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  1. Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiologica...

    Authors: Filip YFL De Vos, Sasja F Mulder, Joost PH Drenth, Iris D Nagtegaal, Jurgen J Fütterer and Winette TA van der Graaf
    Citation: BMC Cancer 2013 13:491
    Content type: Case report Published on:

  2. Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic sali...

    Authors: Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff and Alireza Mirmohammadsadegh
    Citation: BMC Cancer 2013 13:490
    Content type: Research article Published on:

  3. Platinum-based chemotherapy has long been used in the treatment of a variety of cancers and functions by inducing DNA damage. ERCC1 and ERCC4 are involved in the removal of this damage and have previously been...

    Authors: David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Bo Markussen, Sven Müller, Hans Jørgen Nielsen, Nils Brünner and Kirsten Vang Nielsen
    Citation: BMC Cancer 2013 13:489
    Content type: Research article Published on:

  4. Chicken Anemia Virus (CAV) VP3 protein (also known as Apoptin), a basic and proline-rich protein has a unique capability in inducing apoptosis in cancer cells but not in normal cells. Five truncated Apoptin pr...

    Authors: Lim Shen Ni, Zeenathul Nazariah bt Allaudin, Mohd Azmi b Mohd Lila, Abas Mazni b Othman and Fauziah bt Othman
    Citation: BMC Cancer 2013 13:488
    Content type: Research article Published on:

  5. Triple-negative breast cancer (TNBC) remains a challenging topic for clinical oncologists. This study sought to evaluate TNBC versus other breast cancer subtypes with respect to survival parameters. We evaluat...

    Authors: Lukas Schwentner, Achim Wöckel, Jochem König, Wolfgang Janni, Florian Ebner, Maria Blettner, Rolf Kreienberg and Reyn Van Ewijk
    Citation: BMC Cancer 2013 13:487
    Content type: Research article Published on:

  6. Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed ...

    Authors: Bilal O Al-Jiffry, Yasir AlNemary, Samah H Khayat, Moutaz Haiba and Mohammed Hatem
    Citation: BMC Cancer 2013 13:486
    Content type: Case report Published on:

  8. Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified ...

    Authors: Lisa Golmard, Virginie Caux-Moncoutier, Grégoire Davy, Essam Al Ageeli, Brigitte Poirot, Carole Tirapo, Dorothée Michaux, Catherine Barbaroux, Catherine Dubois d’Enghien, André Nicolas, Laurent Castéra, Xavier Sastre-Garau, Marc-Henri Stern, Claude Houdayer and Dominique Stoppa-Lyonnet
    Citation: BMC Cancer 2013 13:484
    Content type: Research article Published on:

  9. Patients diagnosed for a serous ovarian borderline tumor (s-BOT) typically present with an excellent clinical outcome. However there have been controversies concerning the prognostic impact of so-called implan...

    Authors: Sabine Heublein, Katinka Grasse, Harald Hessel, Alexander Burges, Miriam Lenhard, Jutta Engel, Thomas Kirchner, Udo Jeschke and Doris Mayr
    Citation: BMC Cancer 2013 13:483
    Content type: Research article Published on:

  10. The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in tumor cell growth and survival. However, it remains unclear about the clinicopathological significance of ...

    Authors: Kyoichi Kaira, Yutaka Sunose, Yasuhiro Ohshima, Noriko S Ishioka, Kazuhisa Arakawa, Tetsushi Ogawa, Noriaki Sunaga, Kimihiro Shimizu, Hideyuki Tominaga, Noboru Oriuchi, Hideaki Itoh, Shushi Nagamori, Yoshikatsu Kanai, Aiko Yamaguchi, Atsuki Segawa, Munenori Ide…
    Citation: BMC Cancer 2013 13:482
    Content type: Research article Published on:

  11. TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potent...

    Authors: Shanique K E Edwards, Carissa R Moore, Yan Liu, Sukhdeep Grewal, Lori R Covey and Ping Xie
    Citation: BMC Cancer 2013 13:481
    Content type: Research article Published on:

  12. The presence of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients is associated with reduced clinical outcome. Bisphosphonate treatment was shown to eradicate DTC from BM in several ...

