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  1. Contrast enhanced ultrasound (CEUS) is an imaging technique which appeared on the market around the year 2000 and proposed for the detection of liver metastases in gastrointestinal cancer patients, a setting i...

    Authors: Fabio Piscaglia, Francesco Corradi, Mikaela Mancini, Francesco Giangregorio, Stefano Tamberi, Giampaolo Ugolini, Bruno Cola, Alberto Bazzocchi, Roberto Righini, Patrizia Pini, Fabio Fornari and Luigi Bolondi
    Citation: BMC Cancer 2007 7:171
    Content type: Research article Published on:

  2. Male breast cancer (MBC) is a rare disease and little is known about its aetiology. Germ-line mutations of BRCA2 and, at lower frequency, of BRCA1 are implicated in a relatively small proportion of MBC cases. Com...

    Authors: Domenico Palli, Mario Falchetti, Giovanna Masala, Ramona Lupi, Francesco Sera, Calogero Saieva, Cristina D'Amico, Marco Ceroti, Piera Rizzolo, Maria Adelaide Caligo, Ines Zanna and Laura Ottini
    Citation: BMC Cancer 2007 7:170
    Content type: Research article Published on:

  3. The functional and clinical significance of 14-3-3 proteins in human cancers remain largely undetermined. Earlier, we have reported differential expression of 14-3-3ζ mRNA in oral squamous cell carcinoma (OSCC...

    Authors: Ajay Matta, Sudhir Bahadur, Ritu Duggal, Siddhartha D Gupta and Ranju Ralhan
    Citation: BMC Cancer 2007 7:169
    Content type: Research article Published on:

  4. p53 is commonly inactivated by mutations in the DNA-binding domain in a wide range of cancers. As mutant p53 often influences response to therapy, effective and rapid methods to scan for mutations in TP53 are lik...

    Authors: Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell and Alexander Dobrovic
    Citation: BMC Cancer 2007 7:168
    Content type: Research article Published on:

  6. Many patients suffer from severe shoulder complaints after breast cancer surgery and axillary lymph node dissection. Physiotherapy has been clinically observed to improve treatment of these patients. However, ...

    Authors: Carien HG Beurskens, Caro JT van Uden, Luc JA Strobbe, Rob AB Oostendorp and Theo Wobbes
    Citation: BMC Cancer 2007 7:166
    Content type: Research article Published on:

  7. Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasiv...

    Authors: Rose-Marie Amini, Kirsimari Aaltonen, Heli Nevanlinna, Ricardo Carvalho, Laura Salonen, Päivi Heikkilä and Carl Blomqvist
    Citation: BMC Cancer 2007 7:165
    Content type: Research article Published on:

  10. Polymorphisms in DNA repair genes have been associated to repair DNA lesions, and might contribute to the individual susceptibility to develop different types of cancer. Nucleotide excision repair (NER), base ...

    Authors: M Felicitas López-Cima, Patricia González-Arriaga, Laura García-Castro, Teresa Pascual, Manuel G Marrón, Xose S Puente and Adonina Tardón
    Citation: BMC Cancer 2007 7:162
    Content type: Research article Published on:

  11. Induction of apoptosis is one strategy for treatment of prostate cancer. The Shb adapter protein has been found to regulate apoptosis in various cell types and consequently human prostate cancer 3 (PC3) cells ...

    Authors: Padideh Davoodpour, Maréne Landström and Michael Welsh
    Citation: BMC Cancer 2007 7:161
    Content type: Research article Published on:

  12. Young women presenting with breast cancer are more likely to have a genetic predisposition to the disease than breast cancer patients in general. A genetic predisposition is known to increase the risk of new p...

    Authors: Diana Eccles, Sue Gerty, Peter Simmonds, Victoria Hammond, Sarah Ennis and Douglas G Altman
    Citation: BMC Cancer 2007 7:160
    Content type: Study protocol Published on:

  13. Interferon-α (IFN-α) is one of the central agents in immunotherapy for renal cell carcinoma (RCC) and binds to the IFN-α receptor (IFNAR). We investigated the role of IFNAR in RCC.

