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  1. Improvement in treatment for patients with recurrent ovarian cancer is needed. Standard therapy in patients with platinum-sensitive recurrent ovarian cancer consists of platinum-based chemotherapy. Median over...

    Authors: Rafli van de Laar, Petra LM Zusterzeel, Toon Van Gorp, Marrije R Buist, Willemien J van Driel, Katja N Gaarenstroom, Henriette JG Arts, Johannes CM van Huisseling, Ralph HM Hermans, Johanna MA Pijnenborg, Eltjo MJ Schutter, Harold MP Pelikan, Jos HA Vollebergh, Mirjam JA Engelen, Joanna IntHout, Roy FPM Kruitwagen…
    Citation: BMC Cancer 2014 14:22
    Content type: Study protocol Published on:

  2. When treating cerebral metastases all involved multidisciplinary oncological specialists have to cooperate closely to provide the best care for these patients. For the resection of brain metastasis several stu...

    Authors: Thomas Obermueller, Michael Schaeffner, Julia Gerhardt, Bernhard Meyer, Florian Ringel and Sandro M Krieg
    Citation: BMC Cancer 2014 14:21
    Content type: Research article Published on:

  3. Adjuvant and salvage radiotherapy of the prostate bed are established treatment options for prostate cancer. While the benefit of an additional radiotherapy of the pelvic lymph nodes is still under debate, the...

    Authors: Sonja Katayama, Gregor Habl, Kerstin Kessel, Lutz Edler, Juergen Debus, Klaus Herfarth and Florian Sterzing
    Citation: BMC Cancer 2014 14:20
    Content type: Research article Published on:

  4. Primary small cell carcinoma of the esophagus (PSCCE) is a rare and aggressive tumor with poor prognosis. The aim of this study was to investigate the existence of EGFR, KRAS, PIK3CA and PTEN mutations in PSCCE.

    Authors: Zhimin Zhang, Hualiang Xiao, Fei Xie, Hui Zhang, Chuan Chen, He Xiao, Zhenzhou Yang, Dong Wang, Zengpeng Li and Ge Wang
    Citation: BMC Cancer 2014 14:19
    Content type: Research article Published on:

  5. In locally advanced Non-Small-Cell Lung Cancer (LA-NSCLC) patients treated with chemoradiotherapy (CRT), optimal surrogate endpoint for cure has not been fully investigated.

    Authors: Hiroaki Akamatsu, Keita Mori, Tateaki Naito, Hisao Imai, Akira Ono, Takehito Shukuya, Tetsuhiko Taira, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi and Nobuyuki Yamamoto
    Citation: BMC Cancer 2014 14:18
    Content type: Research article Published on:

  6. Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therape...

    Authors: Eun Jung Choi, Bong Jun Cho, David J Lee, Yeo Hyeon Hwang, Sun Ha Chun, Hans H Kim and In Ah Kim
    Citation: BMC Cancer 2014 14:17
    Content type: Research article Published on:

  7. In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormon...

    Authors: Rajesh Thangapazham, Francisco Saenz, Shilpa Katta, Ahmed A Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava and Albert Dobi
    Citation: BMC Cancer 2014 14:16
    Content type: Research article Published on:

  8. CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in head and neck squamous cell cancer (HNSCC). However, the prognostic value of CD44 still re...

    Authors: Jianqiang Chen, Jianding Zhou, Jie Lu, Hua Xiong, Xueli Shi and Liang Gong
    Citation: BMC Cancer 2014 14:15
    Content type: Research article Published on:

  9. Gastric carcinoma remains the second commonest cause of cancer deaths worldwide. Presence of the carcinoma cell in the pulmonary artery is serious condition that might cause remodeling of the pulmonary artery....

    Authors: Takao Ishiwatari, Yoichiro Okubo, Naobumi Tochigi, Megumi Wakayama, Tetsuo Nemoto, Junko Kobayashi, Minoru Shinozaki, Kyoko Aki, Daisuke Sasai, Yoshiro Yamamoto, Haruo Nakayama and Kazutoshi Shibuya
    Citation: BMC Cancer 2014 14:14
    Content type: Research article Published on:

  10. The approval of vemurafenib in the US 2011 and in Europe 2012 improved the therapy of not resectable or metastatic melanoma. Patients carrying a substitution of valine to glutamic acid at codon 600 (p.V600E) o...

