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  1. Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma ...

    Authors: Yantao Du, Zhaojun Liu, Liankun Gu, Jing Zhou, Bu-dong Zhu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2012 12:249
  2. SOX genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status...

    Authors: Wei-de Zhong, Guo-qiang Qin, Qi-shan Dai, Zhao-dong Han, Shan-ming Chen, Xiao-hui Ling, Xin Fu, Chao Cai, Jia-hong Chen, Xi-bin Chen, Zhuo-yuan Lin, Ye-han Deng, Shu-lin Wu, Hui-chan He and Chin-lee Wu
    Citation: BMC Cancer 2012 12:248
  3. Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling pat...

    Authors: Line L Haugan Moi, Marianne Hauglid Flågeng, Jennifer Gjerde, Andre Madsen, Therese Halvorsen Røst, Oddrun Anita Gudbrandsen, Ernst A Lien and Gunnar Mellgren
    Citation: BMC Cancer 2012 12:247
  4. Identification of novel, highly penetrant, breast cancer susceptibility genes will require the application of additional strategies beyond that of traditional linkage and candidate gene approaches. Approximate...

    Authors: Julie K Johnson, Nic Waddell and Georgia Chenevix-Trench
    Citation: BMC Cancer 2012 12:246
  5. Invasion and metastasis are two important hallmarks of malignant tumors caused by complex genetic and epigenetic alterations. The present study investigated the contribution of aberrant methylation profiles of...

    Authors: Zeinab Barekati, Ramin Radpour, Qing Lu, Johannes Bitzer, Hong Zheng, Paolo Toniolo, Per Lenner and Xiao Yan Zhong
    Citation: BMC Cancer 2012 12:244
  6. Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing. Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy ...

    Authors: Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu
    Citation: BMC Cancer 2012 12:243
  7. One of the most important biological characteristics of Glioblastoma multiforme (GBM) is high vascular density. Vadimezan (ASA404, DMXAA) belongs to the class of small molecule vascular disrupting agents (VDA)...

    Authors: Dušan Milanović, Friederike Braun, Wolfgang Weber, Anca Ligia Grosu, Martin Behe and Gabriele Niedermann
    Citation: BMC Cancer 2012 12:242
  8. Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patien...

    Authors: Chia-Lin Hsu, Kuan-Yu Chen, Jin-Yuan Shih, Chao-Chi Ho, Chih-Hsin Yang, Chong-Jen Yu and Pan-Chyr Yang
    Citation: BMC Cancer 2012 12:241
  9. Mammographic population screening in The Netherlands has increased the number of breast cancer patients with small and non-palpable breast tumors. Nevertheless, mammography is not ultimately sensitive and spec...

    Authors: Jeroen F Vermeulen, Aram SA van Brussel, Petra van der Groep, Folkert HM Morsink, Peter Bult, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2012 12:240
  10. Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, an...

    Authors: Amanda Gonçalves Silva, Ingrid Petroni Ewald, Marina Sapienza, Manuela Pinheiro, Ana Peixoto, Amanda França de Nóbrega, Dirce M Carraro, Manuel R Teixeira, Patricia Ashton-Prolla, Maria Isabel W Achatz, Carla Rosenberg and Ana C V Krepischi
    Citation: BMC Cancer 2012 12:237
  11. How to properly manage clinically negative neck of head and neck cancer patients is a controversial topic. Research is now directed toward finding a method sensitive enough to bring the risk of occult metastas...

    Authors: Li-Jen Liao, Wu-Chia Lo, Wan-Lun Hsu, Chi-Te Wang and Mei-Shu Lai
    Citation: BMC Cancer 2012 12:236
  12. Cancer-related genes show racial differences. Therefore, identification and characterization of DNA copy number alteration regions in different racial groups helps to dissect the mechanism of tumorigenesis.

    Authors: Fang-Yi Lo, Jer-Wei Chang, I-Shou Chang, Yann-Jang Chen, Han-Shui Hsu, Shiu-Feng Kathy Huang, Fang-Yu Tsai, Shih Sheng Jiang, Rajani Kanteti, Suvobroto Nandi, Ravi Salgia and Yi-Ching Wang
    Citation: BMC Cancer 2012 12:235
  13. The finite replicative lifespan of cells, termed cellular senescence, has been proposed as a protective mechanism against the proliferation of oncogenically damaged cells, that fuel cancer. This concept is fur...

