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  1. Lymphadenectomy is debated in early stages endometrial cancer. Moreover, a new FIGO classification of endometrial cancer, merging stages IA and IB has been recently published. Therefore, the aims of the presen...

    Authors: Marcos Ballester, Martin Koskas, Charles Coutant, Elisabeth Chéreau, Jeremy Seror, Roman Rouzier and Emile Daraï
    Citation: BMC Cancer 2010 10:465
    Content type: Research article Published on:

  2. Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and ha...

    Authors: Joris D Veltman, Margaretha EH Lambers, Menno van Nimwegen, Rudi W Hendriks, Henk C Hoogsteden, Joachim GJV Aerts and Joost PJJ Hegmans
    Citation: BMC Cancer 2010 10:464
    Content type: Research article Published on:

  3. Giant cell tumour of bone (GCTB) is an expansile osteolytic tumour which contains numerous osteoclast-like giant cells. GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates a...

    Authors: Maurice Balke, Laura Campanacci, Carsten Gebert, Piero Picci, Max Gibbons, Richard Taylor, Pancras Hogendoorn, Judith Kroep, John Wass and Nicholas Athanasou
    Citation: BMC Cancer 2010 10:462
    Content type: Research article Published on:

  5. A major challenge in the interpretation of genomic profiling data generated from breast cancer samples is the identification of driver genes as distinct from bystander genes which do not impact tumorigenesis. ...

    Authors: Lesleyann Hawthorn, Jesse Luce, Leighton Stein and Jenniffer Rothschild
    Citation: BMC Cancer 2010 10:460
    Content type: Research article Published on:

  6. Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We aimed to determine whether inhibitors of differentiation 1 (Id1) were expressed in circulating EPCs of patients with ovarian ...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Jie Bao, Zhen Cai and Ailan Liu
    Citation: BMC Cancer 2010 10:459
    Content type: Research article Published on:

  7. Prognostic factors in patients who are diagnosed with T4 breast carcinomas are widely awaited. We here evaluated the clinical role of some molecular alterations involved in tumorigenesis in a well-characterize...

    Authors: Bruno Massidda, MariaCristina Sini, Mario Budroni, Francesco Atzori, MariaCristina Deidda, Valeria Pusceddu, MariaTeresa Perra, Paola Sirigu, Antonio Cossu, Grazia Palomba, MariaTeresa Ionta and Giuseppe Palmieri
    Citation: BMC Cancer 2010 10:458
    Content type: Research article Published on:

  8. Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma (HCC) in vitro and palliative efficacy in advanced HCC in two independent phase II trials. The aim of ...

    Authors: Matthias M Dollinger, Christine Lautenschlaeger, Joachim Lesske, Andrea Tannapfel, Anna-Dorothea Wagner, Konrad Schoppmeyer, Oliver Nehls, Martin-Walter Welker, Reiner Wiest and Wolfgang E Fleig
    Citation: BMC Cancer 2010 10:457
    Content type: Research article Published on:

  9. Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether si...

    Authors: Jie Liu, Bao Song, Xueli Bai, Wenjian Liu, Zengjun Li, Jialin Wang, Yan Zheng and Zhehai Wang
    Citation: BMC Cancer 2010 10:456
    Content type: Research article Published on:

  10. Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due thei...

    Authors: Henne Holstege, Erik van Beers, Arno Velds, Xiaoling Liu, Simon A Joosse, Sjoerd Klarenbeek, Eva Schut, Ron Kerkhoven, Christiaan N Klijn, Lodewyk FA Wessels, Petra M Nederlof and Jos Jonkers
    Citation: BMC Cancer 2010 10:455
    Content type: Research article Published on:

  11. Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biolo...

    Authors: Juan L Garcia, Maria Perez-Caro, Juan A Gomez-Moreta, Francisco Gonzalez, Javier Ortiz, Oscar Blanco, Magdalena Sancho, Jesus M Hernandez-Rivas, Rogelio Gonzalez-Sarmiento and Manuel Sanchez-Martin
    Citation: BMC Cancer 2010 10:454
    Content type: Research article Published on:

  12. Fatigue is prevalent in breast cancer survivors and has profound effects on daily life. The interference of fatigue with endocrine therapy may be difficult to separate. This study investigates the prevalence a...

