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  1. Well-differentiated (WD) neuroendocrine tumors (NETs) are a group of rare neoplasms with limited therapeutic options. Cabozantinib is an inhibitor of multiple tyrosine kinases with a pivotal role in NET pathog...

    Authors: Francesca Corti, Maria Pia Brizzi, Vito Amoroso, Dario Giuffrida, Francesco Panzuto, Davide Campana, Natalie Prinzi, Massimo Milione, Tommaso Cascella, Carlo Spreafico, Giovanni Randon, Simone Oldani, Rita Leporati, Giulia Scotto, Iolanda Pulice, Benedetta Lombardi Stocchetti…
    Citation: BMC Cancer 2023 23:908
    Content type: Study protocol Published on:

  2. Heterozygous isocitrate dehydrogenase (IDH) mutations occur in about half of conventional central bone chondrosarcomas (CCBC). Aim of this study was to assess the frequency and prognostic impact of IDH mutations ...

    Authors: Elisabetta Setola, S. Benini, A. Righi, G. Gamberi, E. Carretta, C. Ferrari, S. Avnet, E. Palmerini, G. Magagnoli, M. Gambarotti, P. L. Lollini, M. Cesari, S. Cocchi, A. Paioli, A. Longhi, K. Scotlandi…
    Citation: BMC Cancer 2023 23:907
    Content type: Research Published on:

  3. Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by res...

    Authors: Yahong Xu, Yongjie Zhu, Zhenru Wu, Shengfu Li, Mingyang Shao, Qing Tao, Qing Xu, Yuwei Chen, Yuke Shu, Menglin Chen, Yongjie Zhou and Yujun Shi
    Citation: BMC Cancer 2023 23:906
    Content type: Research Published on:

  4. We aimed to evaluate the clinical efficacy and prognostic significance of intensity-modulated radiotherapy (IMRT)-based salvage concurrent chemoradiotherapy (CCRT) for patients with locoregional recurrence cer...

    Authors: Minjie Shan, Yuping Deng, Wen Zou, Shasha Fan, Yanlong Li, Xianling Liu and Jingjing Wang
    Citation: BMC Cancer 2023 23:905
    Content type: Research Published on:

  5. Cancer survival rates are increasing; however, studies on dyslipidemia as a comorbidity of cancer are limited. For efficient management of the disease burden, this study aimed to understand new-onset dyslipide...

    Authors: Yun Hwa Jung, IL Yun, Eun-Cheol Park and Sung-In Jang
    Citation: BMC Cancer 2023 23:904
    Content type: Research Published on:

  6. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is the standard treatment for pseudomyxoma peritonei (PMP). It can significantly prolong the survival of patients, but at the ...

    Authors: Rui Yang, Xin Zhao, Yu-Bin Fu, Yu-Lin Lin, Ru Ma, Yan-Dong Su, He-Liang Wu, Xin-Li Liang and Yan Li
    Citation: BMC Cancer 2023 23:903
    Content type: Research Published on:

  7. The ALTA-1L study compared brigatinib with crizotinib in untreated ALK-rearranged non-small cell lung cancer (NSCLC) patients, demonstrating the efficacy of brigatinib. Although the median progression-free surviv...

    Authors: Kazushige Wakuda, Hirotsugu Kenmotsu, Yuki Sato, Atsushi Nakamura, Hiroaki Akamatsu, Motoko Tachihara, Satoru Miura, Toshihide Yokoyama, Keita Mori, Kazuhiko Nakagawa and Nobuyuki Yamamoto
    Citation: BMC Cancer 2023 23:902
    Content type: Study Protocol Published on:

  8. The application of coagulation-related markers in laryngeal squamous cell carcinoma(LSCC) remains unclear. This study explored the prognostic role of coagulation markers in the progression and metastasis of LSCC.

