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  1. The relationship between the uptake of [18F]fluoroerythronitroimidazole ([18F]FETNIM), blood flow ([15O]H2O) and 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) and immunohistochemically determined biomarkers was evaluat...

    Authors: Tove J Grönroos, Kaisa Lehtiö, Karl-Ove Söderström, Pauliina Kronqvist, Jukka Laine, Olli Eskola, Tapio Viljanen, Reidar Grénman, Olof Solin and Heikki Minn
    Citation: BMC Cancer 2014 14:876
    Content type: Research article Published on:

  2. Locally advanced rectal cancer (LARC) is a heterogeneous group of tumors where a risk-adapted therapeutic strategy is needed. Short-course radiotherapy (SCRT) is a more convenient option for LARC patients than...

    Authors: Antonio Avallone, Maria Carmela Piccirillo, Paolo Delrio, Biagio Pecori, Elena Di Gennaro, Luigi Aloj, Fabiana Tatangelo, Valentina D’Angelo, Cinzia Granata, Ernesta Cavalcanti, Nicola Maurea, Piera Maiolino, Franco Bianco, Massimo Montano, Lucrezia Silvestro, Manuela Terranova Barberio…
    Citation: BMC Cancer 2014 14:875
    Content type: Study protocol Published on:

  3. Breast cancer in women and prostate cancer are the first and second leading tumour respectively in terms of incidence world-wide. Our objective is to ascertain the similarities and differences between mortalit...

    Authors: Gonzalo López-Abente, Sergio Mispireta and Marina Pollán
    Citation: BMC Cancer 2014 14:874
    Content type: Research article Published on:

  4. A remarkable increase in the number of thyroid cancer cases has been reported in recent years; however, the markers to predict high-risk groups have not been fully established.

    Authors: Young Ae Cho, Sun-Young Kong, Aesun Shin, Jeonghee Lee, Eun Kyung Lee, You Jin Lee and Jeongseon Kim
    Citation: BMC Cancer 2014 14:873
    Content type: Research article Published on:

  5. Trastuzumab resistance is almost inevitable in the management of human epidermal growth factor receptor (HER) 2 positive breast cancer, in which phosphatase and tensin homolog deleted from chromosome 10 (PTEN)...

    Authors: Cheng Du, Xiaomin Yi, Wenchao Liu, Tao Han, Zhaozhe Liu, Zhenyu Ding, Zhendong Zheng, Ying Piao, Jianlin Yuan, Yaling Han, Manjiang Xie and Xiaodong Xie
    Citation: BMC Cancer 2014 14:869
    Content type: Research article Published on:

  6. The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of COL11A1, has not been studied ...

    Authors: José A Galván, Jorge García-Martínez, Fernando Vázquez-Villa, Marcos García-Ocaña, Carmen García-Pravia, Primitiva Menéndez-Rodríguez, Carmen González-del Rey, Luis Barneo-Serra and Juan R de los Toyos
    Citation: BMC Cancer 2014 14:867
    Content type: Research article Published on:

  7. Signal transducer and activator of transcription 3 (STAT3) is an important transcriptional factor frequently associated with the proliferation and survival of a large number of distinct cancer types. However, ...

    Authors: André L Mencalha, Stephany Corrêa, Daniela Salles, Bárbara Du Rocher, Marcelo F Santiago and Eliana Abdelhay
    Citation: BMC Cancer 2014 14:866
    Content type: Research article Published on:

  8. This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS col...

    Authors: Julen Fernandez-Plana, Carlos Pericay, Guillermo Quintero, Vicente Alonso, Antonieta Salud, Miguel Mendez, Mercedes Salgado, Eugeni Saigi and Luis Cirera
    Citation: BMC Cancer 2014 14:865
    Content type: Research article Published on:

  9. Several studies have shown that the immunophenotype of distant breast cancer metastases may differ significantly from that of the primary tumor, especially with regard to differences in the level of hormone re...

    Authors: Laura S Jiwa, Paul J van Diest, Laurien D Hoefnagel, Jelle Wesseling, Pieter Wesseling and Cathy B Moelans
    Citation: BMC Cancer 2014 14:864
    Content type: Research article Published on:

  10. The ErbB family consists of four proteins including (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4, and plays a crucial role in the promotion of multiple tumorigenic processes. In addition to the traditional pathways o...

