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  1. Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensificatio...

    Authors: Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Almaz Desta, Gregor Habl, Athanasios Mavtratzas, Christine Windemuth-Kiesselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:182
  2. This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting of 2-4 cyc...

    Authors: Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus and Ate van der Gaast
    Citation: BMC Cancer 2011 11:181
  3. Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly re...

    Authors: Leslie G Walker, Jennifer M Eremin, Mark M Aloysius, Wichai Vassanasiri, Mary B Walker, Mohamed El-Sheemy, Ged Cowley, Jeanette Beer, Srila Samphao, Janice Wiseman, Jibril A Jibril, David Valerio, David J Clarke, Mujahid Kamal, Gerald W Thorpe, Karin Baria…
    Citation: BMC Cancer 2011 11:179
  4. To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.

    Authors: Jing Gao, Ming Lu, Jing-wei Yu, Yan-yan Li and Lin Shen
    Citation: BMC Cancer 2011 11:177
  5. Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a...

    Authors: Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg and Michael K Gibson
    Citation: BMC Cancer 2011 11:176
  6. Tazarotene-induced gene 1 (TIG1) is a retinoid-inducible type II tumour suppressor gene. The B isoform of TIG1 (TIG1B) inhibits growth and invasion of cancer cells. Expression of TIG1B is frequently downregula...

    Authors: Chang-Chieh Wu, Fu-Ming Tsai, Rong-Yaun Shyu, Ya-Ming Tsai, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: BMC Cancer 2011 11:175
  7. The DNA repair gene Ku70, an important member of non-homologous end-joining repair system, is thought to play an important role in the repairing of DNA double strand breaks. It is known that defects in double str...

    Authors: Mei-Due Yang, Hwei-Chung Wang, Wen-Shin Chang, Chia-Wen Tsai and Da-Tian Bau
    Citation: BMC Cancer 2011 11:174
  8. MAP2K4 is a putative tumor and metastasis suppressor gene frequently found to be deleted in various cancer types. We aimed to conduct a comprehensive analysis of this gene to assess its involvement in ovarian ca...

    Authors: Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell and Kylie L Gorringe
    Citation: BMC Cancer 2011 11:173
  9. A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the ge...

    Authors: Irene Centeno, Pilar Blay, Iñigo Santamaría, Aurora Astudillo, Ana S Pitiot, Fernando G Osorio, Patricia González-Arriaga, Fernando Iglesias, Primitiva Menéndez, Adonina Tardón, Jose M Freije and Milagros Balbín
    Citation: BMC Cancer 2011 11:172
  10. Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low...

    Authors: Tito S Patrelli, Enrico M Silini, Salvatore Gizzo, Roberto Berretta, Laura Franchi, Elena Thai, Adolf Lukanovic, Giovanni B Nardelli and Alberto Bacchi Modena
    Citation: BMC Cancer 2011 11:171
  11. Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii, which exhibits significant antitumor activity in different cancer models in vitro and in vivo; however, the lac...

    Authors: Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du and Xiaodan Yu
    Citation: BMC Cancer 2011 11:170
  12. Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical...

    Authors: Gavin J Gordon, Raphael Bueno and David J Sugarbaker
    Citation: BMC Cancer 2011 11:169
  13. Bladder cancer, the 5th most common malignancy in the USA, is often detected as a result of incidental findings or by presenting hematuria. Once diagnosed the disease is one of the costliest cancers to treat due ...

    Authors: Anuradha Murali, Laura Kasman and Christina Voelkel-Johnson
    Citation: BMC Cancer 2011 11:168
  14. The cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are upregulated under hypoxic conditions. We examined the staining patterns and co-expression of ...

    Authors: Saskia E Rademakers, Jasper Lok, Albert J van der Kogel, Johan Bussink and Johannes HAM Kaanders
    Citation: BMC Cancer 2011 11:167
  15. Rhabdomyosarcoma is a solid tumor, resulting from dysregulation of the skeletal myogenesis program. For rhabdomyosarcomas (RMS) with a predilection for the head and neck, genitourinary tract, extremities, trun...

    Authors: Wojciech Kukwa, Piotr Wojtowicz, Beata Jagielska, Grzegorz Sobczyk, Andrzej Kukwa and Anna M Czarnecka
    Citation: BMC Cancer 2011 11:166
  16. Partnership for Health-2 (PFH-2) is a web-based version of Partnership for Health, an evidence-based smoking cessation intervention for childhood cancer survivors. This paper describes the PFH-2 intervention a...