    Authors: Malgorzata Banys, Erich-Franz Solomayer, Gerhard Gebauer, Wolfgang Janni, Natalia Krawczyk, Hans-Joachim Lueck, Sven Becker, Jens Huober, Bernhard Kraemer, Birgit Wackwitz, Peter Hirnle, Diethelm Wallwiener and Tanja Fehm
    Citation: BMC Cancer 2013 13:480
    Content type: Research article Published on:

  13. Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targe...

    Authors: Wen-guo Jiang, Xin-an Lu, Bo-yang Shang, Yan Fu, Sheng-hua Zhang, Daifu Zhou, Liang Li, Yi Li, Yongzhang Luo and Yong-su Zhen
    Citation: BMC Cancer 2013 13:479
    Content type: Research article Published on:

  14. MiR-106a is frequently down-regulated in various types of human cancer. However the underlying mechanism of miR-106a involved in glioma remains elusive.

    Authors: Dong-Wei Dai, Qiong Lu, Lai-Xing Wang, Wen-Yuan Zhao, Yi-Qun Cao, Ya-Nan Li, Guo-Sheng Han, Jian-Min Liu and Zhi-Jian Yue
    Citation: BMC Cancer 2013 13:478
    Content type: Research article Published on:

  15. Lung cancer is the leading cause of cancer death in North America and Western Europe. Patients with lung cancer in general have reduced physical capacity, functional capacity, poor quality of life and increase...

    Authors: Morten Quist, Seppo W Langer, Mikael Rørth, Karl Bang Christensen and Lis Adamsen
    Citation: BMC Cancer 2013 13:477
    Content type: Study protocol Published on:

  16. Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This...

    Authors: Carmela Ricciardelli, Miranda P Ween, Noor A Lokman, Izza A Tan, Carmen E Pyragius and Martin K Oehler
    Citation: BMC Cancer 2013 13:476
    Content type: Research article Published on:

  17. Obesity has been shown to be inversely associated with breast cancer risk in premenopausal women, while increasing risk in postmenopausal women. However, the current evidence is largely based on studies in Cau...

    Authors: Elisa V Bandera, Urmila Chandran, Gary Zirpoli, Zhihong Gong, Susan E McCann, Chi-Chen Hong, Gregory Ciupak, Karen Pawlish and Christine B Ambrosone
    Citation: BMC Cancer 2013 13:475
    Content type: Research article Published on:

  18. The role of chemotherapy given concurrently with thoracic three-dimensional radiotherapy for stage IV non-small cell lung cancer (NSCLC) is not well defined. We performed this study to investigate overall surv...

    Authors: Sheng-Fa Su, Yin-Xiang Hu, Wei-Wei Ouyang, Bing Lu, Zhu Ma, Qing-Song Li, Hui-Qin Li and Yi-Chao Geng
    Citation: BMC Cancer 2013 13:474
    Content type: Research article Published on:

  19. Long-term estrogen deprivation models are widely employed in an in vitro setting to recapitulate the hormonal milieu of breast cancer patients treated with endocrine therapy. Despite the wealth information we hav...

    Authors: Jelena Milosevic, Johanna Klinge, Anna-Lena Borg, Theodoros Foukakis, Jonas Bergh and Nicholas P Tobin
    Citation: BMC Cancer 2013 13:473
    Content type: Research article Published on:

  20. Knowledge about tumour gene mutation status is essential for the treatment of increasing numbers of cancer patients, and testing quality has a major impact on treatment response and cost. In 2012, 4,629 tests ...

    Authors: Jean-François Emile, Julie Tisserand, Loic Bergougnoux, Frédérique Nowak, Gladwys Faucher, Sylvie Surel, Aude Lamy, Delphine Lecorre, Zofia Helias-Rodzewicz, Paul Hofman, Jean-Christophe Sabourin and Pierre Laurent-Puig
    Citation: BMC Cancer 2013 13:472
    Content type: Research article Published on:

  21. Activation of the protein kinase B/mammalian target of rapamycin (AKT/mTOR) pathway has been demonstrated to be involved in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated tumorigenesis in anaplast...

