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  1. The phase 3 RECORD-1 trial (NCT00410124) established the efficacy and safety of everolimus in patients with metastatic renal cell carcinoma (mRCC) who progress on sunitinib or sorafenib. In RECORD-1, patients ...

    Authors: Andrew Stein, Wenping Wang, Alison A Carter, Ovidiu Chiparus, Norbert Hollaender, Hyewon Kim, Robert J Motzer and Celine Sarr
    Citation: BMC Cancer 2012 12:311
    Content type: Research article Published on:

  2. Renal cell carcinoma (RCC) is characterized by a number of diverse molecular aberrations that differ among individuals. Recent approaches to molecularly classify RCC were based on clinical, pathological as wel...

    Authors: Manfred Beleut, Philip Zimmermann, Michael Baudis, Nicole Bruni, Peter Bühlmann, Oliver Laule, Van-Duc Luu, Wilhelm Gruissem, Peter Schraml and Holger Moch
    Citation: BMC Cancer 2012 12:310
    Content type: Research article Published on:

  3. Tumor formation is a complex process which involves constitutive activation of oncogenes and suppression of tumor suppressor genes. Receptor EphA2 and its ligand ephrin-A1 form an important cell communication ...

    Authors: Bhagyalaxmi Sukka-Ganesh, Kamal A Mohammed, Frederic Kaye, Eugene P Goldberg and Najmunnisa Nasreen
    Citation: BMC Cancer 2012 12:309
    Content type: Research article Published on:

  4. The advanced phases of chronic myeloid leukemia (CML) are known to be more resistant to therapy. This resistance has been associated with the overexpression of ABCB1, which gives rise to the multidrug resistance ...

    Authors: Stephany Corrêa, Renata Binato, Bárbara Du Rocher, Morgana TL Castelo-Branco, Luciana Pizzatti and Eliana Abdelhay
    Citation: BMC Cancer 2012 12:303
    Content type: Research article Published on:

  6. The median age of newly diagnosed patients with non-small cell lung cancer (NSCLC) is 67 years, and one-third of patients are older than 75 years. Elderly patients are more vulnerable to the adverse effects of...

    Authors: Chouaid Christos, Le Caer Hervé, Locher Chrystelle, Dujon Cecile, Thomas Pascal, Auliac Jean Bernard, Monnet Isabelle and Vergnenegre Alain
    Citation: BMC Cancer 2012 12:301
    Content type: Research article Published on:

  7. Little is known about the supportive care needs of Indigenous people with cancer and to date, existing needs assessment tools have not considered cultural issues for this population. We aimed to adapt an exist...

    Authors: Gail Garvey, Vanessa L Beesley, Monika Janda, Catherine Jacka, Adèle C Green, Peter O’Rourke and Patricia C Valery
    Citation: BMC Cancer 2012 12:300
    Content type: Research article Published on:

  8. Evaluating the cost-effectiveness of breast cancer screening requires estimates of the absolute risk of breast cancer, which is modified by various risk factors. Breast cancer incidence, and thus mortality, is...

    Authors: Sharareh Taghipour, Dragan Banjevic, Joanne Fernandes, Anthony B Miller, Neil Montgomery, Andrew K S Jardine and Bart J Harvey
    Citation: BMC Cancer 2012 12:299
    Content type: Research article Published on:

  9. Inflammatory breast cancer (IBC) is a highly angiogenic disease; thus, antiangiogenic therapy should result in a clinical response. However, clinical trials have demonstrated only modest responses, and the rea...

    Authors: Hugo Arias-Pulido, Nabila Chaher, Yun Gong, Clifford Qualls, Jake Vargas and Melanie Royce
    Citation: BMC Cancer 2012 12:298
    Content type: Research article Published on:

  10. Colorectal cancer (CRC) care has improved considerably, particularly since the implementation of a quality of care program centered on national evidence-based guidelines. Formal quality assessment is however s...

    Authors: Simone Mathoulin-Pélissier, Yves Bécouarn, Geneviève Belleannée, Elodie Pinon, Anne Jaffré, Gaëlle Coureau, Dominique Auby, Jean-Louis Renaud-Salis and Eric Rullier
    Citation: BMC Cancer 2012 12:297
    Content type: Research article Published on:

  11. Erlotinib and pemetrexed have been approved for the second-line treatment of non-small cell lung cancer (NSCLC). These two agents have different mechanisms of action. Combined treatment with erlotinib and peme...

