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  1. Hepatocellular carcinoma (HCC) still represents an unmet medical need. Epigenetic inactivation of tumor suppressor genes like RASSF1A or APC by overexpression of DNA methyltransferases (DNMTs) has been shown t...

    Authors: Steffen Zopf, Matthias Ocker, Daniel Neureiter, Beate Alinger, Susanne Gahr, Markus F Neurath and Pietro Di Fazio
    Citation: BMC Cancer 2012 12:386
    Content type: Research article Published on:

  3. Colorectal cancer is a major public health problem in Malaysia. However, it is also one of the most treatable cancers, resulting in significant numbers of survivors. Therefore, the impact of surviving treatmen...

    Authors: Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani, Ismail Sagap, Jasiah Zakaria, Jane M Blazeby and Chee Wei Law
    Citation: BMC Cancer 2012 12:384
    Content type: Study protocol Published on:

  4. ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism i...

    Authors: Pin Chen, Lin Zhao, Peng Zou, Haitao Xu, Ailin Lu and Peng Zhao
    Citation: BMC Cancer 2012 12:383
    Content type: Research article Published on:

  5. The full extent of chromosomal alterations and their biological implications in early breast carcinogenesis has not been well examined. In this study, we aimed to identify chromosomal alterations associated wi...

    Authors: Seung-Hyun Jung, Ahwon Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choe and Yeun-Jun Chung
    Citation: BMC Cancer 2012 12:382
    Content type: Research article Published on:

  6. Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to che...

    Authors: Allan D Heibein, Baoqing Guo, Jason A Sprowl, David A MacLean and Amadeo M Parissenti
    Citation: BMC Cancer 2012 12:381
    Content type: Research article Published on:

  7. Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as pr...

    Authors: Christoph Standfuß, Heike Pospisil and Andreas Klein
    Citation: BMC Cancer 2012 12:380
    Content type: Research article Published on:

  8. Cell line models have proven to be effective tools to investigate a variety of ovarian cancer features. Due to the limited number of cell lines, particularly of the serous subtype, the heterogeneity of the dis...

    Authors: Isabelle J Létourneau, Michael CJ Quinn, Lu-Lin Wang, Lise Portelance, Katia Y Caceres, Louis Cyr, Nathalie Delvoye, Liliane Meunier, Manon de Ladurantaye, Zhen Shen, Suzanna L Arcand, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2012 12:379
    Content type: Research article Published on:

  9. MicroRNAs (miRNAs) and their role during tumor development have been studied in great detail during the last decade, albeit their expression pattern and regulation during normal development are however not so ...

    Authors: Jelena Põlajeva, Fredrik J Swartling, Yiwen Jiang, Umashankar Singh, Kristian Pietras, Lene Uhrbom, Bengt Westermark and Pernilla Roswall
    Citation: BMC Cancer 2012 12:378
    Content type: Research article Published on:

  10. The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC) emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechan...

    Authors: Miyuki Shimoda, Tsuyoshi Sugiura, Ikumi Imajyo, Kotaro Ishii, Satomi Chigita, Katsuhiro Seki, Yousuke Kobayashi and Kanemitsu Shirasuna
    Citation: BMC Cancer 2012 12:377
    Content type: Research article Published on:

  11. Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene. This study aimed to investigate the impact of BRMS1 on metastasis in nasopharyngeal carcinoma (NPC) and to evaluate the prognostic...

    Authors: Rui-Xue Cui, Na Liu, Qing-Mei He, Wen-Fei Li, Bi-Jun Huang, Ying Sun, Ling-Long Tang, Mo Chen, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zeng, Ying Guo, Hui-Yun Wang and Jun Ma
    Citation: BMC Cancer 2012 12:376
    Content type: Research article Published on:

  12. Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. In pre-clinical research aiming at the identifi...

