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  1. Chemokine (C–C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study wa...

    Authors: Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu and Jianming Guo
    Citation: BMC Cancer 2017 17:117
  2. As in many other European countries, a nationwide screening program for colorectal cancer (CRC) has recently been introduced in the Netherlands. As a side effect, such a screening program will inherently yield...

    Authors: Meta C. J. van Lanschot, Beatriz Carvalho, Veerle M. H. Coupé, Manon van Engeland, Evelien Dekker and Gerrit A. Meijer
    Citation: BMC Cancer 2017 17:116
  3. Breast cancer is a heterogeneous and a hormone-dependent disease. The detection of the estrogen receptor (ER) and progesterone receptor (PgR) is crucial for prognostic evaluation and treatment choice of breast...

    Authors: Ahoua Benjamin Effi, Nguiessan Alphonse Aman, Baumaney Sylvanus Koui, Kouadio Donatien Koffi, Zie Cheick Traoré and Mohamed Kouyate
    Citation: BMC Cancer 2017 17:115
  4. The incidence of thyroid cancer among South Koreans is more than 10-fold greater than its incidence in other countries, although its associated mortality rate is similar. Amidst concerns regarding the over-dia...

    Authors: Yoon Jae Cho, Do Young Kim, Eun-Cheol Park and Kyu-Tae Han
    Citation: BMC Cancer 2017 17:114
  5. Protease activated receptor (PAR)-1 expression is increased in a variety of tumor cells. In preclinical models, tumor cell PAR-1 appeared to be involved in the regulation of lung tumor growth and metastasis; h...

    Authors: Cong Lin, Christof J. Majoor, Joris J. T. H. Roelofs, Martijn D. de Kruif, Hugo M. Horlings, Keren Borensztajn and C. Arnold Spek
    Citation: BMC Cancer 2017 17:113
  6. Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazi...

    Authors: Lisanne S. Rigter, Manon C. W. Spaander, Leon M. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, John M. M. Raemaekers, Richard W. M. van der Maazen, Annemieke Cats, Eveline M. A. Bleiker, Petur Snaebjornsson, Beatriz Carvalho…
    Citation: BMC Cancer 2017 17:112
  7. The French EMS study prospectively collected exhaustive data from STS patients diagnosed in the Rhone-Alpes region from 2005 to 07.

    Authors: Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani and Jean-Yves Blay
    Citation: BMC Cancer 2017 17:111
  8. The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia” (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clin...

    Authors: M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, A. J. M. van de Sande, C. G. Gerestein, H. W. Nijman and R. F. P. M. Kruitwagen
    Citation: BMC Cancer 2017 17:110
  9. Gastric cancer is one of the most common malignancies worldwide. Recent studies have shown that microRNAs play crucial roles in regulating cellular proliferation process in gastric cancer. MicroRNA-29c (miR-29...

    Authors: Beiqin Yu, Xuehua Chen, Jianfang Li, Qinlong Gu, Zhenggang Zhu, Chen Li, Liping Su and Bingya Liu
    Citation: BMC Cancer 2017 17:109
  10. Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.

    Authors: Lina Leiss, Ercan Mutlu, Anne Øyan, Tao Yan, Oleg Tsinkalovsky, Linda Sleire, Kjell Petersen, Mohummad Aminur Rahman, Mireille Johannessen, Sidhartha S. Mitra, Hege K. Jacobsen, Krishna M. Talasila, Hrvoje Miletic, Inge Jonassen, Xingang Li, Nicolaas H. Brons…
    Citation: BMC Cancer 2017 17:108
  11. Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell tumors. The molecular diagnostic marker is the t(11...

    Authors: S. Uboldi, I. Craparotta, G. Colella, E. Ronchetti, L. Beltrame, S. Vicario, S. Marchini, N. Panini, G. Dagrada, F. Bozzi, S. Pilotti, C. M. Galmarini, M. D’Incalci and R. Gatta
    Citation: BMC Cancer 2017 17:107
  12. Colorectal cancer (CRC) survivors are at increased risk of developing the disease again. Surveillance guidelines are aimed at maximising the early detection of recurring or new cancers and pre-cancerous polyps...

    Authors: Mariko Carey, Robert Sanson-Fisher, Finlay Macrae, Emilie Cameron, David Hill, Catherine D’Este and Christopher Doran
    Citation: BMC Cancer 2017 17:106
  13. Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated...