    Authors: Seigo Minami, Takashi Kijima, Ryo Takahashi, Hiroshi Kida, Takeshi Nakatani, Masanari Hamaguchi, Yoshiko Takeuchi, Izumi Nagatomo, Suguru Yamamoto, Isao Tachibana, Kiyoshi Komuta and Ichiro Kawase
    Citation: BMC Cancer 2012 12:296
    Content type: Research article Published on:

  12. To evaluate the use of intraoperative radiation therapy (IORT) in the multimodality treatment of patients with isolated local recurrences of pancreatic cancer.

    Authors: Falk Roeder, Carmen Timke, Matthias Uhl, Gregor Habl, Frank W Hensley, Markus W Buechler, Robert Krempien, Peter E Huber, Juergen Debus and Jens Werner
    Citation: BMC Cancer 2012 12:295
    Content type: Research article Published on:

  14. Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypo...

    Authors: Sreenivasulu Chintala, Tanbir Najrana, Karoly Toth, Shousong Cao, Farukh A Durrani, Roberto Pili and Youcef M Rustum
    Citation: BMC Cancer 2012 12:293
    Content type: Research article Published on:

  15. KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor (EGFR) antibodies in metastatic colorectal cancer (mCRC). Novel predictive markers are required to further i...

    Authors: Leonie JM Mekenkamp, Jolien Tol, Jeroen R Dijkstra, Inge de Krijger, M Elisa Vink-Börger, Shannon van Vliet, Steven Teerenstra, Eveline Kamping, Eugène Verwiel, Miriam Koopman, Gerrit A Meijer, J Han JM van Krieken, Roland Kuiper, Cornelis JA Punt and Iris D Nagtegaal
    Citation: BMC Cancer 2012 12:292
    Content type: Research article Published on:

  16. Ligand-dependent activation of the estrogen receptor (ER) as well as of the insulin-like growth factor type 1 (IGF1R) induces the proliferation of luminal breast cancer cells. These two pathways cooperate and ...

    Authors: Anne-Marie Gaben, Michèle Sabbah, Gérard Redeuilh, Monique Bedin and Jan Mester
    Citation: BMC Cancer 2012 12:291
    Content type: Research article Published on:

  17. ZIC1, a vital transcription factor with zinc finger domains, has been implicated in the process of neural development. We previously showed that ZIC1 may function as a tumour suppressor in gastrointestinal can...

    Authors: Jing Zhong, Shujie Chen, Meng Xue, Qin Du, Jianting Cai, Hongchuan Jin, Jianmin Si and Liangjing Wang
    Citation: BMC Cancer 2012 12:290
    Content type: Research article Published on:

  18. Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-a...

    Authors: Yanming Zhou, Yanfang Zhao, Bin Li, Jiyi Huang, Lupeng Wu, Donghui Xu, Jiamei Yang and Jia He
    Citation: BMC Cancer 2012 12:289
    Content type: Research article Published on:

  19. Chemotherapy is the mainstay of non-Hodgkin lymphoma (NHL) treatment. Based on expert opinion, the use of radiotherapy (RT) is currently preferred in some institutions as consolidative treatment for patients w...

    Authors: Lucas Vieira dos Santos, JoãoPaulodaSilveiraNogueira Lima, Carmens Sílvia Passos Lima, Emma Chen Sasse and André Deeke Sasse
    Citation: BMC Cancer 2012 12:288
    Content type: Research article Published on:

  20. Local control rates in patients with retroperitoneal soft tissue sarcoma (RSTS) remain disappointing even after gross total resection, mainly because wide margins are not achievable in the majority of patients...

    Authors: Falk Roeder, Daniela Schulz-Ertner, Anna V Nikoghosyan, Peter E Huber, Lutz Edler, Gregor Habl, Robert Krempien, Susanne Oertel, Ladan Saleh-Ebrahimi, Frank W Hensley, Markus W Buechler, Juergen Debus, Moritz Koch, Juergen Weitz and Marc Bischof
    Citation: BMC Cancer 2012 12:287
    Content type: Study protocol Published on:

  21. The BH3-only members of the Bcl-2 protein family have been proposed to play a key role in the control of apoptosis and in the initiation of the apoptotic pathways. In this study, we evaluated the expression of...

