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  1. Conflicting data exist about the prevalence of HER-2/neu overexpression in colorectal cancer ranging from 0 to 83 %. In our study we tried to clarify the extent of expression and its relationship to clinicopat...

    Authors: B Schuell, T Gruenberger, W Scheithauer, Ch Zielinski and F Wrba

    Citation: BMC Cancer 2006 6:123

    Content type: Research article

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  2. Unresectable biliary tract carcinoma is known to demonstrate a poor prognosis. We conducted a single arm phase II study of LFP therapy (5-FU (5-fluorourasil) continuous infusion (CVI) and Low-dose consecutive ...

    Authors: Kazuma Kobayashi, Akihito Tsuji, Sojiro Morita, Tadashi Horimi, Tetsuhiko Shirasaka and Takashi Kanematsu

    Citation: BMC Cancer 2006 6:121

    Content type: Research article

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  3. Advances in molecular biology and growing requirements from biomarker validation studies have generated a need for tissue banks to provide quality-controlled tissue samples with standardized clinical annotatio...

    Authors: Ashokkumar A Patel, John R Gilbertson, Anil V Parwani, Rajiv Dhir, Milton W Datta, Rajnish Gupta, Jules J Berman, Jonathan Melamed, Andre Kajdacsy-Balla, Jan Orenstein and Michael J Becich

    Citation: BMC Cancer 2006 6:120

    Content type: Research article

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  4. Phytopharmacological studies of different Calendula extracts have shown anti-inflamatory, anti-viral and anti-genotoxic properties of therapeutic interest. In this study, we evaluated the in vitro cytotoxic anti-...

    Authors: Eva Jiménez-Medina, Angel Garcia-Lora, Laura Paco, Ignacio Algarra, Antonia Collado and Federico Garrido

    Citation: BMC Cancer 2006 6:119

    Content type: Research article

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  5. Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm. There are no conclusive data in the literature on the optimal radiation therapy (RT) dose in SP. Therefore, in this large retrospective st...

    Authors: David Knobel, Abderrahim Zouhair, Richard W Tsang, Philip Poortmans, Yazid Belkacémi, Michel Bolla, Fazilet Dinçbas Oner, Christine Landmann, Bernard Castelain and Mahmut Ozsahin

    Citation: BMC Cancer 2006 6:118

    Content type: Research article

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  6. Primary pancreatic lymphomas (PPL) are rare tumours of the pancreas. Symptoms, imaging and tumour markers can mimic pancreatic adenocarcinoma, but they are much more amenable to treatment. Treatment for PPL re...

    Authors: Peter S Grimison, Melvin T Chin, Michelle L Harrison and David Goldstein

    Citation: BMC Cancer 2006 6:117

    Content type: Case report

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  7. Breast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individu...

    Authors: Venüs Ümmiye Onay, Laurent Briollais, Julia A Knight, Ellen Shi, Yuanyuan Wang, Sean Wells, Hong Li, Isaac Rajendram, Irene L Andrulis and Hilmi Ozcelik

    Citation: BMC Cancer 2006 6:114

    Content type: Research article

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  8. Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARδ) activity...

    Authors: Karen R Reed, Owen J Sansom, Anthony J Hayes, Andreas J Gescher, Jeffrey M Peters and Alan R Clarke

    Citation: BMC Cancer 2006 6:113

    Content type: Research article

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  9. Prostate cancer that has recurred after local therapy or disseminated distantly is usually treated with androgen deprivation therapy; however, most men will eventually experience disease progression within 12 ...

    Authors: Eric Winquist, Tricia Waldron, Scott Berry, D Scott Ernst, Sébastien Hotte and Himu Lukka

    Citation: BMC Cancer 2006 6:112

    Content type: Research article

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  10. The poly Q polymorphism in AIB1 (amplified in breast cancer) gene is usually assessed by fragment length analysis which does not reveal the actual sequence variation. The purpose of this study is to investigate t...

