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  1. With a median age at diagnosis of 70, lung cancer remains a significant public health challenge for older Americans. Surgery is a key component in treating most patients with non-metastatic lung cancer. These ...

    Authors: Virginia Sun, Katherine A. Guthrie, Kathryn B. Arnold, Mara Antonoff, Loretta Erhunmwunsee, Andrea Borondy-Kitts, Judy Johnson, Lee Jones, Maria Ramirez, Betty C. Tong, Jacob R. Moremen, Chi-Fu Jeffrey Yang, Thomas Ng, Samuel S. Kim, Lisa M. Brown, Justin D. Blasberg…
    Citation: BMC Cancer 2024 24:976
    Content type: Study Protocol Published on:

  3. Several studies have explored the potential link between gut microbiota and breast cancer; nevertheless, the causal relationship between gut microbiota and breast cancer remains unclear.

    Authors: Wei Lin, Chenghao Gu, Zheyin Chen, Shihang Xue, Haiyan Wu and Liuhai Zeng
    Citation: BMC Cancer 2024 24:970
    Content type: Research Published on:

  4. This study aimed to evaluate the effectiveness and safety of recombinant human endostatin (Rh-endostatin) plus programmed cell death 1 (PD-1) inhibitors and chemotherapy as first-line treatment for advanced or...

    Authors: Jing Zhang, Pei-Yuan Lv, Xiao Zhao, Ming-Lu Liu, Lu-Peng Qiu, Zi-Zhong Yang, Sheng-Jie Sun and Guo-Qing Zhang
    Citation: BMC Cancer 2024 24:967
    Content type: Research Published on:

  5. Renal cell carcinoma (RCC), one of the most fatal urologic tumors, accounts for approximately 3% of all adult cancers and exhibits a high metastatic index at diagnosis and a high rate of relapse. Radical or pa...

    Authors: Po-Hung Lin, Chin-Hsuan Hsieh, Kai-Jie Yu, I-Hung Shao, Cheng-Keng Chuang, Todd Hsu, Wen-Hui Weng and See-Tong Pang
    Citation: BMC Cancer 2024 24:966
    Content type: Research Published on:

  6. This study explores integrating clinical features with radiomic and dosiomic characteristics into AI models to enhance the prediction accuracy of radiation dermatitis (RD) in breast cancer patients undergoing ...

    Authors: Tsair-Fwu Lee, Chu-Ho Chang, Chih-Hsuan Chi, Yen-Hsien Liu, Jen-Chung Shao, Yang-Wei Hsieh, Pei-Ying Yang, Chin-Dar Tseng, Chien-Liang Chiu, Yu-Chang Hu, Yu-Wei Lin, Pei-Ju Chao, Shen-Hao Lee and Shyh-An Yeh
    Citation: BMC Cancer 2024 24:965
    Content type: Research Published on:

  7. Malignant chest wall tumors need to be excised with wide resection to ensure tumor free margins, and the reconstruction method should be selected according to the depth and dimensions of the tumor. Vascularize...

    Authors: Kunihiro Asanuma, Masaya Tsujii, Tomohito Hagi, Tomoki Nakamura, Takeshi Kataoka, Teruya Uchiyama, Ryohei Adachi and Akihiro Sudo
    Citation: BMC Cancer 2024 24:964
    Content type: Research Published on:

  8. The aim of this study was to investigate the incidence and risk factors of new-onset hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenomas in a single center.

    Authors: Jinxiu Yu, Jiaming Fu, Yanli Li, Guangxin Hu, Guanye Hu, Wentao Hu, Detian Liu and Junyi Fu
    Citation: BMC Cancer 2024 24:963
    Content type: Research Published on:

  9. Typically, researchers and clinicians determine the agenda in sarcoma research. However, patient involvement can have a meaningful impact on research. Therefore, the Patient-Powered Research Network (PPRN) of ...

    Authors: E. Roets, K. Schuster, S. Bickley, M. Wartenberg, O. Gonzato, N. Fernandez, B. Kasper, K. Pilgermann, R. Wilson, N. Steeghs, W. T. A. van der Graaf, G. van Oortmerssen and O. Husson
    Citation: BMC Cancer 2024 24:962
    Content type: Research Published on:

  10. Pancreatic cancer (PaCa) is one of the most intractable and fatal malignancies and is associated with the dysregulation of long noncoding RNAs (lncRNAs), which are a large class of noncoding RNAs larger than 2...