    Authors: Keigo Mitsui, Masaoki Yonezawa, Atsushi Tatsuguchi, Seiichi Shinji, Katya Gudis, Shu Tanaka, Shunji Fujimori and Choitsu Sakamoto
    Citation: BMC Cancer 2014 14:863
    Content type: Research article Published on:

  11. Pancreatic cancer is one of the deadliest human malignancies, with few therapeutic options. Re-activation of embryonic signaling pathways is commonly in human pancreatic cancer and provided rationale to explor...

    Authors: Marsha M Thomas, Yaqing Zhang, Esha Mathew, Kevin T Kane, Ivan Maillard and Marina Pasca di Magliano
    Citation: BMC Cancer 2014 14:862
    Content type: Research article Published on:

  12. Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer...

    Authors: Patricia Rodrigues, Griselda de Marco, Jessica Furriol, Maria Luisa Mansego, Mónica Pineda-Alonso, Anna Gonzalez-Neira, Juan Carlos Martin-Escudero, Javier Benitez, Ana Lluch, Felipe J Chaves and Pilar Eroles
    Citation: BMC Cancer 2014 14:861
    Content type: Research article Published on:

  13. Despite many prospective and retrospective studies about the association of dietary habit and lung cancer, the topic still remains controversial. So, this study aims to investigate the association of lung canc...

    Authors: Mostafa Hosseini, Parisa Adimi Naghan, Ali Moghadas Jafari, Mahmoud Yousefifard, Shervin Taslimi, Kian Khodadad, Forouzan Mohammadi, Makan Sadr, Mansour Rezaei, Esmaeil Mortaz and Mohammad Reza Masjedi
    Citation: BMC Cancer 2014 14:860
    Content type: Research article Published on:

  14. Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- o...

    Authors: Martin Mørck Mortensen, Søren Høyer, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Lars Dyrskjøt and Michael Borre
    Citation: BMC Cancer 2014 14:859
    Content type: Research article Published on:

  15. Circulating baseline levels of the plasma-protein osteopontin (OPN) have been suggested as a prognostic indicator in chemotherapy and surgery for lung cancer. However, the role of this hypoxia-related protein ...

    Authors: Christian Ostheimer, Matthias Bache, Antje Güttler, Thomas Reese and Dirk Vordermark
    Citation: BMC Cancer 2014 14:858
    Content type: Research article Published on:

  16. Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumou...

    Authors: Lin Jiang, Cécile Campagne, Elisabeth Sundström, Pedro Sousa, Saima Imran, Monika Seltenhammer, Gerli Pielberg, Mats J Olsson, Giorgia Egidy, Leif Andersson and Anna Golovko
    Citation: BMC Cancer 2014 14:857
    Content type: Research article Published on:

  17. To investigate the impact of physician-assessed late toxicities on patient-reported quality of life (QoL) for nasopharyngeal carcinoma (NPC) patients with long-term survival.

    Authors: Wen-Ling Tsai, Tai-Lin Huang, Kuan-Cho Liao, Hui-Ching Chuang, Yu-Tsai Lin, Tsair-Fwu Lee, Hsuan-Ying Huang and Fu-Min Fang
    Citation: BMC Cancer 2014 14:856
    Content type: Research article Published on:

  18. Pulmonary neuroendocrine tumors (Pulmonary NETs) include a wide spectrum of tumors, from the low-grade typical carcinoid (TC) and the intermediate-grade atypical carcinoid (AC), to the high-grade large-cell ne...

    Authors: Jose A Galván, Aurora Astudillo, Aitana Vallina, Guillermo Crespo, Maria Victoria Folgueras and Maria Victoria González
    Citation: BMC Cancer 2014 14:855
    Content type: Research article Published on:

  19. Chromosomal instability in exfoliated urothelial cells has been associated with the development of bladder cancer. Here, we analyzed the accumulation of copy number variations (CNVs) using fluorescence in situ...

    Authors: Nadine Bonberg, Beate Pesch, Thomas Behrens, Georg Johnen, Dirk Taeger, Katarzyna Gawrych, Christian Schwentner, Harald Wellhäußer, Matthias Kluckert, Gabriele Leng, Michael Nasterlack, Christoph Oberlinner, Arnulf Stenzl and Thomas Brüning
    Citation: BMC Cancer 2014 14:854
    Content type: Research article Published on:

  20. The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we...

    Authors: John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli and Per Sunnerhagen
    Citation: BMC Cancer 2014 14:853
    Content type: Research article Published on:

  21. Expression of NRIF3 (Nuclear Receptor Interacting Factor-3) rapidly and selectively leads to apoptosis of breast cancer cells. This occurs through binding of NRIF3 or its 30 amino acid Death Domain-1 (DD1) reg...

