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  1. While weight gain following breast cancer is considered common, results supporting these findings are dated. This work describes changes in body weight following breast cancer over 72 months, compares weight w...

    Authors: Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders and Sandra C Hayes
    Citation: BMC Cancer 2015 15:28
    Content type: Research article Published on:

  2. Caveolin-1 (CAV1) may be upregulated by hypoxia and acts in a tumor-dependent manner. We investigated CAV1 in tongue squamous cell carcinoma (TSCC) and its association with clinical outcomes, and studied in vitro

    Authors: Marilena Vered, Meri Lehtonen, Lari Hotakainen, Emma Pirilä, Susanna Teppo, Pia Nyberg, Raija Sormunen, Ayelet Zlotogorski-Hurvitz, Tuula Salo and Dan Dayan
    Citation: BMC Cancer 2015 15:25
    Content type: Research article Published on:

  3. The discovery of cancer stem cells and tumor heterogeneity prompted the exploration of additional mechanisms aside from genetic mutations for carcinogenesis and cancer progression. The aim of the present study...

    Authors: Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang and Liwei Zhu
    Citation: BMC Cancer 2015 15:24
    Content type: Research article Published on:

  4. Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a paraneoplastic ocular syndrome occurring in patients with systemic, often occult but advanced carcinoma and is the hallmark of poor prognosis. Ocu...

    Authors: Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio and Mandeep S Sagoo
    Citation: BMC Cancer 2015 15:23
    Content type: Case report Published on:

  5. A breast cancer susceptibility locus has been mapped to the gene encoding TOX3. Little is known regarding the expression pattern or biological role of TOX3 in breast cancer or in the mammary gland. Here we ana...

    Authors: Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari and Jonathan Kaye
    Citation: BMC Cancer 2015 15:22
    Content type: Research article Published on:

  6. Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. How...

    Authors: Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez
    Citation: BMC Cancer 2015 15:21
    Content type: Research article Published on:

  7. PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss resul...

    Authors: Catherine E Bond, Mark L Bettington, Sally-Ann Pearson, Diane M McKeone, Barbara A Leggett and Vicki LJ Whitehall
    Citation: BMC Cancer 2015 15:20
    Content type: Research article Published on:

  8. Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...

    Authors: Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong and Kyung Seok Han
    Citation: BMC Cancer 2015 15:19
    Content type: Research article Published on:

  9. EphA5 is a member of the Eph/ephrin family and plays a critical role in the regulation of carcinogenesis. A significant reduction of EphA5 transcripts in high-grade prostate cancer tissue was shown using a tra...

    Authors: Shibao Li, Yingfeng Zhu, Chunguang Ma, Zhenhua Qiu, Xinju Zhang, Zhihua Kang, Zhiyuan Wu, Hua Wang, Xiao Xu, Hu Zhang, Guoqiang Ren, Jianmin Tang, Xiangyu Li and Ming Guan
    Citation: BMC Cancer 2015 15:18
    Content type: Research article Published on:

  10. DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli
    Citation: BMC Cancer 2015 15:17
    Content type: Research article Published on:

  11. Ewing sarcoma is a rare tumor that occurs commonly in the long bones of children or adolescents that can also arise in soft tissues including the extremities, retroperitoneum, chest wall, and rarely in the liv...

    Authors: Yukinori Ozaki, Yuji Miura, Shigehiro Koganemaru, Koichi Suyama, Naoko Inoshita, Takeshi Fujii, Masaji Hashimoto, Tetsuo Tamura, Kazuo Takeuchi and Toshimi Takano
    Citation: BMC Cancer 2015 15:16
    Content type: Case report Published on:

  12. SBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.

    Authors: Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham and Ian Chau
    Citation: BMC Cancer 2015 15:15
    Content type: Research article Published on:

  13. Metastatic dissemination can exist before a pathologically and clinically detectable manifestation. The structural heterogeneity of colon cancer (CC) in histological sections with respect to the morphology of ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki and Charles James Kirkpatrick
    Citation: BMC Cancer 2015 15:14
    Content type: Research article Published on:

  14. The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) an...

    Authors: Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang and Jianfeng Li
    Citation: BMC Cancer 2015 15:13
    Content type: Research article Published on:

  17. Anthracycline adjuvant therapy has taken a particular role in the treatment of early stage breast cancer with an associated decrease in rates of both relapse and death. Their success however has been limited b...