    Authors: Xiaomeng He, Litian Chen, Yang Di, Wenyang Li, Xin Zhang, Zhihui Bai, Zhefeng Wang, Shanshan Liu, Christopher Corpe and Jin Wang
    Citation: BMC Cancer 2024 24:961
    Content type: Research Published on:

  11. DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim of this study was to evaluate and compare salivary levels of the oxidative stress biomarker 8-...

    Authors: Mario Alberto Alarcón-Sánchez, Lilibeth-Stephania Escoto-Vasquez and Artak Heboyan
    Citation: BMC Cancer 2024 24:960
    Content type: Research Published on:

  12. Despite recent advances in lung cancer therapeutics and improving overall survival, disparities persist among socially disadvantaged populations. This study aims to determine the effects of neighborhood depriv...

    Authors: Kathleen Kennedy, Ignacio Jusue-Torres, Ian D. Buller, Emily Rossi, Apurva Mallisetty, Kristen Rodgers, Beverly Lee, Martha Menchaca, Mary Pasquinelli, Ryan H. Nguyen, Frank Weinberg, Israel Rubinstein, James G. Herman, Malcolm Brock, Lawrence Feldman, Melinda C. Aldrich…
    Citation: BMC Cancer 2024 24:959
    Content type: Research Published on:

  13. Muscle-invasive bladder cancer (MIBC) is a prevalent and aggressive malignancy. Ferroptosis and cuproptosis are recently discovered forms of programmed cell death (PCD) that have attracted much attention. Howe...

    Authors: Sida Hao, Zitong Yang, Gang Wang, Guofeng Cai and Yong Qin
    Citation: BMC Cancer 2024 24:958
    Content type: Research Published on:

  14. Exosomal microRNAs have been identified as important mediators of communication between tumor cells and macrophages in the microenvironment. miR-541-5p was reported to be involved in hepatocellular carcinoma p...

    Authors: Haimin Xiao, Jia Fu, Ruiting Liu, Likun Yan, Zheqi Zhou and Jinyan Yuan
    Citation: BMC Cancer 2024 24:957
    Content type: Research Published on:

  15. Owing to the lack of evidence-based medical studies with large sample sizes, the surgical approach for the radical resection of rectal neuroendocrine tumors remains controversial.

    Authors: Xinyu Zeng, Chengguo Li, Minhao Yu, Rui Zhang, Guole Lin, Maojun Di, Hongxue Wu, Yueming Sun, Zhiguo Xiong, Congqing Jiang, Bin Yu, Shengning Zhou, Yong Li, Xiaofeng Liao, Lijian Xia, Wei Zhang…
    Citation: BMC Cancer 2024 24:956
    Content type: Research Published on:

  16. For myeloid neoplasms with t(7;11)(p15;p15) translocation, the prognosis is quite dismal. Because these tumors are rare, most occurrences are reported as single cases. Clinical results and optimal treatment ap...

    Authors: Lin Liu, Shuqi Zhao, Lu Wang, Huan Xu, Zhimei Chen, Jifang Tu, Jiansong Huang, Jie Jin and Hongyan Tong
    Citation: BMC Cancer 2024 24:955
    Content type: Research Published on:

  17. Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, is overexpressed in various cancers and facilitates immune evasion by inhibiting T-cell activation. GDFATHER-TRIAL’s phase 2a resul...

    Authors: Orhun Akdogan, Betul Ogut, Osman Sutcuoglu, Aysenur Sert, Fatih Gurler, Nalan Akyurek, Nuriye Ozdemir, Ahmet Ozet and Ozan Yazici
    Citation: BMC Cancer 2024 24:954
    Content type: Research Published on:

  18. In the context of the widespread availability of magnetic resonance imaging (MRI) and aggressive salvage irradiation techniques, there has been controversy surrounding the use of prophylactic cranial irradiati...

    Authors: Nan Yao, Zhaohui Qin, Meng Chen, Lingling Hu, Ji Ma, Jiaying Lu, Shaodong Tong, Na Li and Yuanhu Yao
    Citation: BMC Cancer 2024 24:953
    Content type: Research Published on:

  20. Limited data exists on the efficacy of immune checkpoint inhibitor (ICI) combinations in non-small-cell lung cancer (NSCLC) with uncommon driver alterations in genes such as ERBB2, BRAF, RET, and MET. This study ...

    Authors: Haoyue Qin, Huan Yan, Yangqian Chen, Qinqin Xu, Zhe Huang, Wenjuan Jiang, Zhan Wang, Li Deng, Xing Zhang, Lin Zhang, Nong Yang, Liang Zeng and Yongchang Zhang
    Citation: BMC Cancer 2024 24:952
    Content type: Research Published on:

  21. Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10–20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear...

