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  1. It is clear that genetic variations in the fat mass and obesity-associated (FTO) gene affect body mass index and the risk of obesity. Given the mounting evidence showing a positive association between obesity ...

    Authors: Yingsong Lin, Junko Ueda, Kiyoko Yagyu, Hiroshi Ishii, Makoto Ueno, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo and Shogo Kikuchi
    Citation: BMC Cancer 2013 13:337
    Content type: Research article Published on:

  2. Cysteinyl leukotrienes (CysLTs) are potent pro-inflammatory mediators that are increased in samples from patients with inflammatory bowel diseases (IBDs). Individuals with IBDs have enhanced susceptibility to ...

    Authors: Astrid M Bengtsson, Gunilla Jönsson, Cecilia Magnusson, Tavga Salim, Cecilia Axelsson and Anita Sjölander
    Citation: BMC Cancer 2013 13:336
    Content type: Research article Published on:

  3. Cryptogenic hepatocellular carcinoma (HCC) is thought to arise due to non-alcoholic fatty liver disease (NAFLD). This study investigated the prevalence, clinical features, and outcomes of cryptogenic HCC and c...

    Authors: Sang Soo Lee, Sook-Hyang Jeong, Young-Sang Byoun, Seong Min Chung, Mun Hyuk Seong, Hyung Rae Sohn, Bo-young Min, Eun Sun Jang, Jin-Wook Kim, Guan Jung Park, Yoon Jin Lee, Kyoung Ho Lee and Soyeon Ahn
    Citation: BMC Cancer 2013 13:335
    Content type: Research article Published on:

  4. Thyroid hormones have been shown to regulate breast cancer cells growth, the absence or reduction of thyroid hormones in cells could provoke a proliferation arrest in G0-G1 or weak mitochondrial activity, whic...

    Authors: Jianbo Huang, Liangbin Jin, Guangyan Ji, Lei Xing, Chaobo Xu, Xiong Xiong, Hongyuan Li, Kainan Wu, Guosheng Ren and Lingquan Kong
    Citation: BMC Cancer 2013 13:334
    Content type: Research article Published on:

  5. Considerable global variation in the incidence of lip, of oral cavity and of pharyngeal cancers exists. Whilst this reflects regional or population differences in risk, interpretation is uncertain due to heter...

    Authors: Anura Ariyawardana and Newell W Johnson
    Citation: BMC Cancer 2013 13:333
    Content type: Research article Published on:

  6. To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).

    Authors: Shimiao Zhu, Yang Tang, Kai Li, Zhiqun Shang, Ning Jiang, Xuewu Nian, Libin Sun and Yuanjie Niu
    Citation: BMC Cancer 2013 13:332
    Content type: Research article Published on:

  7. Environment inside even a small tumor is characterized by total (anoxia) or partial oxygen deprivation, (hypoxia). It has been shown that radiotherapy and some conventional chemotherapies may be less effective...

    Authors: Sara Strese, Mårten Fryknäs, Rolf Larsson and Joachim Gullbo
    Citation: BMC Cancer 2013 13:331
    Content type: Research article Published on:

  8. Post-surgery therapies are given to early-stage breast cancer patients due to the possibility of residual micrometastasis, and optimized by clincopathological parameters such as tumor stage, and hormone recept...

    Authors: Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young
    Citation: BMC Cancer 2013 13:330
    Content type: Research article Published on:

  9. Due to changes in cancer-related risk factors, improvements in diagnostic procedures and treatments, and the aging of the population, in most developed countries cancer accounts for an increasing proportion of...

    Authors: Silvia Francisci, Stefano Guzzinati, Maura Mezzetti, Emanuele Crocetti, Francesco Giusti, Guido Miccinesi, Eugenio Paci, Catia Angiolini and Anna Gigli
    Citation: BMC Cancer 2013 13:329
    Content type: Research article Published on:

  10. Tumour size in breast cancer influences therapeutic decisions. The purpose of this study was to evaluate sizing of primary breast cancer using mammography, sonography and magnetic resonance imaging (MRI) and t...

    Authors: Ines V Gruber, Miriam Rueckert, Karl O Kagan, Annette Staebler, Katja C Siegmann, Andreas Hartkopf, Diethelm Wallwiener and Markus Hahn
    Citation: BMC Cancer 2013 13:328
    Content type: Research article Published on:

  11. Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic ap...

    Authors: Mingo Ming Ho Yung, David Wai Chan, Vincent Wing Sun Liu, Kwok-Ming Yao and Hextan Yuen-Sheung Ngan
    Citation: BMC Cancer 2013 13:327
    Content type: Research article Published on:

  13. The influence of variants at the 9p21 locus on melanoma risk has been reported through investigation of CDKN2A variants through candidate gene approach as well as by genome wide association studies (GWAS).

