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  1. Two-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guide...

    Authors: YuFeng Ren, QuanCheng Zhao, Hui Liu, YingJuan Huang, ZhenYu Wang, XinPing Cao, Bin S Teh and BiXiu Wen
    Citation: BMC Cancer 2014 14:894
    Content type: Research article Published on:

  2. There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage....

    Authors: Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz and Ashraf EK Ibrahim
    Citation: BMC Cancer 2014 14:891
    Content type: Research article Published on:

  4. A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan
    Citation: BMC Cancer 2014 14:889
    Content type: Research article Published on:

  5. There is no general agreement about whether patients who have already received neoadjuvant chemoradiotherapy need further postoperative chemotherapy based on 5-fluorouracil(5-FU) or 5-FU plus oxaliplatin.

    Authors: Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Ying-ying Xu, Jun-hua Zhao, Xuan-zhang Huang, Hui-mian Xu and Zhen-ning Wang
    Citation: BMC Cancer 2014 14:888
    Content type: Research article Published on:

  6. Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatment. The ai...

    Authors: Petra Martin, Sinead Noonan, Michael P Mullen, Caitriona Scaife, Miriam Tosetto, Blathnaid Nolan, Kieran Wynne, John Hyland, Kieran Sheahan, Giuliano Elia, Diarmuid O’Donoghue, David Fennelly and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:887
    Content type: Research article Published on:

  7. We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In thi...

    Authors: Shaolei Zang, Na Liu, Hongchun Wang, David N Wald, Na Shao, Jingru Zhang, Daoxin Ma, Chunyan Ji and William Tse
    Citation: BMC Cancer 2014 14:886
    Content type: Research article Published on:

  8. Upregulator of cell proliferation 4 (URG4) has been implicated in the oncogenesis of certain cancers. However, the correlation between URG4 expression and clinicopathological significance in human cancer remai...

    Authors: Lan Zhang, He Huang, Longjuan Zhang, Teng Hou, Shu Wu, Qidan Huang, Libing Song and Jihong Liu
    Citation: BMC Cancer 2014 14:885
    Content type: Research article Published on:

  9. Endometrial cancer (EC) is the 8th leading cause of cancer death amongst American women. Most ECs are endometrioid, serous, or clear cell carcinomas, or an admixture of histologies. Serous and clear ECs are clini...

    Authors: Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino and Daphne W Bell
    Citation: BMC Cancer 2014 14:884
    Content type: Research article Published on:

  10. We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment...

    Authors: Seung Tae Kim, Yong Sang Hong, Ho Yeong Lim, Jeeyun Lee, Tae Won Kim, Kyu-Pyo Kim, Sun Young Kim, Ji Yeon Baek, Jee Hyun Kim, Keun-Wook Lee, Ik-Joo Chung, Sang-Hee Cho, Kyung Hee Lee, Sang Joon Shin, Hye Jin Kang, Dong Bok Shin…
    Citation: BMC Cancer 2014 14:883
    Content type: Research article Published on:

  11. Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell in...

    Authors: Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh and Takuya Matsunaga
    Citation: BMC Cancer 2014 14:882
    Content type: Research article Published on:

  12. Polymorphisms in angiogenesis-related genes and metabolic syndrome (MetS) risk factors play important roles in cancer development. Moreover, recent studies have reported associations between a number of 3′-UTR...

    Authors: Young Joo Jeon, Jong Woo Kim, Hye Mi Park, Hyo Geun Jang, Jung O Kim, Jisu Oh, So Young Chong, Sung Won Kwon, Eo Jin Kim, Doyeun Oh and Nam Keun Kim
    Citation: BMC Cancer 2014 14:881
    Content type: Research article Published on:

  13. Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. MicroRNAs (miRNAs) represent a class of short, non-coding, regulatory RNAs which play a criti...

    Authors: Francesca Megiorni, Samantha Cialfi, Heather P McDowell, Armando Felsani, Simona Camero, Alessandro Guffanti, Barry Pizer, Anna Clerico, Alessandra De Grazia, Antonio Pizzuti, Anna Moles and Carlo Dominici
    Citation: BMC Cancer 2014 14:880
    Content type: Research article Published on:

  14. Hepatocyte nuclear factor-3β (HNF-3β) plays a critical role in hepatocyte differentiation and controls liver-specific gene expression during the development of hepatocellular carcinoma (HCC), but the molecular...