    Authors: Sharmistha Das, Kay T Yeung, Muktar A Mahajan and Herbert H Samuels
    Citation: BMC Cancer 2014 14:852
    Content type: Research article Published on:

  22. Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced sur...

    Authors: Daniela D’Angelo, Paula Mussnich, Roberta Rosa, Roberto Bianco, Giampaolo Tortora and Alfredo Fusco
    Citation: BMC Cancer 2014 14:851
    Content type: Research article Published on:

  23. One of the hallmarks of cancer is the occurrence of high levels of chromosomal rearrangements as a result of inaccurate repair of double-strand breaks (DSB). Germline mutations in BRCA and RAD51 genes, involved i...

    Authors: Ana Paula Carneiro Brandalize, Lavínia Schüler-Faccini, Jean-Sébastien Hoffmann, Maira Caleffi, Christophe Cazaux and Patricia Ashton-Prolla
    Citation: BMC Cancer 2014 14:850
    Content type: Research article Published on:

  24. This study was designed to evaluate the effectiveness of radiofrequency ablation in patients with intermediate (BCLC B) stage hepatocellular carcinoma who underwent transcatheter arterial chemoembolization.

    Authors: Xin Yin, Lan Zhang, Yan-Hong Wang, Bo-Heng Zhang, Yu-Hong Gan, Ning-Lin Ge, Yi Chen, Li-Xin Li and Zheng-Gang Ren
    Citation: BMC Cancer 2014 14:849
    Content type: Research article Published on:

  25. Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vasc...

    Authors: Jian Li, Yi-Ming Hu, Yong-Jie Du, Li-Rong Zhu, Hai Qian, Yan Wu and Wei-Lin Shi
    Citation: BMC Cancer 2014 14:848
    Content type: Research article Published on:

  26. Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing h...

    Authors: Stephan Seitz, Stefan Buchholz, Andrew Victor Schally, Florian Weber, Monika Klinkhammer-Schalke, Elisabeth C Inwald, Roberto Perez, Ferenc G Rick, Luca Szalontay, Florian Hohla, Sabine Segerer, Chui Wai Kwok, Olaf Ortmann and Jörg Bernhard Engel
    Citation: BMC Cancer 2014 14:847
    Content type: Research article Published on:

  27. To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of...

    Authors: Denys J Loeffelbein, Michael Souvatzoglou, Veronika Wankerl, Julia Dinges, Lucas M Ritschl, Thomas Mücke, Anja Pickhard, Matthias Eiber, Markus Schwaiger and Ambros J Beer
    Citation: BMC Cancer 2014 14:846
    Content type: Research article Published on:

  28. The procoagulant state in cancer increases the thrombotic risk, but also supports tumor progression. To investigate the molecular mechanisms controlling cancer and hemostasis, we conducted a case-control study...

    Authors: Mari Tinholt, Marte Kathrine Viken, Anders Erik Dahm, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Øystein Garred, Anne-Lise Børresen-Dale, Anne Flem Jacobsen, Vessela Kristensen, Ida Bukholm, Rolf Kåresen, Ellen Schlichting, Grethe Skretting, Benedicte Alexandra Lie, Per Morten Sandset and Nina Iversen
    Citation: BMC Cancer 2014 14:845
    Content type: Research article Published on:

  29. Previous studies have shown that preoperative anemia is correlated with the prognoses of various solid tumors. This study was performed to determine the effect of preoperative anemia on relapse and survival in...

    Authors: YingJun Zhang, YuYang Chen, DongTai Chen, Yu Jiang, Wan Huang, HanDong Ouyang, Wei Xing, MuSheng Zeng, XiaoMing Xie and Weian Zeng
    Citation: BMC Cancer 2014 14:844
    Content type: Research article Published on:

  30. We sought to determine the comparative diagnostic performance of standard b-value (800–1000 s/mm2) versus low b-value (400–500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of ren...

    Authors: Yanlong Tang, Yue Zhou, Wei Du, Ning Liu, Chengzhi Zhang, Tianzhao Ouyang and Jinbo Hu
    Citation: BMC Cancer 2014 14:843
    Content type: Research article Published on:

  31. The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer respon...

    Authors: Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust and Leszek Wojnowski
    Citation: BMC Cancer 2014 14:842
    Content type: Research article Published on:

  32. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH). EETs have been associated with cardiovascular disease, diabetes a...

