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  1. Matrix metalloproteinases (MMPs) are enzymes that degrade all the components of extra cellular matrix and collagen. Various types of MMPs are known to be expressed and activated in patients with oral submucous...

    Authors: Ajay K Chaudhary, Mamta Singh, Alok C Bharti, Mangal Singh, Shirish Shukla, Atul K Singh and Ravi Mehrotra
    Citation: BMC Cancer 2010 10:369
    Content type: Research article Published on:

  2. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were discovered to induce cell growth and cell cycle pro...

    Authors: Zhang Chun-zhi, Han Lei, Zhang An-ling, Fu Yan-chao, Yue Xiao, Wang Guang-xiu, Jia Zhi-fan, Pu Pei-yu, Zhang Qing-yu and Kang Chun-sheng
    Citation: BMC Cancer 2010 10:367
    Content type: Research article Published on:

  3. DNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a frequent event, yet the factors which dictate ...

    Authors: David Mossman, Kyu-Tae Kim and Rodney J Scott
    Citation: BMC Cancer 2010 10:366
    Content type: Research article Published on:

  4. Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic ...

    Authors: Xiqiang Liu, Anxun Wang, Lorenzo Lo Muzio, Antonia Kolokythas, Shihu Sheng, Corrado Rubini, Hui Ye, Fei Shi, Tianwei Yu, David L Crowe and Xiaofeng Zhou
    Citation: BMC Cancer 2010 10:365
    Content type: Research article Published on:

  5. The formation of metastasis is the most common cause of death in patients with lung cancer. A major implement to understand the molecular mechanisms involved in lung cancer metastasis has been the lack of suit...

    Authors: Deshui Jia, Mingxia Yan, Xiaomin Wang, Xiangfang Hao, Linhui Liang, Lei Liu, Hanwei Kong, Xianghuo He, Jinjun Li and Ming Yao
    Citation: BMC Cancer 2010 10:364
    Content type: Research article Published on:

  6. The majority of cancer patients experience dramatic weight loss, due to cachexia and consisting of skeletal muscle and fat tissue wasting. Cachexia is a negative prognostic factor, interferes with therapy and ...

    Authors: Paola Aulino, Emanuele Berardi, Veronica M Cardillo, Emanuele Rizzuto, Barbara Perniconi, Carla Ramina, Fabrizio Padula, Enrico P Spugnini, Alfonso Baldi, Fabio Faiola, Sergio Adamo and Dario Coletti
    Citation: BMC Cancer 2010 10:363
    Content type: Research article Published on:

  7. Molecular heterogeneity of colorectal carcinoma (CRC) is well recognized, forming the rationale for molecular tests required before administration of some of the novel targeted therapies that now are rapidly e...

    Authors: Michael Linnebacher, Claudia Maletzki, Christiane Ostwald, Ulrike Klier, Mathias Krohn, Ernst Klar and Friedrich Prall
    Citation: BMC Cancer 2010 10:362
    Content type: Research article Published on:

  8. Psychological distress (i.e. depression and anxiety) is a strong predictor of functional status and other aspects of quality of life in autologous stem cell transplantation following high-dose chemotherapy. Tr...

    Authors: Annemarie MJ Braamse, Berno van Meijel, Otto Visser, Patricia van Oppen, Annette D Boenink, Corien Eeltink, Pim Cuijpers, Peter C Huijgens, Aartjan TF Beekman and Joost Dekker
    Citation: BMC Cancer 2010 10:361
    Content type: Study protocol Published on:

  9. A patient with nevoid basal cell carcinoma syndrome (Gorlin syndrome) presented with two unusual clinical features, i.e. adenocarcinoma of the small bowel and extensive mesenchymal proliferation of the lower g...

    Authors: Peter M Prodinger, Mario Sarbia, Jörg Maßmann, Christian Straka, Günther Meyer and Ortrud K Steinlein
    Citation: BMC Cancer 2010 10:360
    Content type: Case report Published on:

  10. Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this...

    Authors: Caiyun Liu, Bin Dong, Aiping Lu, Like Qu, Xiaofang Xing, Lin Meng, Jian Wu, Y Eric Shi and Chengchao Shou
    Citation: BMC Cancer 2010 10:359
    Content type: Research article Published on:

  11. Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of diff...

    Authors: JiaJia Huang, WenQi Jiang, RuiHua Xu, HuiQiang Huang, Yue Lv, ZhongJun Xia, XiaoFei Sun, ZhongZhen Guan, TongYu Lin and ZhiMing Li
    Citation: BMC Cancer 2010 10:358
    Content type: Research article Published on:

  12. There is a paucity of recent epidemiological data on bone cancers. The aim of this study was to describe incidence and survival patterns for bone cancers diagnosed during 1981 - 2002.