    Authors: Li Lin, Hongwei Liang, Yanbo Wang, Xiaomao Yin, Yanwei Hu, Jinlan Huang, Tingyu Ren, Hui Xu, Lei Zheng and Xi Chen
    Citation: BMC Cancer 2014 14:879
    Content type: Research article Published on:

  15. The optimal treatment for adrenal metastases from hepatocellular carcinoma (HCC) has not been established. This study analyzed the effects of radiation therapy (RT) for such metastases and identified clinical ...

    Authors: Le-Yuan Zhou, Zhao-Chong Zeng, Jia Fan, Bing Chen, Sheng-xiang Rao, Jian He, Ping Yang, Jia-zhou Hou, Zhi-feng Wu, Jian-ying Zhang and Yong Hu
    Citation: BMC Cancer 2014 14:878
    Content type: Research article Published on:

  16. Glycemic index (GI) and glycemic load (GL) have been investigated as etiologic factors for some cancers, but epidemiological data on possible associations between dietary carbohydrate intake and esophageal can...

    Authors: Petra H Lahmann, Torukiri I Ibiebele, Penelope M Webb, Christina M Nagle and David C Whiteman
    Citation: BMC Cancer 2014 14:877
    Content type: Research article Published on:

  17. The relationship between the uptake of [18F]fluoroerythronitroimidazole ([18F]FETNIM), blood flow ([15O]H2O) and 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) and immunohistochemically determined biomarkers was evaluat...

    Authors: Tove J Grönroos, Kaisa Lehtiö, Karl-Ove Söderström, Pauliina Kronqvist, Jukka Laine, Olli Eskola, Tapio Viljanen, Reidar Grénman, Olof Solin and Heikki Minn
    Citation: BMC Cancer 2014 14:876
    Content type: Research article Published on:

  18. Locally advanced rectal cancer (LARC) is a heterogeneous group of tumors where a risk-adapted therapeutic strategy is needed. Short-course radiotherapy (SCRT) is a more convenient option for LARC patients than...

    Authors: Antonio Avallone, Maria Carmela Piccirillo, Paolo Delrio, Biagio Pecori, Elena Di Gennaro, Luigi Aloj, Fabiana Tatangelo, Valentina D’Angelo, Cinzia Granata, Ernesta Cavalcanti, Nicola Maurea, Piera Maiolino, Franco Bianco, Massimo Montano, Lucrezia Silvestro, Manuela Terranova Barberio…
    Citation: BMC Cancer 2014 14:875
    Content type: Study protocol Published on:

  19. Breast cancer in women and prostate cancer are the first and second leading tumour respectively in terms of incidence world-wide. Our objective is to ascertain the similarities and differences between mortalit...

    Authors: Gonzalo López-Abente, Sergio Mispireta and Marina Pollán
    Citation: BMC Cancer 2014 14:874
    Content type: Research article Published on:

  20. A remarkable increase in the number of thyroid cancer cases has been reported in recent years; however, the markers to predict high-risk groups have not been fully established.

    Authors: Young Ae Cho, Sun-Young Kong, Aesun Shin, Jeonghee Lee, Eun Kyung Lee, You Jin Lee and Jeongseon Kim
    Citation: BMC Cancer 2014 14:873
    Content type: Research article Published on:

  21. The clinical behaviour of colon cancer is heterogeneous. Five-year overall survival is 50-65% with all stages included. Recurring somatic chromosomal alterations have been identified and some have shown potent...

    Authors: Markus Mayrhofer, Hanna Göransson Kultima, Helgi Birgisson, Magnus Sundström, Lucy Mathot, Karolina Edlund, Björn Viklund, Tobias Sjöblom, Johan Botling, Patrick Micke, Lars Påhlman, Bengt Glimelius and Anders Isaksson
    Citation: BMC Cancer 2014 14:872
    Content type: Research article Published on:

  23. Few targeted therapies (TTs) are registered for sarcoma treatment despite numerous phase II studies and yet there are potential treatment options for patients after standard treatment escape. The French Sarcom...