    Authors: Javiera Garrido, Yanara Bernal, Evelin González, Alejandro Blanco, Gonzalo Sepúlveda-Hermosilla, Matías Freire, Karen Oróstica, Solange Rivas, Katherine Marcelain, Gareth Owen, Carolina Ibañez, Alejandro Corvalan, Marcelo Garrido, Rodrigo Assar, Rodrigo Lizana, Javier Cáceres-Molina…
    Citation: BMC Cancer 2024 24:951
    Content type: Research Published on:

  22. To investigate the impact of response to induction chemotherapy (IC) on survival outcomes in patients with locally advanced nasopharyngeal carcinoma (LANPC) and evaluate the efficacy of adding nimotuzumab to c...

    Authors: Lin-Feng Guo, Ming-Yue Rao, Yi-Feng Yu, Qin Lin and San-Gang Wu
    Citation: BMC Cancer 2024 24:950
    Content type: Research Published on:

  23. Structured exercise has an important role in mitigating the extensive side effects caused by ongoing prostate cancer treatments, specifically androgen deprivation therapy (ADT) and radiation therapy (RT). Litt...

    Authors: Kira Murphy, Bróna Kehoe, Suzanne Denieffe, Aisling McGrath, Dayle Hacking, Ciaran M. Fairman and Michael Harrison
    Citation: BMC Cancer 2024 24:949
    Content type: Research Published on:

  24. Hepatoid adenocarcinoma of the lung (HAL) is a distinctly uncommon subtype of lung adenocarcinoma (LAC), characterized by hepatoid features and an alarmingly low 5-year survival rate of approximately 8%. The s...

    Authors: Huijing Deng, Luyao Wang, Zewei Li, Tao Zhan and Liu Huang
    Citation: BMC Cancer 2024 24:948
    Content type: Systematic Review Published on:

  25. Although immunotherapy shows tremendous potential in the treatment of bladder cancer (BLCA), the overall prognosis and response rates to immunotherapy in BLCA remain suboptimal.

    Authors: Renyu Liu, Ting Yang, Jinyu Huang, Zicheng Xiao, Jinhui Liu, Zhenghao Li and Shiyu Tong
    Citation: BMC Cancer 2024 24:947
    Content type: Research Published on:

  26. Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death in men in Algeria. Little is known about the characteristics of lung cancer in Algeria. This study aimed to deter...

    Authors: Mohamed Lahmadi, Leila Beddar, Souad Ketit, Tarek Makhbouche, Narriman Laouar and Taha Filali
    Citation: BMC Cancer 2024 24:946
    Content type: Research Published on:

  27. Many patients undergo dose reduction or early termination of chemotherapy to reduce chemoradiotherapy-related toxicity, which may increase their risk of survival. However, this strategy may result in underdosi...

    Authors: Li Jiang, Jie Zhu, Xue Chen, Yi Wang, Lei Wu, Gang Wan, Yongtao Han, Xuefeng Leng, Jun Zhang, Lin Peng and Qifeng Wang
    Citation: BMC Cancer 2024 24:945
    Content type: Research Published on:

  28. Currently, family with sequence similarity 65 member A (FAM65A) is reported as a pivotal regulator in various cancers. However, the effect of FAM65A in lung squamous cell carcinoma (LSCC) is still unclear, the...

    Authors: Fangjun Chen, Peng Ren, Rui Xu, Jin Zhang, Chaoyang Liang and Guangliang Qiang
    Citation: BMC Cancer 2024 24:944
    Content type: Research Published on:

  29. Paediatric solid tumours, both benign and malignant, present significant health challenges, particularly in Sub-Saharan Africa where comprehensive data is limited. This study aims to elucidate the prevalence, ...

    Authors: Chisom Adaobi Nri-Ezedi, Thomas Obiajulu Ulasi, Felix Emeka Menkiti, Chinedu Onwuka Ndukwe, Chinelo M. Igwenagu and Frank Chinedu Akpuaka
    Citation: BMC Cancer 2024 24:943
    Content type: Research Published on:

  30. Lung cancer is the third most common cancer in the UK and the leading cause of cancer mortality globally. NHS England guidance for optimum lung cancer care recommends management and treatment by a specialist t...

