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Gastro-intestinal symptoms as clinical manifestation of peritoneal and retroperitoneal spread of an invasive lobular breast cancer: report of a case and review of the literature
© Franceschini et al; licensee BioMed Central Ltd. 2006
Received: 13 April 2006
Accepted: 19 July 2006
Published: 19 July 2006
Distant spread from breast cancer is commonly found in bones, lungs, liver and central nervous system. Metastatic involvement of peritoneum and retroperitoneum is unusual and unexpected.
We report the case of a 67 year-old-woman who presented with gastrointestinal symptoms which revealed to be the clinical manifestations of peritoneal and retroperitoneal metastatic spread of an invasive lobular breast cancer diagnosed 15 years before.
To the best of our knowledge, the case presented is the third one reported in literature showing a wide peritoneal and extraperitoneal diffusion of an invasive lobular breast cancer. The long and complex diagnostic work up which led us to the diagnosis is illustrated, with particular emphasis on the multidisciplinary approach, which is mandatory to obtain such a result in these cases. Awareness of such a condition by clinicians is mandatory in order to make an early diagnosis and start a prompt and correct therapeutic approach.
Invasive lobular breast cancer (ILC) takes origin in the milk-producing glands of the breast and is the most common histological breast cancer after the ductal carcinoma (DC), accounting for 8–14% of cases . The typical histologic picture is characterized by small, regular, non-cohesive cells arranged in the so called "Indian file" appearance ; the neoplastic cells infiltrate the parenchyma around non-neoplastic ducts, inducing little connective tissue response . Being physical examination and mammography often non-specific, contrast-enhanced magnetic resonance imaging (MRI) represents the gold standard for a correct diagnosis . ILC has a higher tendency than DC to be multi-focal and bilateral . Also the pattern of metastatic spread differs significantly between these 2 kinds of breast tumours, with a more common occurrence of unusual location of distant neoplastic foci, especially in the gastrointestinal tract, the genitourinary system and the peritoneum or retroperitoneum, secondary to ILC. This event is unexpected, usually with a long interval after the initial diagnosis of ILC, and the presenting symptoms as well as the endoscopic and the radiographic pictures are often non-specific. These conditions lead to a frequent delay in diagnosis which prevents the prompt starting of systemic treatment necessary to obtain a good control of symptoms. The case reported gives an example of this unusual metastatic diffusion and of the complex diagnostic work up which led us to he diagnosis.
A computerised tomography (CT) scan of the abdomen and pelvis showed how the pelvic cavity was almost completely occupied by neoplastic tissue which infiltrated the rectal wall, causing marked stenosis, both the ovaries, the fundus of the vagina and the left lateral wall of the bladder, with involvement of the left ureter and concurrent hydronephrosis. Multiple enlarged lymph-nodes were identified in the perirectal fat, along the common iliac artery and the obturator chain and in the inter-aortocaval space. The liver and the chest appeared normal. Mammographic and ultrasonographic picture of the left breast and of both axilla were normal. On the basis of the diagnosis of wide peritoneal and extraperitoneal metastatic spread of ILC, the patient entered a protocol of systemic chemotherapy and hormonal therapy after the placement of a J ureteral stent to pass through the stenosis evidenced by the CT scan and confirmed by cystoscopy.
It is well known that the pattern of metastatic spread differs dramatically between ductal and lobular breast cancer [6, 7]. In particular, the retrospective series by Borst et al, comparing metastatic rates between these 2 histological subtypes in 2605 cases of breast cancer, showed statistically significant differences for metastases in the gastrointestinal tract (4,5% in ILC vs 0,2% in DC), gynaecological organs (4,5% in ILC vs 0,8 in DC) and peritoneum/retroperitoneum (3,1% in ILC vs 0,6% in DC) . The 50% of metastasis to the gastrointestinal tract from ILC affects the small bowel  while involvement of the large bowel, especially of the rectum, is infrequent  and often multifocal . The metastatic spread may develop into the peritoneum, in the form of small or confluent nodules , or into the retroperitoneum, often resulting in ureteric obstruction and hydronephrosis . Only 19 cases of bladder location of metastases from breast cancer are reported in the English literature till 2000 and only 33% were secondary to ILC among them . The gynaecological organs are not spared by metastatic spread from ILC, expecially the uterus and the ovary, which account for the 80% of all gynaecological metastastases from ILC . Concomitant multiple peritoneal and extraperitoneal locations of metastatic disease from ILC, as in the case reported, is an even more rare evenience; to the best of our knowledge, apart from the present report, only other two cases have been published in literature till know [11, 14].
The most representative series of metastatic ILC, focused on the specific sites of involvement, are summarized in table I [see additional file 1].