    Authors: Lee-Jun C Wong, Pu Dai, Jyh-Feng Lu, Mary Ann Lou, Robert Clarke and Viktor Nazarov

    Citation: BMC Cancer 2006 6:111

    Content type: Research article

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  11. Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study i...

    Authors: Minglei Guo, Jinjun Li, Dafang Wan and Jianren Gu

    Citation: BMC Cancer 2006 6:109

    Content type: Research article

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  12. ACTH overproduction within the pituitary gland or ectopically leads to hypercortisolism. Here, we report the first case of Cushing' syndrome caused by an ectopic ACTH-secreting neuroendocrine carcinoma of the ...

    Authors: Mathias Fasshauer, Thomas Lincke, Helmut Witzigmann, Regine Kluge, Andrea Tannapfel, Michael Moche, Michael Buchfelder, Stephan Petersenn, Juergen Kratzsch, Ralf Paschke and Christian A Koch

    Citation: BMC Cancer 2006 6:108

    Content type: Case report

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  13. New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy,...

    Authors: Julian J Raffoul, Yu Wang, Omer Kucuk, Jeffrey D Forman, Fazlul H Sarkar and Gilda G Hillman

    Citation: BMC Cancer 2006 6:107

    Content type: Research article

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  14. SSeCKS is a major protein kinase C substrate with kinase scaffolding and metastasis-suppressor activity whose expression is severely downregulated in Src- and Ras-transformed fibroblast and epithelial cells an...

    Authors: Yongzhong Liu, Lingqiu Gao and Irwin H Gelman

    Citation: BMC Cancer 2006 6:105

    Content type: Research article

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  15. Mathematical models of cancer relevant processes are being developed at an increasing rate. Conceptual frameworks are needed to support new treatment designs based on such models.

    Authors: Tomas Radivoyevitch, Kenneth A Loparo, Robert C Jackson and W David Sedwick

    Citation: BMC Cancer 2006 6:104

    Content type: Research article

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  16. Twenty years after the nuclear accident in Chernobyl (Eastern Europe), there is still a controversial debate concerning a possible effect of the radioactive iodines, especially I-131, on the increase of thyroi...

    Authors: René Scheiden, Marc Keipes, Carlo Bock, Walter Dippel, Nelly Kieffer and Catherine Capesius

    Citation: BMC Cancer 2006 6:102

    Content type: Research article

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  17. While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive. Our study aimed to ...

    Authors: Tatiana Burjanivova, Jozef Madzo, Katerina Muzikova, Claus Meyer, Bjoern Schneider, Felix Votava, Rolf Marschalek, Jan Stary, Jan Trka and Jan Zuna

    Citation: BMC Cancer 2006 6:100

    Content type: Research article

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  18. Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we c...

    Authors: Mariana Fernandez-Cobo, James F Holland and Beatriz GT Pogo

    Citation: BMC Cancer 2006 6:99

    Content type: Research article

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  19. A critical choice facing breast cancer patients is which surgical treatment – mastectomy or breast conserving surgery (BCS) – is most appropriate. Several studies have investigated factors that impact the type...

    Authors: Michael A Martin, Ramona Meyricke, Terry O'Neill and Steven Roberts

    Citation: BMC Cancer 2006 6:98

    Content type: Research article

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  20. We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival. To investi...

    Authors: Yu Liang, Andrew W Bollen, Ken D Aldape and Nalin Gupta

    Citation: BMC Cancer 2006 6:97

    Content type: Research article

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  21. Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mu...

    Authors: Jane Fridlyand, Antoine M Snijders, Bauke Ylstra, Hua Li, Adam Olshen, Richard Segraves, Shanaz Dairkee, Taku Tokuyasu, Britt Marie Ljung, Ajay N Jain, Jane McLennan, John Ziegler, Koei Chin, Sandy Devries, Heidi Feiler, Joe W Gray…

    Citation: BMC Cancer 2006 6:96

    Content type: Research article

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  22. Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cance...

