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  1. Atypical teratoid rhabdoid tumor (ATRT) patients display a dismal median overall survival of less than 1 year. A consistent fraction of cases carries de-novo SMARCB1/INI1 constitutional mutations in the setting o...

    Authors: Piergiorgio Modena, Iacopo Sardi, Monica Brenca, Laura Giunti, Anna Maria Buccoliero, Bianca Pollo, Veronica Biassoni, Lorenzo Genitori, Manila Antonelli, Roberta Maestro, Felice Giangaspero and Maura Massimino
    Citation: BMC Cancer 2013 13:100
    Content type: Case report Published on:

  2. Many studies support the hypothesis that specific microRNA (miRNA) expression in various human cancers including hepatocarcinogenesis is closely associated with diagnosis and prognosis. In hepatocellular carci...

    Authors: Yoshiki Murakami, Akihiro Tamori, Saori Itami, Toshihito Tanahashi, Hidenori Toyoda, Masami Tanaka, Weihong Wu, Nariso Brojigin, Yuji Kaneoka, Atsuyuki Maeda, Takashi Kumada, Norifumi Kawada, Shoji Kubo and Masahiko Kuroda
    Citation: BMC Cancer 2013 13:99
    Content type: Research article Published on:

  3. Intraoperative detection of 18F-FDG-avid tissue sites during 18F-FDG-directed surgery can be very challenging when utilizing gamma detection probes that rely on a fixed target-to-background (T/B) ratio (ratiometr...

    Authors: Stephen P Povoski, Gregg J Chapman, Douglas A Murrey, Robert Lee, Edward W Martin and Nathan C Hall
    Citation: BMC Cancer 2013 13:98
    Content type: Research article Published on:

  4. The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinica...

    Authors: Maria C Katapodi, Laurel L Northouse, Ann M Schafenacker, Debra Duquette, Sonia A Duffy, David L Ronis, Beth Anderson, Nancy K Janz, Jennifer McLosky, Kara J Milliron, Sofia D Merajver, Linh M Duong and Glenn Copeland
    Citation: BMC Cancer 2013 13:97
    Content type: Study protocol Published on:

  5. The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an exce...

    Authors: Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, Georg Schäfer, Sara Lehmusvaara, Tapio Visakorpi, Helmut Klocker, Andrew C B Cato and Danilo Maddalo
    Citation: BMC Cancer 2013 13:96
    Content type: Research article Published on:

  6. Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass ...

    Authors: Paola Longati, Xiaohui Jia, Johannes Eimer, Annika Wagman, Michael-Robin Witt, Stefan Rehnmark, Caroline Verbeke, Rune Toftgård, Matthias Löhr and Rainer L Heuchel
    Citation: BMC Cancer 2013 13:95
    Content type: Research article Published on:

  7. Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, ther...

    Authors: Melony G King, Sara H Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez and Elisa V Bandera
    Citation: BMC Cancer 2013 13:94
    Content type: Research article Published on:

  8. The development of resistance to chemotherapies represents a significant barrier to successful cancer treatment. Resistance mechanisms are complex, can involve diverse and often unexpected cellular processes, ...

    Authors: Li Chen, Lynda Stuart, Toshiro K Ohsumi, Shawn Burgess, Gaurav K Varshney, Anahita Dastur, Mark Borowsky, Cyril Benes, Adam Lacy-Hulbert and Emmett V Schmidt
    Citation: BMC Cancer 2013 13:93
    Content type: Research article Published on:

  9. Prostaglandin (PG) E2 plays a critical role in colorectal cancer (CRC) progression, including epithelial-mesenchymal transition (EMT). Activity of the rate-limiting enzyme for PGE2 catabolism (15-hydroxyprostagla...

    Authors: Alastair L Young, Claire R Chalmers, Gillian Hawcroft, Sarah L Perry, Darren Treanor, Giles J Toogood, Pamela F Jones and Mark A Hull
    Citation: BMC Cancer 2013 13:92
    Content type: Research article Published on:

  10. Recent studies suggest that bacterial endotoxins may be associated with various chronic diseases, including colorectal adenomas and cancer. Given the evidence linking inflammation and colorectal cancer, we sou...

    Authors: Melissa Kang, Patrick Edmundson, Felix Araujo-Perez, Amber N McCoy, Joseph Galanko and Temitope O Keku
    Citation: BMC Cancer 2013 13:91
    Content type: Research article Published on:

  11. Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapi...

    Authors: Fang-Fang Bi, Da Li and Qing Yang
    Citation: BMC Cancer 2013 13:90
    Content type: Research article Published on:

  12. Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate c...

    Authors: Suzanne K Chambers, David P Smith, Martin Berry, Stephen J Lepore, Elizabeth Foley, Samantha Clutton, Robert McDowall, Stefano Occhipinti, Mark Frydenberg and Robert A Gardiner
    Citation: BMC Cancer 2013 13:89
    Content type: Study protocol Published on:

  14. Colorectal cancer (CRC) survival depends mostly on stage at the time of diagnosis. However, symptom duration at diagnosis or treatment have also been considered as predictors of stage and survival. This study ...

    Authors: Magdalena Esteva, Alfonso Leiva, María Ramos, Salvador Pita-Fernández, Luis González-Luján, Montse Casamitjana, María A Sánchez, Sonia Pértega-Díaz, Amador Ruiz, Paloma Gonzalez-Santamaría, María Martín-Rabadán, Ana M Costa-Alcaraz, Alejandro Espí, Francesc Macià, Josep M Segura, Sergio Lafita…
    Citation: BMC Cancer 2013 13:87
    Content type: Research article Published on:

  15. Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by it...