    Authors: Jolieke G van Oosterwijk, Danielle de Jong, Maayke AJH van Ruler, Pancras CW Hogendoorn, PD Sander Dijkstra, Carla SP van Rijswijk, Isidro Machado, Antonio Llombart-Bosch, Karoly Szuhai and Judith VMG Bovée
    Citation: BMC Cancer 2012 12:375
    Content type: Research article Published on:

  14. The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in...

    Authors: Nasir Kamat, Mohammed A Khidhir, Mohammed Jaloudi, Sabir Hussain, Mouied M Alashari, Khaled H Al Qawasmeh and Ulf Rannug
    Citation: BMC Cancer 2012 12:373
    Content type: Research article Published on:

  15. Thrombospondin (TSP) is a multi-functional protein that appears to have dual roles in cancer, that is, either as a promoter or a suppressor. 4N1K is a TSP-derived peptide that has been reported to be associate...

    Authors: Yasuyoshi Miyata, Shin-ichi Watanabe, Hiroshi Kanetake and Hideki Sakai
    Citation: BMC Cancer 2012 12:372
    Content type: Research article Published on:

  16. Despite a lack of consensus regarding effectiveness, androgen deprivation therapy (ADT) is a common treatment for non-metastatic, low-risk prostate cancer. To examine a particular clinical concern regarding th...

    Authors: Herta H Chao, Edward Uchio, Sheng Zhang, Sien Hu, Sarah R Bednarski, Xi Luo, Michal Rose, John Concato and Chiang-shan R Li
    Citation: BMC Cancer 2012 12:371
    Content type: Research article Published on:

  17. NDRG2, a member of N-Myc downstream regulated gene family, plays some roles in cellular stress, cell differentiation and tumor suppression. We have found that NDRG2 expression in cervical cancer Hela cells inc...

    Authors: Junye Liu, Le Yang, Jian Zhang, Jing Zhang, Yongbin Chen, Kangchu Li, Yurong Li, Yan Li, Libo Yao and Guozhen Guo
    Citation: BMC Cancer 2012 12:370
    Content type: Research article Published on:

  18. Alterations of mTOR gene expression have been implicated in the pathogenesis of endometrioid endometrial cancer however only few studies explored the cause of increased mTOR activation in this malignancy. miRN...

    Authors: Anna Torres, Kamil Torres, Anna Pesci, Marcello Ceccaroni, Tomasz Paszkowski, Paola Cassandrini, Giuseppe Zamboni and Ryszard Maciejewski
    Citation: BMC Cancer 2012 12:369
    Content type: Research article Published on:

  19. Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitiv...

    Authors: Katie Twigger, Victoria Roulstone, Joan Kyula, Eleni M Karapanagiotou, Konstantinos N Syrigos, Richard Morgan, Christine White, Shreerang Bhide, Gerard Nuovo, Matt Coffey, Brad Thompson, Adel Jebar, Fiona Errington, Alan A Melcher, Richard G Vile, Hardev S Pandha…
    Citation: BMC Cancer 2012 12:368
    Content type: Research article Published on:

  20. Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squa...

    Authors: Jia-Jie Hao, Zhi-Zhou Shi, Zhi-Xin Zhao, Yu Zhang, Ting Gong, Chun-Xiang Li, Ting Zhan, Yan Cai, Jin-Tang Dong, Song-Bin Fu, Qi-Min Zhan and Ming-Rong Wang
    Citation: BMC Cancer 2012 12:367
    Content type: Research article Published on:

  21. Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may ...

    Authors: Simon Schäfer, Stephanie Weibel, Ulrike Donat, Qian Zhang, Richard J Aguilar, Nanhai G Chen and Aladar A Szalay
    Citation: BMC Cancer 2012 12:366
    Content type: Research article Published on:

  22. Increase of Serum amyloid A (SAA) level has been observed in patients with a variety of cancers. The objective of this study was to determined whether SAA level could be used as a prognostic parameter in patie...

    Authors: Jun-Ye Wang, Yu-Zhen Zheng, Juan Yang, Yue-Hao Lin, Shu-Qin Dai, Ge Zhang and Wan-Li Liu
    Citation: BMC Cancer 2012 12:365
    Content type: Research article Published on:

  23. Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will...