    Authors: Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang and Yuan Li
    Citation: BMC Cancer 2017 17:105
  14. Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Authors: Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy
    Citation: BMC Cancer 2017 17:104
  15. Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance...

    Authors: Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy McKiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran and Daniel A. Galvão
    Citation: BMC Cancer 2017 17:103
  16. Ovarian cancer remains the most deadly gynecological cancer with a poor aggregate survival rate; however, the specific rates are highly dependent on the stage of the disease upon diagnosis. Current screening a...

    Authors: Karissa B. Tilbury, Kirby R. Campbell, Kevin W. Eliceiri, Sana M. Salih, Manish Patankar and Paul J. Campagnola
    Citation: BMC Cancer 2017 17:102
  17. Body mass index (BMI) is largely investigated as a prognostic and predictive factor in triple-negative breast cancer (TNBC). Overweight and obesity are linked to a variety of pathways regulating tumor-promotin...

    Authors: Maddalena Barba, Patrizia Vici, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Anna Di Benedetto, Cristiana Ercolani, Francesca Sperati, Irene Terrenato, Claudio Botti, Lucia Mentuccia, Laura Iezzi, Teresa Gamucci, Clara Natoli, Ilio Vitale, Marcella Mottolese…
    Citation: BMC Cancer 2017 17:101
  18. Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve p...

    Authors: Y. Wengström, K. A. Bolam, S. Mijwel, C. J. Sundberg, M. Backman, M. Browall, J. Norrbom and H. Rundqvist
    Citation: BMC Cancer 2017 17:100
  19. Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 mo...

    Authors: Zachary C. Gersey, Gregor A. Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M. Walters, Kelechi C. Ohaeto, Ricardo J. Komotar and Regina M. Graham
    Citation: BMC Cancer 2017 17:99
  20. Despite advances in cancer diagnosis and treatment have significantly improved survival rates, patients post-treatment-related health needs are often not adequately addressed by current health services. The ai...

    Authors: Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells…
    Citation: BMC Cancer 2017 17:98

    The Erratum to this article has been published in BMC Cancer 2017 17:196

  21. The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an i...

    Authors: Liv B. Gansmo, Merete Bjørnslett, Mari Kyllesø Halle, Helga B. Salvesen, Pål Romundstad, Kristian Hveem, Lars Vatten, Anne Dørum, Per E. Lønning and Stian Knappskog
    Citation: BMC Cancer 2017 17:97
  22. The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence and poor diagnosis in specific histological classifications of lung ...

    Authors: Li Zhang, Dan Liu, Lei Li, Dan Pu, Ping Zhou, Yuting Jing, He Yu, Yanwen Wang, Yihan Zhu, Yanqi He, Yalun Li, Shuang Zhao, Zhixin Qiu and Weimin Li
    Citation: BMC Cancer 2017 17:96
  23. Australia and New Zealand have the highest incidence of colorectal cancer (CRC) in the world, presenting considerable health, economic, and societal burden. Over a third of the Australian population live in re...

    Authors: Michael J. Ireland, Sonja March, Fiona Crawford-Williams, Mandy Cassimatis, Joanne F. Aitken, Melissa K. Hyde, Suzanne K. Chambers, Jiandong Sun and Jeff Dunn
    Citation: BMC Cancer 2017 17:95
  24. Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 to 70% in first-line therapy...

    Authors: Sergey A. Dyshlovoy, Ramin Madanchi, Jessica Hauschild, Katharina Otte, Winfried H. Alsdorf, Udo Schumacher, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer and Gunhild von Amsberg
    Citation: BMC Cancer 2017 17:93
  25. Multiple types of extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (EXOs), are released by all cells constituting part of the cellular EV secretome. The bioactive cargo of EVs can be sh...

    Authors: Elisa Lázaro-Ibáñez, Taral R. Lunavat, Su Chul Jang, Carmen Escobedo-Lucea, Jorge Oliver-De La Cruz, Pia Siljander, Jan Lötvall and Marjo Yliperttula
    Citation: BMC Cancer 2017 17:92
  26. The purpose of this study was to develop an effective nomogram capable of estimating the individual survival outcomes of patients with hepatocellular carcinoma (HCC), and compare the predictive accuracy and di...

    Authors: Gang Wan, Fangyuan Gao, Jialiang Chen, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng and Xianbo Wang
    Citation: BMC Cancer 2017 17:91
  27. The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopat...

