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  1. The prognostic value of circulating tumor cells (CTCs) detected with the CellSearch System in patients with colorectal cancer (CRC) is controversial. The aim of our meta-analysis was to evaluate whether the de...

    Authors: Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Huimian Xu and Zhenning Wang
    Citation: BMC Cancer 2015 15:202
    Content type: Research article Published on:

  2. The prognoses of young breast cancer patients are poor. The purpose of this study is to evaluate the different characteristics and prognoses among different subtypes of young breast cancer patients.

    Authors: Li-Chen Tang, Xi Jin, Hai-Yuan Yang, Min He, Helena Chang, Zhi-Ming Shao and Gen-Hong Di
    Citation: BMC Cancer 2015 15:201
    Content type: Research article Published on:

  3. Cutaneous melanoma is the most lethal skin cancer and its incidence in developed countries has dramatically increased over the past decades. Localized tumors are easily treated by surgery, but advanced melanom...

    Authors: Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian and Jean-Jacques Lebrun
    Citation: BMC Cancer 2015 15:200
    Content type: Research article Published on:

  4. Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small ...

    Authors: Juan Martínez-Aguilar, Roderick Clifton-Bligh and Mark P Molloy
    Citation: BMC Cancer 2015 15:199
    Content type: Technical advance Published on:

  5. The role of interim PET/CT in peripheral T-cell lymphoma (PTCL) is less identified compared to other subtype of lymphoma. This study prospectively investigated the prognostic accuracy of sequential interim PET...

    Authors: Sung-Hoon Jung, Jae-Sook Ahn, Yeo-Kyeoung Kim, Sun-Seog Kweon, Jung-Joon Min, Hee-Seung Bom, Hyeoung-Joon Kim, Yee Soo Chae, Joon Ho Moon, Sang Kyun Sohn, Sang Woo Lee, Byung Hyun Byun, Young Rok Do, Je-Jung Lee and Deok-Hwan Yang
    Citation: BMC Cancer 2015 15:198
    Content type: Research article Published on:

  8. There is a growing body of evidence that immune response plays a large role in cancer outcome. The neutrophil to lymphocyte ratio (NLR) has been used as a simple parameter of systemic inflammation in several t...

    Authors: Mirco Pistelli, Mariagrazia De Lisa, Zelmira Ballatore, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Matteo Santoni, Elena Maccaroni, Raffaella Bracci, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi and Stefano Cascinu
    Citation: BMC Cancer 2015 15:195
    Content type: Research article Published on:

  9. Our previous study suggested that the recurrent CHEK2 H371Y mutation is a novel pathogenic mutation that confers an increased risk of breast cancer. The purpose of this study was to investigate whether breast can...

    Authors: Yin Liu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin and Yuntao Xie
    Citation: BMC Cancer 2015 15:194
    Content type: Research article Published on:

  10. Since recent studies revealed the feasibility to detect blood-based microRNAs (miRNAs, miRs) in breast cancer (BC) patients a new field has been opened for circulating miRNAs as potential biomarkers in BC. In ...

    Authors: Thalia Erbes, Marc Hirschfeld, Gerta Rücker, Markus Jaeger, Jasmin Boas, Severine Iborra, Sebastian Mayer, Gerald Gitsch and Elmar Stickeler
    Citation: BMC Cancer 2015 15:193
    Content type: Research article Published on:

  11. The standard trimodal treatment concept in locally advanced and non-metastasized non-small-cell superior sulcus tumors consists of a preoperative chemoradiation followed by surgical resection. High linear ener...

    Authors: Henrik Hauswald, Stefan Rieken, Hendrik C Dienemann, Michael Thomas, Meinhard Kieser, Jürgen Debus and Klaus Herfarth
    Citation: BMC Cancer 2015 15:192
    Content type: Study protocol Published on:

  12. Factors beyond the individual level such as those characterizing the residential environment may be important to breast cancer outcomes. We provide a systematic review and results of meta-analysis of the publi...

    Authors: Tomi F Akinyemiju, Jeanine M Genkinger, Maggie Farhat, Adrienne Wilson, Tiffany L Gary-Webb and Parisa Tehranifar
    Citation: BMC Cancer 2015 15:191
    Content type: Research article Published on:

  13. To determine whether the effect of androgen deprivation therapy (ADT) on the risk of biochemical failure varies at different doses of radiation in patients treated with definitive external beam radiation for i...