    Authors: Livia Maccioni, Panduranga Sivaramakrishna Rachakonda, Justo Lorenzo Bermejo, Dolores Planelles, Celia Requena, Kari Hemminki, Eduardo Nagore and Rajiv Kumar
    Citation: BMC Cancer 2013 13:325
    Content type: Research article Published on:

  14. Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette
    Citation: BMC Cancer 2013 13:324
    Content type: Research article Published on:

  15. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus–associated malignancy that is most common in East Asia, Africa, and Alaska. Radiotherapy is the main treatment option; unfortunately, disease response to...

    Authors: Yunbao Pan, Mengyao Wang, Xianzhang Bu, Yinglin Zuo, Sumei Wang, Dujuan Wang, Qing Liu, Bojin Su, Tao Xu, Chunhua Wang, Francois X Claret and Huiling Yang
    Citation: BMC Cancer 2013 13:323
    Content type: Research article Published on:

  16. Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, co...

    Authors: Makito Miyake, Adrienne Lawton, Steve Goodison, Virginia Urquidi, Evan Gomes-Giacoia, Ge Zhang, Shanti Ross, Jeongsoon Kim and Charles J Rosser
    Citation: BMC Cancer 2013 13:322
    Content type: Research article Published on:

  17. Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this stu...

    Authors: Harsharan Randhawa, Shireen Chikara, Drew Gehring, Tuba Yildirim, Jyotsana Menon and Katie M Reindl
    Citation: BMC Cancer 2013 13:321
    Content type: Research article Published on:

  18. Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence...

    Authors: Oleksandr Ekshyyan, Tara N Moore-Medlin, Matthew C Raley, Kunal Sonavane, Xiaohua Rong, Michael A Brodt, Fleurette Abreo, Jonathan Steven Alexander and Cherie-Ann O Nathan
    Citation: BMC Cancer 2013 13:320
    Content type: Research article Published on:

  19. Understanding the physical activity experiences of patients with multiple myeloma (MM) is essential to inform the development of evidence-based interventions and to quantify the benefits of physical activity. ...

    Authors: Melinda J Craike, Kaye Hose, Kerry S Courneya, Simon J Harrison and Patricia M Livingston
    Citation: BMC Cancer 2013 13:319
    Content type: Research article Published on:

  20. To present our experience of intensity-modulated radiotherapy (IMRT) with simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC).

    Authors: Muhammad M Fareed, Abdullah S AlAmro, Yasser Bayoumi, Mutahir A Tunio, Abdul S Ismail, Rashad Akasha, Mohamed Mubasher and Mushabbab Al Asiri
    Citation: BMC Cancer 2013 13:318
    Content type: Research article Published on:

  21. Sox2, an embryonic stem cell marker, is aberrantly expressed in a subset of breast cancer (BC). While the aberrant expression of Sox2 has been shown to significantly correlate with a number of clinicopathologi...

    Authors: Fang Wu, Xiaoxia Ye, Peng Wang, Karen Jung, Chengsheng Wu, Donna Douglas, Norman Kneteman, Gilbert Bigras, Yupo Ma and Raymond Lai
    Citation: BMC Cancer 2013 13:317
    Content type: Research article Published on:

  22. Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signa...

    Authors: Dawn T Bravo, Yi-Lin Yang, Kristopher Kuchenbecker, Ming-Szu Hung, Zhidong Xu, David M Jablons and Liang You
    Citation: BMC Cancer 2013 13:316
    Content type: Research article Published on:

  23. There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and...

    Authors: Sillarine Kurkalang, Atanu Banerjee, Nitin Ghoshal, Hughbert Dkhar and Anupam Chatterjee
    Citation: BMC Cancer 2013 13:315
    Content type: Research article Published on:

  24. Circulating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagn...

    Authors: Lanhua Tang, Shushan Zhao, Wei Liu, Nicholas F Parchim, Jin Huang, Youhong Tang, Pingping Gan and Meizuo Zhong
    Citation: BMC Cancer 2013 13:314
    Content type: Research article Published on:

  25. Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during norm...

    Authors: James F Amatruda, Julie A Ross, Brock Christensen, Nicholas J Fustino, Kenneth S Chen, Anthony J Hooten, Heather Nelson, Jacquelyn K Kuriger, Dinesh Rakheja, A Lindsay Frazier and Jenny N Poynter
    Citation: BMC Cancer 2013 13:313
    Content type: Research article Published on:

  26. Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic sus...

    Authors: Muhammad U Rashid, Noor Muhammad, Saima Faisal, Asim Amin and Ute Hamann
    Citation: BMC Cancer 2013 13:312
    Content type: Research article Published on:

  28. Increasing evidence suggests that a history of diabetes mellitus (DM) may be associated with an increased risk of bladder cancer. We performed a systematic review with meta-analysis to explore this relationship.