    Authors: Qiongling Huang, Jing Chen, Yanjun Huang, Yu Xiong, Jiao Zhou, Yizheng Zhang, Ming Lu, Weipeng Hu, Feng Zheng and Chaohui Zheng
    Citation: BMC Cancer 2023 23:901
    Content type: Research Published on:

  9. Early-stage colorectal cancer had excellent outcomes after curative resection, typically. However, a perplexing survival paradox between stage II and stage III was noted. This paradox could be influenced by th...

    Authors: Yen-Lin Yu, Wen-Ko Tseng, Chun-Kai Liao, Chien-Yuh Yeh, Hong-Hwa Chen, Yu-Hsuan Liu, Yu-Wei Liaw and Chung-Wei Fan
    Citation: BMC Cancer 2023 23:900
    Content type: Research Published on:

  10. Studies have demonstrated that Sorting nexin 7 (SNX7) functions as an anti-apoptotic protein in liver tissue and plays a crucial role in the survival of hepatocytes during early embryonic development. However,...

    Authors: Jianlin Chen, Gan Gao, Yi Zhang, Peng Dai and Yi Huang
    Citation: BMC Cancer 2023 23:899
    Content type: Research Published on:

  11. Long non-coding RNAs play an important role in the development of colorectal cancer (CRC), while many CRC-related lncRNAs have not yet been identified.

    Authors: Ganglin Ren, Hongyan Li, Dan Hong, Fangyu Hu, Rongjia Jin, Shuang Wu, Wenhao Sun, Honglei Jin, Lingling Zhao, Xiaodong Zhang, Dongxiang Liu, Chuanshu Huang and Haishan Huang
    Citation: BMC Cancer 2023 23:898
    Content type: Research Published on:

  12. Lung adenocarcinoma (LUAD) is an extraordinarily malignant tumor, with rapidly increasing morbidity and poor prognosis. Immunotherapy has emerged as a hopeful therapeutic modality for lung adenocarcinoma. Furt...

    Authors: Qianhe Ren, Qifan Li, Chenye Shao, Pengpeng Zhang, Zhuangzhuang Hu, Jun Li, Wei Wang and Yue Yu
    Citation: BMC Cancer 2023 23:897
    Content type: Research Published on:

  13. The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient, high doses of chemotherapeutic agent doxorubicin can be released from t...

    Authors: Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton and Constantin Coussios
    Citation: BMC Cancer 2023 23:896
    Content type: Study protocol Published on:

  14. Although a long-term goal of cancer therapy always has been the development of agents that selectively destroy cancer cells, more recent trends have been to seek secondary agents that sensitize cancer cells to...

    Authors: D. Alimbetov, B. Umbayev, A. Tsoy, D. Begimbetova, T. Davis, D. Kipling and Sh. Askarova
    Citation: BMC Cancer 2023 23:895
    Content type: Research Published on:

  15. The incidence of peripherally inserted central catheter (PICC)-related complications is higher in cancer patients than in noncancer patients. However, the pattern of specific complication occurrence over time ...

    Authors: Ruixia Liu, Huiqiong Xu, Lihui Pu, Xiaofeng Xie, Hongxiu Chen, Zhoupeng Wu, Huirong Chen and Xiaoxia Zhang
    Citation: BMC Cancer 2023 23:894
    Content type: Research Published on:

  16. Pancreatic cancer is a growing public health concern in China, and depicting it from different perspectives would provide a comprehensive understanding of its epidemiological characteristics.

    Authors: Yangyang Xu, Wei Liu, Zheng Long, Lijun Wang, Maigeng Zhou and Peng Yin
    Citation: BMC Cancer 2023 23:893
    Content type: Research Published on:

  17. The current National Comprehensive Cancer Network (NCCN) guidelines recommend that at least 16 lymph nodes should be examined for gastric cancer patients to reduce staging migration. However, there is still de...