    Authors: Rachel Eyre, Richard G Feltbower, Peter W James, Karen Blakey, Emmanuel Mubwandarikwa, David Forman, Patricia A McKinney, Mark S Pearce and Richard JQ McNally
    Citation: BMC Cancer 2010 10:357
    Content type: Research article Published on:

  13. Hepatocellular carcinoma (HCC) is one of the world's leading causes of death among cancer patients. It is important to find a new biomarker that diagnoses HCC and monitors its treatment. In our previous work, ...

    Authors: Huaqing Cui, Feng Wu, Yanling Sun, Guocai Fan and Qingming Wang
    Citation: BMC Cancer 2010 10:356
    Content type: Research article Published on:

  14. Targeted colonosocopic screening is recommended for first-degree relatives of colorectal cancer patients diagnosed before the age of 60 and offers the possibility of reducing morbidity and mortality, but parti...

    Authors: Myriam Taouqi, Isabelle Ingrand, Michel Beauchant, Virginie Migeot and Pierre Ingrand
    Citation: BMC Cancer 2010 10:355
    Content type: Research article Published on:

  15. In recent years, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma. In our previous studies, a set of miRNAs were revealed to be dysregulated in HCC ...

    Authors: Jipeng Li, Hanjiang Fu, Chengwang Xu, Yi Tie, Ruiyun Xing, Jie Zhu, Yide Qin, Zhixian Sun and Xiaofei Zheng
    Citation: BMC Cancer 2010 10:354
    Content type: Research article Published on:

  16. Hsp90 (heat shock protein90) is a chaperone protein essential for preserving and regulating the function of various cellular proteins. Elevated Hsp90 expression seems to be a trait of breast cancer and may be ...

    Authors: Flora Zagouri, Theodoros N Sergentanis, Afrodite Nonni, Christos A Papadimitriou, Nikolaos V Michalopoulos, Philip Domeyer, George Theodoropoulos, Andreas Lazaris, Effstratios Patsouris, Eleni Zogafos, Anastazia Pazaiti and George C Zografos
    Citation: BMC Cancer 2010 10:353
    Content type: Research article Published on:

  17. Glutathione S-transferase pi (GST pi) is a subgroup of GST family, which provides cellular protection against free radical and carcinogenic compounds due to its detoxifying function. Expression patterns of GST...

    Authors: Zhihui Wang, Wei He, Guanrui Yang, Junsheng Wang, Zhong Wang, Jahn M Nesland, Ruth Holm and Zhenhe Suo
    Citation: BMC Cancer 2010 10:352
    Content type: Research article Published on:

  18. Novel therapeutic agents that selectively induce tumor cell death are urgently needed in the clinical management of cancers. Such agents would constitute effective adjuvant approaches to traditional chemothera...

    Authors: W Wei-Lynn Wong, Paul C Boutros, Amanda R Wasylishen, Kristal D Guckert, Erin M O'Brien, Rebecca Griffiths, Anna R Martirosyan, Christina Bros, Igor Jurisica, Richard F Langler and Linda Z Penn
    Citation: BMC Cancer 2010 10:351
    Content type: Research article Published on:

  19. Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatmen...

    Authors: Julian Dorn, Hanno Spatz, Michael Schmieder, Thomas FE Barth, Annette Blatz, Doris Henne-Bruns, Uwe Knippschild and Klaus Kramer
    Citation: BMC Cancer 2010 10:350
    Content type: Research article Published on:

  20. Development of innovative, effective therapies against recurrent/chemotherapy-resistant ovarian cancer remains a high priority. Using high-throughput technologies to analyze genetic fingerprints of ovarian can...

    Authors: Emiliano Cocco, Francesca Casagrande, Stefania Bellone, Christine E Richter, Marta Bellone, Paola Todeschini, Jennie C Holmberg, Han Hsuan Fu, Michele K Montagna, Gil Mor, Peter E Schwartz, Dan Arin-Silasi, Masoud Azoudi, Thomas J Rutherford, Maysa Abu-Khalaf, Sergio Pecorelli…
    Citation: BMC Cancer 2010 10:349
    Content type: Research article Published on:

  21. Deregulated c-Myc expression is a hallmark of several human cancers where it promotes proliferation and an aggressive tumour phenotype. Myc overexpression is associated with reduced activity of Rel/NF-κB, tran...

    Authors: Ulrich Keller, Jürgen Huber, Jonas A Nilsson, Mohammad Fallahi, Mark A Hall, Christian Peschel and John L Cleveland
    Citation: BMC Cancer 2010 10:348
    Content type: Research article Published on:

  22. Recently, serum 25-hydroxyvitamin D (25OHD) levels were shown to be associated with the survival of patients with colorectal cancer. However, 25OHD levels were measured a median of 6 years before diagnosis or ...