    Authors: Martin Dreilich, Michael Bergqvist, Martin Moberg, Daniel Brattström, Inger Gustavsson, Stefan Bergström, Alkwin Wanders, Patrik Hesselius, Gunnar Wagenius and Ulf Gyllensten

    Citation: BMC Cancer 2006 6:94

    Content type: Research article

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  23. The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation s...

    Authors: Duan-Jun Tan, Julia Chang, Ling-Ling Liu, Ren-Kui Bai, Yu-Fen Wang, Kun-Tu Yeh and Lee-Jun C Wong

    Citation: BMC Cancer 2006 6:93

    Content type: Research article

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  24. A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment, which is a serious problem commonly encountered in clinical practice. We tried to find novel progn...

    Authors: Wonshik Han, Mi-Ryung Han, Jason Jongho Kang, Ji-Yeon Bae, Ji Hyun Lee, Young Ju Bae, Jeong Eon Lee, Hyuk-Jae Shin, Ki-Tae Hwang, Sung-Eun Hwang, Sung-Won Kim and Dong-Young Noh

    Citation: BMC Cancer 2006 6:92

    Content type: Research article

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  25. Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous study of microarray, ribosomal pro...

    Authors: Hui Wang, Li-Na Zhao, Kai-Zong Li, Rui Ling, Xiao-Jun Li and Ling Wang

    Citation: BMC Cancer 2006 6:91

    Content type: Research article

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  26. WT1 is a tumor suppressor gene responsible for Wilms' tumor. WT1 reactivity is limited to ovarian serous carcinomas. Recent studies have shown that WT1 plays an important role in the progression of disease and...

    Authors: Wirote Netinatsunthorn, Jitti Hanprasertpong, Chavaboon Dechsukhum, Roengsak Leetanaporn and Alan Geater

    Citation: BMC Cancer 2006 6:90

    Content type: Research article

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  27. Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling....

    Authors: Sonia Di Gioia, Paolo Bianchi, Annarita Destro, Fabio Grizzi, Alberto Malesci, Luigi Laghi, Massimo Levrero, Alberto Morabito and Massimo Roncalli

    Citation: BMC Cancer 2006 6:89

    Content type: Research article

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  28. Mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2), two members of the secretoglobin superfamily, are known to be co-expressed in breast cancer, where their proteins form a covalent complex. Based on the relative...

    Authors: Menelaos Zafrakas, Beate Petschke, Andreas Donner, Florian Fritzsche, Glen Kristiansen, Ruth Knüchel and Edgar Dahl

    Citation: BMC Cancer 2006 6:88

    Content type: Research article

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  29. Hematopoietic stem cell transplantation is being increasingly used in cancer therapy. Diffuse alveolar hemorrhage, an early complication of stem cell transplant, results from bacterial, viral and fungal infect...

    Authors: Sachin Gupta, Amit Jain, Tina V Fanning, Daniel R Couriel, Carlos A Jimenez and Georgie A Eapen

    Citation: BMC Cancer 2006 6:87

    Content type: Case report

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  30. Sensitivity of breast tumors to anticancer drugs depends upon dynamic interactions between epithelial tumor cells and their microenvironment including stromal cells and extracellular matrix. To study drug-sens...

    Authors: Heiko van der Kuip, Thomas E Mürdter, Maike Sonnenberg, Monika McClellan, Susanne Gutzeit, Andreas Gerteis, Wolfgang Simon, Peter Fritz and Walter E Aulitzky

    Citation: BMC Cancer 2006 6:86

    Content type: Technical advance

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  31. Prospective investigations of complete decongestive lymphatic physiotherapy (CDPT), including manual lymphatic drainage (MLD), have validated the efficacy of these interventions for the initial reduction of ed...

    Authors: Olivia Wilburn, Paul Wilburn and Stanley G Rockson

    Citation: BMC Cancer 2006 6:84

    Content type: Research article

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  32. Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a ...