    Authors: Ju Gao, Minzhi Yin, Yiping Zhu, Ling Gu, Yanle Zhang, Qiang Li, Cangsong Jia and Zhigui Ma
    Citation: BMC Cancer 2013 13:471
    Content type: Research article Published on:

  22. Follow-up rate after a fecal occult blood test (FOBT) is low worldwide. In order to increase the follow-up rate, segmentation of the target population has been proposed as a promising strategy, because an inte...

    Authors: Yoshiki Ishikawa, Ying-Fang Zheng, Hiromu Nishiuchi, Takeo Suda, Tadahiko Hasumi and Hiroshi Saito
    Citation: BMC Cancer 2013 13:470
    Content type: Research article Published on:

  23. microRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC b...

    Authors: Guangxian Xu, Yilin Zhang, Jun Wei, Wei Jia, Zhaohui Ge, Zhaobo Zhang and Xiaoming Liu
    Citation: BMC Cancer 2013 13:469
    Content type: Research article Published on:

  24. Accumulating evidence has suggested the importance of glutamate signaling in cancer growth, yet the signaling pathway has not been fully elucidated. N-methyl-D-aspartic acid (NMDA) receptor activates intracell...

    Authors: Fuminori Yamaguchi, Yuko Hirata, Hossain Akram, Kazuyo Kamitori, Youyi Dong, Li Sui and Masaaki Tokuda
    Citation: BMC Cancer 2013 13:468
    Content type: Research article Published on:

  25. Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that ind...

    Authors: Cheng Shen, Huan Xu, Lunxu Liu, Yubin Zhou, Dali Chen, Heng Du, Zhaojie Han and Guowei Che
    Citation: BMC Cancer 2013 13:467
    Content type: Research article Published on:

  26. The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small ce...

    Authors: Morten F Gjerstorff, Mette Pøhl, Karen E Olsen and Henrik J Ditzel
    Citation: BMC Cancer 2013 13:466
    Content type: Research article Published on:

  27. A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation o...

    Authors: Atsushi Baba, Masahito Shimizu, Tomohiko Ohno, Yohei Shirakami, Masaya Kubota, Takahiro Kochi, Daishi Terakura, Hisashi Tsurumi and Hisataka Moriwaki
    Citation: BMC Cancer 2013 13:465
    Content type: Research article Published on:

  28. The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. H...

    Authors: Xiang-hua Liu, Zhi-li Liu, Ming Sun, Jing Liu, Zhao-xia Wang and Wei De
    Citation: BMC Cancer 2013 13:464
    Content type: Research article Published on:

  29. A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibi...

    Authors: Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick and Devasis Chatterjee
    Citation: BMC Cancer 2013 13:463
    Content type: Research article Published on:

  30. MT1G inactivation mediated by promoter methylation has been reported in thyroid cancer. However, the role of MT1G in thyroid carcinogenesis remains unclear. The aim of this study is to examine the biological fun...

    Authors: Jiao Fu, Hongjun Lv, Haixia Guan, Xiaoying Ma, Meiju Ji, Nongyue He, Bingyin Shi and Peng Hou
    Citation: BMC Cancer 2013 13:462
    Content type: Research article Published on:

  31. Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for under...

    Authors: Kai-hua Lu, Wei Li, Xiang-hua Liu, Ming Sun, Mei-ling Zhang, Wei-qin Wu, Wei-ping Xie and Ya-yi Hou
    Citation: BMC Cancer 2013 13:461
    Content type: Research article Published on:

  32. Cabazitaxel is approved in patients with metastatic hormone-refractory prostate cancer previously treated with a docetaxel-containing regimen. This study evaluated a weekly cabazitaxel dosing regimen. Primary ...