    Authors: Zhaowei Zhu, Xianjin Wang, Zhoujun Shen, Yingli Lu, Shan Zhong and Chen Xu
    Citation: BMC Cancer 2013 13:310
    Content type: Research article Published on:

  29. Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...

    Authors: Rui Niimi, Akihiko Matsumine, Takahiro Iino, Shigeto Nakazora, Tomoki Nakamura, Atsumasa Uchida and Akihiro Sudo
    Citation: BMC Cancer 2013 13:309
    Content type: Research article Published on:

  30. The current standard treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma (DLBCL) primarily consists of intensified salvage therapy and, if the disease is chemo-sensitive, high ...

    Authors: Mathias Witzens-Harig, Marie Luise Memmer, Martin Dreyling and Georg Hess
    Citation: BMC Cancer 2013 13:308
    Content type: Study protocol Published on:

  31. Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome ha...

    Authors: Jinlong Jian, Qing Yang, Yongzhao Shao, Deborah Axelrod, Julia Smith, Baljit Singh, Stephanie Krauter, Luis Chiriboga, Zhaoxu Yang, Jinqing Li and Xi Huang
    Citation: BMC Cancer 2013 13:307
    Content type: Research article Published on:

  32. We studied the relationships among Cx43, CD105, and VEGF in specimens of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) with different serum AFP levels with respect to recurrence and metastasis.

    Authors: Zu-Sen Wang, Li-Qun Wu, Xin Yi, Chao Geng, Yu-Jun Li and Ru-Yong Yao
    Citation: BMC Cancer 2013 13:306
    Content type: Research article Published on:

  33. It is currently unclear whether a correlation exists between N-myc downstream-regulated gene 2 (NDRG2) expression and oesophageal squamous cell carcinoma (ESCC). The aim of this study was to examine the underl...

    Authors: Wei Cao, Guozheng Yu, Qiang Lu and Juliang Zhang
    Citation: BMC Cancer 2013 13:305
    Content type: Research article Published on:

  34. We usually report five-year survival from population-based cancer registries in Japan; however these survival estimates may be pessimistic for cancer survivors, because many patients with unfavourable prognosi...

    Authors: Yuri Ito, Tomio Nakayama, Isao Miyashiro, Akiko Ioka and Hideaki Tsukuma
    Citation: BMC Cancer 2013 13:304
    Content type: Research article Published on:

  35. The X-linked ribosomal protein S4 (RPS4X), which is involved in cellular translation and proliferation, has previously been identified as a partner of the overexpressed multifunctional protein YB-1 in several ...

    Authors: Serges P Tsofack, Liliane Meunier, Lilia Sanchez, Jason Madore, Diane Provencher, Anne-Marie Mes-Masson and Michel Lebel
    Citation: BMC Cancer 2013 13:303
    Content type: Research article Published on:

  36. There is a strong need for early assessment of tumor response to chemotherapy in order to avoid the adverse effects of unnecessary chemotherapy and to allow early transition to second-line therapy. The purpose...

    Authors: Chun-yi Lin, Long-hui Cao, Jian-wei Wang, Wei Zheng, Yao Chen, Zi-zhen Feng, An-hua Li and Jian-hua Zhou
    Citation: BMC Cancer 2013 13:302
    Content type: Research article Published on:

  37. The benefit of induction chemotherapy in locally advanced oral squamous cell carcinoma (OSCC) remains to be clearly defined. Induction chemotherapy is likely to be effective for biologically distinct subgroups...

    Authors: Dong-wang Zhu, Ying Liu, Xiao Yang, Cheng-zhe Yang, Jie Ma, Xi Yang, Jin-ke Qiao, Li-zhen Wang, Jiang Li, Chen-ping Zhang, Zhi-yuan Zhang and Lai-ping Zhong
    Citation: BMC Cancer 2013 13:301
    Content type: Research article Published on:

  38. More than 25% of patients diagnosed with endometrial carcinoma have an invasive primary cancer accompanied by metastases. Gonadotropin-releasing hormone (GnRH) plays an important role in reproduction. In mamma...

    Authors: Hsien-Ming Wu, Hsin-Shih Wang, Hong-Yuan Huang, Chyong-Huey Lai, Chyi-Long Lee, Yung-Kuei Soong and Peter CK Leung
    Citation: BMC Cancer 2013 13:300
    Content type: Research article Published on:

  39. The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a hum...

    Authors: Maria Teresa Solomón, Julio César Selva, Javier Figueredo, José Vaquer, Carolina Toledo, Nelson Quintanal, Silvia Salva, Rafael Domíngez, José Alert, Jorge Juan Marinello, Mauricio Catalá, Martha González Griego, Juan Antonio Martell, Patricia Lorenzo Luaces, Javier Ballesteros, Niurys de-Castro…
    Citation: BMC Cancer 2013 13:299
    Content type: Research article Published on:

  40. Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates were unknown. The relationshi...