    Authors: Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser and Arafat Tfayli
    Citation: BMC Cancer 2015 15:10
    Content type: Research article Published on:

  18. Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients even...

    Authors: Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan and David J Elliott
    Citation: BMC Cancer 2015 15:9
    Content type: Research article Published on:

  21. c-Met, one of current potential hot targets, has been suggested as a potential tumor marker in the development of esophageal squamous cell carcinoma (ESCC). Our aim was to investigate the expression of c-Met i...

    Authors: Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li and Lin Shen
    Citation: BMC Cancer 2015 15:6
    Content type: Research article Published on:

  22. The transcription factor nuclear factor (erythroid-2)–related factor 2 (Nrf2) was originally identified as a critical regulator of intracellular anti-oxidants and of phase II detoxification enzymes through its...

    Authors: Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:5
    Content type: Research article Published on:

  23. Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer...

    Authors: Sofia Sousa, Seppo Auriola, Jukka Mönkkönen and Jorma Määttä
    Citation: BMC Cancer 2015 15:4
    Content type: Research article Published on:

  24. Adult T-cell Leukemia (ATL) is a disease with no known cure. The disease manifests itself as an aggressive proliferation of CD4+ cells with the human T-cell Lymphotropic virus type 1 (HTLV-1). The leukemogenesis ...

    Authors: Steve Harakeh, Rania Azar, Esam Azhar, Ghazi A Damanhouri, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed H Alqahtani, Taha Kumosani, Aleksandra Niedzwiecki, Mathias Rath, Ahmed Al-Hejin, Elie Barbour and Mona Diab-Assaf
    Citation: BMC Cancer 2015 15(Suppl 1):S2
    Content type: Research Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  25. The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existenc...

    Authors: Sara Santos Franco, Hadas Raveh-Amit, Julianna Kobolák, Mohammed H Alqahtani, Ali Mobasheri and András Dinnyes
    Citation: BMC Cancer 2015 15(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  26. Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, ...

    Authors: Sarah M Judge, Chia-Ling Wu, Adam W Beharry, Brandon M Roberts, Leonardo F Ferreira, Susan C Kandarian and Andrew R Judge
    Citation: BMC Cancer 2014 14:997
    Content type: Research article Published on:

  27. Aberrantly expressed and constitutively active STAT3 signaling plays a pivotal role in initiation and progression of human papillomavirus-induced cervical carcinogenesis. However, the underlying mechanism(s) r...

    Authors: Gauri Shishodia, Gaurav Verma, Yogesh Srivastava, Ravi Mehrotra, Bhudev Chandra Das and Alok Chandra Bharti
    Citation: BMC Cancer 2014 14:996
    Content type: Research article Published on:

  28. The calpains are intracellular cysteine proteases that function in a variety of important cellular functions, including signalling, motility, apoptosis and survival. In breast cancer high calpain-1 and calpain...

    Authors: Jillian Davis, Stewart G Martin, Poulam M Patel, Andrew R Green, Emad A Rakha, Ian O Ellis and Sarah J Storr
    Citation: BMC Cancer 2014 14:995
    Content type: Research article Published on:

  29. It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate...

    Authors: Marjolaine Ngollo, Andre Lebert, Aslihan Dagdemir, Gaelle Judes, Seher Karsli-Ceppioglu, Marine Daures, Jean-Louis Kemeny, Frederique Penault-Llorca, Jean-Paul Boiteux, Yves-Jean Bignon, Laurent Guy and Dominique Bernard-Gallon
    Citation: BMC Cancer 2014 14:994
    Content type: Research article Published on:

  30. Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-ind...

    Authors: Susanna B Park, John B Kwok, Clement T Loy, Michael L Friedlander, Cindy S-Y Lin, Arun V Krishnan, Craig R Lewis and Matthew C Kiernan
    Citation: BMC Cancer 2014 14:993
    Content type: Research article Published on:

  31. Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor in adults. Despite multimodal therapies, almost all GBM recur within a narrow margin around the initial resected lesion. Thus, n...