    Authors: Xiaolong Wei, Donghong Zhang, Xiaowei Dou, Na Niu, Wenhe Huang, Jingwen Bai and Guojun Zhang
    Citation: BMC Cancer 2014 14:841
    Content type: Research article Published on:

  33. Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested to comprise tumor suppressor genes o...

    Authors: Sandra Ackermann, Hayriye Kocak, Barbara Hero, Volker Ehemann, Yvonne Kahlert, André Oberthuer, Frederik Roels, Jessica Theißen, Margarete Odenthal, Frank Berthold and Matthias Fischer
    Citation: BMC Cancer 2014 14:840
    Content type: Research article Published on:

  34. Indigenous and/or minority ethnic women are known to experience longer delays for treatment of breast cancer, which has been shown to contribute to ethnic inequities in breast cancer mortality. We examined fac...

    Authors: Sanjeewa Seneviratne, Ian Campbell, Nina Scott, Marion Kuper-Hommel, Glenys Round and Ross Lawrenson
    Citation: BMC Cancer 2014 14:839
    Content type: Research article Published on:

  35. Percutaneous needle aspiration or biopsy (PCNA or PCNB) is an established diagnostic technique that has a high diagnostic yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) is ...

    Authors: Jaeyoung Cho, Sung-Jun Ko, Se Joong Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Jae Ho Lee and Choon-Taek Lee
    Citation: BMC Cancer 2014 14:838
    Content type: Research article Published on:

  36. Primary systemic treatment for ovarian cancer is surgery, followed by platinum based chemotherapy. Platinum resistant cancers progress/recur in approximately 25% of cases within six months. We aimed to identif...

    Authors: Zsófia Pénzváltó, András Lánczky, Julianna Lénárt, Nóra Meggyesházi, Tibor Krenács, Norbert Szoboszlai, Carsten Denkert, Imre Pete and Balázs Győrffy
    Citation: BMC Cancer 2014 14:837
    Content type: Research article Published on:

  37. Current knowledge about the molecular properties and prognostic markers of upper tract urothelial carcinoma (UTUC) is sparse and often based on bladder urothelial carcinoma (UC), which is thought to share comm...

    Authors: Song Wu, Jiahao Chen, Pei Dong, Shiqiang Zhang, Yingying He, Liang Sun, Jialou Zhu, Yanbing Cheng, Xianxin Li, Aifa Tang, Yi Huang, Yaoting Gui, Chunxiao Liu, Guosheng Yang, Fangjian Zhou, Zhiming Cai…
    Citation: BMC Cancer 2014 14:836
    Content type: Research article Published on:

  38. EBV-encoded latent membrane protein 1 (EBV-LMP1) is an important oncogenic protein for nasopharyngeal carcinoma (NPC) and has been shown to engage a plethora of signaling pathways. Correspondingly, an LMP1-tar...

    Authors: Wei-Hua Liao, Li-Fang Yang, Xiao-Yu Liu, Gao-Feng Zhou, Wu-Zhong Jiang, Bob-Lei Hou, Lun-Quan Sun, Ya Cao and Xiao-Yi Wang
    Citation: BMC Cancer 2014 14:835
    Content type: Research article Published on:

  39. The translocations of the anaplastic lymphoma kinase (ALK) gene with the echinoderm microtubule-associated protein-like 4 (EML4) gene on chromosome 2p have been identified in non-small-cell lung cancers (NSCLCs) ...

    Authors: Yongjun Guo, Jie Ma, Xiaodong Lyu, Hai Liu, Bing Wei, Jiuzhou Zhao, Shuang Fu, Lu Ding and Jihong Zhang
    Citation: BMC Cancer 2014 14:834
    Content type: Research article Published on:

  40. To appraise the role of volumetric modulated arc (RapidArc, RA) in the treatment of anal canal carcinoma (ACC).

    Authors: Angelo Tozzi, Luca Cozzi, Cristina Iftode, Annamaria Ascolese, Maria Concetta Campisi, Elena Clerici, Tiziana Comito, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Pietro Mancosu, Piera Navarria, Stefano Tomatis, Elisa Villa and Marta Scorsetti
    Citation: BMC Cancer 2014 14:833
    Content type: Research article Published on:

  41. To evaluate the prognostic significance of paranasal sinus invasion for patients with NPC and to provide empirical proofs for the T-staging category of paranasal sinus invasion according to the AJCC staging sy...