    Authors: Takao Kamai, Yoshiaki Yanai, Kyoko Arai, Hideyuki Abe, Tomonori Yamanishi, Masashi Kurimoto and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2007 7:159
    Content type: Research article Published on:

  14. Interferons are a group of proteins that trigger multiple responses including prevention of viral replication, inhibition of cell growth, and modulation of cell differentiation. In different mammary carcinoma ...

    Authors: Ignacio García-Tuñón, Mónica Ricote, Antonio Ruiz A, Benito Fraile, Ricardo Paniagua and Mar Royuela
    Citation: BMC Cancer 2007 7:158
    Content type: Research article Published on:

  15. Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence ...

    Authors: Amal Abdul-Hussein, Pierre A Morris and Tsveti Markova
    Citation: BMC Cancer 2007 7:157
    Content type: Case report Published on:

  16. Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tu...

    Authors: David Bacman, Susanne Merkel, Roland Croner, Thomas Papadopoulos, Wolfgang Brueckl and Arno Dimmler
    Citation: BMC Cancer 2007 7:156
    Content type: Research article Published on:

  17. Combination of platinum derivatives with paclitaxel is currently the standard front line regimen for patients with epithelial ovarian carcinoma, and represents also an active regimen in patients with metastati...

    Authors: Bohuslav Melichar, Radomír Hyšpler, Emanuela Dragounová, Josef Dvořák, Hana Kalábová and Alena Tichá
    Citation: BMC Cancer 2007 7:155
    Content type: Research article Published on:

  18. Colorectal cancer (CRC) diagnosis and the ensuing treatments can have a substantial impact on the physical and psychological health of survivors. As the number of CRC survivors increases, so too does the need ...

    Authors: Rosalind R Spence, Kristiann C Heesch, Elizabeth G Eakin and Wendy J Brown
    Citation: BMC Cancer 2007 7:154
    Content type: Study protocol Published on:

  19. Breast cancer is the most common cancer in women in the U.S. and Western Europe. Amplification of the her-2/neu gene occurs in approximately 25% of invasive ductal carcinomas of the breast. The first HER-2/neu...

    Authors: Gustavo A Viani, Sergio L Afonso, Eduardo J Stefano, Ligia I De Fendi and Francisco V Soares
    Citation: BMC Cancer 2007 7:153
    Content type: Research article Published on:

  22. Erlotinib is a Human Epidermal Growth Factor Receptor Type 1/tyrosine kinase (EGFR) inhibitor which is used for non-small-cell lung cancer treatment. Despite that erlotinib is considered to have a favorable sa...

    Authors: Demosthenes Makris, Arnaud Scherpereel, Marie Christine Copin, Guillaume Colin, Luc Brun, Jean Jacques Lafitte and Charles Hugo Marquette
    Citation: BMC Cancer 2007 7:150
    Content type: Case report Published on:

  24. C4-2 prostate cancer (CaP) cells grown in mouse tibiae cause a mixed osteoblastic/osteolytic response with increases in osteoclast numbers and bone resorption. Administration of osteoprotegerin (OPG) blocks th...

    Authors: Colm Morrissey, Paul L Kostenuik, Lisha G Brown, Robert L Vessella and Eva Corey
    Citation: BMC Cancer 2007 7:148
    Content type: Research article Published on:

  25. The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration ...

    Authors: Jayson Wang, Gary Cook, John Frank, Roberto Dina, Naomi Livni, John Lynn, William Fleming and Michael J Seckl
    Citation: BMC Cancer 2007 7:147
    Content type: Case report Published on:

  27. c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7 resulted in increased AP-1 activity, ...

    Authors: Yan Zhang, Xiaoyun Pu, Ming Shi, Liyong Chen, Yuhua Song, Lu Qian, Guogang Yuan, Hao Zhang, Ming Yu, Meiru Hu, Beifen Shen and Ning Guo
    Citation: BMC Cancer 2007 7:145
    Content type: Research article Published on:

  28. Synoptic reporting, either as part of the pathology report or replacing some free text component incorporates standardized data elements in the form of checklists for pathology reporting. This ensures the path...