    Authors: Michaela Angelika Ihle, Jana Fassunke, Katharina König, Inga Grünewald, Max Schlaak, Nicole Kreuzberg, Lothar Tietze, Hans-Ulrich Schildhaus, Reinhard Büttner and Sabine Merkelbach-Bruse
    Citation: BMC Cancer 2014 14:13
    Content type: Research article Published on:

  11. The reasons for the increasing breast cancer incidence in indigenous Māori compared to non-Māori New Zealand women are unknown. The aim of this study was to assess the association of an index of combined healt...

    Authors: Fiona McKenzie, Lis Ellison-Loschmann, Mona Jeffreys, Ridvan Firestone, Neil Pearce and Isabelle Romieu
    Citation: BMC Cancer 2014 14:12
    Content type: Research article Published on:

  12. Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is ...

    Authors: Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang and Dong Wang
    Citation: BMC Cancer 2014 14:11
    Content type: Research article Published on:

  13. Progesterone is essential for the proliferation and differentiation of mammary gland epithelium. Studies of breast cancer cells have demonstrated a biphasic progesterone response consisting of an initial proli...

    Authors: Min Wei, Qi He, Zhongyin Yang, Zhiwei Wang, Qing Zhang, Bingya Liu, Qinlong Gu, Liping Su, Yingyan Yu, Zhenggang Zhu and Guofeng Zhang
    Citation: BMC Cancer 2014 14:10
    Content type: Research article Published on:

  14. Detection of microcalcifications on mammograms indicates the presence of breast lesion, and the shapes of the microcalcifications as seen by conventional mammography correlates with the probability of malignan...

    Authors: Inneke Willekens, Elke Van de Casteele, Nico Buls, Frederik Temmermans, Bart Jansen, Rudi Deklerck and Johan de Mey
    Citation: BMC Cancer 2014 14:9
    Content type: Research article Published on:

  15. Lymph nodal involvement is an important clinical-pathological sign in primary cutaneous lymphoma (PCL), as it marks the transformation/evolution of the disease from localized to systemic; therefore the surveil...

    Authors: Elena Vigliar, Immacolata Cozzolino, Marco Picardi, Anna Lucia Peluso, Laura Virginia Sosa Fernandez, Antonio Vetrani, Gerardo Botti, Fabrizio Pane, Carmine Selleri and Pio Zeppa
    Citation: BMC Cancer 2014 14:8
    Content type: Research article Published on:

  16. Hepatocellular carcinoma (HCC) is a particularly severe disease characterized by a high rate of recurrence and death even after surgical resection. Molecular characterization of HCC helps refine prognosis and ...

    Authors: Adeodat Ilboudo, Jean-Charles Nault, Hélène Dubois-Pot-Schneider, Anne Corlu, Jessica Zucman-Rossi, Michel Samson and Jacques Le Seyec
    Citation: BMC Cancer 2014 14:7
    Content type: Research article Published on:

  17. Benzene is an established human leukemogen, with a ubiquitous environmental presence leading to significant population exposure. In a genome-wide functional screen in the yeast Saccharomyces cerevisiae, inactivat...

    Authors: Matthew North, Joe Shuga, Michele Fromowitz, Alexandre Loguinov, Kevin Shannon, Luoping Zhang, Martyn T Smith and Chris D Vulpe
    Citation: BMC Cancer 2014 14:6
    Content type: Research article Published on:

  18. Candidate predictive biomarkers for epidermal growth factor receptor inhibitors (EGFRi), skin rash and serum proteomic assays, require further qualification to improve EGFRi therapy in non-small cell lung canc...

    Authors: Michael L Maitland, Matthew R Levine, Mario E Lacouture, Kristen E Wroblewski, Christine H Chung, Ilyssa O Gordon, Livia Szeto, Gail Ratko, Keyoumars Soltani, Mark F Kozloff, Philip C Hoffman, Ravi Salgia, David P Carbone, Theodore G Karrison and Everett E Vokes
    Citation: BMC Cancer 2014 14:5
    Content type: Research article Published on:

  19. Neoadjuvant chemotherapy (NC) is an established therapy in breast cancer, able to downstage positive axillary lymph nodes, but might hamper their detectibility. Even if clinical observations suggest lower lymp...

    Authors: Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Gerta Rücker, Sebastian Mayer, Matthias Voigt, Juliane Farthmann, Severine Iborra, Marc Hirschfeld, Philipp T Meyer, Gerald Gitsch and Elmar Stickeler
    Citation: BMC Cancer 2014 14:4
    Content type: Research article Published on:

  20. Lung cancer is the leading cause of cancer death worldwide and characterized by a poor prognosis. It has a major impact on the psychological wellbeing of patients and their partners. Recently, it has been show...

