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  1. Inflammation is commonly associated with lung tumors. Since inflammatory mediators, including members of the interleukin-6 (IL-6) cytokine family, suppress proliferation of normal epithelial cells, we hypothes...

    Authors: Gregory M Loewen, Erin Tracy, Frédéric Blanchard, Dongfeng Tan, Jihnhee Yu, Sameera Raza, Sei-Ichi Matsui and Heinz Baumann
    Citation: BMC Cancer 2005 5:145
  2. Although bone marrow metastases can be found commonly in some malignant tumors, diagnosing a nonhematologic malignancy from marrow is not a usual event.

    Authors: Fahir Ozkalemkas, Rıdvan Ali, Vildan Ozkocaman, Tulay Ozcelik, Ulku Ozan, Hulya Ozturk, Ender Kurt, Turkkan Evrensel, Omer Yerci and Ahmet Tunali
    Citation: BMC Cancer 2005 5:144
  3. Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate in utero exposure to pregnancy hormones in the offspring. To evaluate the association between paternal a...

    Authors: Ji-Yeob Choi, Kyoung-Mu Lee, Sue Kyung Park, Dong-Young Noh, Sei-Hyun Ahn, Keun-Young Yoo and Daehee Kang
    Citation: BMC Cancer 2005 5:143
  4. Fibrolamellar Carcinoma (FLC), a subtype of hepatocellular carcinoma (HCC), is a rare primary hepatic malignancy. Several aspects of the clinic features and epidemiology of FLC remain unclear because most of t...

    Authors: Laura E Moreno-Luna, Oscar Arrieta, Jorge García-Leiva, Braulio Martínez, Aldo Torre, Misael Uribe and Eucario León-Rodríguez
    Citation: BMC Cancer 2005 5:142
  5. Cigarette smoking is the primary cause of bronchogenic carcinoma (BC), yet only 10–15% of heavy smokers develop BC and it is likely that this variation in risk is, in part, genetically determined. We previousl...

    Authors: D'Anna N Mullins, Erin L Crawford, Sadik A Khuder, Dawn-Alita Hernandez, Youngsook Yoon and James C Willey
    Citation: BMC Cancer 2005 5:141
  6. The retinoic acid receptor beta 2 (RARβ2) gene modulates proliferation and survival of cultured human breast cancer cells. Previously we showed that ectopic expression of RARβ2 in a mouse xenograft model preve...

    Authors: Brett Wallden, Mary Emond, Mari E Swift, Mary L Disis and Karen Swisshelm
    Citation: BMC Cancer 2005 5:140
  7. The involvement of Heat Shock Proteins (HSP) in cancer development and progression is a widely debated topic. The objective of the present study was to evaluate the presence and expression of HSP60 and HSP10 i...

    Authors: Francesco Cappello, Sabrina David, Francesca Rappa, Fabio Bucchieri, Lorenzo Marasà, Tommaso E Bartolotta, Felicia Farina and Giovanni Zummo
    Citation: BMC Cancer 2005 5:139
  8. The burden of cancer metastases within an individual is commonly used to clinically characterize a tumor's biological behavior. Assessments like these implicitly assume that spurious effects can be discounted....

    Authors: Wayne S Kendal
    Citation: BMC Cancer 2005 5:138
  9. Inflammatory breast cancer (IBC) had been perceived to have a poor prognosis. Oncologists were not enthusiastic in the past to give aggressive treatment. Single institution studies tend to have small patient n...

    Authors: Patricia Tai, Edward Yu, Ross Shiels, Juan Pacella, Kurian Jones, Evgeny Sadikov and Shazia Mahmood
    Citation: BMC Cancer 2005 5:137
  10. UV-induced damage can induce apoptosis or trigger DNA repair mechanisms. Minor DNA damage is thought to halt the cell cycle to allow effective repair, while more severe damage can induce an apoptotic program. ...

    Authors: Hsin-Lung Lo, Satoshi Nakajima, Lisa Ma, Barbara Walter, Akira Yasui, Douglas W Ethell and Laurie B Owen
    Citation: BMC Cancer 2005 5:135
  11. Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations ...

    Authors: Pedro Kringen, Yun Wang, Vanessa Dumeaux, Jahn M Nesland, Gunnar Kristensen, Anne-Lise Borresen-Dale and Anne Dorum
    Citation: BMC Cancer 2005 5:134
  12. Transthyretin (TTR), a traditional biomarker for nutritional and inflammatory status exists in different molecular variants of yet unknown importance. A truncated form of TTR has recently been described to be ...

    Authors: Beate Gericke, Jens Raila, Jalid Sehouli, Sophie Haebel, Dominique Könsgen, Alexander Mustea and Florian J Schweigert
    Citation: BMC Cancer 2005 5:133
  13. To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy.