    Authors: Rachel Dankner, Ran Balicer, Paolo Boffetta, Lital Keinan Boker, Sylvan Wallenstein, Laurence Freedman, Margalit Goldfracht, Jesse Roth, Ronald Tamler and Derek LeRoith
    Citation: BMC Cancer 2012 12:364
    Content type: Study protocol Published on:

  24. Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect ...

    Authors: Annelies Overbeek, Marleen H van den Berg, Leontien CM Kremer, Marry M van den Heuvel-Eibrink, Wim JE Tissing, Jacqueline J Loonen, Birgitta Versluys, Dorine Bresters, Gertjan JL Kaspers, Cornelis B Lambalk, Flora E van Leeuwen and Eline van Dulmen-den Broeder
    Citation: BMC Cancer 2012 12:363
    Content type: Study protocol Published on:

  25. Economic implications of chemotherapy-induced febrile neutropenia (FN) in European and Australian clinical practice are largely unknown.

    Authors: Derek Weycker, Aurelie Danel, Anne Marciniak, Kate Bendall, Michael Lipsitz and Ruth Pettengell
    Citation: BMC Cancer 2012 12:362
    Content type: Research article Published on:

  26. The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2) and uses Salmonella typhi Ty21a as a vector. The immune reaction elicited by VXM01 is expected to dis...

    Authors: Andreas G Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W Buchler, Moritz Koch, Jürgen Weitz, Walter E Haefeli and Friedrich H Schmitz-Winnenthal
    Citation: BMC Cancer 2012 12:361
    Content type: Study protocol Published on:

  27. The aim of the present study was to determine the feasibility of detecting sentinel lymph node (SLN) metastases using interstitial magnetic resonance (MR) lymphography in patients with cervical cancer. MR data...

    Authors: Ying Hong, Luojun Xiang, Yali Hu, Zhengyang Zhou, Haiping Yu and Bing Zhu
    Citation: BMC Cancer 2012 12:360
    Content type: Research article Published on:

  28. In ovarian cancer, massive intraperitoneal dissemination is due to exfoliated tumor cells in ascites. Tumor-initiating cells (TICs or cancer stem cells) and cells showing epithelial-mesenchymal-transition (EMT...

    Authors: My Wintzell, Elisabet Hjerpe, Elisabeth Åvall Lundqvist and Maria Shoshan
    Citation: BMC Cancer 2012 12:359
    Content type: Research article Published on:

  29. Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing ...

    Authors: Massimiliano Monticone, Antonio Daga, Simona Candiani, Francesco Romeo, Valentina Mirisola, Silvia Viaggi, Ilaria Melloni, Simona Pedemonte, Gianluigi Zona, Walter Giaretti, Ulrich Pfeffer and Patrizio Castagnola
    Citation: BMC Cancer 2012 12:358
    Content type: Research article Published on:

  30. AMP-activated protein kinase (AMPK) has recently been considered as a potential target for cancer therapy. However, the expression status of various subunits of the heterotrimeric AMPK in human cancers is rarely...

    Authors: Cuilan Li, Vincent WS Liu, Pui M Chiu, David W Chan and Hextan YS Ngan
    Citation: BMC Cancer 2012 12:357
    Content type: Research article Published on:

  31. More than half of patients with colorectal cancer will develop metastatic disease either evident at the time of initial diagnosis or during their course of disease. Besides multidisciplinary management further...

    Authors: Alexander Stein, Gabriel Glockzin, Andreas Wienke, Dirk Arnold, Thomas Edelmann, Bert Hildebrandt, Stephan Hollerbach, Gerald Illerhaus, Alfred Königsrainer, Michael Richter, Hans J Schlitt and Hans-Joachim Schmoll
    Citation: BMC Cancer 2012 12:356
    Content type: Study protocol Published on:

  32. Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibitio...