    Authors: Lulu Zhao, Fan Zhang, Fuzhi Jiao, Xiadong Zhou, Penghui Niu, Xue Han, Wanqing Wang, Xiaoyi Luan, Mingyan He, Quanlin Guan, Yumin Li, Dongbing Zhao, Jidong Gao and Yingtai Chen
    Citation: BMC Cancer 2023 23:892
    Content type: Research Published on:

  18. For patients with pancreatic ductal adenocarcinoma (PDAC), surgical resection remains the only potentially curative treatment. Surgery is generally followed by postoperative chemotherapy associated with improv...

    Authors: Christelle Bouchart, Julie Navez, Ivan Borbath, Karen Geboes, Timon Vandamme, Jean Closset, Luigi Moretti, Pieter Demetter, Marianne Paesmans and Jean-Luc Van Laethem
    Citation: BMC Cancer 2023 23:891
    Content type: Study Protocol Published on:

  19. The expansion of antiretroviral therapy (ART) eligibility could lead to earlier initiation of Human Immunodeficiency Virus (HIV) treatment and consequently reduce the risk of HIV-associated Kaposi Sarcoma (KS)...

    Authors: Maxwell. O. Akanbi, Lucy. A. Bilaver, Chad Achenbach, Lisa. R. Hirschhorn, Adovich. S. Rivera, Orimisan. S. Adekolujo, Kehinde. U. A. Adekola, Olugbenga. A. Silas, Patricia. A. Agaba, Oche Agbaji, Nathan. Y. Shehu, Solomon. A. Sagay, Lifang Hou and Robert. L. Murphy
    Citation: BMC Cancer 2023 23:890
    Content type: Research Published on:

  20. Exerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during and after physical exercise. Exerkines liberated from skeletal muscle (myokines), the heart (cardiokines), liver ...

    Authors: Amirhossein Ahmadi Hekmatikar, André Nelson and Aaron Petersen
    Citation: BMC Cancer 2023 23:889
    Content type: Review Published on:

  21. Endometrial carcinoma (EC) is one of the most commonly diagnosed gynecologic malignancy in China. However, the genetic profile of Chinese EC patients has not been well established yet.

    Authors: Jin Li, Xiaoqi Li, Chenlian Quan, Xiaoqiu Li, Chong Wan and Xiaohua Wu
    Citation: BMC Cancer 2023 23:888
    Content type: Research Published on:

  22. The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) an...

    Authors: Tian Fang, Zhihao Zhang, Huijie Zhou, Wanchun Wu, Fuqing Ji and Liqun Zou
    Citation: BMC Cancer 2023 23:887
    Content type: Research Published on:

  23. Glioblastoma (GBM), a prevalent and malignant brain tumor, poses a challenge in surgical resection due to its invasive nature within the brain parenchyma. CDKN1A (p21, Waf-1), a cyclin-dependent kinase inhibit...

    Authors: Wen-Yu Cheng, Chiung-Chyi Shen, Yea-Jiuen Liang, Ming-Tsang Chiao, Yi-Chin Yang, Wan-Yu Hsieh, Cheng-Hui Lin and Jun-Peng Chen
    Citation: BMC Cancer 2023 23:886
    Content type: Research Published on:

  24. Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with p...

    Authors: Simon Crabb, Robin Wickens, Sarah Jane-Bibby, Denise Dunkley, Megan Lawrence, Allen Knight, Robert Jones, Alison Birtle, Robert Huddart, Mark Linch, Jonathan Martin, Adam Coleman, Konstantinos Boukas, Hannah Markham and Gareth Griffiths
    Citation: BMC Cancer 2023 23:885
    Content type: Study Protocol Published on:

  25. The relationship between sleep disturbances and lung cancer is complex and bidirectional. This meta-epidemiological study aimed to explore the potential association between sleep disruption and the risk of pul...

    Authors: Tong Zhou, Zichen Wang, Chenxi Qiao, Shuo Wang, Shuaihang Hu, Xinyan Wang, Xiumei Ma, Dandan Wang, Jinglei Li, Zheng Li and Wei Hou
    Citation: BMC Cancer 2023 23:884
    Content type: Research Published on:

  26. Triple negative breast cancers (TNBC) account for approximately 15% of all breast cancers and are associated with a shorter median survival mainly due to locally advanced tumor and high risk of metastasis. The...