    Authors: Julie Lafontaine, Guergana Tchakarska, Francis Rodier and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2012 12:234
  14. The ubiquitin-proteasome system (UPS) and the heat shock response (HSR) are two critical regulators of cell homeostasis, as their inhibition affects growth and survival of normal cells, as well as stress respo...

    Authors: Marica Peron, Paolo Bonvini and Angelo Rosolen
    Citation: BMC Cancer 2012 12:233
  15. MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently de...

    Authors: Lea H Gregersen, Anders Jacobsen, Lisa B Frankel, Jiayu Wen, Anders Krogh and Anders H Lund
    Citation: BMC Cancer 2012 12:232
  16. Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular...

    Authors: Maria Abbondanza Pantaleo, Anna Mandrioli, Maristella Saponara, Margherita Nannini, Giovanna Erente, Cristian Lolli and Guido Biasco
    Citation: BMC Cancer 2012 12:231
  17. This randomised controlled trial (RCT) aims to evaluate the effectiveness of a guided self-help cognitive behavioural intervention to alleviate problematic hot flushes (HF) and night sweats (NS) in men who are...

    Authors: Omar Yousaf, Evgenia Stefanopoulou, Elizabeth A Grunfeld and Myra S Hunter
    Citation: BMC Cancer 2012 12:230
  18. Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma defined by the presence of chromosomal translocations involving the ALK tyrosine kinase gene. These translocati...

    Authors: Joel D Pearson, Zubair Mohammed, Julinor T C Bacani, Raymond Lai and Robert J Ingham
    Citation: BMC Cancer 2012 12:229
  19. Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that inc...

    Authors: Mi Hee Park, MiRan Jo, Dohee Won, Ho Sueb Song, Sang Bae Han, Min Jong Song and Jin Tae Hong
    Citation: BMC Cancer 2012 12:228
  20. miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. ...

    Authors: Jian Wang, Jingwu Li, Junling Shen, Chen Wang, Lili Yang and Xinwei Zhang
    Citation: BMC Cancer 2012 12:227
  21. Treatment options for pancreatic ductal adenocarcinoma (PDAC) are limited. Histone deacetylase inhibitors are a new and promising drug family with strong anticancer activity. The aim of this study was to exami...

    Authors: Dmitriy I Dovzhanskiy, Stefanie M Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathalia Giese and Jens Werner
    Citation: BMC Cancer 2012 12:226
  22. Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER...

    Authors: Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Rouba Ali-Fehmi, Judith Abrams, Ze Zheng, Kezhong Zhang, Stephen Ethier and Zeng-Quan Yang
    Citation: BMC Cancer 2012 12:225
  23. Struma ovarii (SO) is a rare form of ovarian mature teratoma in which thyroid tissue is the predominant element. Because of its rarity, the differential diagnosis between benign and malignant SO has not been c...

    Authors: Boban Stanojevic, Radan Dzodic, Vladimir Saenko, Zorka Milovanovic, Vesna Krstevski, Petar Radlovic, Marko Buta, Bozidar Rulic, Lidija Todorovic, Bogomir Dimitrijevic and Shunichi Yamashita
    Citation: BMC Cancer 2012 12:224
  24. Regional lymph node (LN) status is a well-known prognostic factor for vulvar carcinoma (VC) patients. Although the reliable LN assessment in VC is crucial, it presents significant diagnostic problems. We aimed...

    Authors: Magdalena Kowalewska, Jakub Radziszewski, Krzysztof Goryca, Mateusz Bujko, Malgorzata Oczko-Wojciechowska, Michal Jarzab, Janusz Aleksander Siedlecki and Mariusz Bidzinski
    Citation: BMC Cancer 2012 12:223
  25. Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and the third most common in men in Singapore. This population-based study describes trends in the incidence and mortality...