The clinical manifestations in such cases are usually non-specific, and strikingly similar to that of primary gastrointestinal and genitourinary malignancies [15, 16]. The median interval between presentation of metastasis and diagnosis of ILC is five to six years [8, 15]; an interval of more than 10 years, up to 15 years as in our case, have rarely been described [8, 15, 17]. Both the above reported conditions make differential diagnosis between a primary tumour and metastatic ILC, difficult. Moreover, if the clinical picture is often inconclusive, also conventional imaging techniques and endoscopy show potential limitations in obtaining a differential diagnosis [8, 15, 16, 18, 19]. At CT scan our case showed a picture that may be considered typical, made of huge parietal thickening of several pelvic organs such as rectum, bladder and vagina, as well as bilateral hydronephrosis due to retroperitoneal involvement. This characteristic infiltrative pattern of diffusion is non-specific for metastatic desease from breast cancer, as may resemble the picture of primary neoplasms of gastrointestinal or genitourinary systems. A recent report failed to demonstrate any diagnostic advantage of MRI and PET . Endoscopy with biopsy appears an essential step in the diagnostic work up, as it is showed in the present case: we found the typical endoscopic picture of a colorectal metastatic lesion, characterized by diffuse thickening and rigidity of the rectal wall, but no endoluminal masses. Histological finding on biopsy samples gave us the definitive confirmation of the metastatic nature of the lesion. As already stressed in most recent reports, the common finding of a "signet ring" pattern neoplasia can be misleading, as it may suggest a primitive origin from the gastro-intestinal tract , but the lack of dysplasia or atypia of the rectal glandular epithelium let us state the metastatic nature of the malignancy, and the specific origin from ILC was strongly suggested by the typical "Indian file" arrangement of the neoplastic cells [19, 21]. A further confirmation came from immunohistochemistry. Metastatic breast carcinomas are often positive for Cytokeratin 7(CK7), GCDFP-15, ER and/or PgR. This was true in our case. Moreover, the immunohistochemical negativity for CA125 and WT1 ruled out a possible ovarian origin and the negativity for Cytokeratin 20(CK20) and CDX2 excluded the colic one [22, 23]. (Table 2) [see additional file 1]
The therapeutic approach to these patients is still object of debate. Surgery is mainly indicated to solve stenotic or hemorrhagic evolution of the colorectal locations. Although some authors suggest a potential benefit of surgical debulking procedures followed by chemotherapy , systemic treatment (chemotherapy, endocrine treatment or both) is considered the therapy of choice in patients with metastases to the peritoneum and retroperitoneum involving multiple organs [8, 15]. The prognosis remains poor with a partial response in about 50% of patients and a median survival time from diagnosis of about 1 year . Many authors suggest the importance of early diagnosis, which enables prompt initiation of systemic treatment, with or without surgery, thus giving advantage in terms of survival.
The case reported is peculiar, as it focuses on an extremely rare condition which, if ignored, leads to a delayed treatment, thus worsening the prognosis in terms of survival. The long and complex diagnostic workup described, draws the attention to the difficulty of making a correct diagnosis, also because the long interval after the initial diagnosis of breast cancer makes the occurrence of metastasic disease an unexpected event.
This report stresses the importance for the clinician to be aware of the eventuality of a wide peritoneal/extraperitoneal metastatic diffusion, when dealing with a patient with previous diagnosis of ILC and presenting for gastrointestinal or genitourinary symptoms. Only bearing in mind such a possibility, the aggressive, multidisciplinary approach necessary to make diagnosis can be early undertaken and an optimal therapeutic approach promptly performed.