    Authors: Xu Huang, Qingyuan Zhang, Xinmei Kang, Ying Song and Wenhui Zhao
    Citation: BMC Cancer 2010 10:453
    Content type: Research article Published on:

  13. Patterns of diagnosis and management for men diagnosed with prostate cancer in Queensland, Australia, have not yet been systematically documented and so assumptions of equity are untested. This longitudinal st...

    Authors: Peter D Baade, Joanne F Aitken, Megan Ferguson, Robert A Gardiner and Suzanne K Chambers
    Citation: BMC Cancer 2010 10:452
    Content type: Study protocol Published on:

  14. Platinum-based drugs, such as cisplatin and oxaliplatin, are well-known for inducing chronic sensory neuropathies but their acute and motor neurotoxicities are less well characterised. Use was made of nerve co...

    Authors: Andrew Hill, Peter Bergin, Fritha Hanning, Paul Thompson, Michael Findlay, Dragan Damianovich and Mark J McKeage
    Citation: BMC Cancer 2010 10:451
    Content type: Research article Published on:

  15. Desmoplasia in medulloblastoma is often diagnosed in adult patients and was repeatedly associated with improved results. Today, all medulloblastoma patients receive intensive multimodal treatment including sur...

    Authors: Stefan Rieken, Timo Gaiser, Angela Mohr, Thomas Welzel, Olaf Witt, Andreas E Kulozik, Wolfgang Wick, Jürgen Debus and Stephanie E Combs
    Citation: BMC Cancer 2010 10:450
    Content type: Research article Published on:

  16. Transformed phenotypes are common to cell lines derived from various cancers. Proteome profiling is a valuable tool that may reveal uncharacteristic cell phenotypes in transformed cells. Changes in expression ...

    Authors: Jana Mladkova, Miloslav Sanda, Eva Matouskova and Irena Selicharova
    Citation: BMC Cancer 2010 10:449
    Content type: Research article Published on:

  17. Studies about the biology, treatment pattern, and treatment outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few.

    Authors: Su-Jung Kim, Jin Won Kim, Sae-Won Han, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2010 10:448
    Content type: Research article Published on:

  18. Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized tha...

    Authors: Andreas Hadjisavvas, Maria A Loizidou, Nicos Middleton, Thalia Michael, Rena Papachristoforou, Eleni Kakouri, Maria Daniel, Panayiotis Papadopoulos, Simon Malas, Yiola Marcou and Kyriacos Kyriacou
    Citation: BMC Cancer 2010 10:447
    Content type: Research article Published on:

  19. Nasopharyngeal carcinoma (NPC) is rare in most parts of the world but is a common malignancy in southern China, especially in Guangdong. Dietary habit is regarded as an important modifier of NPC risk in severa...

    Authors: Wei-Hua Jia, Xiang-Yu Luo, Bing-Jian Feng, Hong-Lian Ruan, Jin-Xin Bei, Wen-Sheng Liu, Hai-De Qin, Qi-Sheng Feng, Li-Zhen Chen, Shugart Yin Yao and Yi-Xin Zeng
    Citation: BMC Cancer 2010 10:446
    Content type: Research article Published on:

  20. Resveratrol (RES), a natural phytoalexin found at high levels in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. However, the underlying molecular mec...

    Authors: Ying Yan, Yan-Yan Gao, Bao-Qin Liu, Xiao-Fang Niu, Ying Zhuang and Hua-Qin Wang
    Citation: BMC Cancer 2010 10:445
    Content type: Research article Published on:

  21. Tumour phenotype is regulated in a complex fashion as a result of interactions between malignant cells and the tumour stroma. Fibroblasts are the most abundant and perhaps most active part of the tumour stroma...

    Authors: Charlotta J Olsen, José Moreira, Eugene M Lukanidin and Noona S Ambartsumian
    Citation: BMC Cancer 2010 10:444
    Content type: Research article Published on:

  22. In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mec...

    Authors: Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa and Akio Yamaguchi
    Citation: BMC Cancer 2010 10:443
    Content type: Research article Published on:

  23. Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity...

    Authors: Nikolaos Stefanou, Vassilis Papanikolaou, Yoichi Furukawa, Yusuke Nakamura and Aspasia Tsezou
    Citation: BMC Cancer 2010 10:442
    Content type: Research article Published on:

  24. Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-diflu...