    Authors: Michelle S Ludwig, Deborah A Kuban, Xianglin L Du, David S Lopez, Jose-Miguel Yamal and Sara S Strom
    Citation: BMC Cancer 2015 15:190
    Content type: Research article Published on:

  14. Colorectal cancer is strongly associated with lipid metabolism. NPC1L1, a sterol transporter, plays a key role in modulating lipid homeostasis in vivo. Its inhibitor, ezetimibe, began to be used clinically to ...

    Authors: Jianming He, Hyunsu Shin, Xing Wei, Anil Kumar G Kadegowda, Rui Chen and Sandy Krystal Xie
    Citation: BMC Cancer 2015 15:189
    Content type: Research article Published on:

  15. The presence of tumor supporting cells in various cancer, including in hepatocellular carcinoma (HCC), has become an important target in the study of carcinogenesis. The cancer-associated fibroblast (CAF), one...

    Authors: Caecilia Hapsari Ceriapuri Sukowati, Beatrice Anfuso, Lory Saveria Crocé and Claudio Tiribelli
    Citation: BMC Cancer 2015 15:188
    Content type: Research article Published on:

  16. Over the past years knowledge about benefits of physical activity after cancer is evolving from randomized exercise intervention trials. However, it has been argued that results may be biased by selective part...

    Authors: Sandra M Gollhofer, Joachim Wiskemann, Martina E Schmidt, Oliver Klassen, Cornelia M Ulrich, Jan Oelmann, Holger Hof, Karin Potthoff and Karen Steindorf
    Citation: BMC Cancer 2015 15:186
    Content type: Research article Published on:

  19. Patients with dedifferentiated or anaplastic thyroid carcinomas currently lack appropriate treatment options. Kinase inhibitors are among the most promising new agents as alternative strategies. The BRAF- and ...

    Authors: Martina Broecker-Preuss, Stefan Müller, Martin Britten, Karl Worm, Kurt Werner Schmid, Klaus Mann and Dagmar Fuhrer
    Citation: BMC Cancer 2015 15:184
    Content type: Research article Published on:

  20. Neurofibromatosis 1 is one of the most common genetic diseases in humans, presenting with multiple neurofibromas and an increased risk of various benign and malignant tumors, including breast cancer.

    Authors: André Vallejo Da Silva, Fabiana Resende Rodrigues, Mônica Pureza, Vania Gloria Silami Lopes and Karin Soares Cunha
    Citation: BMC Cancer 2015 15:183
    Content type: Case report Published on:

  21. Recent studies have shown that miR-372 plays important roles in hepatocellular carcinoma (HCC) progression. However, results have been conflicting regarding its expression levels and role in HCC.

    Authors: Gang Wu, Yawei Wang, Xiaojun Lu, Hui He, Haiyang Liu, Xiangyu Meng, Shuguan Xia, Kunming Zheng and Boqian Liu
    Citation: BMC Cancer 2015 15:182
    Content type: Research article Published on:

  22. Germline mutations in breast cancer susceptibility gene 1 (BRCA1) increase the risk of breast and ovarian cancers. However, no association between BRCA1 germline mutation and glioblastoma malignancy has ever been...

    Authors: Meriem Boukerroucha, Claire Josse, Karin Segers, Sonia El-Guendi, Pierre Frères, Guy Jerusalem and Vincent Bours
    Citation: BMC Cancer 2015 15:181
    Content type: Case report Published on:

  23. Efforts to improve the outcome of liver surgery by combining curative resection with chemotherapy have failed to demonstrate definite overall survival benefit. This may partly be due to the fact that these stu...

    Authors: Ninos Ayez, Eric P van der Stok, Hans de Wilt, Sandra A Radema, Richard van Hillegersberg, Rudi M Roumen, Gerard Vreugdenhil, Pieter J Tanis, Cornelis J Punt, Cornelis H Dejong, Rob L Jansen, Henk M Verheul, Koert P de Jong, Geke A Hospers, Joost M Klaase, Marie-Cecile Legdeur…
    Citation: BMC Cancer 2015 15:180
    Content type: Study protocol Published on:

  24. Systematic analysis of cancer gene-expression patterns using high-throughput transcriptional profiling technologies has led to the discovery and publication of hundreds of gene-expression signatures. However, ...