    Authors: Zohreh Ghoreishi, Ali Esfahani, Abolghasem Djazayeri, Mahmoud Djalali, Banafsheh Golestan, Hormoz Ayromlou, Shahriar Hashemzade, Mohammad Asghari Jafarabadi, Vahid Montazeri, Seyed Ali Keshavarz and Masoud Darabi
    Citation: BMC Cancer 2012 12:355
    Content type: Research article Published on:

  35. Development of breast cancer is a multistage process influenced by hormonal and environmental factors as well as by genetic background. The search for genes underlying this malignancy has recently been highly ...

    Authors: Emma Samuelson, Sara Karlsson, Karolina Partheen, Staffan Nilsson, Claude Szpirer and Afrouz Behboudi
    Citation: BMC Cancer 2012 12:352
    Content type: Research article Published on:

  36. It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons...

    Authors: Julie Gentil, Tienhan Sandrine Dabakuyo, Samiratou Ouedraogo, Marie-Laure Poillot, Olivier Dejardin and Patrick Arveux
    Citation: BMC Cancer 2012 12:351
    Content type: Research article Published on:

  37. Overexpression of the human epidermal growth factor receptor (HER) 2 is associated with poor prognosis and shortened survival in breast cancer patients. HER2 is a potent activator of several signaling pathways...

    Authors: Elisabet Tina, Breezy Malakkaran Lindqvist, Marike Gabrielson, Zelmina Lubovac, Pia Wegman and Sten Wingren
    Citation: BMC Cancer 2012 12:350
    Content type: Research article Published on:

  38. To evaluate the value of KRAS codon 13 mutations in patients with advanced colorectal cancer (advanced CRC) treated with oxaliplatin and fluoropyrimidines.

    Authors: Anke Reinacher-Schick, Karsten Schulmann, Dominik P Modest, Nina Bruns, Ulrich Graeven, Malgorzata Jaworska, Richard Greil, Rainer Porschen, Dirk Arnold, Wolff Schmiegel and Andrea Tannapfel
    Citation: BMC Cancer 2012 12:349
    Content type: Research article Published on:

  39. MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several...

    Authors: Xiang-hua Liu, Kai-hua Lu, Ke-ming Wang, Ming Sun, Er-bao Zhang, Jin-song Yang, Dan-dan Yin, Zhi-li Liu, Jing Zhou, Zhi-jun Liu, Wei De and Zhao-xia Wang
    Citation: BMC Cancer 2012 12:348
    Content type: Research article Published on:

  40. We evaluated the association between a KRAS mutational status and various clinicopathologic features including the metastatic pattern in patients with metastatic or recurrent colorectal cancer (MRCRC). The con...

    Authors: Mi-Jung Kim, Hye Seung Lee, Jee Hyun Kim, Yu Jung Kim, Ji Hyun Kwon, Jeong-Ok Lee, Soo-Mee Bang, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Jae-Sung Kim, Jong Seok Lee and Keun-Wook Lee
    Citation: BMC Cancer 2012 12:347
    Content type: Research article Published on:

  41. The identification of circulating tumour cells (CTCs) in peripheral blood is a useful approach to estimate prognosis, monitor disease progression, and measure treatment effects in various malignancies. However...

    Authors: Hiroaki Ito, Haruhiro Inoue, Norimasa Sando, Satoshi Kimura, Keigo Gohda, Jun Sato, Katsuhiro Murakami, Shun Ito, Noriko Odaka, Hitoshi Satodate and Shin-ei Kudo
    Citation: BMC Cancer 2012 12:346
    Content type: Research article Published on:

  42. Near infrared (NIR) photoimmunotherapy (PIT) is a new type of cancer treatment based on a monoclonal antibody (mAb)-NIR phthalocyanine dye, (IR700) conjugate. In vitro cancer-specific cell death occurs during NIR...