    Authors: Pierre Fumoleau, Jose Manuel Trigo, Nicolas Isambert, Dorothée Sémiond, Sunil Gupta and Mario Campone
    Citation: BMC Cancer 2013 13:460
    Content type: Research article Published on:

  33. High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic p...

    Authors: Zhengrong Sun, Zhitao Lu, Jianhua Liu, Guili Wang, Weiqiang Zhou, Lianxia Yang, Chao Liu, Bo Wang and Qiang Ruan
    Citation: BMC Cancer 2013 13:459
    Content type: Research article Published on:

  34. Cancer is a serious health issue in China, but accurate national counts for cancer incidence are not currently available. Knowledge of the cancer burden is necessary for national cancer control planning. In th...

    Authors: Wanqing Chen, Bruce K Armstrong, Rongshou Zheng, Siwei Zhang, Xueqin Yu and Mark Clements
    Citation: BMC Cancer 2013 13:458
    Content type: Research article Published on:

  35. The MRE11, RAD50, and NBN genes encode proteins of the MRE11-RAD50-NBN (MRN) complex involved in cellular response to DNA damage and the maintenance of genome stability. In our previous study we showed that the g...

    Authors: Maria Mosor, Iwona Ziółkowska-Suchanek, Karina Nowicka, Agnieszka Dzikiewicz-Krawczyk, Danuta Januszkiewicz–Lewandowska and Jerzy Nowak
    Citation: BMC Cancer 2013 13:457
    Content type: Research article Published on:

  36. Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylat...

    Authors: Jovana Klajic, Thomas Fleischer, Emelyne Dejeux, Hege Edvardsen, Fredrik Warnberg, Ida Bukholm, Per Eystein Lønning, Hiroko Solvang, Anne-Lise Børresen-Dale, Jörg Tost and Vessela N Kristensen
    Citation: BMC Cancer 2013 13:456
    Content type: Research article Published on:

  37. The quality of communication in medical care has been shown to influence health outcomes. Cancer patients, a highly diverse population, communicate with their clinical care team in diverse ways over the course...

    Authors: Brittany C Kimball, Katherine M James, Kathleen J Yost, Cara A Fernandez, Ashok Kumbamu, Aaron L Leppin, Marguerite E Robinson, Gail Geller, Debra L Roter, Susan M Larson, Heinz-Josef Lenz, Agustin A Garcia, Clarence H Braddock III, Aminah Jatoi, María Luisa Zúñiga de Nuncio, Victor M Montori…
    Citation: BMC Cancer 2013 13:455
    Content type: Study protocol Published on:

  38. Current guidelines recommend treatment with capecitabine and bevacizumab for patients (pts) with non-resectable metastatic colorectal cancer (mCRC), although clinical data in this particular patient group are ...

    Authors: Alexander Stein, Albrecht Kretzschmar, Dirk Behringer, Thomas Wolff, Joachim Zimber, Susanna Hegewisch-Becker, Erika Kettner, Karl-Heinz Pflüger, Andreas Kirsch and Dirk Arnold
    Citation: BMC Cancer 2013 13:454
    Content type: Research article Published on:

  39. In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an adaptive immune system until 14 days post-fertilization,...

    Authors: Yong Teng, Xiayang Xie, Steven Walker, David T White, Jeff S Mumm and John K Cowell
    Citation: BMC Cancer 2013 13:453
    Content type: Research article Published on:

  40. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe. Th...

    Authors: Annette Künkele, Anja Grosse-Lordemann, Alexander Schramm, Angelika Eggert, Johannes H Schulte and Hagen S Bachmann
    Citation: BMC Cancer 2013 13:452
    Content type: Research article Published on:

  41. Human homeobox genes encode nuclear proteins that act as transcription factors involved in the control of differentiation and proliferation. Currently, the role of these genes in development and tumor progress...

    Authors: Thais Chile, Maria Angela Henriques Zanella Fortes, Maria Lúcia Cardillo Corrêa-Giannella, Helena Paula Brentani, Durvanei Augusto Maria, Renato David Puga, Vanessa de Jesus R de Paula, Marcia Saldanha Kubrusly, Estela Maria Novak, Telésforo Bacchella and Ricardo Rodrigues Giorgi
    Citation: BMC Cancer 2013 13:451
    Content type: Research article Published on:

  42. Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data ...