    Authors: Daisy McInnerney, Samantha L. Quaife, Samuel Cooke, Lucy Mitchinson, Zara Pogson, William Ricketts, Adam Januszewski, Anna Lerner, Dawn Skinner, Sarah Civello, Ros Kane, Ava Harding-Bell, Lynn Calman, Peter Selby, Michael D. Peake and David Nelson
    Citation: BMC Cancer 2024 24:942
    Content type: Study Protocol Published on:

  31. Advanced pancreatic adenocarcinoma lacks effective treatment options, and systemic gemcitabine-based chemotherapy offers only marginal survival benefits at the cost of significant toxicities and adverse events...

    Authors: Changjing Huang, Chien-shan Cheng, Yehua Shen, Hao Chen, Junhua Lin, Yongqiang Hua, Lanyun Feng, Caijun Wu, Peng Wang, Zhen Chen and Zhiqiang Meng
    Citation: BMC Cancer 2024 24:941
    Content type: Research Published on:

  32. Stereotactic irradiation has become the mainstay treatment for brain metastases (BM), and whole-brain radiotherapy (WBRT) is often used for symptom palliation. However, the survival time of patients with BM un...

    Authors: Toshiaki Hirose, Shoichi Deguchi, Kazuaki Yasui, Minoru Inoue, Tsuyoshi Onoe, Hirofumi Ogawa, Hirofumi Asakura, Koichi Mitsuya, Hideyuki Harada, Shigeyuki Murayama, Nakamasa Hayashi, Tetsuo Nishimura and Ryuta Saito
    Citation: BMC Cancer 2024 24:940
    Content type: Research Published on:

  33. The randomized, dose-optimization, open-label ReDOS study in US patients with metastatic colorectal cancer (CRC) showed that, compared with a standard dosing approach, initiating regorafenib at 80 mg/day and e...

    Authors: Tanios Bekaii-Saab, Nasreen Khan, Helene Ostojic, XiaoLong Jiao, Guifang Chen, Wenlong Lin and Amanda Bruno
    Citation: BMC Cancer 2024 24:939
    Content type: Research Published on:

  34. Sarcomatoid carcinoma of the lung is a rare histological type of non-small cell lung cancer with a poor prognosis. We aimed to investigate the clinicopathological characteristics and prognostic factors of surg...

    Authors: Kaoru Kaseda, Keisuke Asakura, Yasushi Shintani, Jiro Okami, Shinichi Toyooka, Yukio Sato, Shun-Ichi Watanabe, Masayuki Chida, Hidemi Suzuki, Etsuo Miyaoka, Ichiro Yoshino and Hiroshi Date
    Citation: BMC Cancer 2024 24:938
    Content type: Research Published on:

  35. Neuropeptide Y is a neurotransmitter in the nervous system and belongs to the orexigenic system that increases appetite. Its excessive secretion leads to obesity. Leptin is a pro-inflammatory adipokine (produc...

    Authors: Małgorzata Frąk, Anna Grenda, Paweł Krawczyk, Barbara Kuźnar-Kamińska, Paweł Pazdrowski, Karolina Kędra, Izabela Chmielewska and Janusz Milanowski
    Citation: BMC Cancer 2024 24:937
    Content type: Research Published on:

  36. To evaluate the dosimetric characteristics of ZAP-X stereotactic radiosurgery (SRS) for single brain metastasis by comparing with two mature SRS platforms.

    Authors: Jinyuan Wang, Qingzeng Zheng, Yanping Wang, Chengcheng Wang, Shouping Xu, Zhongjian Ju, Longsheng Pan, Jingmin Bai, Yunmo Liu, Baolin Qu and Xiangkun Dai
    Citation: BMC Cancer 2024 24:936
    Content type: Research Published on:

  37. Lymph node (LN) metastasis is an established prognostic factor for patients with surgically resected ampulla of Vater (AoV) cancer. The standard procedure for radical resection, including removal of regional L...

    Authors: So Jeong Yoon, Seung Soo Hong, Kee-Taek Jang, So Kyung Yoon, Hongbeom Kim, Sang Hyun Shin, Jin Seok Heo, Chang Moo Kang, Kyung Sik Kim, Ho Kyoung Hwang and In Woong Han
    Citation: BMC Cancer 2024 24:935
    Content type: Research Published on:

  38. Due to the close proximity of the prostate and rectum, rectal toxicity remains a major problem in patient treated by radiotherapy for prostate adenocarcinoma. One method of increasing the distance between the ...

    Authors: G. Janoray, E. Bruguière, J. Mazurier, P. Dudouet, J. Guillotreau, C. Tollon, P. Labarthe, P. Seguin and I. Latorzeff
    Citation: BMC Cancer 2024 24:934
    Content type: Research Published on:

  39. Cervical cancer remains a significant but preventable threat to women’s health throughout much of the developing world, including Uganda. Cervical cancer screening and timely treatment of pre-cancerous lesions...