    Authors: Melanie PJ Schellekens, Desiree GM van den Hurk, Judith B Prins, Johan Molema, A Rogier T Donders, Willem H Woertman, Miep A van der Drift and Anne EM Speckens
    Citation: BMC Cancer 2014 14:3
    Content type: Study protocol Published on:

  21. Mitogen-activated protein kinase kinase kinase3 (MAP3K3/MEKK3) was identified to be differentially expressed in esophageal squamous cell carcinoma (ESCC) using cDNA microarrays by our laboratory. Here in we de...

    Authors: Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K Chattopadhyay, Siddartha DattaGupta, Paul G Walfish, Shyam S Chauhan and Ranju Ralhan
    Citation: BMC Cancer 2014 14:2
    Content type: Research article Published on:

  22. Increased collagen deposition provides physical and biochemical signals to support tumor growth and invasion during breast cancer development. Therefore, inhibition of collagen synthesis and deposition has bee...

    Authors: Gaofeng Xiong, Lei Deng, Jieqing Zhu, Piotr G Rychahou and Ren Xu
    Citation: BMC Cancer 2014 14:1
    Content type: Research article Published on:

  23. Cortidis rhizoma (Huanglian) and its major therapeutic component, berberine, have drawn extensive attention in recent years for their anti-cancer properties. Growth inhibitory effects of berberine on multiple ty...

    Authors: Chi Man Tsang, Yuk Chun Cheung, Vivian Wai-Yan Lui, Yim Ling Yip, Guitao Zhang, Victor Weitao Lin, Kenneth Chat-Pan Cheung, Yibin Feng and Sai Wah Tsao
    Citation: BMC Cancer 2013 13:619
    Content type: Research article Published on:

  25. Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug therapy is a major clinical problem resulting in a poor patient’s prognosis. Beside promoter methylation of the O 6 ...

    Authors: Moritz C Oberstadt, Sandra Bien-Möller, Kerstin Weitmann, Susann Herzog, Katharina Hentschel, Christian Rimmbach, Silke Vogelgesang, Ellen Balz, Matthias Fink, Heike Michael, Jan-Philip Zeden, Henrike Bruckmüller, Anneke N Werk, Ingolf Cascorbi, Wolfgang Hoffmann, Dieter Rosskopf…
    Citation: BMC Cancer 2013 13:617
    Content type: Research article Published on:

  26. Knowledge on immunosuppressive factors in the pathogenesis of endometrial cancer is scarce. The aim of this study was to assess Glycodelin (Gd) and its immunosuppressive isoform Glycodelin A (GdA) in endometri...

    Authors: Miriam Lenhard, Sabine Heublein, Christiane Kunert-Keil, Thomas Vrekoussis, Isabel Lomba, Nina Ditsch, Doris Mayr, Klaus Friese and Udo Jeschke
    Citation: BMC Cancer 2013 13:616
    Content type: Research article Published on:

  27. The gold standard of HER2 status assessment in breast cancer is still debated. Immunohistochemistry (IHC) and in-situ technology as fluorescent-labeled methodology (FISH) can be influenced by pre-analytical facto...

    Authors: Zsuzsanna Varga, Aurelia Noske, Constanze Ramach, Barbara Padberg and Holger Moch
    Citation: BMC Cancer 2013 13:615
    Content type: Research article Published on:

  28. There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifeti...

    Authors: Eiliv Lund, Nicolle Mode, Marit Waaseth and Jean-Christophe Thalabard
    Citation: BMC Cancer 2013 13:614
    Content type: Research article Published on:

  29. Cancer vaccine is one of the attractive treatment modalities for patients with castration-resistant prostate cancer (CRPC). However, because of delayed immune responses, its clinical benefits, besides for over...

    Authors: Masanori Noguchi, Fukuko Moriya, Shigetaka Suekane, Rei Ohnishi, Satoko Matsueda, Tetsuro Sasada, Akira Yamada and Kyogo Itoh
    Citation: BMC Cancer 2013 13:613
    Content type: Research article Published on:

  30. Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a r...