    Authors: Brian David Lehmann, Yan Ding, Daniel Joseph Viox, Ming Jiang, Yi Zheng, Wang Liao, Xi Chen, Wei Xiang and Yajun Yi
    Citation: BMC Cancer 2015 15:179
    Content type: Research article Published on:

  25. Experimental analysis of the metastatic cascade requires suitable model systems which allow tracing of disseminated tumor cells and the identification of factors leading to metastatic outgrowth in distant orga...

    Authors: Claudia Maenz, Eva Lenfert, Klaus Pantel, Udo Schumacher, Wolfgang Deppert and Florian Wegwitz
    Citation: BMC Cancer 2015 15:178
    Content type: Research article Published on:

  26. Cadmium is classified as a human lung carcinogen based on evidence from high-exposure occupational settings. Though cadmium has no physiological role, increasing evidence suggests cadmium may mimic steroid hor...

    Authors: Kirsten T Eriksen, Jytte Halkjær, Jaymie R Meliker, Jane A McElroy, Mette Sørensen, Anne Tjønneland and Ole Raaschou-Nielsen
    Citation: BMC Cancer 2015 15:177
    Content type: Research article Published on:

  27. To investigate the efficacy and safety of FOLFIRI plus bevacizumab regimen with irinotecan (180 mg/m2) in patients with advanced or recurrent colorectal cancer who were of the wild-type or heterozygous group for

    Authors: Mitsukuni Suenaga, Tomohiro Nishina, Nobuyuki Mizunuma, Hisateru Yasui, Takashi Ura, Tadamichi Denda, Junichi Ikeda, Taito Esaki, Hogara Nishisaki, Yoshinao Takano, Yasuyuki Sugiyama and Kei Muro
    Citation: BMC Cancer 2015 15:176
    Content type: Research article Published on:

  28. Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in p...

    Authors: Michael J Wagner, Leo Ismaila Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Stephanie C Manson, José Diaz, Maureen P Neary and George D Demetri
    Citation: BMC Cancer 2015 15:175
    Content type: Research article Published on:

  29. We have developed a new diagnostic method using the photosensitizer 5-aminolevulinic acid (5ALA) for diagnosing intrathoracic malignant lesions. When ingested exogenously, 5ALA is metabolized to a heme precurs...

    Authors: Masahiro Kitada, Yoshinobu Ohsaki, Yoshinari Matsuda, Satoshi Hayashi and Kei Ishibashi
    Citation: BMC Cancer 2015 15:174
    Content type: Research Published on:

  30. Authors: Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Marc Van den Eynde, Raphaël Maréchal, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried…
    Citation: BMC Cancer 2015 15:173
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2013 13:190

  31. Mutant Ras plays multiple functions in tumorigenesis including tumor formation and metastasis. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a metastasis inhibitor gene, suppresses matrix ...

    Authors: Hsuan-Heng Yeh, Yu-Fen Tseng, Yu-Chiao Hsu, Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Da-En Cheng, Ying-Ray Lee, Tsuey-Yu Chang, Nan-Haw Chow, Wen-Chun Hung and Hsiao-Sheng Liu
    Citation: BMC Cancer 2015 15:172
    Content type: Research article Published on:

  32. Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due t...

    Authors: Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu and Wenzhi Tian
    Citation: BMC Cancer 2015 15:170
    Content type: Research article Published on:

  33. Overexpression of HER2 is observed in 20 to 30% of breast carcinomas. The use of trastuzumab has improved the treatment of these patients, especially when it is associated with docetaxel. To optimize the use o...

    Authors: Esther Schmitt, Frédérique Végran, Sandy Chevrier, Laura Burillier, Muriel Cadouot, Sarab Lizard-Nacol, Bruno Coudert, Pierre Fumoleau, Laurent Arnould and Romain Boidot
    Citation: BMC Cancer 2015 15:169
    Content type: Research article Published on:

  34. Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome. They have important regulatory functions in chromatin remodeling and gene expression. Dysregulated lncRNAs have been studied in cancers...