    Authors: Kathryn Bouskill, Glenn J. Wagner, Mahlet Gizaw, Joseph KB Matovu, Margrethe Juncker, Eve Namisango, Sylvia Nakami, Jolly Beyeza-Kashesya, Emmanuel Luyirika and Rhoda K. Wanyenze
    Citation: BMC Cancer 2024 24:933
    Content type: Research Published on:

  40. Esophageal carcinoma is a growing concern in regions that have a high incidence of human papillomavirus (HPV) infection such as East Africa. HPV, particularly the high-risk genotypes, is increasingly recognize...

    Authors: Lilian M. Ndemela, Oscar M. Ottoman, Heaven D. Chitemo, Caroline Anold Minja, Peter F. Rambau and Benson R. Kidenya
    Citation: BMC Cancer 2024 24:932
    Content type: Research Published on:

  41. Despite the recent advances in cancer treatment, the therapeutic options for patients with biliary tract cancer are still very limited and the prognosis very poor. More than 50% of newly diagnosed patients wit...

    Authors: Constantin Schmidt, Antonia Zapf, Ann-Kathrin Ozga, Ali Canbay, Ulrike Denzer, Enrico N. De Toni, Ansgar W. Lohse, Kornelius Schulze, Thomas Rösch, Alexander Stein, Henning Wege and Johann von Felden
    Citation: BMC Cancer 2024 24:931
    Content type: Study Protocol Published on:

  42. Betel quid chewing, prevalent in Southeast Asia and South Asia, involves components such as betel leaf, areca nut, slaked lime, and sometimes tobacco. This study aims to assess buccal mucosa changes in betel q...

    Authors: Hamrish Kumar Rajakumar, Varsha Coimbatore Sathyabal, Kolsamma Nasrin Jabarulla and Pushpa Balamurugesan
    Citation: BMC Cancer 2024 24:930
    Content type: Research Published on:

  43. In this study, we aimed to establish nomograms to predict the microvascular invasion (MVI) and early recurrence in patients with small hepatocellular carcinoma (SHCC), thereby guiding individualized treatment ...

    Authors: Xi Wang, Xinqun Chai, Ji Zhang, Ruiya Tang and Qinjunjie Chen
    Citation: BMC Cancer 2024 24:929
    Content type: Research Published on:

  44. Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhance...

    Authors: Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li and Jian Pan
    Citation: BMC Cancer 2024 24:928
    Content type: Research Published on:

  45. This study aims to explore ADH4 expression in hepatocellular carcinoma (HCC), its prognostic impact, and its immune correlation to provide novel insights into HCC prognostication and treatment.

    Authors: Ling Li, Yong-ta Huang, Li-ting Wang, Xiao-ling Wang, Zhen-yu Chen, Shao-lan Jiang, Qiu-ling Zeng, Hui-pin Huang and Xiao-long Li
    Citation: BMC Cancer 2024 24:927
    Content type: Research Published on:

  46. As the most malignant tumor of the female reproductive system, ovarian cancer (OC) has garnered increasing attention. The Warburg effect, driven by glycolysis, accounts for tumor cell proliferation under aerob...

    Authors: Jinting Ji, Fangfang Bi, Xiaocui Zhang, Zhiming Zhang, Yichi Xie and Qing Yang
    Citation: BMC Cancer 2024 24:926
    Content type: Research Published on:

  47. Lung adenocarcinoma is a high-mortality rate cancer. Within this category, Lung mucinous adenocarcinoma (LMAC) is a rare and distinct subtype of lung adenocarcinoma necessitating further investigation. The stu...

    Authors: Qi-Yue Ge, Chao Zheng, Guo-Chao Zhang, Zhuang-Zhuang Cong, Jing Luo, Yang Xu, Chang-Yong Wang, Chao Luo, Wei Wei, Zhi-Hui Yang, Ming-Ze Li, Yu-Heng Wu, Yu-Yang Wang, Qi Xue and Yi Shen
    Citation: BMC Cancer 2024 24:925
    Content type: Research Published on:

  50. The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain...

    Authors: Teuta Zoto Mustafayev, Menekse Turna, Yasemin Bolukbasi, Evrim Tezcanli, Yildiz Guney, Fazilet Oner Dincbas, Beste Melek Atasoy, Gamze Ugurluer, Hale Basak Caglar, Banu Atalar and Enis Ozyar
    Citation: BMC Cancer 2024 24:918
    Content type: Research Published on:

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