    Authors: Hidetoshi Mezawa, Tsutomu Sugiura, Michiaki Watanabe, Chihiro Norizoe, Daisuke Takahashi, Akira Shimojima, Seryna Tamez, Yusuke Tsutsumi, Katsuhiko Yanaga and Mitsuyoshi Urashima
    Citation: BMC Cancer 2010 10:347
    Content type: Research article Published on:

  23. Aneuploidy has long been recognized to be associated with cancer. A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at th...

    Authors: Yao Li, Arthur Berg, Louie R Wu, Zhong Wang, Gang Chen and Rongling Wu
    Citation: BMC Cancer 2010 10:346
    Content type: Research article Published on:

  24. Compared to healthy controls, cancer patients have a higher risk of unemployment, which has negative social and economic impacts on the patients and on society at large. Therefore, return-to-work of cancer pat...

    Authors: Sietske J Tamminga, Angela GEM de Boer, Jos HAM Verbeek, Taina Taskila and Monique HW Frings-Dresen
    Citation: BMC Cancer 2010 10:345
    Content type: Study protocol Published on:

  25. In Tanzania, the International Working Formulation [WF] rather than the WHO Classification is still being used in diagnosing malignant lymphomas (ML) and the biological characterization including the HIV/EBV a...

    Authors: Amos R Mwakigonja, Ephata E Kaaya, Thomas Heiden, German Wannhoff, Juan Castro, Fatemeh Pak, Anna Porwit and Peter Biberfeld
    Citation: BMC Cancer 2010 10:344
    Content type: Research article Published on:

  27. Modulation of pre-mRNA splicing by antisense molecules is a promising mechanism of action for gene therapeutic drugs. In this study, we have examined the potential of peptide nucleic acid (PNA) 9-aminoacridine...

    Authors: Takehiko Shiraishi, Jonhard Eysturskarð and Peter E Nielsen
    Citation: BMC Cancer 2010 10:342
    Content type: Research article Published on:

  28. The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression o...

    Authors: Kristian Ikenberg, Florian R Fritzsche, Ursina Zuerrer-Haerdi, Irina Hofmann, Thomas Hermanns, Helge Seifert, Michael Müntener, Maurizio Provenzano, Tullio Sulser, Silvia Behnke, Josefine Gerhardt, Ashkan Mortezavi, Peter Wild, Ferdinand Hofstädter, Maximilian Burger, Holger Moch…
    Citation: BMC Cancer 2010 10:341
    Content type: Research article Published on:

  29. Activity of cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor, is largely attributed to its direct antiproliferative and proapoptotic effects. Antibody-dependent cell-med...

    Authors: Raphaël Maréchal, Jef De Schutter, Nathalie Nagy, Pieter Demetter, Arnaud Lemmers, Jacques Devière, Isabelle Salmon, Sabine Tejpar and Jean-Luc Van Laethem
    Citation: BMC Cancer 2010 10:340
    Content type: Research article Published on:

  31. Ovarian germ cell tumours (OGCT) are rare but are usually curable with chemotherapy, even when presenting with advanced disease. The majority of OGCT produce the tumour markers, hCG and/or AFP which can be hel...

    Authors: Serena Rakha, Clare Bayliss, Frances Sanderson, Richard Smith, Michael Seckl and Philip Savage
    Citation: BMC Cancer 2010 10:338
    Content type: Case report Published on:

  32. We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma.

    Authors: Lesley A Smith, Victoria R Cornelius, Christopher J Plummer, Gill Levitt, Mark Verrill, Peter Canney and Alison Jones
    Citation: BMC Cancer 2010 10:337
    Content type: Research article Published on:

  33. Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant r...

    Authors: Iker Sánchez-Navarro, Angelo Gámez-Pozo, Álvaro Pinto, David Hardisson, Rosario Madero, Rocío López, Belén San José, Pilar Zamora, Andrés Redondo, Jaime Feliu, Paloma Cejas, Manuel González Barón, Juan Ángel Fresno Vara and Enrique Espinosa
    Citation: BMC Cancer 2010 10:336
    Content type: Research article Published on:

  34. MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo mode...

    Authors: Nam K Yoon, Erin L Maresh, Yahya Elshimali, Ai Li, Steve Horvath, David B Seligson, David Chia and Lee Goodglick
    Citation: BMC Cancer 2010 10:335
    Content type: Research article Published on:

  36. Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate t...

    Authors: Loretta De Chiara, Ana M Rodríguez-Piñeiro, Francisco J Rodríguez-Berrocal, Oscar J Cordero, David Martínez-Ares and María Páez de la Cadena
    Citation: BMC Cancer 2010 10:333
    Content type: Research article Published on:

  37. Diagnosing colorectal cancer (CRC) at an early stage improves survival. To what extent any delay affects outcome once patients are symptomatic is still unclear.