    Authors: Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen and Wei Cao
    Citation: BMC Cancer 2015 15:168
    Content type: Research article Published on:

  35. To determine the prevalence of RET rearrangement genes, RET copy number gains and expression in tumor samples from four Phase III non-small-cell lung cancer (NSCLC) trials of vandetanib, a selective inhibitor of ...

    Authors: Adam Platt, John Morten, Qunsheng Ji, Paul Elvin, Chris Womack, Xinying Su, Emma Donald, Neil Gray, Jessica Read, Graham Bigley, Laura Blockley, Carl Cresswell, Angela Dale, Amanda Davies, Tianwei Zhang, Shuqiong Fan…
    Citation: BMC Cancer 2015 15:171
    Content type: Research article Published on:

  36. Molecularly defined subgroups of tumors characterized by specific driver mutations have been identified in the majority of cancers. The availability of novel drugs capable of targeting signaling pathways activ...

    Authors: Nicola Normanno and Ian A Cree
    Citation: BMC Cancer 2015 15:141
    Content type: Commentary Published on:

  37. There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies ...

    Authors: Jung-Yun Lee, Jina Youm, Jae-Weon Kim, Jeong Yeon Cho, Min A Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Noh Hyun Park and Yong-Sang Song
    Citation: BMC Cancer 2015 15:167
    Content type: Research article Published on:

  38. 17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting conditions leads to recovery of a homeostatic...

    Authors: Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu and Shirley ShiDu Yan
    Citation: BMC Cancer 2015 15:166
    Content type: Research article Published on:

  39. Electroporation is a novel treatment technique utilizing electric pulses, traveling between two or more electrodes, to ablate targeted tissue. The first in human studies have proven the safety of IRE for the a...

    Authors: Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette and M Pilar Laguna Pes
    Citation: BMC Cancer 2015 15:165
    Content type: Study protocol Published on:

  40. The EphB4 receptor tyrosine kinase is overexpressed in many cancers including prostate cancer. The molecular mechanisms by which this ephrin receptor influences cancer progression are complex as there are tumo...

    Authors: Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington and Sally-Anne Stephenson
    Citation: BMC Cancer 2015 15:164
    Content type: Research article Published on:

  41. Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with ca...

    Authors: Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein and Sanjay Popat
    Citation: BMC Cancer 2015 15:163
    Content type: Research article Published on:

  42. The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected b...

    Authors: Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle and Kathryn A Robb
    Citation: BMC Cancer 2015 15:162
    Content type: Research article Published on:

  44. Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as m...

    Authors: Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli and Ulrike Stein
    Citation: BMC Cancer 2015 15:160
    Content type: Research article Published on:

  45. High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key act...

    Authors: Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang and Qibing Zhou
    Citation: BMC Cancer 2015 15:159
    Content type: Research article Published on:

  46. Although microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC). The purpose of our study is to syst...

    Authors: Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li and Huixing Kang
    Citation: BMC Cancer 2015 15:158
    Content type: Research article Published on:

  47. Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic t...

    Authors: Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre and Elena Bonora
    Citation: BMC Cancer 2015 15:157
    Content type: Research article Published on:

  48. We systematically reviewed the evidence for the interaction of microsatellite instability status (MSI) and treatment with 5FU in colorectal cancer to determine how well MSI status predicts health outcomes in p...

    Authors: Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor and Katrina AB Goddard
    Citation: BMC Cancer 2015 15:156
    Content type: Research article Published on:

  49. The role of urine markers in the surveillance of patients with non-muscle invasive bladder cancer (NMIBC) is discussed extensively. In case of negative cystoscopy the additional prognostic value of these marke...

    Authors: Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl and Christian Schwentner
    Citation: BMC Cancer 2015 15:155
    Content type: Research article Published on:

  50. We retrospectively reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase angiogenesis inhibitor, in patients with advanced soft tissue sarcoma, a rare and heterogeneous tumor group with ...

    Authors: Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee and Sun Young Rha
    Citation: BMC Cancer 2015 15:154
    Content type: Research article Published on:

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