    Authors: Sambit K Mohanty, Anthony L Piccoli, Lisa J Devine, Ashokkumar A Patel, Gross C William, Sharon B Winters, Michael J Becich and Anil V Parwani
    Citation: BMC Cancer 2007 7:144
    Content type: Research article Published on:

  29. Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fracti...

    Authors: Daniela Schilling, Christine Bayer, Anneke Geurts-Moespot, Fred CGJ Sweep, Martin Pruschy, Karin Mengele, Lisa D Sprague and Michael Molls
    Citation: BMC Cancer 2007 7:143
    Content type: Research article Published on:

  30. Docetaxel is the standard first-line agent for the treatment of androgen-independent prostate cancer (AIPC). The combination of docetaxel with molecularly targeted therapies may offer the potential to increase...

    Authors: Mitchell Gross, Celestia Higano, Allan Pantuck, Olga Castellanos, Erica Green, Koo Nguyen and David B Agus
    Citation: BMC Cancer 2007 7:142
    Content type: Research article Published on:

  31. Metastases to the central nervous system from different primary cancers are an oncologic challenge as the overall prognosis for these patients is generally poor. The incidence of brain metastases varies with t...

    Authors: Torill E Sjøbakk, Roar Johansen, Tone F Bathen, Ursula Sonnewald, Kjell A Kvistad, Steinar Lundgren and Ingrid S Gribbestad
    Citation: BMC Cancer 2007 7:141
    Content type: Research article Published on:

  32. Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression. Recent studies have suggested that APN/CD13 plays an important role in tumor...

    Authors: Mikio Terauchi, Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Shigehiko Mizutani and Fumitaka Kikkawa
    Citation: BMC Cancer 2007 7:140
    Content type: Research article Published on:

  33. HIF2α/EPAS1 is a hypoxia-inducible transcription factor involved in catecholamine homeostasis, vascular remodelling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, ...

    Authors: Judith Favier, Stéphanie Lapointe, Ricardo Maliba and Martin G Sirois
    Citation: BMC Cancer 2007 7:139
    Content type: Research article Published on:

  34. Arachidonate metabolites are important regulators of human breast cancer cells. Production of bioactive lipids are frequently initiated by the enzyme phospholipase A2 which releases arachidonic acid (AA) that ...

    Authors: Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das and Marti Jett
    Citation: BMC Cancer 2007 7:138
    Content type: Research article Published on:

  35. The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinoma...

    Authors: Katherine AB Knostman, James A McCubrey, Carl D Morrison, Zhaoxia Zhang, Charles C Capen and Sissy M Jhiang
    Citation: BMC Cancer 2007 7:137
    Content type: Research article Published on:

  36. Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest th...

    Authors: Michael C Haffner, Barbara Petridou, Jean Phillipe Peyrat, Françoise Révillion, Elisabeth Müller-Holzner, Günter Daxenbichler, Christian Marth and Wolfgang Doppler
    Citation: BMC Cancer 2007 7:136
    Content type: Research article Published on:

  37. Inflammatory cytokines may promote tumorigenesis. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with regulatory properties over tumor suppressor proteins involved in bladder cancer...

    Authors: John A Taylor III, George A Kuchel, Poornima Hegde, Olga S Voznesensky, Kevin Claffey, John Tsimikas, Lin Leng, Richard Bucala and Carol Pilbeam
    Citation: BMC Cancer 2007 7:135
    Content type: Research article Published on:

  38. Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical (...

    Authors: Marc Tischkowitz, Jean-Sébastien Brunet, Louis R Bégin, David G Huntsman, Maggie CU Cheang, Lars A Akslen, Torsten O Nielsen and William D Foulkes
    Citation: BMC Cancer 2007 7:134
    Content type: Research article Published on:

  39. Aberrant promoter hypermethylation of cancer-associated genes occurs frequently during carcinogenesis and may serve as a cancer biomarker. In this study we aimed at defining a quantitative gene promoter methyl...