    Authors: Jun Sakakibara-Konishi, Satoshi Oizumi, Junko Kikuchi, Eiki Kikuchi, Hidenori Mizugaki, Ichiro Kinoshita, Hirotoshi Dosaka-Akita and Masaharu Nishimura
    Citation: BMC Cancer 2012 12:286
    Content type: Research article Published on:

  22. Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in ne...

    Authors: Fieke Lamers, Linda Schild, Jan Koster, Frank Speleman, Ingrid Øra, Ellen M Westerhout, Peter van Sluis, Rogier Versteeg, Huib N Caron and Jan J Molenaar
    Citation: BMC Cancer 2012 12:285
    Content type: Research article Published on:

  23. Cell lines represent a key tool in cancer research allowing the generation of neoplasias which resemble initial tumours in in-vivo animal models. The characterisation of early tumour development is of major inter...

    Authors: Katharina A Sterenczak, Martin Meier, Silke Glage, Matthias Meyer, Saskia Willenbrock, Patrick Wefstaedt, Martina Dorsch, Jörn Bullerdiek, Hugo Murua Escobar, Hans Hedrich and Ingo Nolte
    Citation: BMC Cancer 2012 12:284
    Content type: Research article Published on:

  24. Recently published results of quality of life (QoL) studies indicated different outcomes of palliative radiotherapy for brain metastases. This prospective multi-center QoL study of patients with brain metastas...

    Authors: Diana Steinmann, Yvonne Paelecke-Habermann, Hans Geinitz, Raimund Aschoff, Anja Bayerl, Tobias Bölling, Elisabeth Bosch, Frank Bruns, Ute Eichenseder-Seiss, Johanna Gerstein, Nadine Gharbi, Juliane Hagg, Matthias Hipp, Irmgard Kleff, Axel Müller, Christof Schäfer…
    Citation: BMC Cancer 2012 12:283
    Content type: Research article Published on:

  25. Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. We recently demonstrate...

    Authors: Anna Larsson, Marie Fridberg, Alexander Gaber, Björn Nodin, Per Levéen, Göran Jönsson, Mathias Uhlén, Helgi Birgisson and Karin Jirström
    Citation: BMC Cancer 2012 12:282
    Content type: Research article Published on:

  26. Adjuvant chemotherapy for stage III colon cancer is internationally accepted as standard treatment with established efficacy, but the usefulness of adjuvant chemotherapy for stage II colon cancer remains contr...

    Authors: Megumi Ishiguro, Hidetaka Mochizuki, Naohiro Tomita, Yasuhiro Shimada, Keiichi Takahashi, Kenjiro Kotake, Masahiko Watanabe, Yukihide Kanemitsu, Hideki Ueno, Toshiaki Ishikawa, Hiroyuki Uetake, Shigeyuki Matsui, Satoshi Teramukai and Kenichi Sugihara
    Citation: BMC Cancer 2012 12:281
    Content type: Study protocol Published on:

  27. Fatty acid synthase (FASN) is overexpressed and hyperactivated in several human carcinomas, including lung cancer. We characterize and compare the anti-cancer effects of the FASN inhibitors C75 and (−)-epigall...

    Authors: Joana Relat, Adriana Blancafort, Glòria Oliveras, Sílvia Cufí, Diego Haro, Pedro F Marrero and Teresa Puig
    Citation: BMC Cancer 2012 12:280
    Content type: Research article Published on:

  28. With the growing recognition that patients and partners react to a cancer diagnosis as an interdependent system and increasing evidence that psychosocial interventions can be beneficial to both patients and pa...

    Authors: Tim W Regan, Sylvie D Lambert, Afaf Girgis, Brian Kelly, Karen Kayser and Jane Turner
    Citation: BMC Cancer 2012 12:279
    Content type: Research article Published on:

  30. Transglutaminase 2 (TG2) and its phosphorylation have been consistently found to be upregulated in a number of cancer cell types. At the molecular level, TG2 has been associated with the activation of nuclear ...