    Authors: Nynke GL Jager, Rutger HT Koornstra, Andrew D Vincent, Ron HN van Schaik, Alwin DR Huitema, Tiny M Korse, Jan HM Schellens, Sabine C Linn and Jos H Beijnen
    Citation: BMC Cancer 2013 13:612
    Content type: Research article Published on:

  31. Optimization of chemotherapy effectiveness in metastatic colorectal cancers (mCRC) is a major endpoint to enhance the possibility of curative intent surgery. FOLFIRI3 has shown promising results as second-line...

    Authors: Stefano Kim, Erion Dobi, Marine Jary, Franck Monnien, Elsa Curtit, Thierry NGuyen, Zaher Lakkis, Bruno Heyd, Serge Fratte, Denis Cléau, Najib Lamfichekh, Virginie Nerich, Boris Guiu, Martin Demarchi and Christophe Borg
    Citation: BMC Cancer 2013 13:611
    Content type: Research article Published on:

  32. Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because m...

    Authors: Michael Schlumpf, Claude Fischer, Diana Naehrig, Christoph Rochlitz and Martin Buess
    Citation: BMC Cancer 2013 13:610
    Content type: Research article Published on:

  33. Information on the underlying cause of death of cancer patients is of interest because it can be used to estimate net survival. The population-based Geneva Cancer Registry is unique because registrars are able...

    Authors: Robin Schaffar, Elisabetta Rapiti, Bernard Rachet and Laura Woods
    Citation: BMC Cancer 2013 13:609
    Content type: Research article Published on:

  34. Aberrant methylation at imprinted differentially methylated regions (DMRs) in human 11p15.5 has been reported in many tumors including hepatoblastoma. However, the methylation status of imprinted DMRs in impri...

    Authors: Janette Mareska Rumbajan, Toshiyuki Maeda, Ryota Souzaki, Kazumasa Mitsui, Ken Higashimoto, Kazuhiko Nakabayashi, Hitomi Yatsuki, Kenichi Nishioka, Ryoko Harada, Shigehisa Aoki, Kenichi Kohashi, Yoshinao Oda, Kenichiro Hata, Tsutomu Saji, Tomoaki Taguchi, Tatsuro Tajiri…
    Citation: BMC Cancer 2013 13:608
    Content type: Research article Published on:

  35. A pathway-based genotyping analysis suggested rs2078486 was a novel TP53 SNP, but very few studies replicate this association. TP53 rs1042522 is the most commonly studied SNP, but very few studies examined its po...

    Authors: Yanli Li, Shen-Chih Chang, Rungui Niu, Li Liu, Christina R Crabtree-Ide, Baoxing Zhao, Jianping Shi, Xiaoyou Han, Jiawei Li, Jia Su, Lin Cai, Shunzhang Yu, Zuo-Feng Zhang and Lina Mu
    Citation: BMC Cancer 2013 13:607
    Content type: Research article Published on:

  36. Despite an initial good response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), resistance to treatment eventually develops. Although several resistance mechanisms have been discov...

    Authors: Wonjun Ji, Chang-Min Choi, Jin Kyung Rho, Se Jin Jang, Young Soo Park, Sung-Min Chun, Woo Sung Kim, Jung-Shin Lee, Sang-We Kim, Dae Ho Lee and Jae Cheol Lee
    Citation: BMC Cancer 2013 13:606
    Content type: Research article Published on:

  38. Chk1 inhibitors have emerged as promising anticancer therapeutic agents particularly when combined with antimetabolites such as gemcitabine, cytarabine or hydroxyurea. Here, we address the importance of approp...

    Authors: Ryan Montano, Ruth Thompson, Injae Chung, Huagang Hou, Nadeem Khan and Alan Eastman
    Citation: BMC Cancer 2013 13:604
    Content type: Research article Published on:

  39. Nonpolypoid adenomas are a subgroup of colorectal adenomas that have been associated with a more aggressive clinical behaviour compared to their polypoid counterparts. A substantial proportion of nonpolypoid a...

    Authors: Quirinus JM Voorham, Jerry Janssen, Marianne Tijssen, Suzanne Snellenberg, Sandra Mongera, Nicole CT van Grieken, Heike Grabsch, Martin Kliment, Bjorn J Rembacken, Chris JJ Mulder, Manon van Engeland, Gerrit A Meijer, Renske DM Steenbergen and Beatriz Carvalho
    Citation: BMC Cancer 2013 13:603
    Content type: Research article Published on:

  40. Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the g...

