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  1. The malignant transformation of precancerous colorectal lesions involves progressive alterations at both the molecular and morphologic levels, the latter consisting of increases in size and in the degree of ce...

    Authors: Rosalia Maglietta, Vania Cosma Liuzzi, Elisa Cattaneo, Endre Laczko, Ada Piepoli, Anna Panza, Massimo Carella, Orazio Palumbo, Teresa Staiano, Federico Buffoli, Angelo Andriulli, Giancarlo Marra and Nicola Ancona
    Citation: BMC Cancer 2012 12:608
    Content type: Research article Published on:

  2. Neoplastic transformation of cultured cells by a number of oncogenes such as src suppresses gap junctional, intercellular communication (GJIC); however, the role of Src and its effector Signal transducer and acti...

    Authors: Mulu Geletu, Rozanne Arulanandam, Samantha Greer, Aaron Trotman-Grant, Evangelia Tomai and Leda Raptis
    Citation: BMC Cancer 2012 12:605
    Content type: Research article Published on:

  3. The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences.

    Authors: Maximino Redondo, Rafael Funez, Francisco Medina-Cano, Isabel Rodrigo, Mercedes Acebal, Teresa Tellez, M Jose Roldan, M Luisa Hortas, Ana Bellinvia, Teresa Pereda, Laia Domingo, María Morales-Suarez Varela, Maria Sala and Antonio Rueda
    Citation: BMC Cancer 2012 12:604
    Content type: Research article Published on:

  4. Chemotherapy induced nausea and vomiting (CINV) remains a major problem that seriously impairs the quality of life (QoL) in cancer patients receiving chemotherapy regimens. Complementary medicines, including h...

    Authors: David Pérol, Jocelyne Provençal, Anne-claire Hardy-Bessard, David Coeffic, Jean-Phillipe Jacquin, Cécile Agostini, Thomas Bachelot, Jean-Paul Guastalla, Xavier Pivot, Jean-Pierre Martin, Agathe Bajard and Isabelle Ray-Coquard
    Citation: BMC Cancer 2012 12:603
    Content type: Research article Published on:

  5. Esophageal squamous cell carcinoma (ESCC) shows geographic variations in incidence, with high incidences (>50/105 person-years) in central Asia, including North Eastern Iran (Golestan) and Northern India (Kashmir...

    Authors: Behnoush Abedi-Ardekani, Nazir Ahmad Dar, Mohammad Muzaffar Mir, Showkat Ahmad Zargar, M Muqbool Lone, Ghyslaine Martel-Planche, Stéphanie Villar, Mounia Mounawar, Farrokh Saidi, Reza Malekzadeh and Pierre Hainaut
    Citation: BMC Cancer 2012 12:602
    Content type: Research article Published on:

  6. Caldesmon (CaD), a major actin-associated protein, is found in smooth muscle and non-muscle cells. Smooth muscle caldesmon, h-CaD, is a multifunctional protein, and non-muscle cell caldesmon, l-CaD, plays a role ...

    Authors: Kyung-Hee Kim, Seung-Gu Yeo, Won Ki Kim, Dae Yong Kim, Hyun Yang Yeo, Jun Pyu Hong, Hee Jin Chang, Ji Won Park, Sun Young Kim, Byung Chang Kim and Byong Chul Yoo
    Citation: BMC Cancer 2012 12:601
    Content type: Research article Published on:

  7. Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker ass...

    Authors: Verena Engelstaedter, Sabine Heublein, Anamur Lan Schumacher, Miriam Lenhard, Helen Engelstaedter, Ulrich Andergassen, Margit Guenthner-Biller, Christina Kuhn, Brigitte Rack, Markus Kupka, Doris Mayr and Udo Jeschke
    Citation: BMC Cancer 2012 12:600
    Content type: Research article Published on:

  8. Androgen receptors (AR) are frequently expressed in breast cancers, but their implication in cancer growth is still controversial. In the present study, we further investigated the role of the androgen/AR path...

