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  1. Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present ...

    Authors: Junyi Chen, Li Jiao, Chuanliang Xu, Yongwei Yu, Zhensheng Zhang, Zheng Chang, Zhen Deng and Yinghao Sun
    Citation: BMC Cancer 2012 12:593
    Content type: Research article Published on:

  2. Tamoxifen is used in hormone therapy for estrogen-receptor (ER)-positive breast cancer, but also has chemopreventative effects against ER-negative breast cancers. This study sought to investigate whether oral ...

    Authors: Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano and Geoffrey W Krissansen
    Citation: BMC Cancer 2012 12:591
    Content type: Research article Published on:

  3. Psoriasin (S100A7) is a member of the S100 gene family. Alteration of Psoriasin expression has previously been reported to play an important role in cancer aggressive behaviour. The current study sought to inv...

    Authors: Mu Hu, Lin Ye, Fiona Ruge, Xiuyi Zhi, Lijian Zhang and Wen G Jiang
    Citation: BMC Cancer 2012 12:588
    Content type: Research article Published on:

  4. Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and...

    Authors: Martina Mayr, Karen Becker, Nadine Schulte, Sebastian Belle, Ralf Hofheinz, Annekatrin Krause, Roland M Schmid, Christoph Röcken and Matthias P Ebert
    Citation: BMC Cancer 2012 12:587
    Content type: Research article Published on:

  5. Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin l...

    Authors: Sylvia Hartmann, Claudio Agostinelli, Jürgen Diener, Claudia Döring, Stefano Fanti, Pier Luigi Zinzani, Andrea Gallamini, Lothar Bergmann, Stefano Pileri and Martin-Leo Hansmann
    Citation: BMC Cancer 2012 12:586
    Content type: Research article Published on:

  6. The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a d...

    Authors: Hyeong-Gon Moon, Jae Kyo Yi, Hee Sung Kim, Hea Young Lee, Kyung-Min Lee, Minju Yi, Sookyung Ahn, Hee-Chul Shin, Ji-hyun Ju, Incheol Shin, Wonshik Han and Dong-Young Noh
    Citation: BMC Cancer 2012 12:585
    Content type: Research article Published on:

  7. Liver transplantation is the most effective therapy for cirrhosis-associated hepatocellular carcinoma (HCC) but its utility is limited by post-transplant tumor recurrence. Use of the Milan, size-based criteria...

    Authors: Zhen Zeng, Jinyu Ren, Maura O’Neil, Jie Zhao, Brian Bridges, Josiah Cox, Bashar Abdulkarim, Timothy M Schmitt, Sean C Kumer and Steven A Weinman
    Citation: BMC Cancer 2012 12:584
    Content type: Research article Published on:

  8. Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15– 30% of breast cancer patients develop brain metastasis. However, relatively little is known about how these...

    Authors: Hui Liu, Yukinari Kato, Stephanie A Erzinger, Galina M Kiriakova, Yongzhen Qian, Diane Palmieri, Patricia S Steeg and Janet E Price
    Citation: BMC Cancer 2012 12:583
    Content type: Research article Published on:

  9. There are limited population-based studies focusing on the chemopreventive effects of selective cyclooxygenase-2 (COX-2) inhibitors against colorectal cancer. The purpose of this study is to assess the trends ...

    Authors: Yi-Hsin Yang, Yea-Huei Kao Yang, Ching-Lan Cheng, Pei-Shan Ho and Ying-Chin Ko
    Citation: BMC Cancer 2012 12:582
    Content type: Research article Published on:

  10. Neurotoxicity caused by treatment for a brain tumor is a major cause of neurocognitive decline in survivors. Studies have shown that neurofeedback may enhance neurocognitive functioning. This paper describes t...

    Authors: Marieke A de Ruiter, Antoinette YN Schouten-Van Meeteren, Rosa van Mourik, Tieme WP Janssen, Juliette EM Greidanus, Jaap Oosterlaan and Martha A Grootenhuis
    Citation: BMC Cancer 2012 12:581
    Content type: Study protocol Published on:

  11. Cancer research has devoted most of its energy over the past decades on unraveling the control mechanisms within tumor cells that govern its behavior. From this we know that the onset of cancer is the result o...

    Authors: Marlies E Heuvers, Joachim G Aerts, Robin Cornelissen, Harry Groen, Henk C Hoogsteden and Joost P Hegmans
    Citation: BMC Cancer 2012 12:580
    Content type: Review Published on:

  12. Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine h...