    Authors: Yi Wang, Sudharsana R Ande and Suresh Mishra
    Citation: BMC Cancer 2012 12:277
    Content type: Research article Published on:

  31. Endogenous estrogens may play a vital role in colorectal tumorigenesis. Estrogen receptor beta is the predominant subtype which mediates the biological effect of estrogens, while loss of expression of estrogen...

    Authors: Huanlei Wu, Li Xu, Jigui Chen, Junbo Hu, Shiying Yu, Guangyuan Hu, Liu Huang, Xiaoping Chen, Xianglin Yuan and Guojun Li
    Citation: BMC Cancer 2012 12:276
    Content type: Research article Published on:

  33. A candidate oncogene GIG47, previously known as a neudesin with a neurotrophic activity, was identified by applying the differential expression analysis method.

    Authors: Kyou-Hoon Han, Si-Hyung Lee, Seon-Ah Ha, Hyun Kee Kim, CheWook Lee, Do-Hyoung Kim, Kee Hwan Gong, JinAh Yoo, Sanghee Kim and Jin Woo Kim
    Citation: BMC Cancer 2012 12:274
    Content type: Research article Published on:

  34. Lung cancer is one of the most lethal malignancies worldwide, but useful biomarkers of lung cancer are still insufficient. The aim of this study is to identify some membrane-bound protein(s) associated with mi...

    Authors: Wen-Liang Chen, Kuang-Tai Kuo, Teh-Ying Chou, Chien-Lung Chen, Chih-Hao Wang, Yau-Huei Wei and Liang-Shun Wang
    Citation: BMC Cancer 2012 12:273
    Content type: Research article Published on:

  35. Argonaute genes are essential for RNA interference, stem cell maintenance and differentiation. The Piwi-like genes, a subclass of the Argonaute genes, are expressed mainly in the germline. These genes may be re-e...

    Authors: Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Steffen Göbel, Hans-Jürgen Holzhausen, Sven Wach, Peter Würl and Helge Taubert
    Citation: BMC Cancer 2012 12:272
    Content type: Research article Published on:

  36. The aim was to compare two standard chemotherapy regimens combined with bevacizumab as first-line treatment in patients with metastatic colorectal cancer.

    Authors: Dimitrios Pectasides, George Papaxoinis, Konstantine T Kalogeras, Anastasia G Eleftheraki, Ioannis Xanthakis, Thomas Makatsoris, Epaminondas Samantas, Ioannis Varthalitis, Pavlos Papakostas, Nikitas Nikitas, Christos N Papandreou, George Pentheroudakis, Eleni Timotheadou, Angelos Koutras, Joseph Sgouros, Dimitrios Bafaloukos…
    Citation: BMC Cancer 2012 12:271
    Content type: Research article Published on:

  37. The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide inf...

    Authors: Richard J Q McNally, Karen Blakey, Roger C Parslow, Peter W James, Basilio Gómez Pozo, Charles Stiller, Tim J Vincent, Paul Norman, Patricia A McKinney, Michael F Murphy, Alan W Craft and Richard G Feltbower
    Citation: BMC Cancer 2012 12:270
    Content type: Research article Published on:

  38. The transcription factor SOX11 is of diagnostic and prognostic importance in mantle cell lymphoma (MCL) and epithelial ovarian cancer (EOC), respectively. Thus, there is an unmet clinical and experimental need...

    Authors: Lena Nordström, Ulrika Andréasson, Mats Jerkeman, Michael Dictor, Carl Borrebaeck and Sara Ek
    Citation: BMC Cancer 2012 12:269
    Content type: Technical advance Published on:

  39. Pancreatic carcinoma is a significant cause of cancer-related death in developed countries. As the level of circulating endothelial cells (CECs) is known to increase in response to various cancers, we investig...

    Authors: Shunsuke Kondo, Hideki Ueno, Jun Hashimoto, Chigusa Morizane, Fumiaki Koizumi, Takuji Okusaka and Kenji Tamura
    Citation: BMC Cancer 2012 12:268
    Content type: Research article Published on:

  40. Tumor suppressor genes function to regulate and block tumor cell proliferation. To explore the mechanisms underlying the tumor suppression of BLU/ZMYND10 gene on a frequently lost human chromosomal region, an ade...