    Authors: Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Maria Luisa Carcangiu, Biagio Paolini, Roberto Agresti, Cristina Pellitteri, Franco Berrino, Massimo Gion, Patrizia Cogliati, Giuseppina Saragò and Andrea Micheli
    Citation: BMC Cancer 2012 12:599
    Content type: Research article Published on:

  9. Over recent years a number of novel therapies have shown promise in advanced renal cell carcinoma (RCC). Internationally the standard of care of first-line therapy is sunitinib™, after a clear survival benefit...

    Authors: Fiona J Collinson, Walter M Gregory, Chris McCabe, Helen Howard, Catherine Lowe, DrBarbara Potrata, Sandy Tubeuf, Pat Hanlon, Lucy McParland, T Wah, Peter J Selby, Jenny Hewison, Julia Brown and Janet Brown
    Citation: BMC Cancer 2012 12:598
    Content type: Study protocol Published on:

  10. Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may...

    Authors: Nuran Bektas Serce, Andreas Boesl, Irina Klaman, Sonja von Serényi, Erik Noetzel, Michael F Press, Arno Dimmler, Arndt Hartmann, Jalid Sehouli, Ruth Knuechel, Matthias W Beckmann, Peter A Fasching and Edgar Dahl
    Citation: BMC Cancer 2012 12:597
    Content type: Research article Published on:

  11. Several studies have suggested a cancer risk reduction in statin users although the evidence remains weak for stomach cancer. The purpose of this study was to use an exact-matching case–control design to exami...

    Authors: Jeeyun Lee, Soo Hyeon Lee, Kyu Yeon Hur, Sook Young Woo, Sun Woo Kim and Won Ki Kang
    Citation: BMC Cancer 2012 12:596
    Content type: Research article Published on:

  12. Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in populati...

    Authors: Paul J Villeneuve, Marie-Élise Parent, Shelley A Harris and Kenneth C Johnson
    Citation: BMC Cancer 2012 12:595
    Content type: Research article Published on:

  13. In the past few years, the number of clinical trials has increased rapidly in East Asia, especially for gastric and hepatobiliary cancer that are prevalent in Asian populations. However, the actual degree of u...

    Authors: Su Jin Lee, Lee Chun Park, Jeeyun Lee, Seonwoo Kim, Moon Ki Choi, Jung Yong Hong, Sylvia Park, Chi Hoon Maeng, Wonjin Chang, Young Saing Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang and Young Suk Park
    Citation: BMC Cancer 2012 12:594
    Content type: Research article Published on:

  14. Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present ...

    Authors: Junyi Chen, Li Jiao, Chuanliang Xu, Yongwei Yu, Zhensheng Zhang, Zheng Chang, Zhen Deng and Yinghao Sun
    Citation: BMC Cancer 2012 12:593
    Content type: Research article Published on:

  15. To evaluate disease control, overall survival and prognostic factors in patients with locally recurrent rectal cancer after IOERT-containing multimodal therapy.

    Authors: Falk Roeder, Joerg-Michael Goetz, Gregor Habl, Marc Bischof, Robert Krempien, Markus W Buechler, Frank W Hensley, Peter E Huber, Juergen Weitz and Juergen Debus
    Citation: BMC Cancer 2012 12:592
    Content type: Research article Published on:

  16. Tamoxifen is used in hormone therapy for estrogen-receptor (ER)-positive breast cancer, but also has chemopreventative effects against ER-negative breast cancers. This study sought to investigate whether oral ...

    Authors: Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano and Geoffrey W Krissansen
    Citation: BMC Cancer 2012 12:591
    Content type: Research article Published on:

  17. Sorafenib is an orally available kinase inhibitor with activity at Raf, PDGFβ and VEGF receptors that is licensed for the treatment of advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Cu...