    Authors: Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu and Ge Zhang
    Citation: BMC Cancer 2017 17:90
  28. BK-UM (CRM197) is a mutant form of diphtheria toxin and a specific inhibitor of heparin-binding epidermal growth factor-like growth factor (HB-EGF). We assessed the safety, pharmacokinetics, recommended dose, ...

    Authors: Shingo Miyamoto, Fusanori Yotsumoto, Taeko Ueda, Tatsuya Fukami, Ayako Sanui, Kohei Miyata, Sung Ouk Nam, Satoshi Fukagawa, Takahiro Katsuta, Miyako Maehara, Haruhiko Kondo, Daisuke Miyahara, Kyoko Shirota, Toshiyuki Yoshizato, Masahide Kuroki, Hiroaki Nishikawa…
    Citation: BMC Cancer 2017 17:89
  29. The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss...

    Authors: Nicole Lavender, Jinming Yang, Sheau-Chiann Chen, Jiqing Sai, C. Andrew Johnson, Philip Owens, Gregory D. Ayers and Ann Richmond
    Citation: BMC Cancer 2017 17:88
  30. Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that utilizes collagen as a ligand, is a key molecule in the progression of solid tumors as it regulates the interaction of cancer cells with the ...

    Authors: Hoon Hur, In-Hye Ham, Dakeun Lee, Hyejin Jin, Kristina Y. Aguilera, Hye Jeong Oh, Sang-Uk Han, Ji Eun Kwon, Young-Bae Kim, Ke Ding and Rolf A. Brekken
    Citation: BMC Cancer 2017 17:87
  31. Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is frequently ineffective in patients with advanced dise...

    Authors: Martin McLaughlin, Holly E. Barker, Aadil A. Khan, Malin Pedersen, Magnus Dillon, David C. Mansfield, Radhika Patel, Joan N. Kyula, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting and Kevin J. Harrington
    Citation: BMC Cancer 2017 17:86
  32. Cancers of Unknown Primary (CUP) are the 3-4th most common causes of cancer death and recent clinical guidelines recommend that patients should be directed to a team dedicated to their care. Our aim was to inform...

    Authors: William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster and David S. Morrison
    Citation: BMC Cancer 2017 17:85
  33. Atypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC...

    Authors: Robert A. Vierkant, Amy C. Degnim, Derek C. Radisky, Daniel W. Visscher, Ethan P. Heinzen, Ryan D. Frank, Stacey J. Winham, Marlene H. Frost, Christopher G. Scott, Matthew R. Jensen, Karthik Ghosh, Armando Manduca, Kathleen R. Brandt, Dana H. Whaley, Lynn C. Hartmann and Celine M. Vachon
    Citation: BMC Cancer 2017 17:84
  34. Colorectal cancer survivors are not only at risk for recurrent disease but also at increased risk of comorbidities such as other cancers, cardiovascular disease, diabetes, hypertension and functional decline. ...

    Authors: Hege Berg Henriksen, Hanna Ræder, Siv Kjølsrud Bøhn, Ingvild Paur, Ane Sørlie Kværner, Siv Åshild Billington, Morten Tandberg Eriksen, Gro Wiedsvang, Iris Erlund, Arne Færden, Marit Bragelien Veierød, Manuela Zucknick, Sigbjørn Smeland and Rune Blomhoff
    Citation: BMC Cancer 2017 17:83
  35. In recent years, there has been an increased research focus on adolescent and young adult (AYA) cancer patients. Few longitudinal studies have taken into consideration the specifics of their life situation and...

    Authors: Katja Leuteritz, Michael Friedrich, Erik Nowe, Annekathrin Sender, Yve Stöbel-Richter and Kristina Geue
    Citation: BMC Cancer 2017 17:82
  36. Fatigue is a common and debilitating symptom for patients with incurable cancer receiving systemic treatment with palliative intent. There is evidence that non-pharmacological interventions such as graded exer...

    Authors: Hanneke Poort, Constans A. H. H. V. M. Verhagen, Marlies E. W. J. Peters, Martine M. Goedendorp, A. Rogier T. Donders, Maria T. E. Hopman, Maria W. G. Nijhuis-van der Sanden, Thea Berends, Gijs Bleijenberg and Hans Knoop
    Citation: BMC Cancer 2017 17:81
  37. The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rec...