    Authors: Simion I Chiosea, Jennifer R Grandis, Vivian W Y Lui, Brenda Diergaarde, Jessica H Maxwell, Robert L Ferris, Seungwon W Kim, Alyssa Luvison, Megan Miller and Marina N Nikiforova
    Citation: BMC Cancer 2013 13:602
    Content type: Research article Published on:

  41. Glutaminase 2 (Gls2) is a p53 target gene and is known to play an important role in energy metabolism. Gls2 has been reported to be downregulated in human hepatocellular carcinomas (HCC). However, the underlyi...

    Authors: Jianbin Zhang, Cheng Wang, Mingquan Chen, Jianping Cao, Ying Zhong, Liting Chen, Han-Ming Shen and Dajing Xia
    Citation: BMC Cancer 2013 13:601
    Content type: Research article Published on:

  43. The epidermal growth factor receptor (EGFR)/RAS/RAF/MEK/MAPK pathway is an important pathway in the carcinogenesis, invasion and metastasis of colorectal cancers (CRCs). We conducted a retrospective study to d...

    Authors: Ching-Wen Huang, Hsiang-Lin Tsai, Yi-Ting Chen, Chun-Ming Huang, Cheng-Jen Ma, Chien-Yu Lu, Chao-Hung Kuo, Deng-Chyang Wu, Chee-Yin Chai and Jaw-Yuan Wang
    Citation: BMC Cancer 2013 13:599
    Content type: Research article Published on:

  44. Worldwide more than one million women are annually diagnosed with breast cancer. A considerable fraction of these women receive systemic adjuvant therapy; however, some are cured by primary surgery and radioth...

    Authors: Stine B Thorsen, Sarah LT Christensen, Sidse Ø Würtz, Martin Lundberg, Birgitte S Nielsen, Lena Vinther, Mick Knowles, Nick Gee, Simon Fredriksson, Susanne Møller, Nils Brünner, Anne-Sofie Schrohl and Jan Stenvang
    Citation: BMC Cancer 2013 13:598
    Content type: Research article Published on:

  45. Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to ...

    Authors: Gregor Auf, Arnaud Jabouille, Maylis Delugin, Sylvaine Guérit, Raphael Pineau, Sophie North, Natalia Platonova, Marlène Maitre, Alexandre Favereaux, Peter Vajkoczy, Masaharu Seno, Andreas Bikfalvi, Dmitri Minchenko, Oleksandr Minchenko and Michel Moenner
    Citation: BMC Cancer 2013 13:597
    Content type: Research article Published on:

  47. Androgen deprivation therapy (ADT) is a cornerstone in the treatment of advanced prostate cancer. Adverse musculoskeletal and cardiovascular effects of ADT are widely reported and investigations into the poten...

    Authors: Jacob Uth, Jakob Friis Schmidt, Jesper Frank Christensen, Therese Hornstrup, Lars Juel Andersen, Peter Riis Hansen, Karl Bang Christensen, Lars Louis Andersen, Eva Wulff Helge, Klaus Brasso, Mikael Rørth, Peter Krustrup and Julie Midtgaard
    Citation: BMC Cancer 2013 13:595
    Content type: Study protocol Published on:

  48. Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of ora...

    Authors: Enjiao Zhang, Zhigang Cui, Zhongfei Xu, Weiyi Duan, Shaohui Huang, Xuexin Tan, Zhihua Yin, Changfu Sun and Li Lu
    Citation: BMC Cancer 2013 13:594
    Content type: Research article Published on:

  49. Src tyrosine kinase activates inducible nitric oxide synthase (iNOS) and, in turn, nitric oxide production as a means to transduce cell migration. Src tyrosine kinase plays a key proximal role to control α9β1 ...

    Authors: Thompson Zhuang, Bharath Chelluboina, Shivani Ponnala, Kiran Kumar Velpula, Azeem A Rehman, Chandramu Chetty, Eleonora Zakharian, Jasti S Rao and Krishna Kumar Veeravalli
    Citation: BMC Cancer 2013 13:590
    Content type: Research article Published on:

  50. Dovitinib (TKI-258) is a receptor tyrosine kinase (RTK) inhibitor targeting fibroblast growth factor receptor (FGFR) and further related RTKs. TKI-258 is under investigation as anticancer drug for the treatmen...

    Authors: Jörg Hänze, Marcus Henrici, Axel Hegele, Rainer Hofmann and Peter J Olbert
    Citation: BMC Cancer 2013 13:589
    Content type: Research article Published on:

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