    Authors: Frank A Giordano, Stefanie Brehmer, Yasser Abo-Madyan, Grit Welzel, Elena Sperk, Anke Keller, Frank Schneider, Sven Clausen, Carsten Herskind, Peter Schmiedek and Frederik Wenz
    Citation: BMC Cancer 2014 14:992
    Content type: Study protocol Published on:

  32. In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of ri...

    Authors: Mourad Chaari, Ines Ayadi, Aurelie Rousseau, Eleftheria Lefkou, Patrick Van Dreden, Fatoumata Sidibe, Hela Ketatni, Vassiliki Galea, Amir Khaterchi, Racem Bouzguenda, Mounir Frikha, Lilia Ghorbal, Jamel Daoud, Choumous Kallel, Martin Quinn, Joseph Gligorov…
    Citation: BMC Cancer 2014 14:991
    Content type: Research article Published on:

  33. There are many molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers. Recent analyses have shown that the former can be divided into two subtypes, luminal A and lumina...

    Authors: Yumi Endo, Hiroko Yamashita, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Tomoko Asano, Yukari Hato, Yu Dong, Yoshitaka Fujii and Tatsuya Toyama
    Citation: BMC Cancer 2014 14:990
    Content type: Research article Published on:

  34. Response Evaluation Criteria in Solid Tumors (RECIST) are widely used to assess the effect of chemotherapy in patients with cancer. We hypothesised that the change in unidimensional tumour size handled as a co...

    Authors: Anne-Claire Toffart, Denis Moro-Sibilot, Sébastien Couraud, Patrick Merle, Maurice Perol, Nicolas Girard, Pierre-Jean Souquet, Bénédicte Mastroianni, Gilbert R Ferretti, Philippe Romand, Patrick Chatellain, Aurélien Vesin, Elisabeth Brambilla, Christian Brambilla and Jean-François Timsit
    Citation: BMC Cancer 2014 14:989
    Content type: Research article Published on:

  36. Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai
    Citation: BMC Cancer 2014 14:987
    Content type: Research article Published on:

  37. The purpose of this phase II study was to evaluate the safety and efficacy of weekly irinotecan and capecitabine (wXELIRI) treatment in patients with metastatic colorectal cancer, specifically the rate of seve...

    Authors: Wenhua Li, Jianming Xu, Lin Shen, Tianshu Liu, Weijian Guo, Wen Zhang, Zhiyu Chen, Xiaodong Zhu and Jin Li
    Citation: BMC Cancer 2014 14:986
    Content type: Research article Published on:

  38. Raised serum glucose has been linked to increased risk of many solid cancers. We performed a meta-analysis to quantify and summarise the evidence for this link.

    Authors: Danielle J Crawley, Lars Holmberg, Jennifer C Melvin, Massimo Loda, Simon Chowdhury, Sarah M Rudman and Mieke Van Hemelrijck
    Citation: BMC Cancer 2014 14:985
    Content type: Research article Published on:

  39. To analyze and compare the economic outcomes of adjuvant chemotherapy with capecitabine plus oxaliplatin (referred to as the XELOX strategy) and of S-1 (the S-1 strategy) for gastric cancer patients after D2 g...

    Authors: Bin Wu, Te Li, Jian Cai, Yuejuan Xu and Gang Zhao
    Citation: BMC Cancer 2014 14:984
    Content type: Research article Published on:

  40. BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased s...

    Authors: Shibani Nicum, Corran Roberts, Lucy Boyle, Sylwia Kopijasz, Charlie Gourley, Marcia Hall, Ana Montes, Christopher Poole, Linda Collins, Anna Schuh and Susan J Dutton
    Citation: BMC Cancer 2014 14:983
    Content type: Study protocol Published on:

  41. Ovarian low-grade serous carcinoma (LGSC) has fewer mutations than ovarian high-grade serous carcinoma (HGSC) and a less aggressive clinical course. However, an overwhelming majority of LGSC patients do not re...