    Authors: Lauriane Eberst, Claire Cropet, Axel Le Cesne, Patricia Pautier, Nicolas Penel, Antoine Adenis, Christine Chevreau, Jacques-Olivier Bay, Olivier Collard, Didier Cupissol, Florence Duffaud, Jean-Claude Gentet, Sophie Piperno-Neumann, Perrine Marec-Berard, Emmanuelle Bompas, Antoine Thyss…
    Citation: BMC Cancer 2014 14:870
    Content type: Research article Published on:

  24. Trastuzumab resistance is almost inevitable in the management of human epidermal growth factor receptor (HER) 2 positive breast cancer, in which phosphatase and tensin homolog deleted from chromosome 10 (PTEN)...

    Authors: Cheng Du, Xiaomin Yi, Wenchao Liu, Tao Han, Zhaozhe Liu, Zhenyu Ding, Zhendong Zheng, Ying Piao, Jianlin Yuan, Yaling Han, Manjiang Xie and Xiaodong Xie
    Citation: BMC Cancer 2014 14:869
    Content type: Research article Published on:

  25. We wished to estimate the proportion of patients with breast cancer eligible for an exclusive targeted intraoperative radiotherapy (TARGIT) and to evaluate their survival without local recurrence.

    Authors: Amira Ziouèche-Mottet, Gilles Houvenaeghel, Jean Marc Classe, Jean Rémi Garbay, Sylvia Giard, Hélène Charitansky, Monique Cohen, Catherine Belichard, Christelle Faure, Elisabeth Chéreau Ewald, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet…
    Citation: BMC Cancer 2014 14:868
    Content type: Research article Published on:

  26. The human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of COL11A1, has not been studied ...

    Authors: José A Galván, Jorge García-Martínez, Fernando Vázquez-Villa, Marcos García-Ocaña, Carmen García-Pravia, Primitiva Menéndez-Rodríguez, Carmen González-del Rey, Luis Barneo-Serra and Juan R de los Toyos
    Citation: BMC Cancer 2014 14:867
    Content type: Research article Published on:

  27. Signal transducer and activator of transcription 3 (STAT3) is an important transcriptional factor frequently associated with the proliferation and survival of a large number of distinct cancer types. However, ...

    Authors: André L Mencalha, Stephany Corrêa, Daniela Salles, Bárbara Du Rocher, Marcelo F Santiago and Eliana Abdelhay
    Citation: BMC Cancer 2014 14:866
    Content type: Research article Published on:

  28. This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS col...

    Authors: Julen Fernandez-Plana, Carlos Pericay, Guillermo Quintero, Vicente Alonso, Antonieta Salud, Miguel Mendez, Mercedes Salgado, Eugeni Saigi and Luis Cirera
    Citation: BMC Cancer 2014 14:865
    Content type: Research article Published on:

  29. Several studies have shown that the immunophenotype of distant breast cancer metastases may differ significantly from that of the primary tumor, especially with regard to differences in the level of hormone re...

    Authors: Laura S Jiwa, Paul J van Diest, Laurien D Hoefnagel, Jelle Wesseling, Pieter Wesseling and Cathy B Moelans
    Citation: BMC Cancer 2014 14:864
    Content type: Research article Published on:

  30. The ErbB family consists of four proteins including (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4, and plays a crucial role in the promotion of multiple tumorigenic processes. In addition to the traditional pathways o...

    Authors: Keigo Mitsui, Masaoki Yonezawa, Atsushi Tatsuguchi, Seiichi Shinji, Katya Gudis, Shu Tanaka, Shunji Fujimori and Choitsu Sakamoto
    Citation: BMC Cancer 2014 14:863
    Content type: Research article Published on:

  31. Pancreatic cancer is one of the deadliest human malignancies, with few therapeutic options. Re-activation of embryonic signaling pathways is commonly in human pancreatic cancer and provided rationale to explor...