    Authors: Jordane Divoux, Romane Florent, Margaux Jacobs, Justine Lequesne, Jean-Michel Grellard, Chankannira San, Sara Grossi, Katia Kerdja, Bénédicte Clarisse, Gwenaelle Boudier, François Cherifi, Mélanie Briand, Enora Dolivet, Alisson Johnson, Brice Dubois, Valentin Harter…
    Citation: BMC Cancer 2023 23:883
    Content type: Study Protocol Published on:

  27. Thyroid cancer (TC) is one of the most common endocrine malignancies, and its morbidity continues to rise. N6-methyladenosine (m6A) RNA methylation, an epigenetic modification, is an important regulator of gene e...

    Authors: Yihan Zhang, Ying Chen, Ruihua Chen, Hong Zhou, Yi Lin, Bingxin Li, Huaidong Song, Guoqiang Zhou, Mei Dong and Huanbai Xu
    Citation: BMC Cancer 2023 23:882
    Content type: Research Published on:

  28. Breast cancer is the commonest cancer among women in India, yet the uptake of early detection programs is poor. This leads to late presentation, advanced stage at the time of diagnosis, and high mortality. Poo...

    Authors: Riya Sawhney, Priyansh Nathani, Priti Patil, Prashant Bhandarkar, Deepa Kizhakke Veetil, Jubina Balan Venghateri, Nobhojit Roy and Anita Gadgil
    Citation: BMC Cancer 2023 23:881
    Content type: Research Published on:

  29. Guidelines recommend total thyroidectomy (TT) to facilitate radioactive ablation and serological follow-up for intermediate- to high-risk papillary thyroid carcinoma (PTC). However, the association between sur...

    Authors: Siyuan Xu, Hui Huang, Huilei Dong, Xiaolei Wang, Zhengang Xu, Shaoyan Liu and Jie Liu
    Citation: BMC Cancer 2023 23:880
    Content type: Research Published on:

  30. The epithelial-mesenchymal transition (EMT) plays an indispensable role in the development and progression of Endometrial cancer (EC). Nevertheless, little evidence is reported to uncover the functionality and...

    Authors: Yonghui Yu, Yiwen Zhang, Zhi Li, Yongshun Dong, Hongmei Huang, Binyao Yang, Eryong Zhao, Yongxiu Chen, Lei Yang, Jiachun Lu and Fuman Qiu
    Citation: BMC Cancer 2023 23:879
    Content type: Research Published on:

  31. Colorectal cancer (CRC) is one of the malignant tumors with the highest morbidity and mortality and poor prognosis. The mammalian gene family of Cab45/reticulocalbin/ERC-45/calumenin (CREC) consists of RCN1, R...

    Authors: Junya Ning, Min Liu, Jing Shen, Deping Wang, Lijuan Gao, Huiyu Li and Jimin Cao
    Citation: BMC Cancer 2023 23:878
    Content type: Research Published on:

  32. Real-world data on treatment patterns/outcomes for metastatic pancreatic cancer (mPAC) are limited. This study aims to assess real-world treatment patterns, survival outcomes, and prognostic/predictive factors...

    Authors: Julien Taieb, Thomas Seufferlein, Michele Reni, Daniel H. Palmer, John A. Bridgewater, Antonio Cubillo, Gerald W. Prager, Alice Vermeire, Fabienne Hédouin-Biville, Zhaoyang Teng and Teresa Macarulla
    Citation: BMC Cancer 2023 23:877
    Content type: Research Published on:

  33. Pancreatic cancer poses a serious medical problem worldwide. Countries in the Western Pacific Region are facing public health challenges from cancer. This study assesses the time trends of pancreatic cancer mo...