    Authors: An Wouters, Bea Pauwels, Filip Lardon, Greet GO Pattyn, Hilde AJ Lambrechts, Marc Baay, Paul Meijnders and Jan B Vermorken
    Citation: BMC Cancer 2010 10:441
    Content type: Research article Published on:

  25. Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical tri...

    Authors: Jan N Kreutzer, Maria Ruzzene and Barbara Guerra
    Citation: BMC Cancer 2010 10:440
    Content type: Research article Published on:

  26. DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs either as a byproduct of oxidative metabolism or as a ...

    Authors: Randa A El-Zein, Claudia M Monroy, Andrea Cortes, Margaret R Spitz, Anthony Greisinger and Carol J Etzel
    Citation: BMC Cancer 2010 10:439
    Content type: Research article Published on:

  27. Imatinib mesylate has been used for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST). The current recommended dose of imatinib is 400 mg/day that is increased to 800 mg/day in...

    Authors: Jun-Eul Hwang, Ju-Young Yoon, Woo-Kyun Bae, Hyun-Jeong Shim, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2010 10:438
    Content type: Case report Published on:

  28. Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment in many cancer types. However, the significance of NF-κB pathway for compl...

    Authors: Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang and Wan-tao Chen
    Citation: BMC Cancer 2010 10:437
    Content type: Research article Published on:

  30. We investigated the distribution and clinical significance of mobilized endothelial progenitor cells (EPCs) in hepatocellular carcinoma (HCC). We found that many more EPCs were recruited to nonmalignant liver ...

    Authors: De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang and Yi-tao Ding
    Citation: BMC Cancer 2010 10:435
    Content type: Research article Published on:

  31. Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors,...

    Authors: Georgios Boukakis, Meropi Patrinou-Georgoula, Maria Lekarakou, Christos Valavanis and Apostolia Guialis
    Citation: BMC Cancer 2010 10:434
    Content type: Research article Published on:

  32. Increased concentrations of choline-containing compounds are frequently observed in breast carcinomas, and may serve as biomarkers for both diagnostic and treatment monitoring purposes. However, underlying mec...

    Authors: Siver A Moestue, Eldrid Borgan, Else M Huuse, Evita M Lindholm, Beathe Sitter, Anne-Lise Børresen-Dale, Olav Engebraaten, Gunhild M Mælandsmo and Ingrid S Gribbestad
    Citation: BMC Cancer 2010 10:433
    Content type: Research article Published on:

  33. Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which...

    Authors: Frank A Policht, Minghao Song, Svetlana Sitailo, Anna O'Hare, Raheela Ashfaq, Carolyn Y Muller, Larry E Morrison, Walter King and Irina A Sokolova
    Citation: BMC Cancer 2010 10:432
    Content type: Research article Published on:

  34. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally...

    Authors: Xiaoxiang Guan, Ming Yin, Qingyi Wei, Hui Zhao, Zhensheng Liu, Li-E Wang, Xianglin Yuan, Michael S O'Reilly, Ritsuko Komaki and Zhongxing Liao
    Citation: BMC Cancer 2010 10:431
    Content type: Research article Published on:

  35. The integration of the non-cross-resistant chemotherapeutic agents capecitabine and vinorelbine into an intensified dose-dense sequential anthracycline- and taxane-containing regimen in high-risk early breast ...

    Authors: Volkmar Müller, Christoph Thomssen, Marcus Schmidt, Manfred Glados, Christian Jackisch, Volker Heilmann, Axel Hinke, Antje Lehnert, Henryk Borowicz and Volker Möbus
    Citation: BMC Cancer 2010 10:430
    Content type: Research article Published on:

  37. The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play an important role in carcinogenesis and cancer metastasis, yet its role in the developmen...

    Authors: Ke Liu, Gefang Wang, Houzhong Ding, Ying Chen, Guanzhen Yu and Jiejun Wang
    Citation: BMC Cancer 2010 10:428
    Content type: Research article Published on:

  38. Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibrobl...

    Authors: Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael Jones, Angela Norton, Alicia Gómez-Yafal, Michael W Heartlein, Michael F Concino, Lucy Liaw and Paolo GV Martini
    Citation: BMC Cancer 2010 10:427
    Content type: Research article Published on:

  39. We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes betwee...

    Authors: Xinglai Ji, Jie Tang, Richard Halberg, Dana Busam, Steve Ferriera, Maria Marjorette O Peña, Chinnambally Venkataramu, Timothy J Yeatman and Shaying Zhao
    Citation: BMC Cancer 2010 10:426
    Content type: Research article Published on:

  40. As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membr...

    Authors: Jung-Young Shin, Jeong-Oh Kim, Suk Kyeong Lee, Hiun-Suk Chae and Jin-Hyoung Kang
    Citation: BMC Cancer 2010 10:425
    Content type: Research article Published on:

  41. Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to inves...