    Authors: Cynthia Chen, Nasheen Naidoo, Qian Yang, Mikael Hartman, Helena M Verkooijen, En Yun Loy, Christine Bouchardy, Kee Seng Chia and Sin Eng Chia
    Citation: BMC Cancer 2012 12:222
  26. TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here...

    Authors: Neka A K Simms, Ashwani Rajput, Elizabeth A Sharratt, Melanie Ongchin, Carol A Teggart, Jing Wang and Michael G Brattain
    Citation: BMC Cancer 2012 12:221
  27. Melanocytic meningeal tumours are rare extra-axial neoplasms of the nervous system, with only three reported cases in the cavernous sinus. Herein we describe for the first time the association of ocular melano...

    Authors: Francesco Doglietto, Cesare Colosimo, Libero Lauriola, Mario Balducci, Pasquale De Bonis, Nicola Montano, Gelareh Zadeh, Giulio Maira and Roberto Pallini
    Citation: BMC Cancer 2012 12:220
  28. MYCT1, previously named MTLC, is a novel candidate tumor suppressor gene. MYCT1 was cloned from laryngeal squamous cell cancer (LSCC) and has been found to be down-regulated in LSCC; however, the regulatory deta...

    Authors: Min Yang, Wei Li, Yi-Ying Liu, Shuang Fu, Guang-Bin Qiu, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2012 12:219
  29. Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study pr...

    Authors: Daina Skiriute, Paulina Vaitkiene, Viktoras Saferis, Virginija Asmoniene, Kestutis Skauminas, Vytenis Pranas Deltuva and Arimantas Tamasauskas
    Citation: BMC Cancer 2012 12:218
  30. Li-Fraumeni-Syndrome (LFS) is an autosomal-dominant, inherited tumour predisposition syndrome associated with heterozygous germline mutations in the TP53 gene. Patients with LFS are at a high risk to develop earl...

    Authors: Karin Kast, Mechthild Krause, Markus Schuler, Katrin Friedrich, Barbara Thamm, Andrea Bier, Wolfgang Distler and Stefan Krüger
    Citation: BMC Cancer 2012 12:217
  31. International treatment guidelines recommend administration of adjuvant chemotherapy in early breast cancer based on clinical, prognostic and predictive parameters.

    Authors: Matteo Clavarezza, Giorgio Mustacchi, Andrea Casadei Gardini, Lucia Del Mastro, Andrea De Matteis, Ferdinando Riccardi, Vincenzo Adamo, Enrico Aitini, Domenico Amoroso, Paolo Marchetti, Stefania Gori, Francesco Carrozza, Evaristo Maiello, Francesco Giotta, Davide Dondi and Marco Venturini
    Citation: BMC Cancer 2012 12:216
  32. Hodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin ...

    Authors: Christoph Renné, Alexander H Benz and Martin L Hansmann
    Citation: BMC Cancer 2012 12:215
  33. Limited penetration of anticancer drugs in solid tumours is a probable cause of drug resistance. Our previous results indicate that drug penetration depends on cellular packing density and adhesion between can...

    Authors: Rama H Grantab and Ian F Tannock
    Citation: BMC Cancer 2012 12:214
  34. The Wnt/β-catenin signalling is aberrantly activated in primary B cell chronic lymphocytic leukaemia (CLL). Epigenetic silencing of pathway inhibitor genes may be a mechanism for its activation. In this study,...

    Authors: Evgeny A Moskalev, Katrin Luckert, Ivan A Vorobjev, Sergey E Mastitsky, Aleena A Gladkikh, Achim Stephan, Marita Schrenk, Kamil D Kaplanov, Olga B Kalashnikova, Oliver Pötz, Thomas O Joos and Jörg D Hoheisel
    Citation: BMC Cancer 2012 12:213
  35. Limiting oxidative stress to the ovarian epithelium has been proposed as a first-line defense against ovarian cancer. Although evidence for an association between individual dietary antioxidant intake and ovar...

    Authors: Dina Gifkins, Sara H Olson, Lisa Paddock, Melony King, Kitaw Demissie, Shou-En Lu, Ah-Ng Tony Kong, Lorna Rodriguez-Rodriguez and Elisa V Bandera
    Citation: BMC Cancer 2012 12:211
  36. Historically, the median overall survival for follicular lymphoma (FL) has been considered to be 9-10 years, and no treatment had ever prolonged this time period. Studies conducted more than 20 years ago demon...