    Authors: Karyn S Ho, Peter C Poon, Shawn C Owen and Molly S Shoichet
    Citation: BMC Cancer 2012 12:579
    Content type: Research article Published on:

  13. There is a lack of psychotherapeutic trials of treatments of comorbid depression in cancer patients. Our study determines the efficacy of a manualized short-term psychodynamic psychotherapy and predictors of o...

    Authors: Rüdiger Zwerenz, Manfred E Beutel, Barbara H Imruck, Jörg Wiltink, Antje Haselbacher, Christian Ruckes, Heinz Schmidberger, Gerald Hoffmann, Marcus Schmidt, Uwe Köhler, Dagmar Langanke, Rolf-Dieter Kortmann, Susanne Kuhnt, Gregor Weißflog, Yvette Barthel, Katja Leuteritz…
    Citation: BMC Cancer 2012 12:578
    Content type: Study protocol Published on:

  14. Women with cancer are significantly more likely to fall than women without cancer placing them at higher risk of fall-related fractures, other injuries and disability. Currently, no evidence-based fall prevent...

    Authors: Kerri M Winters-Stone, Fuzhong Li, Fay Horak, Shiuh-Wen Luoh, Jill A Bennett, Lillian Nail and Nathan Dieckmann
    Citation: BMC Cancer 2012 12:577
    Content type: Study protocol Published on:

  15. The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat an...

    Authors: Mario Menschikowski, Uwe Platzbecker, Albert Hagelgans, Margot Vogel, Christian Thiede, Claudia Schönefeldt, Renate Lehnert, Graeme Eisenhofer and Gabriele Siegert
    Citation: BMC Cancer 2012 12:576
    Content type: Research article Published on:

  16. Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no s...

    Authors: Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano, Massimiliano Cazzaniga, Serena Mora, Chiara Casadio, Costantino Jemos, Maria Pizzamiglio, Laura Cortesi, Davide Radice and Bernardo Bonanni
    Citation: BMC Cancer 2012 12:575
    Content type: Study protocol Published on:

  17. Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and...

    Authors: Aika Matsunoki, Kazuyuki Kawakami, Masanori Kotake, Mami Kaneko, Hirotaka Kitamura, Akishi Ooi, Go Watanabe and Toshinari Minamoto
    Citation: BMC Cancer 2012 12:574
    Content type: Research article Published on:

  19. People with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and...

    Authors: Haryana M Dhillon, Hidde P van der Ploeg, Melanie L Bell, Michael Boyer, Stephen Clarke and Janette Vardy
    Citation: BMC Cancer 2012 12:572
    Content type: Study protocol Published on:

  20. Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by t...

    Authors: Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Katrin Orlowski, Martin Pruschy and Rolf A Stahel
    Citation: BMC Cancer 2012 12:571
    Content type: Research article Published on:

  21. Pyloric gland adenoma consists of closely packed pyloric-type glands lined by mucus-secreting cells. To date, approximately 230 cases have been reported, mostly of gastric localization with a tumour size up to...

    Authors: Inga-Marie Schaefer, Silke Cameron, Peter Middel, Kia Homayounfar, Harald Schwörer, Michael Vieth and Lothar Veits
    Citation: BMC Cancer 2012 12:570
    Content type: Case report Published on:

  22. Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to m...

    Authors: Isabela Martins Gonzaga, Sheila Coelho Soares-Lima, Paulo Thiago Souza de Santos, Tania Cristina Moita Blanco, Bruno Souza Bianchi de Reis, Danielle Carvalho Quintella, Ivanir Martins de Oliveira, Paulo Antonio Silvestre de Faria, Cleber Dario Pinto Kruel, Nelson Adami Andreollo, Tatiana Almeida de Simão and Luis Felipe Ribeiro Pinto
    Citation: BMC Cancer 2012 12:569
    Content type: Research article Published on:

  23. Rash, liver dysfunction, and diarrhea are known major adverse events associated with erlotinib and gefitinib. However, clinical trials with gefitinib have reported different proportions of adverse events compa...

    Authors: Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Kuniomi Matsuura, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Toshiyuki Nakai and Kazuto Hirata
    Citation: BMC Cancer 2012 12:568
    Content type: Research article Published on:

  24. With advances in modern radiotherapy (RT), many patients with head and neck (HN) cancer can be effectively cured. However, xerostomia is a common complication in patients after RT for HN cancer. The purpose of...

    Authors: Tsair-Fwu Lee, Pei-Ju Chao, Hung-Yu Wang, Hsuan-Chih Hsu, PaoShu Chang and Wen-Cheng Chen
    Citation: BMC Cancer 2012 12:567
    Content type: Research article Published on:

  25. Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile o...