    Authors: L Lim, P Gibbs, D Yip, JD Shapiro, R Dowling, D Smith, A Little, W Bailey and M Liechtenstein
    Citation: BMC Cancer 2005 5:132
  14. Pancreatic cancer is the fourth commonest cause of death from cancer in men and women. Advantages in surgical techniques, radiation therapy techniques, chemotherapeutic regimes, and different combined-modality...

    Authors: R Krempien, MW Muenter, PE Huber, S Nill, H Friess, C Timke, B Didinger, P Buechler, S Heeger, KK Herfarth, A Abdollahi, MW Buchler and J Debus
    Citation: BMC Cancer 2005 5:131
  15. Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and its expression has been correlated with increased tumour angiogenesis. Although numerous publications dealing with the m...

    Authors: Ratchada Cressey, Onusa Wattananupong, Nirush Lertprasertsuke and Usanee Vinitketkumnuen
    Citation: BMC Cancer 2005 5:128
  16. Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer. We performed this st...

    Authors: Myung Ah Lee, Gyeong-sin Park, Hee-Jung Lee, Ji-Han Jung, Jin-Hyoung Kang, Young Seon Hong, Kyung Shik Lee, Dong-gu Kim and Seung-Nam Kim
    Citation: BMC Cancer 2005 5:127
  17. The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in l...

    Authors: Peter Calabrese, Jukka-Pekka Mecklin, Heikki J Järvinen, Lauri A Aaltonen, Simon Tavaré and Darryl Shibata
    Citation: BMC Cancer 2005 5:126
  18. The transcription factor activator protein-1 (AP-1) has been implicated in a large variety of biological processes including oncogenic transformation. The tyrosine kinases of the epidermal growth factor recept...

    Authors: Michael O'Grady, Debasish Raha, Bonnie J Hanson, Michaeline Bunting and George T Hanson
    Citation: BMC Cancer 2005 5:125
  19. Osteosarcoma is the most common type of primary bone tumor. The use of aggressive chemotherapy has drastically improved the prognosis of the patients with non-metastatic osteosarcomas, however the prognosis of...

    Authors: S Théoleyre, K Mori, B Cherrier, N Passuti, F Gouin, F Rédini and D Heymann
    Citation: BMC Cancer 2005 5:123
  20. Presently available flow cytometric methods of bromodeoxyuridine (BrdUrd) labelling do not provide information on the cell cycle time (TC) and the growth fraction (GF). In this paper, we describe a novel and simp...

    Authors: Rimantas Eidukevicius, Dainius Characiejus, Ramunas Janavicius, Nijole Kazlauskaite, Vita Pasukoniene, Mykolas Mauricas and Willem Den Otter
    Citation: BMC Cancer 2005 5:122

    The Erratum to this article has been published in BMC Cancer 2006 6:184

  21. The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral f...

    Authors: Michael Samoszuk, Emi Kanakubo and John K Chan
    Citation: BMC Cancer 2005 5:121
  22. PKH67 labelling was compared for classical proliferation assessment (using S phase evaluation) to analyse the cell proliferation of 29 AML patients treated or not with various drugs. Among these drugs, the eff...

    Authors: Jean Boutonnat, Anne-Marie Faussat, Jean-Pierre Marie, Jérôme Bignon, Johanna Wdzieczak-Bakala, Magali Barbier, Josiane Thierry, Xavier Ronot and Pierre-Emmanuel Colle
    Citation: BMC Cancer 2005 5:120
  23. The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported.

    Authors: Yen-Ching Lee, Janeanne R Perren, Evelyn L Douglas, Michael P Raynor, Maria A Bartley, Peter G Bardy and Sally-Anne Stephenson
    Citation: BMC Cancer 2005 5:119
  24. Most cervical cancer patients with pelvic recurrent or persistent disease are not candidates for exenteration, therefore, they only receive palliative chemotherapy. Here we report the results of a novel treatm...

    Authors: Carlos Lopez-Graniel, Rigoberto Dolores, Lucely Cetina, Aaron Gonzalez, David Cantu, Jose Chanona, Jesus Uribe, Myrna Candelaria, Rocio Brom, Jaime de la Garza and Alfonso Duenas-Gonzalez
    Citation: BMC Cancer 2005 5:118
  25. The oral cavity is a rare but occasional target for metastases, which may masquerade as various benign and inflammatory lesions, and sometimes also be asymptomatic. Oral metastatic lesions have been described ...

    Authors: Piergiuseppe Colombo, Luca Tondulli, Giovanna Masci, Andrea Muzza, Lorenza Rimassa, Duccio Petrella and Armando Santoro
    Citation: BMC Cancer 2005 5:117
  26. New chemotherapy regimens for patients with colorectal cancer have improved survival, but at the cost of clinical toxicity. Oxaliplatin, an agent used in first-line therapy for metastatic colorectal cancer, ca...