    Authors: Doo-Sik Kong, Sung Tae Kim, Jung-Il Lee, Yeon-Lim Suh, Do Hoon Lim, Won Seog Kim, Ki-Hoon Kwon, Kwan Park, Jong Hyun Kim and Do-Hyun Nam
    Citation: BMC Cancer 2010 10:424
    Content type: Research article Published on:

  42. Skeletal metastases are often accompanied by bone pain. To investigate the clinical meaning of bone pain associated with skeletal metastasis in breast cancer patients after surgery, we explored whether the pre...

    Authors: Mitsuru Koizumi, Masataka Yoshimoto, Fujio Kasumi, Takuji Iwase and Etsuro Ogata
    Citation: BMC Cancer 2010 10:423
    Content type: Research article Published on:

  43. Cigarette smoking is the most established risk factor, and genetic variants and/or gene promoter methylations are also considered to play an essential role in development of lung cancer, but the pathogenesis o...

    Authors: Yongtang Jin, Heyun Xu, Chunye zhang, Yunming Kong, Yong Hou, Yingchun Xu and Shaoli Xue
    Citation: BMC Cancer 2010 10:422
    Content type: Research article Published on:

  44. Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic disea...

    Authors: Hezhi Fang, Lijun Shen, Tao Chen, Jing He, Zhinan Ding, Jia Wei, Jianchun Qu, Guorong Chen, Jianxin Lu and Yidong Bai
    Citation: BMC Cancer 2010 10:421
    Content type: Research article Published on:

  45. CYP1B1 is a P450 enzyme which is involved in the activation of pro-carcinogens to carcinogens as well as sex hormone metabolism. Because differences in the activity of the enzyme have been correlated with vari...

    Authors: Joanna Trubicka, Ewa Grabowska-KÅ‚ujszo, Janina Suchy, BartÅ‚omiej Masojć, Pablo Serrano-Fernandez, Grzegorz Kurzawski, Cezary Cybulski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Elżbieta ZÅ‚owocka, Józef KÅ‚adny, Zbigniew Banaszkiewicz, RafaÅ‚ WiÅ›niowski, Elżbieta Kowalska…
    Citation: BMC Cancer 2010 10:420
    Content type: Research article Published on:

  46. H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there i...

    Authors: Chenghai Zhao, Xiaomei Lu, Xianmin Bu, Ning Zhang and Wei Wang
    Citation: BMC Cancer 2010 10:419
    Content type: Research article Published on:

  47. Prostate cancer is a leading cause of cancer-related death in men worldwide. Survivin is a member of the inhibitor of apoptosis (IAP) protein family that is expressed in the majority of human tumors including ...

    Authors: Xichun Liu, Ruijuan Gao, Yan Dong, Lifang Gao, Yanying Zhao, Lijuan Zhao, Xuejian Zhao and Haitao Zhang
    Citation: BMC Cancer 2010 10:418
    Content type: Research article Published on:

  48. Lymphatic vessel spread is considered a major route for head and neck squamous cell carcinoma metastasis. Formation of new lymphatic vessels could facilitate the process, raising the malignant potential of the...

    Authors: Darío Garcia-Carracedo, Juan Pablo Rodrigo, Aurora Astudillo, Carlos Suarez Nieto and Maria Victoria Gonzalez
    Citation: BMC Cancer 2010 10:416
    Content type: Research article Published on:

  49. Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the dir...

    Authors: Chao Wang, Shouqiang Cao, Ying Yan, Qiao Ying, Tao Jiang, Ke Xu and Anhua Wu
    Citation: BMC Cancer 2010 10:415
    Content type: Research article Published on:

  50. In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype. However, the MCF-7 cell line, which has a luminal ep...

    Authors: Masahiro Uchino, Hiroko Kojima, Kenta Wada, Mika Imada, Fumitoshi Onoda, Hiroyuki Satofuka, Takahiko Utsugi and Yasufumi Murakami
    Citation: BMC Cancer 2010 10:414
    Content type: Research article Published on:

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