    Authors: BP Fairfax, S Pratap, ISD Roberts, J Collier, R Kaplan, AM Meade, AW Ritchie, T Eisen, VM Macaulay and A Protheroe
    Citation: BMC Cancer 2012 12:590
    Content type: Case report Published on:

  18. The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and...

    Authors: Ning Wang, Shizhuo Wang, Qiao Zhang, Yanming Lu, Heng Wei, Wei Li, Shulan Zhang, Duo Yin and Yangling Ou
    Citation: BMC Cancer 2012 12:589
    Content type: Research article Published on:

  19. Psoriasin (S100A7) is a member of the S100 gene family. Alteration of Psoriasin expression has previously been reported to play an important role in cancer aggressive behaviour. The current study sought to inv...

    Authors: Mu Hu, Lin Ye, Fiona Ruge, Xiuyi Zhi, Lijian Zhang and Wen G Jiang
    Citation: BMC Cancer 2012 12:588
    Content type: Research article Published on:

  20. Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and...

    Authors: Martina Mayr, Karen Becker, Nadine Schulte, Sebastian Belle, Ralf Hofheinz, Annekatrin Krause, Roland M Schmid, Christoph Röcken and Matthias P Ebert
    Citation: BMC Cancer 2012 12:587
    Content type: Research article Published on:

  21. Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin l...

    Authors: Sylvia Hartmann, Claudio Agostinelli, Jürgen Diener, Claudia Döring, Stefano Fanti, Pier Luigi Zinzani, Andrea Gallamini, Lothar Bergmann, Stefano Pileri and Martin-Leo Hansmann
    Citation: BMC Cancer 2012 12:586
    Content type: Research article Published on:

  22. The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a d...

    Authors: Hyeong-Gon Moon, Jae Kyo Yi, Hee Sung Kim, Hea Young Lee, Kyung-Min Lee, Minju Yi, Sookyung Ahn, Hee-Chul Shin, Ji-hyun Ju, Incheol Shin, Wonshik Han and Dong-Young Noh
    Citation: BMC Cancer 2012 12:585
    Content type: Research article Published on:

  23. Liver transplantation is the most effective therapy for cirrhosis-associated hepatocellular carcinoma (HCC) but its utility is limited by post-transplant tumor recurrence. Use of the Milan, size-based criteria...

    Authors: Zhen Zeng, Jinyu Ren, Maura O’Neil, Jie Zhao, Brian Bridges, Josiah Cox, Bashar Abdulkarim, Timothy M Schmitt, Sean C Kumer and Steven A Weinman
    Citation: BMC Cancer 2012 12:584
    Content type: Research article Published on:

  24. Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15– 30% of breast cancer patients develop brain metastasis. However, relatively little is known about how these...

    Authors: Hui Liu, Yukinari Kato, Stephanie A Erzinger, Galina M Kiriakova, Yongzhen Qian, Diane Palmieri, Patricia S Steeg and Janet E Price
    Citation: BMC Cancer 2012 12:583
    Content type: Research article Published on:

  25. There are limited population-based studies focusing on the chemopreventive effects of selective cyclooxygenase-2 (COX-2) inhibitors against colorectal cancer. The purpose of this study is to assess the trends ...

    Authors: Yi-Hsin Yang, Yea-Huei Kao Yang, Ching-Lan Cheng, Pei-Shan Ho and Ying-Chin Ko
    Citation: BMC Cancer 2012 12:582
    Content type: Research article Published on:

  26. Neurotoxicity caused by treatment for a brain tumor is a major cause of neurocognitive decline in survivors. Studies have shown that neurofeedback may enhance neurocognitive functioning. This paper describes t...

    Authors: Marieke A de Ruiter, Antoinette YN Schouten-Van Meeteren, Rosa van Mourik, Tieme WP Janssen, Juliette EM Greidanus, Jaap Oosterlaan and Martha A Grootenhuis
    Citation: BMC Cancer 2012 12:581
    Content type: Study protocol Published on:

  27. Cancer research has devoted most of its energy over the past decades on unraveling the control mechanisms within tumor cells that govern its behavior. From this we know that the onset of cancer is the result o...