    Authors: Wenkai Jiang, Caifei Xiang, Yan Du, Xiao Li, Xin Li and Wence Zhou
    Citation: BMC Cancer 2023 23:876
    Content type: Database Published on:

  34. Vietnam and Saudi Arabia have high disease burden of primary hepatocellular carcinoma (HCC). Early detection in asymptomatic patients at risk for HCC is a strategy to improve survival outcomes in HCC managemen...

    Authors: Thai Ngoc Truong, Trang Ngoc Doan Pham, Long Bao Hoang, Van Thi Nguyen, Hang Viet Dao, Diem Vu Bich Dao, Saleh Alessy, Hien Ba Pham, Thuy Thi Thu Pham, Linh Duc Duy Nguyen, Khue Nguyen, Faisal Abaalkhail, Mohammed Manal, Mohammad Mawardi, May AlZahrani, Khalid Alswat…
    Citation: BMC Cancer 2023 23:875
    Content type: Study protocol Published on:

  35. Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability. Dysregulation of telomeres has been implicated in the develop...

    Authors: Gh. Rasool Bhat, Rajeshwer Singh Jamwal, Itty Sethi, Amrita Bhat, Ruchi Shah, Sonali Verma, Minerva Sharma, Hana Q. Sadida, Sara K. Al-Marzooqi, Tariq Masoodi, Sameer Mirza, Mohammad Haris, Muzafar A. Macha, Ammira S. Alshabeeb Akil, Ajaz A. Bhat and Rakesh Kumar
    Citation: BMC Cancer 2023 23:874
    Content type: Research Published on:

  36. The aim of the present study was to assess the efficacy and safety of transarterial chemoembolization (TACE) combined with atezolizumab and bevacizumab (hereafter, TACE-Atez/Bev) in the treatment of advanced h...

    Authors: Fei Cao, Changsheng Shi, Guofu Zhang, Jun Luo, Jiaping Zheng and Weiyuan Hao
    Citation: BMC Cancer 2023 23:873
    Content type: Research Published on:

  37. Lung cancer is a major global threat to public health for which a novel predictive nomogram is urgently needed. Non-small cell lung cancer (NSCLC) which accounts for the main port of lung cancer cases is attra...

    Authors: Zufang Liao, Rongjiong Zheng, Ni Li and Guofeng Shao
    Citation: BMC Cancer 2023 23:872
    Content type: Research Published on:

  38. We aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on the prognostic effect of adjuvant chemotherapy.

    Authors: Kexuan Li, Fuqiang Zhao, Yuchen Guo, Qingbin Wu, Shuangling Luo, Junling Zhang, Heli Li, Shidong Hu, Bin Wu, Guole Lin, Huizhong Qiu, Beizhan Niu, Xiyu Sun, Lai Xu, Junyang Lu, Xiaohui Du…
    Citation: BMC Cancer 2023 23:797
    Content type: Research Published on:

  39. While the treatment guidelines have been established for pure urothelial carcinoma (pUC), patients with variant type urothelial carcinoma (vUC) face limited effective treatment options. The effectiveness of im...

    Authors: Tsung-Han Tsai, Po-Jung Su, Shih-Yu Huang, Ming-Chun Kuo, Chang-Ting Lin, Chia-Che Wu, Hao-Lun Luo, Chien-Hsu Chen, Chih-Chi Chou, Ting-Ting Liu, Chun-Chieh Huang, Kai-Lung Tsai and Yu-Li Su
    Citation: BMC Cancer 2023 23:871
    Content type: Research Published on:

  40. Two thirds of patients with germ-cell cancer (GCC) present as clinical stage I (CSI). Following orchiectomy, active surveillance (AS) has become their standard management. However, 15–50% of patients eventuall...

    Authors: Philip Speicher, Christian D. Fankhauser, Anja Lorch, Davide Ardizzone, Simon Helnwein, Dennis Hoch, Thomas Hermanns, Jörg Beyer and Dilara Akhoundova
    Citation: BMC Cancer 2023 23:870
    Content type: Research Published on:

  42. Novel and effective immunotherapies are required for refractory or recurrent sarcomas. Transforming growth factor-beta (TGF-β) is a diverse regulatory and fibrogenic protein expressed in multiple sarcoma tumo...