    Authors: Hiu-Ying Lau, Chit-Ming Leung, Yap-Hang Chan, Anne Wing-Mui Lee, Dora Lai-Wan Kwong, Maria Li Lung and Tai-Hing Lam
    Citation: BMC Cancer 2013 13:298
    Content type: Research article Published on:

  41. Over-expression of epidermal growth factor receptor (EGFR) or insulin-like growth factor-1 receptor (IGF-1R) have been shown to closely correlate with radioresistance of breast cancer cells. This study aimed t...

    Authors: Ping Li, Marlon R Veldwijk, Qing Zhang, Zhao-bin Li, Wen-cai Xu and Shen Fu
    Citation: BMC Cancer 2013 13:297
    Content type: Research article Published on:

  42. The quadrivalent human papillomavirus vaccine has been provided in Australia through the National Human Papillomavirus Vaccination Program since April 2007. National registry data demonstrates good coverage of...

    Authors: Elisa J Young, Sepehr N Tabrizi, Julia ML Brotherton, John D Wark, Jan Pyman, Marion Saville, C David Wrede, Yasmin Jayasinghe, Jeffrey Tan, Dorota M Gertig, Marian Pitts and Suzanne M Garland
    Citation: BMC Cancer 2013 13:296
    Content type: Study protocol Published on:

  43. Gene expression profiling (GEP) is increasingly used in the rapidly evolving field of personalized medicine. We sought to evaluate the association between GEP-assessed of breast cancer recurrence risk and pati...

    Authors: Valesca P Retèl, Catharina GM Groothuis-Oudshoorn, Neil K Aaronson, Noel T Brewer, Emiel JT Rutgers and Wim H van Harten
    Citation: BMC Cancer 2013 13:295
    Content type: Research article Published on:

  44. Active vitamin D analogs that are less toxic than calcitriol can be useful in the combined treatment of patients suffering from colon cancer. In the present study we demonstrate, for the first time in an in vivo ...

    Authors: Magdalena Milczarek, Mateusz Psurski, Andrzej Kutner and Joanna Wietrzyk
    Citation: BMC Cancer 2013 13:294
    Content type: Research article Published on:

  45. Nasopharyngeal carcinoma (NPC) is a highly metastatic epithelial malignancy showing high prevalence in Southeast Asia and North Africa. The BCL2-associated X (BAX) gene encodes the most important pro-apoptotic me...

    Authors: Christos K Kontos, Ali Fendri, Abdelmajid Khabir, Raja Mokdad-Gargouri and Andreas Scorilas
    Citation: BMC Cancer 2013 13:293
    Content type: Research article Published on:

  46. As the incidence of prostate cancer continues to rise steeply, there is an increasing need to identify more accurate prognostic markers for the disease. There is some evidence that a higher modified Glasgow Pr...

    Authors: Kashif Shafique, Michael J Proctor, Donald C McMillan, Hing Leung, Karen Smith, Billy Sloan and David S Morrison
    Citation: BMC Cancer 2013 13:292
    Content type: Research article Published on:

  47. The inhibitor of differentiation (ID) genes have been implicated as promoters of tumor progression and metastasis in many human cancers. The current study investigated the expression and functional roles of ID...

    Authors: Ji Hoon Phi, Seung Ah Choi, Sang-Hee Lim, Joongyub Lee, Kyu-Chang Wang, Sung-Hye Park and Seung-Ki Kim
    Citation: BMC Cancer 2013 13:291
    Content type: Research article Published on:

  48. Our previous studies showed that SIRT1 was over-expressed in gastric cancer specimens and related with lymph node metastasis. However, the mechanism of SIRT1 up-regulation and its association with metastasis i...

    Authors: Lihua Zhang, Xueqing Wang and Pingsheng Chen
    Citation: BMC Cancer 2013 13:290
    Content type: Research article Published on:

  49. Vulvar squamous cell carcinoma is a cancer form with increasing incidence rate and few treatment options. Wee1 is a central regulator of the G2/M DNA-damage checkpoint, and has in previous studies been describ...

    Authors: Gry Irene Magnussen, Ellen Hellesylt, Jahn M Nesland, Claes G Trope, Vivi Ann Flørenes and Ruth Holm
    Citation: BMC Cancer 2013 13:288
    Content type: Research article Published on:

  50. Cancer survivors are a heterogeneous group with complex health problems. Data concerning its total number and growing dynamics for Switzerland are scarce and outdated.

    Authors: Christian Herrmann, Thomas Cerny, Anita Savidan, Penelope Vounatsou, Isabelle Konzelmann, Christine Bouchardy, Harald Frick and Silvia Ess
    Citation: BMC Cancer 2013 13:287
    Content type: Research article Published on:

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