    Authors: Jochim S Terhaar sive Droste, Frank A Oort, René WM van der Hulst, Veerle MH Coupé, Mike E Craanen, Gerrit A Meijer, Linde M Morsink, Otto Visser, Roy LJ van Wanrooij and Chris JJ Mulder
    Citation: BMC Cancer 2010 10:332
    Content type: Research article Published on:

  38. Proteolytic cleavage of the extracellular domain (EpEx) of Epithelial cell adhesion molecule (EpCAM) and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased...

    Authors: Ranju Ralhan, Jun Cao, Terence Lim, Christina MacMillan, Jeremy L Freeman and Paul G Walfish
    Citation: BMC Cancer 2010 10:331
    Content type: Research article Published on:

  39. The alternatively spliced V region or type III connecting segment III (IIICS) of fibronectin is important in early development, wound healing, and tumorigenesis, however, its role in oral cancer has not been f...

    Authors: Pachiyappan Kamarajan, Angeles Garcia-Pardo, Nisha J D'Silva and Yvonne L Kapila
    Citation: BMC Cancer 2010 10:330
    Content type: Research article Published on:

  40. The HMGA2 gene, coding for an architectural transcription factor involved in mesenchymal embryogenesis, is frequently deranged by translocation and/or amplification in mesenchymal tumours, generally leading to...

    Authors: Jørn Henriksen, Marianne Stabell, Leonardo A Meza-Zepeda, Silje AU Lauvrak, Moustapha Kassem and Ola Myklebost
    Citation: BMC Cancer 2010 10:329
    Content type: Research article Published on:

  42. There is increasing evidence that the toll-like receptor 3 (TLR3) is an interesting target for anti-cancer therapy. Unfortunately, most laboratory investigations about the impact of TLR3 stimulation on human m...

    Authors: Luc Friboulet, Claire Gourzones, Sai Wah Tsao, Yannis Morel, Carine Paturel, Stéphane Témam, Catherine Uzan and Pierre Busson
    Citation: BMC Cancer 2010 10:327
    Content type: Research article Published on:

  43. Several viruses with known oncogenic potential infect prostate tissue, among these are the polyomaviruses BKV, JCV, and SV40; human papillomaviruses (HPVs), and human cytomegalovirus (HCMV) infections. Recentl...

    Authors: Margarita L Martinez-Fierro, Robin J Leach, Lauro S Gomez-Guerra, Raquel Garza-Guajardo, Teresa Johnson-Pais, Joke Beuten, Idelma B Morales-Rodriguez, Mario A Hernandez-Ordoñez, German Calderon-Cardenas, Rocio Ortiz-Lopez, Ana M Rivas-Estilla, Jesus Ancer-Rodriguez and Augusto Rojas-Martinez
    Citation: BMC Cancer 2010 10:326
    Content type: Research article Published on:

  44. The importance of cell-surface nucleolin in cancer biology was recently highlighted by studies showing that ligands of nucleolin play critical role in tumorigenesis and angiogenesis. By using a specific antago...

    Authors: Diala El Khoury, Damien Destouches, Renée Lengagne, Bernard Krust, Yamina Hamma-Kourbali, Marylène Garcette, Sandra Niro, Masashi Kato, Jean-Paul Briand, José Courty, Ara G Hovanessian and Armelle Prévost-Blondel
    Citation: BMC Cancer 2010 10:325
    Content type: Research article Published on:

  45. Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lup...

    Authors: Giuseppe Bifulco, Vincenzo D Mandato, Roberto Piccoli, Pierluigi Giampaolino, Chiara Mignogna, Michele D Mignogna, Luigi Costagliola and Carmine Nappi
    Citation: BMC Cancer 2010 10:324
    Content type: Case report Published on:

  46. The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:323
    Content type: Research article Published on:

  47. The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause disseminat...

    Authors: Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino and Paolo Visca
    Citation: BMC Cancer 2010 10:322
    Content type: Case report Published on:

  48. Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression of angiogenic factors,...

    Authors: Mariusz Koda, Luiza Kanczuga-Koda, Mariola Sulkowska, Eva Surmacz and Stanislaw Sulkowski
    Citation: BMC Cancer 2010 10:320
    Content type: Research article Published on:

  49. We have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. Our current feature set consists of 113 g...

    Authors: Joseph Irgon, C Chris Huang, Yi Zhang, Dmitri Talantov, Gyan Bhanot and Sándor Szalma
    Citation: BMC Cancer 2010 10:319
    Content type: Research article Published on:

  50. Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed t...

    Authors: Christian A Merkel, Rafael B da Silva Soares, Anna Carolina V de Carvalho, Daniela B Zanatta, Marcio C Bajgelman, Paula Fratini, Eugenia Costanzi-Strauss and Bryan E Strauss
    Citation: BMC Cancer 2010 10:316
    Content type: Research article Published on:

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