    Authors: Janet S de Moor, Elaine Puleo, Jennifer S Ford, Mark Greenberg, David C Hodgson, Vida L Tyc, Jamie Ostroff, Lisa R Diller, Andrea Gurmankin Levy, Kim Sprunck-Harrild and Karen M Emmons
    Citation: BMC Cancer 2011 11:165
  17. Gastric and esophageal cancers are among the most lethal human malignancies. Their epidemiology is geographically diverse. This study compares the survival of gastric and esophageal cancer patients among sever...

    Authors: Morteza Bashash, T Greg Hislop, Amil M Shah, Nhu Le, Angela Brooks-Wilson and Chris D Bajdik
    Citation: BMC Cancer 2011 11:164
  18. Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family-Canc...

    Authors: Melanie Bevier, Marianne Weires, Hauke Thomsen, Jan Sundquist and Kari Hemminki
    Citation: BMC Cancer 2011 11:163
  19. Stromal fibroblasts participate in the development of a permissive environment for tumor growth, yet molecular pathways to therapeutically target fibroblasts are poorly defined. CD248, also known as endosialin...

    Authors: Margarida Maia, Astrid DeVriese, Tom Janssens, Michaël Moons, Rik J Lories, Jan Tavernier and Edward M Conway
    Citation: BMC Cancer 2011 11:162
  20. Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in dis...

    Authors: Arne Warth, Thomas Muley, Michael Meister, Esther Herpel, Anita Pathil, Hans Hoffmann, Philipp A Schnabel, Christian Bender, Andreas Buness, Peter Schirmacher and Ruprecht Kuner
    Citation: BMC Cancer 2011 11:161
  21. Childhood cancer differs from most common adult cancers, suggesting a distinct aetiology for some types of childhood cancer. Our objective in this study was to test the difference in incidence rates of 4 non-C...

    Authors: Beatriz de Camargo, Juliana Moreira de Oliveira Ferreira, Rejane de Souza Reis, Sima Ferman, Marceli de Oliveira Santos and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2011 11:160
  22. Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected lumina...

    Authors: Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker and Frank Entschladen
    Citation: BMC Cancer 2011 11:158
  23. The purpose of this study was to assess the feasibility and accuracy of sentinel lymph nodes (SLNs) detection using 99mTc phytate in predicting pelvic lymph nodes status for radical abdominal trachelectomy (RA...

    Authors: Xue-lian Du, Xiu-gui Sheng, Tao Jiang, Qing-shui Li, Hao Yu, Chun-xia Pan, Chun-hua Lu, Cong Wang and Qu-qing Song
    Citation: BMC Cancer 2011 11:157
  24. The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surg...

    Authors: Jantine PosthumaDeBoer, Thomas Würdinger, Harm CA Graat, Victor W van Beusechem, Marco N Helder, Barend J van Royen and Gertjan JL Kaspers
    Citation: BMC Cancer 2011 11:156
  25. Women with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had...

    Authors: Ingrid Millet, Emmanuelle Bouic-Pages, Denis Hoa, David Azria and Patrice Taourel
    Citation: BMC Cancer 2011 11:155
  26. Maslinic acid, a pentacyclic triterpene found in the protective wax-like coating of the leaves and fruit of Olea europaea L., is a promising agent for the prevention of colon cancer. We have shown elsewhere that ...

    Authors: Fernando J Reyes-Zurita, Gisela Pachón-Peña, Daneida Lizárraga, Eva E Rufino-Palomares, Marta Cascante and José A Lupiáñez
    Citation: BMC Cancer 2011 11:154
  27. NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet, it is not clear how they play their protective role. PGE2 is generally shown as the only target of the NSAIDs anticancerous...

    Authors: Lisenn Lalier, François Pedelaborde, Christophe Braud, Jean Menanteau, François M Vallette and Christophe Olivier
    Citation: BMC Cancer 2011 11:153
  28. Authors: Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellato, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise and José Andres Yunes
    Citation: BMC Cancer 2011 11:152

    The original article was published in BMC Cancer 2008 8:357

  29. Hepatocellular carcinoma (HCC) usually has a dismal prognosis because of its limited response to current pharmacotherapy and high metastatic rate. Sulfated oligosaccharide has been confirmed as having potent a...

    Authors: Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan and Wei-Zhong Wu
    Citation: BMC Cancer 2011 11:150
  30. Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of mu...