    Authors: Li Tian, Yi-Zhuo Li, Yun-Xian Mo, Li-Zhi Liu, Chuan-Miao Xie, Xue-Xia Liang, Xiao Gong and Wei Fan
    Citation: BMC Cancer 2014 14:832
    Content type: Research article Published on:

  42. Epidemiological evidence of relationships between endometriosis and epithelial ovarian cancer (EOC) has been obtained mainly from Western countries. Our goal was to determine the risk of EOC due to endometrios...

    Authors: Kuan-Chin Wang, Wen-Hsun Chang, Wen-Ling Lee, Nicole Huang, Hsin-Yi Huang, Ming-Shyen Yen, Chao-Yu Guo and Peng-Hui Wang
    Citation: BMC Cancer 2014 14:831
    Content type: Research article Published on:

  43. BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance of this epigenetic change in white b...

    Authors: Nisreen Al-Moghrabi, Asmaa Nofel, Nujoud Al-Yousef, Safia Madkhali, Suad M Bin Amer, Ayodele Alaiya, Zakia Shinwari, Taher Al-Tweigeri, Bedri Karakas, Asma Tulbah and Abdelilah Aboussekhra
    Citation: BMC Cancer 2014 14:830
    Content type: Research article Published on:

  44. To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC).

    Authors: Bo-lin Liu, Shu-juan Liu, Andrius Baskys, Hong Cheng, Ying Han, Chao Xie, Hui Song, Jia Li and Xiao-yan Xin
    Citation: BMC Cancer 2014 14:829
    Content type: Research article Published on:

  45. Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic an...

    Authors: Patrizia Mondello, Antonio Lacquaniti, Stefania Mondello, Davide Bolignano, Vincenzo Pitini, Carmela Aloisi and Michele Buemi
    Citation: BMC Cancer 2014 14:828
    Content type: Research article Published on:

  46. Gender-based differences in disease onset in murine models of malignant peripheral nerve sheath tumor (MPNST) and in patients with Neurofibromatosis type-1-(NF-1)-associated or spontaneous MPNST has not been w...

    Authors: Elizabeth Shurell, Linh M Tran, Jonathan Nakashima, Kathleen B Smith, Brenna M Tam, Yunfeng Li, Sarah M Dry, Noah Federman, William D Tap, Hong Wu and Fritz C Eilber
    Citation: BMC Cancer 2014 14:827
    Content type: Research article Published on:

  47. Although invasive lobular carcinoma (ILC) of the breast differs from invasive ductal carcinoma (IDC) in numerous respects - including its genetics, clinical phenotype, metastatic pattern, and chemosensitivity ...

    Authors: Hilda Wong, Silvia Lau, Polly Cheung, Ting Ting Wong, Andrew Parker, Thomas Yau and Richard J Epstein
    Citation: BMC Cancer 2014 14:826
    Content type: Research article Published on:

  48. Aggressive metastatic breast cancer cells seemingly evade surgical resection and current therapies, leading to colonization in distant organs and tissues and poor patient prognosis. Therefore, high-throughput in ...

    Authors: Mark Tyler Nelson, Aaron Short, Sara L Cole, Amy C Gross, Jessica Winter, Tim D Eubank and John J Lannutti
    Citation: BMC Cancer 2014 14:825
    Content type: Research article Published on:

  49. Lauren-classification and human epidermal growth factor receptor 2 (HER2) status are two important pathological features of gastric cancer patients. The prognostic value of HER2 in gastric cancer remains contr...

    Authors: Miaozhen Qiu, Yixin Zhou, Xinke Zhang, Zixian Wang, Fang Wang, Jianyong Shao, Jiabin Lu, Ying Jin, Xiaoli Wei, Dongsheng Zhang, Fenghua Wang, Yuhong Li, Dajun Yang and Ruihua Xu
    Citation: BMC Cancer 2014 14:823
    Content type: Research article Published on:

  50. Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-nega...

    Authors: Xichun Hu, Jun Cao, Wenwei Hu, Changping Wu, Yueyin Pan, Li Cai, Zhongsheng Tong, Shusen Wang, Jin Li, Zhonghua Wang, Biyun Wang, Xiaoyu Chen and Hao Yu
    Citation: BMC Cancer 2014 14:820
    Content type: Research article Published on:

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