    Authors: Lu Xie, Xin Liang, Jie Xu, Xin Sun, Kuisheng Liu, Kunkun Sun, Yuan Li, Xiaodong Tang, Xianan Li, Xing Zhan, Xiaohui Niu and Wei Guo
    Citation: BMC Cancer 2023 23:868
    Content type: Research Published on:

  43. The aim of this study is to explore the general impact of COVID-19 on the access and use of BC services and support and overall well-being in women living with a diagnosis of breast cancer (BC) and to investig...

    Authors: Charlotte Myers, Catherine Waldron, Kathleen Bennett and Caitriona Cahir
    Citation: BMC Cancer 2023 23:867
    Content type: Research Published on:

  44. Cardiotoxicity is among the most important adverse effects of childhood cancer treatment. Anthracyclines, mitoxantrone and radiotherapy involving the heart are its main causes. Subclinical cardiac dysfunction ...

    Authors: Theodorus W. Kouwenberg, Elvira C. van Dalen, Elizabeth A. M. Feijen, Stejara A. Netea, Melissa Bolier, Martijn G. Slieker, Firdaus A. A. Mohamed Hoesein, Leontien C. M. Kremer, Heynric B. Grotenhuis and Annelies M. C. Mavinkurve-Groothuis
    Citation: BMC Cancer 2023 23:866
    Content type: Research Published on:

  45. Radiotherapy (RT) following breast-conserving surgery (BCS) is mainly used to decrease the rate of ipsilateral breast tumor recurrence (IBTR) in women with breast ductal carcinoma in situ (DCIS). Recent studie...

    Authors: Sung-Hsin Kuo, Ling-Ming Tseng, Shou-Tung Chen, Yasuaki Sagara, Yuan-Ching Chang, Hsien-Tang Yeh, Yao-Lung Kuo, Chih-Chiang Hung, Tzu-Pin Lu, Yi-Hsuan Lee, Masakazu Toi and Chiun-Sheng Huang
    Citation: BMC Cancer 2023 23:865
    Content type: Study Protocol Published on:

  46. Clear cell renal cell carcinoma (CCRCC) is a common tumor of the urological system for which surgery is the preferred treatment, but there is a lack of therapeutic options after surgery. This study aims to exp...

    Authors: Jun Zheng, Weili Zhang and Junyong Zhang
    Citation: BMC Cancer 2023 23:864
    Content type: Research Published on:

  47. Pain is a common, debilitating, and feared symptom, including among cancer survivors. However, large-scale population-based evidence on pain and its impact in cancer survivors is limited. We quantified the pre...

    Authors: Grace Joshy, Saman Khalatbari-Soltani, Kay Soga, Phyllis Butow, Rebekah Laidsaar-Powell, Bogda Koczwara, Nicole M. Rankin, Sinan Brown, Marianne Weber, Carolyn Mazariego, Paul Grogan, John Stubbs, Stefan Thottunkal, Karen Canfell, Fiona M. Blyth and Emily Banks
    Citation: BMC Cancer 2023 23:774
    Content type: Research article Published on:

  48. Increasing women’s health literacy is the key to preventing cervical cancer, and various tools have been developed to assess women’s cancer health literacy. However, many of these tools come from other countri...

    Authors: Chanchan He, Chenyang Pei and Jing Ma
    Citation: BMC Cancer 2023 23:863
    Content type: Research Published on:

  49. Rectal cancer is one of the most common malignant tumors and has a high incidence rate and fatality rate. Accurate preoperative T staging of rectal cancer is critical for the selection of appropriate rectal ca...

    Authors: Qin Xia, Wei Cheng, Jie Bi, An-Ping Ren, Xiao Chen and Tao Li
    Citation: BMC Cancer 2023 23:860
    Content type: Research Published on:

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