    Authors: Marsha M Thomas, Yaqing Zhang, Esha Mathew, Kevin T Kane, Ivan Maillard and Marina Pasca di Magliano
    Citation: BMC Cancer 2014 14:862
    Content type: Research article Published on:

  32. Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer...

    Authors: Patricia Rodrigues, Griselda de Marco, Jessica Furriol, Maria Luisa Mansego, Mónica Pineda-Alonso, Anna Gonzalez-Neira, Juan Carlos Martin-Escudero, Javier Benitez, Ana Lluch, Felipe J Chaves and Pilar Eroles
    Citation: BMC Cancer 2014 14:861
    Content type: Research article Published on:

  33. Despite many prospective and retrospective studies about the association of dietary habit and lung cancer, the topic still remains controversial. So, this study aims to investigate the association of lung canc...

    Authors: Mostafa Hosseini, Parisa Adimi Naghan, Ali Moghadas Jafari, Mahmoud Yousefifard, Shervin Taslimi, Kian Khodadad, Forouzan Mohammadi, Makan Sadr, Mansour Rezaei, Esmaeil Mortaz and Mohammad Reza Masjedi
    Citation: BMC Cancer 2014 14:860
    Content type: Research article Published on:

  34. Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- o...

    Authors: Martin Mørck Mortensen, Søren Høyer, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Lars Dyrskjøt and Michael Borre
    Citation: BMC Cancer 2014 14:859
    Content type: Research article Published on:

  35. Circulating baseline levels of the plasma-protein osteopontin (OPN) have been suggested as a prognostic indicator in chemotherapy and surgery for lung cancer. However, the role of this hypoxia-related protein ...

    Authors: Christian Ostheimer, Matthias Bache, Antje Güttler, Thomas Reese and Dirk Vordermark
    Citation: BMC Cancer 2014 14:858
    Content type: Research article Published on:

  36. Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumou...

    Authors: Lin Jiang, Cécile Campagne, Elisabeth Sundström, Pedro Sousa, Saima Imran, Monika Seltenhammer, Gerli Pielberg, Mats J Olsson, Giorgia Egidy, Leif Andersson and Anna Golovko
    Citation: BMC Cancer 2014 14:857
    Content type: Research article Published on:

  37. To investigate the impact of physician-assessed late toxicities on patient-reported quality of life (QoL) for nasopharyngeal carcinoma (NPC) patients with long-term survival.

    Authors: Wen-Ling Tsai, Tai-Lin Huang, Kuan-Cho Liao, Hui-Ching Chuang, Yu-Tsai Lin, Tsair-Fwu Lee, Hsuan-Ying Huang and Fu-Min Fang
    Citation: BMC Cancer 2014 14:856
    Content type: Research article Published on:

  38. Pulmonary neuroendocrine tumors (Pulmonary NETs) include a wide spectrum of tumors, from the low-grade typical carcinoid (TC) and the intermediate-grade atypical carcinoid (AC), to the high-grade large-cell ne...

    Authors: Jose A Galván, Aurora Astudillo, Aitana Vallina, Guillermo Crespo, Maria Victoria Folgueras and Maria Victoria González
    Citation: BMC Cancer 2014 14:855
    Content type: Research article Published on:

  39. Chromosomal instability in exfoliated urothelial cells has been associated with the development of bladder cancer. Here, we analyzed the accumulation of copy number variations (CNVs) using fluorescence in situ...

    Authors: Nadine Bonberg, Beate Pesch, Thomas Behrens, Georg Johnen, Dirk Taeger, Katarzyna Gawrych, Christian Schwentner, Harald Wellhäußer, Matthias Kluckert, Gabriele Leng, Michael Nasterlack, Christoph Oberlinner, Arnulf Stenzl and Thomas Brüning
    Citation: BMC Cancer 2014 14:854
    Content type: Research article Published on:

  40. The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we...

    Authors: John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli and Per Sunnerhagen
    Citation: BMC Cancer 2014 14:853
    Content type: Research article Published on:

  41. Expression of NRIF3 (Nuclear Receptor Interacting Factor-3) rapidly and selectively leads to apoptosis of breast cancer cells. This occurs through binding of NRIF3 or its 30 amino acid Death Domain-1 (DD1) reg...