    Authors: Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson and Rafat A Siddiqui
    Citation: BMC Cancer 2011 11:149
  31. Despite the recent publication of results from two randomized clinical trials, prostate specific antigen (PSA) screening for prostate cancer remains a controversial issue. There is lack of agreement across stu...

    Authors: David C Wheeler, Konrad M Szymanski, Amanda Black and David E Nelson
    Citation: BMC Cancer 2011 11:148
  32. Geographical variations in medical practice are expected to be small when the evidence about the effectiveness and safety of a particular technology is abundant. This would be the case of the prescription of c...

    Authors: Manuel Ridao-López, Sandra García-Armesto, Begoña Abadía-Taira, Salvador Peiró-Moreno and Enrique Bernal-Delgado
    Citation: BMC Cancer 2011 11:145
  33. Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effe...

    Authors: Seung Joon Lee, Candice Krauthauser, Victoria Maduskuie, Paul T Fawcett, James M Olson and Sigrid A Rajasekaran
    Citation: BMC Cancer 2011 11:144
  34. Optimizing treatment through microarray-based molecular subtyping is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of dis...

    Authors: Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu and Andrew T Huang
    Citation: BMC Cancer 2011 11:143
  35. Cerebral metastases are a common cause of death in patients with melanoma. Systemic drug treatment of these metastases is rarely effective, and where possible surgical resection and/or stereotactic radiosurger...

    Authors: Gerald Fogarty, Rachael L Morton, Janette Vardy, Anna K Nowak, Catherine Mandel, Peta M Forder, Angela Hong, George Hruby, Bryan Burmeister, Brindha Shivalingam, Haryana Dhillon and John F Thompson
    Citation: BMC Cancer 2011 11:142

    The Update to this article has been published in Trials 2019 20:477

  36. Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to i...

    Authors: Bachok Norsa'adah, Krishna G Rampal, Mohd A Rahmah, Nyi N Naing and Biswa M Biswal
    Citation: BMC Cancer 2011 11:141
  37. Today, more than 70% of patients with primary node-negative breast cancer are cured by local therapy alone. Many patients receive overtreatment by adjuvant chemotherapy due to inadequate risk assessment. So fa...

    Authors: Eva J Kantelhardt, Martina Vetter, Marcus Schmidt, Corinne Veyret, Doris Augustin, Volker Hanf, Christoph Meisner, Daniela Paepke, Manfred Schmitt, Fred Sweep, Gunter von Minckwitz, Pierre-Marie Martin, Fritz Jaenicke, Christoph Thomssen and Nadia Harbeck
    Citation: BMC Cancer 2011 11:140
  38. A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.

    Authors: Chen-Yun Yeh, Shin-Mei Shin, Hsuan-Heng Yeh, Tsung-Jung Wu, Jyh-Wei Shin, Tsuey-Yu Chang, Giri Raghavaraju, Chung-Ta Lee, Jung-Hsien Chiang, Vincent S Tseng, Yuan-Chii G Lee, Cheng-Huang Shen, Nan-Haw Chow and Hsiao-Sheng Liu
    Citation: BMC Cancer 2011 11:139
  39. Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma ...

    Authors: Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler and Stephan A Hahn
    Citation: BMC Cancer 2011 11:137
  40. Medulloblastoma is a highly malignant pediatric brain tumor that requires surgery, whole brain and spine irradiation, and intense chemotherapy for treatment. A more sophisticated understanding of the pathophys...

    Authors: Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard and Harald Sontheimer
    Citation: BMC Cancer 2011 11:136
  41. The standard treatment for patients with advanced transitional cell carcinoma of the bladder is platin based chemotherapy. Only approximately 50% of the patients respond to chemotherapy. Therefore, molecular p...

    Authors: Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft and Karin Birkenkamp-Demtroder
    Citation: BMC Cancer 2011 11:135
  42. The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing r...

    Authors: Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz and Peter E Huber
    Citation: BMC Cancer 2011 11:134
  43. Chemotherapy dose delay and/or reduction lower relative total dose intensity (RTDI) and may affect short- and long-term outcome of metastatic breast cancer (MBC) patients.

    Authors: Sibylle Loibl, Tomas Skacel, Valentina Nekljudova, Hans Joachim Lück, Matthias Schwenkglenks, Thomas Brodowicz, Christoph Zielinski and Gunter von Minckwitz
    Citation: BMC Cancer 2011 11:131

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