    Authors: Alicia A Tone, Melissa K McConechy, Winnie Yang, Jiarui Ding, Stephen Yip, Esther Kong, Kwong-Kwok Wong, David M Gershenson, Helen Mackay, Sohrab Shah, Blake Gilks, Anna V Tinker, Blaise Clarke, Jessica N McAlpine and David Huntsman
    Citation: BMC Cancer 2014 14:982
    Content type: Research article Published on:

  42. Leiomyosarcomas represent the largest subtype of soft tissue sarcomas. Two subgroups can be distinguished, non-uterine (NULMS) and uterine leiomyosarcomas (ULMS). The aim of this retrospective study was to eva...

    Authors: Wolfgang Lamm, Camilla Natter, Sophie Schur, Wolfgang J Köstler, Alexander Reinthaller, Michael Krainer, Christoph Grimm, Reinhard Horvath, Gabriele Amann, Philipp Funovics, Thomas Brodowicz and Stephan Polterauer
    Citation: BMC Cancer 2014 14:981
    Content type: Research article Published on:

  43. Malnutrition is an independent risk factor of postoperative morbidity and mortality and it’s observed in 20 to 50% of surgical patients. Preoperative interventions to optimize the nutritional status, reduce po...

    Authors: Oriana Ciacio, Thibault Voron, Gabriella Pittau, Maité Lewin, Eric Vibert, René Adam, Antonio Sa Cunha, Daniel Cherqui, Astrid Schielke, Olivier Soubrane, Olivier Scatton, Chady Salloum, Daniel Azoulay, Stéphane Benoist, Perrine Goyer, Jean-Christophe Vaillant…
    Citation: BMC Cancer 2014 14:980
    Content type: Study protocol Published on:

  44. Although international comparisons reveal large geographical differences in the incidence of breast and gynaecological cancers, incidence data for ethnic groups in England remains scarce.

    Authors: Megan H Shirley, Isobel Barnes, Shameq Sayeed, Alexander Finlayson and Raghib Ali
    Citation: BMC Cancer 2014 14:979
    Content type: Research article Published on:

  45. SIRT1 is a member of the mammalian sirtuin family with the ability to deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression and tumor metastasis in several types of cancer has a...

    Authors: Chong Hao, Peng-Xi Zhu, Xue Yang, Zhi-Peng Han, Jing-Hua Jiang, Chen Zong, Xu-Guang Zhang, Wen-Ting Liu, Qiu-Dong Zhao, Ting-Ting Fan, Li Zhang and Li-Xin Wei
    Citation: BMC Cancer 2014 14:978
    Content type: Research article Published on:

  46. Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential ...

    Authors: Prabhakar Rajan, Jacqueline Stockley, Ian M Sudbery, Janis T Fleming, Ann Hedley, Gabriela Kalna, David Sims, Chris P Ponting, Andreas Heger, Craig N Robson, Rhona M McMenemin, Ian D Pedley and Hing Y Leung
    Citation: BMC Cancer 2014 14:977
    Content type: Research article Published on:

  47. The prognostic value of circulating tumor cells (CTCs) in colorectal cancer (CRC) patients and their value in predicting tumor response to chemotherapy are controversial. The aim of this meta-analysis was to a...

    Authors: Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Jing Liu, Huimian Xu and Zhenning Wang
    Citation: BMC Cancer 2014 14:976
    Content type: Research article Published on:

  49. Members of the urokinase-type plasminogen activator (uPA) system including uPA, its receptor uPAR and the plasminogen activator inhibitor 1 (PAI-1) play an important role in tumour invasion and progression in ...

    Authors: Susanne Fuessel, Kati Erdmann, Helge Taubert, Andrea Lohse-Fischer, Stefan Zastrow, Matthias Meinhardt, Karen Bluemke, Lorenz Hofbauer, Paolo Fornara, Bernd Wullich, Gustavo Baretton, Viktor Magdolen, Manfred P Wirth and Matthias Kotzsch
    Citation: BMC Cancer 2014 14:974
    Content type: Research article Published on:

  50. Vemurafenib, a selective inhibitor of genetically activated BRAF, is registered for unresectable stage III and stage IV melanomas harboring a BRAF mutation. Photosensitivity related to exposure to sunlight is ...

    Authors: Steve Boudewijns, Winald R Gerritsen and Rutger sH T Koornstra
    Citation: BMC Cancer 2014 14:967
    Content type: Case report Published on:

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