    Authors: Sharmistha Das, Kay T Yeung, Muktar A Mahajan and Herbert H Samuels
    Citation: BMC Cancer 2014 14:852
    Content type: Research article Published on:

  42. Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced sur...

    Authors: Daniela D’Angelo, Paula Mussnich, Roberta Rosa, Roberto Bianco, Giampaolo Tortora and Alfredo Fusco
    Citation: BMC Cancer 2014 14:851
    Content type: Research article Published on:

  43. One of the hallmarks of cancer is the occurrence of high levels of chromosomal rearrangements as a result of inaccurate repair of double-strand breaks (DSB). Germline mutations in BRCA and RAD51 genes, involved i...

    Authors: Ana Paula Carneiro Brandalize, Lavínia Schüler-Faccini, Jean-Sébastien Hoffmann, Maira Caleffi, Christophe Cazaux and Patricia Ashton-Prolla
    Citation: BMC Cancer 2014 14:850
    Content type: Research article Published on:

  44. This study was designed to evaluate the effectiveness of radiofrequency ablation in patients with intermediate (BCLC B) stage hepatocellular carcinoma who underwent transcatheter arterial chemoembolization.

    Authors: Xin Yin, Lan Zhang, Yan-Hong Wang, Bo-Heng Zhang, Yu-Hong Gan, Ning-Lin Ge, Yi Chen, Li-Xin Li and Zheng-Gang Ren
    Citation: BMC Cancer 2014 14:849
    Content type: Research article Published on:

  45. Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vasc...

    Authors: Jian Li, Yi-Ming Hu, Yong-Jie Du, Li-Rong Zhu, Hai Qian, Yan Wu and Wei-Lin Shi
    Citation: BMC Cancer 2014 14:848
    Content type: Research article Published on:

  46. Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing h...

    Authors: Stephan Seitz, Stefan Buchholz, Andrew Victor Schally, Florian Weber, Monika Klinkhammer-Schalke, Elisabeth C Inwald, Roberto Perez, Ferenc G Rick, Luca Szalontay, Florian Hohla, Sabine Segerer, Chui Wai Kwok, Olaf Ortmann and Jörg Bernhard Engel
    Citation: BMC Cancer 2014 14:847
    Content type: Research article Published on:

  47. To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of...

    Authors: Denys J Loeffelbein, Michael Souvatzoglou, Veronika Wankerl, Julia Dinges, Lucas M Ritschl, Thomas Mücke, Anja Pickhard, Matthias Eiber, Markus Schwaiger and Ambros J Beer
    Citation: BMC Cancer 2014 14:846
    Content type: Research article Published on:

  48. The procoagulant state in cancer increases the thrombotic risk, but also supports tumor progression. To investigate the molecular mechanisms controlling cancer and hemostasis, we conducted a case-control study...

    Authors: Mari Tinholt, Marte Kathrine Viken, Anders Erik Dahm, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Øystein Garred, Anne-Lise Børresen-Dale, Anne Flem Jacobsen, Vessela Kristensen, Ida Bukholm, Rolf Kåresen, Ellen Schlichting, Grethe Skretting, Benedicte Alexandra Lie, Per Morten Sandset and Nina Iversen
    Citation: BMC Cancer 2014 14:845
    Content type: Research article Published on:

  49. We sought to determine the comparative diagnostic performance of standard b-value (800–1000 s/mm2) versus low b-value (400–500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of ren...

    Authors: Yanlong Tang, Yue Zhou, Wei Du, Ning Liu, Chengzhi Zhang, Tianzhao Ouyang and Jinbo Hu
    Citation: BMC Cancer 2014 14:843
    Content type: Research article Published on:

  50. Percutaneous needle aspiration or biopsy (PCNA or PCNB) is an established diagnostic technique that has a high diagnostic yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) is ...

    Authors: Jaeyoung Cho, Sung-Jun Ko, Se Joong Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Jae Ho Lee and Choon-Taek Lee
    Citation: BMC Cancer 2014 14:838
    Content type: Research article Published on:

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