- Arpino G, Bardou VJ, Clark GM, Elledge RM: Infiltrating lobular carcinoma of the the breast: tumour characteristics and clinical outcome. Breast Cancer Res. 2004, 6: 149-56. 10.1186/bcr767.View ArticleGoogle Scholar
- Fisher ER, Gregorio RM, Fisher B, Redmond C, Vellios F, Sommers SC: The pathology of invasive breast cancer. Cancer. 1975, 36: 1-85. 10.1002/1097-0142(197507)36:1<1::AID-CNCR2820360102>3.0.CO;2-4.View ArticlePubMedGoogle Scholar
- Harake MDJ, Maxwell AJ, Sukumar SA: Primary and metastatic lobular carcinoma of the breast. Clin Radiol. 2001, 56: 621-30. 10.1053/crad.2001.0766.View ArticlePubMedGoogle Scholar
- Rodenko GN, Harms SE, Pruneda JM, Farrell RS, Evans WP, Copit DS, Krakos PA, Flamig DP: MR Imaging in the management before surgery of lobular carcinoma of the breast. Am J Roentgenol. 1996, 167: 1415-19.View ArticleGoogle Scholar
- Lesser ML, Rosen PP, Kinne DW: Multicentricity and bilaterality in invasive breast carcinoma. Surgery. 1982, 91: 234-40.PubMedGoogle Scholar
- Harris M, Howell A, Chrissohou M, Swindell RI, Hudson M, Sellwood RA: A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer. 1984, 50: 23-30.View ArticlePubMedPubMed CentralGoogle Scholar
- Borst MJ, Ingold JA: Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993, 114: 637-42.PubMedGoogle Scholar
- Taal BG, den Hartog Jager FCA, Steinmetz R, Peterse H: The spectrum of gastrointestinal metastases of breast carcinoma. Gastrointest Endosc. 1992, 38: 136-41.View ArticlePubMedGoogle Scholar
- Dhar S, Kulayat MN, Gordon K, Lall P, Doerr RJ: Solitary papillary carcinoma metatstasis to the large bowel presenting as primary colon carcinoma: case report and review of the literature. Am Surg. 2003, 69: 799-803.PubMedGoogle Scholar
- Dixon AR, Ellis IO, Elston CV, Blamey RW: A comparison of the clinical metastatic patterns of invasive lobular and ductal carcinoma of the breast. Br J Cancer. 1984, 63: 634-35.View ArticleGoogle Scholar
- Doyle DJ, Relihan B, Redmond HP, Barry JE: Metastatic manifestations of invasive lobular breast carcinoma. Clin Radiol. 2005, 60: 271-74. 10.1016/j.crad.2004.09.005.View ArticlePubMedGoogle Scholar
- Feldman PA, Madeb R, Naroditsky I, Halachmi S, Nativ O: Metastatic breast cancer to the bladder: a diagnostic challenge and review of the literature. Urology. 2002, 59: 138xvi-xix. 10.1016/S0090-4295(01)01489-3.View ArticleGoogle Scholar
- Evans WP, Warren Burhenne LJ, Laurie L, O'Shaughnessy KF, castellino RA: Invasive lobular carcinoma of the breast: mammographic characteristics and computer aided detection. Radiology. 2002, 225: 182-89.View ArticlePubMedGoogle Scholar
- Awsare NS, Hambury DC, king CM: Metastatic manifestations of invasive lobular breast carcinoma. Clin Radiol. 2005, 60: 829-10.1016/j.crad.2005.03.007.View ArticlePubMedGoogle Scholar
- Shwarz RE, Klimstra DS, Turnbull ADM: Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol. 1998, 93: 114-14.Google Scholar
- Fayemi AO, Ali M, Braun EV: Metastatic carcinoma simulating linitis plastica of the colon. A case report. Am J Gastroenterol. 1979, 71: 311-14.PubMedGoogle Scholar
- Klein MS, Sherlock P: Gastric and colonic metastases from breast cancer. Am J Dig Dis. 1972, 17: 881-84. 10.1007/BF02239526.View ArticlePubMedGoogle Scholar
- Van Halteren HK, Peters H, Gerlag PGG: Large bowel mucosal metastases from breast cancer. J Clin Oncol. 1998, 16: 3711-131.PubMedGoogle Scholar
- Cervi G, Vettoretto N, Vinco A, Cervi E, Villanacci V, Grigolato P, Giulini SM: Rectal localization of metastatic lobular breast cancer. Report of a case. Dis Colon Rectum. 2001, 44: 453-65. 10.1007/BF02234749.View ArticlePubMedGoogle Scholar
- Bamias A, Baltayiannis G, Kamina S, Fatours M, Lymperopulos E, Agnati N, Tsianos E, Pavlidis N: Rectal metastases from lobular carcinoma of the breast: report of a case and literature review. Ann Oncol. 2001, 12: 715-18. 10.1023/A:1011192827710.View ArticlePubMedGoogle Scholar
- Tavassoli FA: Infiltrating carcinoma: common and familiar special types. Pathology of the breast. 1999, Appleton & Lange, Stanford, CT, 401-480. 2Google Scholar
- O' Connell FP, Wang HH, Odze RD: Utility of immunohistochemestry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Arch Pathol Lab Med. 2005, 129: 338-347.Google Scholar
- Lagendijk JH, Mullink H, van Diest PJ, Meijer GA, Meijer CJ: Immunohistochemical differentiation between primary adenocarcinomas of the ovary and ovarian metastases of colonic and breast origin. Comparison between a statistical and an intuitive approach. J Clin Pathol. 1999, 52: 283-90.View ArticlePubMedPubMed CentralGoogle Scholar
- Van Trappen P, Serreyn R, Elewaut AE, Cocquyt , Van Belle S: Abdominal pain with anorexia in patients with breast carcinoma. Ann Oncol. 1988, 9: 1243-45. 10.1023/A:1008287007819.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/6/193/prepub
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