    Authors: Albrecht Stenzinger, Volker Endris, Frederick Klauschen, Bruno Sinn, Katja Lorenz, Arne Warth, Benjamin Goeppert, Volker Ehemann, Alexander Muckenhuber, Carsten Kamphues, Marcus Bahra, Peter Neuhaus and Wilko Weichert
    Citation: BMC Cancer 2013 13:450
    Content type: Research article Published on:

  43. Racial disparities in breast cancer survival have been well documented. This study examines the association of race/ethnicity and socioeconomic status (SES) on breast cancer-specific mortality in a large popul...

    Authors: Carol A Parise and Vincent Caggiano
    Citation: BMC Cancer 2013 13:449
    Content type: Research article Published on:

  44. MicroRNAs are regulators that can play an essential role in tumorigenesis. Although miR-302 families have been suggested to be tumor repressors in human cancer, the mechanism by which they suppress tumor devel...

    Authors: Lumin Wang, Jiayi Yao, Xin Shi, Lili Hu, Zongfang Li, Tusheng Song and Chen Huang
    Citation: BMC Cancer 2013 13:448
    Content type: Research article Published on:

  45. Although the percentage of patients with renal cell carcinoma (RCC) extending into venous systems is unexpectedly high, the prognostic impact and independency of venous tumor thrombus-related factors on overal...

    Authors: Masanori Hirono, Mikio Kobayashi, Tomoyasu Tsushima, Wataru Obara, Nobuo Shinohara, Keiichi Ito, Masatoshi Eto, Tatsuya Takayama, Yasuhisa Fujii, Masaharu Nishikido, Go Kimura, Takeshi Kishida, Masayuki Takahashi, Noriomi Miyao, Yukio Naya, Takashige Abe…
    Citation: BMC Cancer 2013 13:447
    Content type: Research article Published on:

  46. Patients with acute leukemia experience a substantial symptom burden and are at risk of developing infections throughout the course of repeated cycles of intensive chemotherapy. Physical activity in recent yea...

    Authors: Mary Jarden, Tom Møller, Lars Kjeldsen, Henrik Birgens, Jesper Frank Christensen, Karl Bang Christensen, Finn Diderichsen, Carsten Hendriksen and Lis Adamsen
    Citation: BMC Cancer 2013 13:446
    Content type: Study protocol Published on:

  47. Metaplastic carcinoma, an uncommon subtype of breast cancer, is part of the spectrum of basal-like, triple receptor-negative breast carcinomas. The present study examined 20 surgical specimens of metaplastic b...

    Authors: Roberto Herrera-Goepfert, Teresa Vela-Chávez, Adela Carrillo-García, Marcela Lizano-Soberón, Alfredo Amador-Molina, Luis F Oñate-Ocaña and Rita Sotelo-Regil Hallmann
    Citation: BMC Cancer 2013 13:445
    Content type: Research article Published on:

  48. Trastuzumab is an antibody widely used in the treatment of breast cancer cases that test positive for the human epidermal growth factor receptor 2 (HER2). Many patients, however, become resistant to this antib...

    Authors: Eloah Rabello Suarez, Edgar Julian Paredes-Gamero, Auro Del Giglio, Ivarne Luis dos Santos Tersariol, Helena Bonciani Nader and Maria Aparecida Silva Pinhal
    Citation: BMC Cancer 2013 13:444
    Content type: Research article Published on:

  50. The preoperative ratio of neutrophils to lymphocytes (NLR) has been proposed as a marker of poor outcome in patients having a resection for colorectal cancer (CRC). This study investigated the association betw...

    Authors: Lucy Jankova, Owen F Dent, Charles Chan, Pierre Chapuis and Stephen J Clarke
    Citation: BMC Cancer 2013 13:442
    Content type: Research article Published on:

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