    Authors: Shee-Ping Chen, Shih-Tzu Tsai, Shu-Wen Jao, Yen-Lun Huang, Yu-Chen Chao, Yi-Lin Chen, Chang-Chieh Wu, Shinn-Zong Lin and Horng-Jyh Harn

    Citation: BMC Cancer 2006 6:83

    Content type: Research article

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  33. At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains...

    Authors: Rupert Bartsch, Catharina Wenzel, Ursula Pluschnig, Dagmar Hussian, Ursula Sevelda, Gabriela Altorjai, Gottfried J Locker, Robert Mader, Christoph C Zielinski and Guenther G Steger

    Citation: BMC Cancer 2006 6:81

    Content type: Research article

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  34. The MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce a...

    Authors: Ellen R Copson, Helen E White, Jeremy P Blaydes, David O Robinson, Peter W Johnson and Diana M Eccles

    Citation: BMC Cancer 2006 6:80

    Content type: Research article

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  35. Several small receptor tyrosine kinase inhibitors (RTKI) have entered clinical cancer trials alone and in combination with radiotherapy or chemotherapy. The inhibitory spectrum of these compounds is often not ...

    Authors: Minglun Li, Gong Ping, Christian Plathow, Thuy Trinh, Kenneth E Lipson, Kai Hauser, Robert Krempien, Juergen Debus, Amir Abdollahi and Peter E Huber

    Citation: BMC Cancer 2006 6:79

    Content type: Research article

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  36. This article aims to explain the reasons for the remarkable change in age of breast cancer occurrence in the Swiss canton of Geneva.

    Authors: Christine Bouchardy, Alfredo Morabia, Helena M Verkooijen, Gérald Fioretta, Yves Wespi and Peter Schäfer

    Citation: BMC Cancer 2006 6:78

    Content type: Research article

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  37. Metastasis is a major cause of morbidity and mortality in breast cancer with tumor cell invasion playing a crucial role in the metastatic process. PDK1 is a key molecule that couples PI3K to cell proliferation...

    Authors: Zhihui Xie, Hongyan Yuan, Yuzhi Yin, Xiao Zeng, Renkui Bai and Robert I Glazer

    Citation: BMC Cancer 2006 6:77

    Content type: Research article

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  38. Patients with metastatic breast cancer are frequently treated with anthracyclines and taxanes, which are among the most active agents in this disease. Gemcitabine is an interesting candidate for a three-drug c...

    Authors: Alessandro Passardi, Ilaria Massa, Wainer Zoli, Lorenzo Gianni, Carlo Milandri, Federica Zumaglini, Oriana Nanni, Roberta Maltoni, Giovanni Luca Frassineti and Dino Amadori

    Citation: BMC Cancer 2006 6:76

    Content type: Research article

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  39. CD40L was found to reduce doxorubicin-induced apoptosis in non Hodgkin's lymphoma cell lines through caspase-3 dependent mechanism. Whether this represents a general mechanism for other tumor types is unknown.

    Authors: Nathalie Voorzanger-Rousselot, Laurent Alberti and Jean-Yves Blay

    Citation: BMC Cancer 2006 6:75

    Content type: Research article

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  40. Basic studies of oncogenesis have demonstrated that either the elevated production of particular oncogene proteins or the occurrence of qualitative abnormalities in oncogenes can contribute to neoplastic cellu...

    Authors: Hong Namkoong, Seung Min Shin, Hyun Kee Kim, Seon-Ah Ha, Goang Won Cho, Soo Young Hur, Tae Eung Kim and Jin Woo Kim

    Citation: BMC Cancer 2006 6:74

    Content type: Research article

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  41. Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the COX-2 gene may lead to altered COX-2 production and/or activity, and so they cause inter-individu...

    Authors: Jung Min Park, Jin Eun Choi, Myung Hwa Chae, Won Kee Lee, Sung Ick Cha, Ji-Woong Son, Chang Ho Kim, Sin Kam, Young Mo Kang, Tae Hoon Jung and Jae Yong Park

    Citation: BMC Cancer 2006 6:70

    Content type: Research article

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