    Authors: Antonio Rueda, María Casanova, Maximino Redondo, Elisabeth Pérez-Ruiz and Ángeles Medina-Pérez
    Citation: BMC Cancer 2012 12:210
  37. Numerous transgenic models have been generated to study breast cancer. However, despite many advantages, traditional transgenic models for breast cancer are also burdened with difficulties in early detection a...

    Authors: Agnieszka M Zagozdzon, Patrick O’Leary, John J Callanan, John Crown, William M Gallagher and Radoslaw Zagozdzon
    Citation: BMC Cancer 2012 12:209
  38. Loco-regionally advanced nasopharyngeal carcinomas can be cured by the combination of chemotherapy and radiotherapy. In Eastern countries, plasma levels of viral Epstein-Barr deoxyribonucleic acid (DNA) are ac...

    Authors: Daris Ferrari, Carla Codecà, Cecilia Bertuzzi, Francesca Broggio, Francesca Crepaldi, Andrea Luciani, Irene Floriani, Mohssen Ansarin, Fausto Chiesa, Daniela Alterio and Paolo Foa
    Citation: BMC Cancer 2012 12:208
  39. BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In th...

    Authors: Caterina Iofrida, Erika Melissari, Veronica Mariotti, Chiara Guglielmi, Lucia Guidugli, Maria Adelaide Caligo and Silvia Pellegrini
    Citation: BMC Cancer 2012 12:207
  40. Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and ant...

    Authors: Ulrike Weissenstein, Agnes Schumann, Marcus Reif, Susanne Link, Ulrike D Toffol-Schmidt and Peter Heusser
    Citation: BMC Cancer 2012 12:206
  41. Membrane-anchored heparin-binding epidermal growth factor-like growth factor (proHB-EGF) yields soluble HB-EGF, which is an epidermal growth factor receptor (EGFR) ligand, and a carboxy-terminal fragment of HB...

    Authors: Takaya Shimura, Michihiro Yoshida, Shinji Fukuda, Masahide Ebi, Yoshikazu Hirata, Tsutomu Mizoshita, Satoshi Tanida, Hiromi Kataoka, Takeshi Kamiya, Shigeki Higashiyama and Takashi Joh
    Citation: BMC Cancer 2012 12:205
  42. Pap screening, an effective method for cervical cancer prevention, is now supported by molecular human papillomavirus (HPV) testing. Recently commercialised preventive vaccines also provide new tools for the p...

    Authors: Giovanna Orlando, Elisabetta Tanzi, Liliane Chatenoud, Maria Gramegna and Giuliano Rizzardini
    Citation: BMC Cancer 2012 12:204
  43. Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors h...

    Authors: Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui and Han-Fei Ding
    Citation: BMC Cancer 2012 12:203
  44. Cancer multidisciplinary teams (MDTs) are established in many countries but little is known about how well they function. A core activity is regular MDT meetings (MDMs) where treatment recommendations are agre...

    Authors: Cath Taylor, Louise Atkins, Alison Richardson, Ruth Tarrant and Amanda-Jane Ramirez
    Citation: BMC Cancer 2012 12:202
  45. 5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination...

    Authors: Peter J Hosein, Jessica Macintyre, Carolina Kawamura, Jennifer Cudris Maldonado, Vinicius Ernani, Arturo Loaiza-Bonilla, Govindarajan Narayanan, Afonso Ribeiro, Lorraine Portelance, Jaime R Merchan, Joe U Levi and Caio M Rocha-Lima
    Citation: BMC Cancer 2012 12:199
  46. Hypoxic tumors are refractory to radiation and chemotherapy. High expression of biomarkers related to hypoxia in head and neck cancer is associated with a poorer prognosis. The present study aimed to evaluate ...

    Authors: Yu-Tsai Lin, Hui-Ching Chuang, Chang-Han Chen, Gian Luca Armas, Han-Ku Chen, Fu-Min Fang, Chao-Cheng Huang and Chih-Yen Chien
    Citation: BMC Cancer 2012 12:194

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