    Authors: Lu Gan, Jian He, Xia Zhang, Yong-Jie Zhang, Guan-Zhen Yu, Ying Chen, Jun Pan, Jie-Jun Wang and Xi Wang
    Citation: BMC Cancer 2012 12:566
    Content type: Research article Published on:

  27. Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1,...

    Authors: Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren and Stephen Safe
    Citation: BMC Cancer 2012 12:564
    Content type: Research article Published on:

  28. Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for th...

    Authors: Mamduh Khateb, Nili Ruimi, Hazem Khamisie, Yousef Najajreh, Afsar Mian, Anna Metodieva, Martin Ruthardt and Jamal Mahajna
    Citation: BMC Cancer 2012 12:563
    Content type: Research article Published on:

  29. Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant sys...

    Authors: Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler and Marcus Schmidt
    Citation: BMC Cancer 2012 12:562
    Content type: Research article Published on:

  30. Vaccination against tumor-associated antigens is one promising approach to immunotherapy against malignant gliomas. While previous vaccine efforts have focused exclusively on HLA class I-restricted peptides, c...

    Authors: Shinji Shimato, Lisa M Maier, Richard Maier, Jeffrey N Bruce, Richard CE Anderson and David E Anderson
    Citation: BMC Cancer 2012 12:561
    Content type: Research article Published on:

  32. This study aimed to systematically review the evidence from randomized controlled trials (RCTs) and to conduct a meta-analysis of the effects of yoga on physical and psychosocial outcomes in cancer patients an...

    Authors: Laurien M Buffart, Jannique GZ van Uffelen, Ingrid I Riphagen, Johannes Brug, Willem van Mechelen, Wendy J Brown and Mai JM Chinapaw
    Citation: BMC Cancer 2012 12:559
    Content type: Research article Published on:

  33. Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) is used for the patients with EGFR-mutant lung cancer. Recently, phase...

    Authors: Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima, Yoshihito Tanaka, Michiko Shimada, Akira Kurose, Shingo Takanashi and Ken Okumura
    Citation: BMC Cancer 2012 12:558
    Content type: Case report Published on:

  34. While knowledge and risk perception have been associated with screening for second primary cancer (SPC), there are no clinically useful indicators to identify who is at risk of not being properly screened for ...

    Authors: Beomseok Suh, Dong Wook Shin, So Young Kim, Jae-Hyun Park, Weon Young Chang, Seung Pyung Lim, Chang-Yeol Yim, Be-Long Cho, Eun-Cheol Park and Jong-Hyock Park
    Citation: BMC Cancer 2012 12:557
    Content type: Research article Published on:

  35. Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomyci...

    Authors: Selena Z Kuo, Katherine J Blair, Elham Rahimy, Alan Kiang, Eric Abhold, Jian-Bing Fan, Jessica Wang-Rodriguez, Xabier Altuna and Weg M Ongkeko
    Citation: BMC Cancer 2012 12:556
    Content type: Research article Published on:

  36. Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in th...

    Authors: Arlene Chan, Adrienne Morey, Belinda Brown, Diana Hastrich, Peter Willsher and David Ingram
    Citation: BMC Cancer 2012 12:555
    Content type: Research article Published on:

  37. As high percentage of mammographic densities complicates the assessment of imaging findings, mammographic density may influence the histopathological evaluation of core-biopsies of the breast. We measured the ...

    Authors: Pietro Trocchi, Giske Ursin, Oliver Kuss, Kathrin Ruschke, Andrea Schmidt-Pokrzywniak, Hans-Jürgen Holzhausen, Thomas Löning, Christoph Thomssen, Werner Böcker, Alexander Kluttig and Andreas Stang
    Citation: BMC Cancer 2012 12:554
    Content type: Research article Published on:

  38. There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression ...

    Authors: Miriam Lenhard, Lennerová Tereza, Sabine Heublein, Nina Ditsch, Isabelle Himsl, Doris Mayr, Klaus Friese and Udo Jeschke
    Citation: BMC Cancer 2012 12:553
    Content type: Research article Published on:

  39. Rare, heterozygous germline mutations in the RAD51C gene have been found in breast and ovarian cancer families. In the Finnish population, we have identified two founder mutations in RAD51C that increase the risk...

    Authors: Liisa M Pelttari, Riikka Nurminen, Alexandra Gylfe, Lauri A Aaltonen, Johanna Schleutker and Heli Nevanlinna
    Citation: BMC Cancer 2012 12:552
    Content type: Research article Published on:

  40. Quantitative methylation-specific PCR (qMSP) analysis for determining the methylation status of (candidate) tumor suppressor genes has potential as objective and valuable test to triage high-risk human papillo...