    Authors: Marlies E Heuvers, Joachim G Aerts, Robin Cornelissen, Harry Groen, Henk C Hoogsteden and Joost P Hegmans
    Citation: BMC Cancer 2012 12:580
    Content type: Review Published on:

  28. Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine h...

    Authors: Karyn S Ho, Peter C Poon, Shawn C Owen and Molly S Shoichet
    Citation: BMC Cancer 2012 12:579
    Content type: Research article Published on:

  29. There is a lack of psychotherapeutic trials of treatments of comorbid depression in cancer patients. Our study determines the efficacy of a manualized short-term psychodynamic psychotherapy and predictors of o...

    Authors: Rüdiger Zwerenz, Manfred E Beutel, Barbara H Imruck, Jörg Wiltink, Antje Haselbacher, Christian Ruckes, Heinz Schmidberger, Gerald Hoffmann, Marcus Schmidt, Uwe Köhler, Dagmar Langanke, Rolf-Dieter Kortmann, Susanne Kuhnt, Gregor Weißflog, Yvette Barthel, Katja Leuteritz…
    Citation: BMC Cancer 2012 12:578
    Content type: Study protocol Published on:

  30. Women with cancer are significantly more likely to fall than women without cancer placing them at higher risk of fall-related fractures, other injuries and disability. Currently, no evidence-based fall prevent...

    Authors: Kerri M Winters-Stone, Fuzhong Li, Fay Horak, Shiuh-Wen Luoh, Jill A Bennett, Lillian Nail and Nathan Dieckmann
    Citation: BMC Cancer 2012 12:577
    Content type: Study protocol Published on:

  31. The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat an...

    Authors: Mario Menschikowski, Uwe Platzbecker, Albert Hagelgans, Margot Vogel, Christian Thiede, Claudia Schönefeldt, Renate Lehnert, Graeme Eisenhofer and Gabriele Siegert
    Citation: BMC Cancer 2012 12:576
    Content type: Research article Published on:

  32. Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no s...

    Authors: Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano, Massimiliano Cazzaniga, Serena Mora, Chiara Casadio, Costantino Jemos, Maria Pizzamiglio, Laura Cortesi, Davide Radice and Bernardo Bonanni
    Citation: BMC Cancer 2012 12:575
    Content type: Study protocol Published on:

  33. Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and...

    Authors: Aika Matsunoki, Kazuyuki Kawakami, Masanori Kotake, Mami Kaneko, Hirotaka Kitamura, Akishi Ooi, Go Watanabe and Toshinari Minamoto
    Citation: BMC Cancer 2012 12:574
    Content type: Research article Published on:

  35. People with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and...

    Authors: Haryana M Dhillon, Hidde P van der Ploeg, Melanie L Bell, Michael Boyer, Stephen Clarke and Janette Vardy
    Citation: BMC Cancer 2012 12:572
    Content type: Study protocol Published on:

  36. Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by t...

    Authors: Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Katrin Orlowski, Martin Pruschy and Rolf A Stahel
    Citation: BMC Cancer 2012 12:571
    Content type: Research article Published on:

  37. Pyloric gland adenoma consists of closely packed pyloric-type glands lined by mucus-secreting cells. To date, approximately 230 cases have been reported, mostly of gastric localization with a tumour size up to...

    Authors: Inga-Marie Schaefer, Silke Cameron, Peter Middel, Kia Homayounfar, Harald Schwörer, Michael Vieth and Lothar Veits
    Citation: BMC Cancer 2012 12:570
    Content type: Case report Published on:

  38. Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to m...