    Authors: Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao and Zhiwei He
    Citation: BMC Cancer 2012 12:267
    Content type: Research article Published on:

  41. Recent evidence suggests an emerging role for S100 protein in breast cancer and tumor progression. These ubiquitous proteins are involved in numerous normal and pathological cell functions including inflammato...

    Authors: Jodie M Fleming, Erika Ginsburg, Shannon D Oliver, Paul Goldsmith and Barbara K Vonderhaar
    Citation: BMC Cancer 2012 12:266
    Content type: Research article Published on:

  42. Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimate...

    Authors: Carlos D Gamarra-Luques, Alicia A Goyeneche, Maria B Hapon and Carlos M Telleria
    Citation: BMC Cancer 2012 12:200
    Content type: Research article Published on:

  43. Cancer cachexia is a progressive wasting syndrome and the most prevalent characteristic of cancer in patients with advanced pancreatic adenocarcinoma. We hypothesize that genes expressed in wasted skeletal mus...

    Authors: Alexander Skorokhod, Jeannine Bachmann, Nathalia A Giese, Marc E Martignoni and Holger Krakowski-Roosen
    Citation: BMC Cancer 2012 12:265
    Content type: Research article Published on:

  44. Palliative surgery followed by postoperative chemotherapy is a challenging approach in the treatment of stage IV gastric cancer yet patients must be carefully selected on the basis of likely clinical benefit.

    Authors: John Syrios, Stavros Sougioultzis, Ioannis D Xynos, Nikolaos Kavantzas, Christos Kosmas, George Agrogiannis, John Griniatsos, Ioannis Karavokyros, Emmanouil Pikoulis, Efstratios S Patsouris and Nikolas Tsavaris
    Citation: BMC Cancer 2012 12:264
    Content type: Research article Published on:

  45. The long-term survival in hepatocellullar carcinoma (HCC) patients after transarterial chemoembolization (TACE) remains dismal due to local and/or regional recurrence as well as distant metastasis. The efficac...

    Authors: Xu-Dong Qu, Cheng-Shi Chen, Jian-Hua Wang, Zhi-ping Yan, Jie-min Chen, Gao-quan Gong, Qin-xin Liu, Jian-jun Luo, Lin-xiao Liu, Rong Liu and Sheng Qian
    Citation: BMC Cancer 2012 12:263
    Content type: Research article Published on:

  46. Endometrial carcinoma is a common malignancy of female genital tract. Insulin-like growth factor is known to elicit estrogen-induced mitogenic activity and anti-apoptotic effect in endometrial tissues.

    Authors: Yuan-Jiao Liang, Qun Hao, Hui-Ming Zhang, Yuan-Zhe Wu and Jian-Dong Wang
    Citation: BMC Cancer 2012 12:262
    Content type: Research article Published on:

  47. Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome,...

    Authors: Sarah Douglas, Stefan Huttenlocher, Amira Bajrovic, Volker Rudat, Steven E Schild and Dirk Rades
    Citation: BMC Cancer 2012 12:261
    Content type: Research article Published on:

  48. Colon cancer patients with the same stage show diverse clinical behavior dueto tumor heterogeneity. We aimed to discover distinct classes of tumorsbased on microarray expression patterns, to analyze whether th...

    Authors: Beatriz Perez Villamil, Alejandro Romera Lopez, Susana Hernandez Prieto, Guillermo Lopez Campos, Antonio Calles, Jose Antonio Lopez Asenjo, Julian Sanz Ortega, Cristina Fernandez Perez, Javier Sastre, Rosario Alfonso, Trinidad Caldes, Fernando Martin Sanchez and Eduardo Diaz Rubio
    Citation: BMC Cancer 2012 12:260
    Content type: Research article Published on:

  49. Promoter methylation of the tumor suppressor gene Cyclin A1 could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma. There is disagree...

    Authors: Daniel Weiss, Mario Koopmann, Türker Basel and Claudia Rudack
    Citation: BMC Cancer 2012 12:259
    Content type: Research article Published on:

  50. Risk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising predictors for epithelial ovarian cancer (EOC), however, conflicting results exist in the diagnostic per...

    Authors: Fake Li, Ruxiu Tie, Kai Chang, Feng Wang, Shaoli Deng, Weiping Lu, Lili Yu and Ming Chen
    Citation: BMC Cancer 2012 12:258
    Content type: Research article Published on:

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