    Authors: Suzanne Snellenberg, Lise MA De Strooper, Albertus T Hesselink, Chris JLM Meijer, Peter JF Snijders, Daniëlle AM Heideman and Renske DM Steenbergen
    Citation: BMC Cancer 2012 12:551
    Content type: Technical advance Published on:

  41. Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Ne...

    Authors: Arturo Aguilar-Rojas, Maira Huerta-Reyes, Guadalupe Maya-Núñez, Fabián Arechavaleta-Velásco, P Michael Conn, Alfredo Ulloa-Aguirre and Jesús Valdés
    Citation: BMC Cancer 2012 12:550
    Content type: Research article Published on:

  42. The primary objective of this study was to test whether oncolytic herpes simplex virus type 1 (HSV1) could eradicate chemoresistant cancer stem cells (CSCs).

    Authors: Xiufen Zhuang, Wen Zhang, Yatong Chen, Xiangping Han, Jie Li, Yu Zhang, Youhui Zhang, Shuren Zhang and Binlei Liu
    Citation: BMC Cancer 2012 12:549
    Content type: Research article Published on:

  43. Cancer is an extremely heterogeneous group of diseases traditionally categorized according to tissue of origin. However, even among patients with the same cancer subtype the cellular alterations at the molecul...

    Authors: Lasse Sommer Kristensen, Tina Ellegaard Kjeldsen, Henrik Hager and Lise Lotte Hansen
    Citation: BMC Cancer 2012 12:548
    Content type: Research article Published on:

  44. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Current therapies are insufficient, making HCC an intractable disease. Our previous studies confirmed that inhibi...

    Authors: Wei Li, Dao-Ming Li, Kai Chen, Zheng Chen, Yang Zong, Hong Yin, Ze-Kuan Xu, Yi Zhu, Fei-Ran Gong and Min Tao
    Citation: BMC Cancer 2012 12:547
    Content type: Research article Published on:

  45. A growing body of evidence suggests that microRNAs (miRNAs) play an important role in cancer diagnosis and therapy. MicroRNA-99a (miR-99a), a potential tumor suppressor, is downregulated in several human malig...

    Authors: Li Cui, Hua Zhou, Hu Zhao, Yaojun Zhou, Renfang Xu, Xianlin Xu, Lu Zheng, Zhong Xue, Wei Xia, Bo Zhang, Tao Ding, Yunjie Cao, Zinong Tian, Qianqian Shi and Xiaozhou He
    Citation: BMC Cancer 2012 12:546
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:103

  46. Obesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pat...

    Authors: Andreas Hillenbrand, Juliane Fassler, Nadine Huber, Pengfei Xu, Doris Henne-Bruns, Markus Templin, Hubert Schrezenmeier, Anna Maria Wolf and Uwe Knippschild
    Citation: BMC Cancer 2012 12:545
    Content type: Research article Published on:

  47. High interstitial fluid pressure (IFP) in the primary tumor is associated with poor disease-free survival in locally advanced cervical carcinoma. A noninvasive assay is needed to identify cervical cancer patie...

    Authors: Tord Hompland, Christine Ellingsen and Einar K Rofstad
    Citation: BMC Cancer 2012 12:544
    Content type: Research article Published on:

  48. Prostate cancer (PCa), a leading cause of cancer death in North American men, displays a broad range of clinical outcome from relatively indolent to lethal metastatic disease. Several genomic alterations have ...

    Authors: Khalil Choucair, Joshua Ejdelman, Fadi Brimo, Armen Aprikian, Simone Chevalier and Jacques Lapointe
    Citation: BMC Cancer 2012 12:543
    Content type: Research article Published on:

  49. In 2006, we reported the effectiveness of chemoradiotherapy for postoperative recurrent esophageal cancer with a median observation period of 18 months. The purpose of the present study was to update the resul...

    Authors: Keiichi Jingu, Haruo Matsushita, Ken Takeda, Rei Umezawa, Chiaki Takahashi, Toshiyuki Sugawara, Masaki Kubozono, Keiko Abe, Takaya Tanabe, Yuko Shirata, Takaya Yamamoto, Youjirou Ishikawa and Kenji Nemoto
    Citation: BMC Cancer 2012 12:542
    Content type: Research article Published on:

  50. Clear cell sarcoma (CCS) and malignant melanoma share overlapping immunohistochemistry with regard to the melanocytic markers HMB45, S100, and Melan-A. However, the translocation t(12; 22)(q13; q12) is specifi...

    Authors: Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Yuji Hirata, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji and Toshiaki Hanafusa
    Citation: BMC Cancer 2012 12:538
    Content type: Case report Published on:

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