afshari
    Citation: BMC Cancer 2010 10:275
    Content type: Technical advance Published on:

  38. It is uncertain whether smoking is related to colorectal cancer risk. Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolis...

    Authors: Hoirun Nisa, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya…
    Citation: BMC Cancer 2010 10:274
    Content type: Research article Published on:

  39. Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far.

    Authors: Verena Tischler, Florian R Fritzsche, Peter J Wild, Carsten Stephan, Hans-Helge Seifert, Marc-Oliver Riener, Thomas Hermanns, Ashkan Mortezavi, Josefine Gerhardt, Peter Schraml, Klaus Jung, Holger Moch, Alex Soltermann and Glen Kristiansen
    Citation: BMC Cancer 2010 10:273
    Content type: Research article Published on:

  40. Fatigue is a major problem of cancer patients. Thirty percent of cancer survivors report serious fatigue three years after finishing treatment. There is evidence that physical exercise during cancer treatment ...

    Authors: Miranda J Velthuis, Anne M May, Ria AG Koppejan-Rensenbrink, Brigitte CM Gijsen, Eric van Breda, G Ardine de Wit, Carin D Schröder, Evelyn M Monninkhof, Eline Lindeman, Elsken van der Wall and Petra HM Peeters
    Citation: BMC Cancer 2010 10:272
    Content type: Study protocol Published on:

  41. Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical carcinogenesis. In the present study we examined hTERT promote...

    Authors: Jillian de Wilde, Jan M Kooter, Renée M Overmeer, Debbie Claassen-Kramer, Chris JLM Meijer, Peter JF Snijders and Renske DM Steenbergen
    Citation: BMC Cancer 2010 10:271
    Content type: Research article Published on:

  42. The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the survival of pat...

    Authors: Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu and Weiyi Fang
    Citation: BMC Cancer 2010 10:270
    Content type: Research article Published on:

  43. Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent stud...

    Authors: Xiang Wu, Yu Zhu, Huiqin Yan, Boning Liu, Ying Li, Qinghua Zhou and Ke Xu
    Citation: BMC Cancer 2010 10:269
    Content type: Research article Published on:

  44. High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment.

    Authors: Joon-Khim Loh, Ann-Shung Lieu, Chia-Hua Chou, Fang-Yi Lin, Chia-Hung Wu, Sheng-Long Howng, Chung-Ching Chio and Yi-Ren Hong
    Citation: BMC Cancer 2010 10:268
    Content type: Research article Published on:

  46. Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods...

    Authors: Dirk W Lachenmeier, Maria CP Lima, Ian CC Nóbrega, José AP Pereira, Florence Kerr-Corrêa, Fotis Kanteres and Jürgen Rehm
    Citation: BMC Cancer 2010 10:266
    Content type: Research article Published on:

  47. Melanoma is the most deadly form of skin cancer without effective treatment. Methylthioadenosine (MTA) is a naturally occurring nucleoside with differential effects on normal and transformed cells. MTA has bee...

    Authors: Pedro Andreu-Pérez, Javier Hernandez-Losa, Teresa Moliné, Rosa Gil, Judit Grueso, Anna Pujol, Javier Cortés, Matias A Avila and Juan A Recio
    Citation: BMC Cancer 2010 10:265
    Content type: Research article Published on:

  48. Malignant degeneration in association with orthopaedic implants is a known but rare complication. To our knowledge, no case of osseous malignant fibrous histiocytoma after anterior cruciate ligament reconstruc...

    Authors: Turgay Efe, Thomas J Heyse, Markus D Schofer, Susanne Fuchs-Winkelmann, Peter Rexin and Jan Schmitt
    Citation: BMC Cancer 2010 10:264
    Content type: Case report Published on:

  49. MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool.

    Authors: Petra Leidinger, Andreas Keller, Anne Borries, Jörg Reichrath, Knuth Rass, Sven U Jager, Hans-Peter Lenhof and Eckart Meese
    Citation: BMC Cancer 2010 10:262
    Content type: Research article Published on:

  50. Dendritic Cells (DC) are potent antigen presenting cells with the ability to prime naïve T cells and convert them to cytotoxic T-lymphocytes (CTL). We evaluated the capability of autologous DCs transfected wit...

    Authors: Mehran Gholamin, Omeed Moaven, Moein Farshchian, Mahmoud Mahmoudi, Mojtaba Sankian, Bahram Memar, Mohammad Naser Forghani, Reza Malekzadeh, Mohammad Taghi Rajabi-Mashhadi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:261
    Content type: Research article Published on:

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