    Authors: Isabela Martins Gonzaga, Sheila Coelho Soares-Lima, Paulo Thiago Souza de Santos, Tania Cristina Moita Blanco, Bruno Souza Bianchi de Reis, Danielle Carvalho Quintella, Ivanir Martins de Oliveira, Paulo Antonio Silvestre de Faria, Cleber Dario Pinto Kruel, Nelson Adami Andreollo, Tatiana Almeida de Simão and Luis Felipe Ribeiro Pinto
    Citation: BMC Cancer 2012 12:569
    Content type: Research article Published on:

  39. Rash, liver dysfunction, and diarrhea are known major adverse events associated with erlotinib and gefitinib. However, clinical trials with gefitinib have reported different proportions of adverse events compa...

    Authors: Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Kuniomi Matsuura, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Toshiyuki Nakai and Kazuto Hirata
    Citation: BMC Cancer 2012 12:568
    Content type: Research article Published on:

  40. With advances in modern radiotherapy (RT), many patients with head and neck (HN) cancer can be effectively cured. However, xerostomia is a common complication in patients after RT for HN cancer. The purpose of...

    Authors: Tsair-Fwu Lee, Pei-Ju Chao, Hung-Yu Wang, Hsuan-Chih Hsu, PaoShu Chang and Wen-Cheng Chen
    Citation: BMC Cancer 2012 12:567
    Content type: Research article Published on:

  41. Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile o...

    Authors: Lu Gan, Jian He, Xia Zhang, Yong-Jie Zhang, Guan-Zhen Yu, Ying Chen, Jun Pan, Jie-Jun Wang and Xi Wang
    Citation: BMC Cancer 2012 12:566
    Content type: Research article Published on:

  43. Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1,...

    Authors: Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren and Stephen Safe
    Citation: BMC Cancer 2012 12:564
    Content type: Research article Published on:

  44. Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for th...

    Authors: Mamduh Khateb, Nili Ruimi, Hazem Khamisie, Yousef Najajreh, Afsar Mian, Anna Metodieva, Martin Ruthardt and Jamal Mahajna
    Citation: BMC Cancer 2012 12:563
    Content type: Research article Published on:

  45. Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant sys...

    Authors: Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler and Marcus Schmidt
    Citation: BMC Cancer 2012 12:562
    Content type: Research article Published on:

  46. Vaccination against tumor-associated antigens is one promising approach to immunotherapy against malignant gliomas. While previous vaccine efforts have focused exclusively on HLA class I-restricted peptides, c...

    Authors: Shinji Shimato, Lisa M Maier, Richard Maier, Jeffrey N Bruce, Richard CE Anderson and David E Anderson
    Citation: BMC Cancer 2012 12:561
    Content type: Research article Published on:

  48. This study aimed to systematically review the evidence from randomized controlled trials (RCTs) and to conduct a meta-analysis of the effects of yoga on physical and psychosocial outcomes in cancer patients an...

    Authors: Laurien M Buffart, Jannique GZ van Uffelen, Ingrid I Riphagen, Johannes Brug, Willem van Mechelen, Wendy J Brown and Mai JM Chinapaw
    Citation: BMC Cancer 2012 12:559
    Content type: Research article Published on:

  49. Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) is used for the patients with EGFR-mutant lung cancer. Recently, phase...

    Authors: Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima, Yoshihito Tanaka, Michiko Shimada, Akira Kurose, Shingo Takanashi and Ken Okumura
    Citation: BMC Cancer 2012 12:558
    Content type: Case report Published on:

  50. While knowledge and risk perception have been associated with screening for second primary cancer (SPC), there are no clinically useful indicators to identify who is at risk of not being properly screened for ...

    Authors: Beomseok Suh, Dong Wook Shin, So Young Kim, Jae-Hyun Park, Weon Young Chang, Seung Pyung Lim, Chang-Yeol Yim, Be-Long Cho, Eun-Cheol Park and Jong-Hyock Park
    Citation: BMC Cancer 2012 12:557
    Content type: Research article Published on:

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