    Authors: Vera L Costa, Rui Henrique, Franclim R Ribeiro, Mafalda Pinto, Jorge Oliveira, Francisco Lobo, Manuel R Teixeira and Carmen Jerónimo
    Citation: BMC Cancer 2007 7:133
    Content type: Research article Published on:

  40. The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families. We evaluated bo...

    Authors: Grazia Palomba, Antonio Cossu, Eitan Friedman, Mario Budroni, Antonio Farris, Antonio Contu, Marina Pisano, Paola Baldinu, Maria C Sini, Francesco Tanda and Giuseppe Palmieri
    Citation: BMC Cancer 2007 7:132
    Content type: Research article Published on:

  41. Oestrogen receptor beta (ERβ) modulates ERα activity; wild type ERβ (ERβ1) and its splice variants may therefore impact on hormone responsiveness of breast cancer. ERβ2/ERβcx acts as a dominant negative inhibi...

    Authors: Raman Vinayagam, D Ross Sibson, Christopher Holcombe, Vijay Aachi and Michael PA Davies
    Citation: BMC Cancer 2007 7:131
    Content type: Research article Published on:

  43. The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid...

    Authors: Gautier Defossez, Simone Mathoulin-Pelissier, Isabelle Ingrand, Isabelle Gasquet, Lynda Sifer-Riviere, Pierre Ingrand, Roger Salamon and Virginie Migeot
    Citation: BMC Cancer 2007 7:129
    Content type: Research article Published on:

  44. Gefitinib, a small molecule tyrosine kinase inhibitor of the Epidermal Growth Factor Receptor (EGFR), has shown limited efficacy in the treatment of lung cancer. Recognized clinical predictors of response to this...

    Authors: Trevor J Pugh, Gwyn Bebb, Lorena Barclay, Margaret Sutcliffe, John Fee, Chris Salski, Robert O'Connor, Cheryl Ho, Nevin Murray, Barbara Melosky, John English, Jeurgen Vielkind, Doug Horsman, Janessa J Laskin and Marco A Marra
    Citation: BMC Cancer 2007 7:128
    Content type: Research article Published on:

  45. Medulloblastoma is the most common malignant brain tumor of childhood. Children who relapse usually die of their disease, which reflects resistance to radiation and/or chemotherapy. Improvements in outcome req...

    Authors: Robert C Castellino, Massimiliano De Bortoli, Linda L Lin, Darlene G Skapura, Jessen A Rajan, Adekunle M Adesina, Laszlo Perlaky, Meredith S Irwin and John YH Kim
    Citation: BMC Cancer 2007 7:127
    Content type: Research article Published on:

  46. Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent ...

    Authors: Jian Huang, Yun-Li Zhang, Xiao-Mei Teng, Yun Lin, Da-Li Zheng, Peng-Yuan Yang and Ze-Guang Han
    Citation: BMC Cancer 2007 7:126
    Content type: Research article Published on:

  48. Sialyl Lewis x (sLex) antigen is a carbohydrate antigen that is considered not only a marker for cancer but also implicated functionally in the malignant behaviour of cancer cells. Overexpression of sLex is assoc...

    Authors: Salomé S Pinho, Augusto JF Matos, Célia Lopes, Nuno T Marcos, Júlio Carvalheira, Celso A Reis and Fátima Gärtner
    Citation: BMC Cancer 2007 7:124
    Content type: Research article Published on:

  49. Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.

    Authors: Lara Bethke, Emily Webb, Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi and Richard Houlston
    Citation: BMC Cancer 2007 7:123
    Content type: Research article Published on:

  50. Endoglin (CD105) has been considered a prognostic marker for hepatocellular carcinoma (HCC), and widely used as an appropriate targeting for antiangenesis therapy in some cancers. Our aim was to evaluate the d...

    Authors: Decai Yu, Linyuan Zhuang, Xitai Sun, Jun Chen, Yongzhong Yao, Kui Meng and Yitao Ding
    Citation: BMC Cancer 2007 7:122
    Content type: Research article Published on:

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