    Authors: Makoto Mitsunaga, Takahito Nakajima, Kohei Sano, Gabriela Kramer-Marek, Peter L Choyke and Hisataka Kobayashi
    Citation: BMC Cancer 2012 12:345
    Content type: Research article Published on:

  43. The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histol...

    Authors: Sara Karami, Joanne S Colt, Kendra Schwartz, Faith G Davis, Julie J Ruterbusch, Stella S Munuo, Sholom Wacholder, Patricia A Stewart, Barry I Graubard, Nathanial Rothman, Wong-Ho Chow and Mark P Purdue
    Citation: BMC Cancer 2012 12:344
    Content type: Research article Published on:

  44. C-reactive protein (CRP) and Serum amyloid A protein (SAA) increases with systemic inflammation and are related to worse survival for breast cancer survivors. This study examines the association between percen...

    Authors: Anne Dee, Roberta McKean-Cowdin, Marian L Neuhouser, Cornelia Ulrich, Richard N Baumgartner, Anne McTiernan, Kathy Baumgartner, Catherine M Alfano, Rachel Ballard-Barbash and Leslie Bernstein
    Citation: BMC Cancer 2012 12:343
    Content type: Research article Published on:

  45. BRCA1 (B), ERCC1 (E), RRM1 (R) and TYMS (T) mRNA expression has been extensively studied with respect to NSCLC patient outcome upon various chemotherapy agents. However, these markers have not been introduced ...

    Authors: Vassiliki Kotoula, Dimitrios Krikelis, Vasilios Karavasilis, Triantafillia Koletsa, Anastasia G Eleftheraki, Despina Televantou, Christos Christodoulou, Stefanos Dimoudis, Ippokratis Korantzis, Dimitrios Pectasides, Konstantinos N Syrigos, Paris A Kosmidis and George Fountzilas
    Citation: BMC Cancer 2012 12:342
    Content type: Research article Published on:

  46. Versican is detected in the interstitial tissues at the invasive margins of breast carcinoma, is predictive of relapse, and negatively impacts overall survival rates. The versican G3 domain is important in bre...

    Authors: William Weidong Du, Ling Fang, Weining Yang, Wang Sheng, Yaou Zhang, Arun Seth, Burton B Yang and Albert J Yee
    Citation: BMC Cancer 2012 12:341
    Content type: Research article Published on:

  47. Hepatic resection is currently still the best choice of therapeutic strategies for liver cancer, but the long-term survival rate after surgery is unsatisfactory. Most patients develop intra- and/or extrahepati...

    Authors: Feng Xiaobin, Zheng Shuguo, Zhou Jian, Qiu Yudong, Liang Lijian, Ma Kuansheng, Li Xiaowu, Xia Feng, Yi Dong, Wang Shuguang, Bie Ping and Dong Jiahong
    Citation: BMC Cancer 2012 12:340
    Content type: Study protocol Published on:

  48. A cancer diagnosis is 2.9 times more likely to occur during the adolescent and young adult years than in younger children. This spike in incidence coincides with a life stage characterised by psychological vul...

    Authors: Ursula M Sansom-Daly, Claire E Wakefield, Richard A Bryant, Phyllis Butow, Susan Sawyer, Pandora Patterson, Antoinette Anazodo, Kate Thompson and Richard J Cohn
    Citation: BMC Cancer 2012 12:339
    Content type: Study protocol Published on:

  49. A significant number of cancers are caused by defects in p21 causing functional defects in p21 or p53 tumour-suppressor proteins. This has led to many therapeutic approaches including restoration by gene thera...

    Authors: Christina A Kousparou, Efthymia Yiacoumi, Mahendra P Deonarain and Agamemnon A Epenetos
    Citation: BMC Cancer 2012 12:338
    Content type: Research article Published on:

  50. Bladder cancer results from complex interactions between many genetic and environment factors. The polymorphism Ser326Cys in hOGG1 gene has been reported to be associated with bladder cancer in some studies, thou...

    Authors: Changwei Ji, Zhao Liu, Huimei Chen, Hongqian Guo and Changjian Liu
    Citation: BMC Cancer 2012 12:335
    Content type: Research article Published on:

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