    Authors: Gregory D Leonard, Maurice A Wright, Mary G Quinn, Suzanne Fioravanti, Nancy Harold, Barbara Schuler, Rebecca R Thomas and Jean L Grem
    Citation: BMC Cancer 2005 5:116
  27. Bleomycin is poorly permeant but potent cytotoxic and radiosensitizing drug. The aim of the study was to evaluate whether a physical drug delivery system – electroporation can increase radiosensitising effect ...

    Authors: Simona Kranjc, Maja Cemazar, Alenka Grosel, Marjeta Sentjurc and Gregor Sersa
    Citation: BMC Cancer 2005 5:115
  28. P-glycoprotein is responsible for the ATP-dependent export of certain structurally unrelated compounds including many chemotherapeutic drugs. Amplification of P-glycoprotein activity can result in multi-drug r...

    Authors: Mirela R Fekete, William H McBride and Frank Pajonk
    Citation: BMC Cancer 2005 5:114
  29. The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct evidence for an involvement of eEF1A2...

    Authors: Victoria AL Tomlinson, Helen J Newbery, Naomi R Wray, Juliette Jackson, Alexey Larionov, William R Miller, J Michael Dixon and Catherine M Abbott
    Citation: BMC Cancer 2005 5:113
  30. Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran.

    Authors: Mahboobeh Mahdavinia, Faraz Bishehsari, Reza Ansari, Nasim Norouzbeigi, Ahmad Khaleghinejad, Mahshid Hormazdi, Naser Rakhshani and Reza Malekzadeh
    Citation: BMC Cancer 2005 5:112
  31. The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer.

    Authors: Maria Rosaria Cardillo, Vincenzo Gentile, Mauro Ciccariello, Laura Giacomelli, Silvio Messinetti and Franco Di Silverio
    Citation: BMC Cancer 2005 5:111
  32. Cancer serum protein profiling by mass spectrometry has uncovered mass profiles that are potentially diagnostic for several common types of cancer. However, direct mass spectrometric profiling has a limited dy...

    Authors: Wei-Min Gao, Rork Kuick, Randal P Orchekowski, David E Misek, Ji Qiu, Alissa K Greenberg, William N Rom, Dean E Brenner, Gilbert S Omenn, Brian B Haab and Samir M Hanash
    Citation: BMC Cancer 2005 5:110
  33. Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been r...

    Authors: Alberto Zambelli, Daniele Lilleri, Fausto Baldanti, Mario Scelsi, Laura Villani and Gian Antonio Da Prada
    Citation: BMC Cancer 2005 5:109
  34. The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated...

    Authors: Ashokkumar A Patel, André Kajdacsy-Balla, Jules J Berman, Maarten Bosland, Milton W Datta, Rajiv Dhir, John Gilbertson, Jonathan Melamed, Jan Orenstein, Kuei-Fang Tai and Michael J Becich
    Citation: BMC Cancer 2005 5:108
  35. Chronic lymphocytic leukemia (CLL) is a monoclonal disorder, characterized by a progressive proliferation of functionally incompetent B lymphocytes. There is increased evidence of association between CLL and s...

    Authors: KI Papageorgiou and MG Kaniorou-Larai
    Citation: BMC Cancer 2005 5:106
  36. A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro. In B-type chronic lymphocytic leu...

    Authors: Isrid Sturm, Andrew G Bosanquet, Michael Hummel, Bernd Dörken and Peter T Daniel
    Citation: BMC Cancer 2005 5:105
  37. Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human brea...

    Authors: Howard K Plummer III, Madhu S Dhar, Maria Cekanova and Hildegard M Schuller
    Citation: BMC Cancer 2005 5:104
  38. Despite exciting new targeted therapeutics against non-Hodgkin's lymphoma (NHL), chemotherapy remains a cornerstone of therapy. While purine nucleoside analogs have significant activity in low grade NHL, the p...

    Authors: Mitchell R Smith, Indira Joshi, Fang Jin and Coleman Obasaju
    Citation: BMC Cancer 2005 5:103
  39. The mechanisms of chemoresistance in ovarian cancer patients remain largely to be elucidated. Paclitaxel/cisplatin combination is the standard chemotherapeutic treatment for this disease, although some patient...

    Authors: Bárbara Mesquita, Isabel Veiga, Deolinda Pereira, Ana Tavares, Isabel M Pinto, Carla Pinto, Manuel R Teixeira and Sérgio Castedo
    Citation: BMC Cancer 2005 5:101
  40. The purpose of our study was to investigate the immunohistochemical expression of TGF-β1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We...

    Authors: Nil Culhaci, Ozgul Sagol, Sedat Karademir, Huseyin Astarcioglu, Ibrahim Astarcioglu, Mujde Soyturk, Ilhan Oztop and Funda Obuz
    Citation: BMC Cancer 2005 5:98

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