    Authors: Qingguo Li, Yaqi Li, Weixing Dai, Sheng Wang, Ye Xu, Xinxiang Li and Sanjun Cai
    Citation: BMC Cancer 2017 17:80
  38. Cervical Cancer (CC) has become a public health concern of alarming proportions in many developing countries such as Mexico, particularly in low income sectors and marginalized regions. As such, an early detec...

    Authors: Héctor Guerrero-Flores, Teresa Apresa-García, Ónix Garay-Villar, Alejandro Sánchez-Pérez, David Flores-Villegas, Artfy Bandera-Calderón, Raúl García-Palacios, Teresita Rojas-Sánchez, Pablo Romero-Morelos, Verónica Sánchez-Albor, Osvaldo Mata, Víctor Arana-Conejo, Jesús Badillo-Romero, Keiko Taniguchi, Daniel Marrero-Rodríguez, Mónica Mendoza-Rodríguez…
    Citation: BMC Cancer 2017 17:79
  39. Osteosarcoma (OS) is the most common primary bone tumor, with a propensity to metastasize to the lungs. Five-year survival for metastatic OS is below 30%, and has not improved for several decades despite the i...

    Authors: Shibing Yu, Mitchell Stephen Fourman, Adel Mahjoub, Jonathan Brendan Mandell, Jared Anthony Crasto, Nicholas Giuseppe Greco and Kurt Richard Weiss
    Citation: BMC Cancer 2017 17:78
  40. Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the progn...

    Authors: Hong-Xia Peng, Xiao-Dan Liu, Zi-Yan Luo, Xiao-Hong Zhang, Xue-Qun Luo, Xiao Chen, Hua Jiang and Ling Xu
    Citation: BMC Cancer 2017 17:76
  41. Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are sti...

    Authors: Linlin Wang, Dabei Liu, Jibin Lu, Suning Zhang and Xueying Yang
    Citation: BMC Cancer 2017 17:75
  42. The influence of physical activity on patient-reported recovery of physical functioning after colorectal cancer (CRC) surgery is unknown. Therefore, we studied recovery of physical functioning after hospital d...

    Authors: Moniek van Zutphen, Renate M. Winkels, Fränzel J. B. van Duijnhoven, Suzanne A. van Harten-Gerritsen, Dieuwertje E. G. Kok, Peter van Duijvendijk, Henk K. van Halteren, Bibi M. E. Hansson, Flip M. Kruyt, Ernst J. Spillenaar Bilgen, Johannes H. W. de Wilt, Jaap J. Dronkers and Ellen Kampman
    Citation: BMC Cancer 2017 17:74
  43. This study aimed to determine whether synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (IL-PCI) can be used to investigate the morphological characteristics of tumor neovascularization in ...

    Authors: Beilei Li, Yiqiu Zhang, Weizhong Wu, Guohao Du, Liang Cai, Hongcheng Shi and Shaoliang Chen
    Citation: BMC Cancer 2017 17:73
  44. Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinica...

    Authors: Nelli Roininen, Sari Takala, Kirsi-Maria Haapasaari, Arja Jukkola-Vuorinen, Johanna Mattson, Päivi Heikkilä and Peeter Karihtala
    Citation: BMC Cancer 2017 17:72
  45. Authors: Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal and William E. Grizzle
    Citation: BMC Cancer 2017 17:71

    The original article was published in BMC Cancer 2016 16:61

  46. CC-chemokine receptor seven (CCR7), a G-protein coupled receptor normally facilitating immune cells lymphatic homing, has recently been identified on several cancer cells in promoting invasion and lymphatic sp...

    Authors: Yu Xia, Li Liu, Ying Xiong, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Jiejie Xu and Jianming Guo
    Citation: BMC Cancer 2017 17:70
  47. Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular di...

    Authors: Livia S.A. Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Michele De Laurentiis, Massimo Rinaldo, Massimiliano D’Aiuto, Francesca Catalano, Giuseppe Banna, Francesco Ferrau’, Rosalba Rossello, Diego Serraino, Ettore Bidoli, Samuele Massarut, Guglielmo Thomas, Davide Gatti…
    Citation: BMC Cancer 2017 17:69
  48. The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a subst...

    Authors: Shalini V. Rao, Guri Solum, Barbara Niederdorfer, Kristin G. Nørsett, Geir Bjørkøy and Liv Thommesen
    Citation: BMC Cancer 2017 17:68

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