    Authors: Anahid Ehteda, Peter Galettis, Krishna Pillai and David L Morris
    Citation: BMC Cancer 2013 13:86
    Content type: Research article Published on:

  16. Experimental data suggest that catecholamine hormones are involved in stimulating the aggressiveness of ovarian cancer, but few population-based studies have examined this association. We therefore conducted a...

    Authors: Sigrun A Johannesdottir, Morten Schmidt, Gary Phillips, Ronald Glaser, Eric V Yang, Michael Blumenfeld and Stanley Lemeshow
    Citation: BMC Cancer 2013 13:85
    Content type: Research article Published on:

  17. Failure of locoregional control is the main cause of recurrence in advanced head and neck cancer. This multi-center trial aims to improve outcome in two ways. Firstly, by redistribution of the radiation dose t...

    Authors: Jolien Heukelom, Olga Hamming, Harry Bartelink, Frank Hoebers, Jordi Giralt, Teresa Herlestam, Marcel Verheij, Michiel van den Brekel, Wouter Vogel, Nick Slevin, Eric Deutsch, Jan-Jakob Sonke, Philippe Lambin and Coen Rasch
    Citation: BMC Cancer 2013 13:84
    Content type: Study protocol Published on:

  18. Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2.

    Authors: Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum and Sandeep Mittal
    Citation: BMC Cancer 2013 13:83
    Content type: Research article Published on:

  19. OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well c...

    Authors: Lu Cao, Chunguang Li, Shuwen Shen, Yan Yan, Weidan Ji, Jinghan Wang, Haihua Qian, Xiaoqing Jiang, Zhigang Li, Mengchao Wu, Ying Zhang and Changqing Su
    Citation: BMC Cancer 2013 13:82
    Content type: Research article Published on:

  20. The human ERBB2 gene is frequently amplified in breast tumors, and its high expression is associated with poor prognosis. We previously reported a significant inverse correlation between Myc promoter-binding p...

    Authors: Flavia Contino, Claudia Mazzarella, Arianna Ferro, Mariavera Lo Presti, Elena Roz, Carmelo Lupo, Giovanni Perconti, Agata Giallongo and Salvatore Feo
    Citation: BMC Cancer 2013 13:81
    Content type: Research article Published on:

  21. Phosphatase of regenerating liver-3 (PRL-3), a protein tyrosine phosphatase, is highly expressed in multiple human cancers and strongly implicated in tumor progression and cancer metastasis. However, the mecha...

    Authors: Hao Liu, Abdul Qader Omer Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang and Qi Zeng
    Citation: BMC Cancer 2013 13:80
    Content type: Research article Published on:

  22. Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Rece...

    Authors: Juliana Carvalho Santos, André Uchimura Bastos, Janete Maria Cerutti and Marcelo Lima Ribeiro
    Citation: BMC Cancer 2013 13:79
    Content type: Research article Published on:

  23. Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis of various ...

    Authors: Byong Sun Oh, Jeong Won Jang, Jung Hyun Kwon, Chan Ran You, Kyu Won Chung, Chul Seung Kay, Hyun Suk Jung and Seungok Lee
    Citation: BMC Cancer 2013 13:78
    Content type: Research article Published on:

  24. We have recently reported on the changes in plasma free amino acid (PFAA) profiles in lung cancer patients and the efficacy of a PFAA-based, multivariate discrimination index for the early detection of lung ca...

    Authors: Masato Shingyoji, Toshihiko Iizasa, Masahiko Higashiyama, Fumio Imamura, Nobuhiro Saruki, Akira Imaizumi, Hiroshi Yamamoto, Takashi Daimon, Osamu Tochikubo, Toru Mitsushima, Minoru Yamakado and Hideki Kimura
    Citation: BMC Cancer 2013 13:77
    Content type: Research article Published on:

  25. Randomized controlled trials (RCTs) that are inappropriately designed or executed may provide biased findings and mislead clinical practice. In view of recent interest in the treatment and prevention of thromb...

    Authors: Gabriel Rada, Holger J Schünemann, Nawman Labedi, Pierre El-Hachem, Victor F Kairouz and Elie A Akl
    Citation: BMC Cancer 2013 13:76
    Content type: Research article Published on:

  26. This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenoc...

    Authors: Markus Moehler, Ines Gockel, Hans-Peter Roessler, Dirk Arnold, Tanja Trarbach, Thomas Thomaidis, Gunther Klautke, Claus Rödel, Baruch Brenner, Hauke Lang, Peter R Galle, Carl C Schimanski and Heinz Schmidberger
    Citation: BMC Cancer 2013 13:75
    Content type: Research article Published on:

  27. Recent evidence indicates that methyl jasmonate (MJ), a plant stress hormone, exhibits anti-cancer activity on human cancer cells. The aim of this study is to determine whether sub-cytotoxic MJ can abolish the...

    Authors: Liduan Zheng, Dan Li, Xuan Xiang, Ling Tong, Meng Qi, Jiarui Pu, Kai Huang and Qiangsong Tong
    Citation: BMC Cancer 2013 13:74
    Content type: Research article Published on:

  28. MultiCellular Tumor Spheroid (MCTS) mimics the organization of a tumor and is considered as an invaluable model to study cancer cell biology and to evaluate new antiproliferative drugs. Here we report how the ...

    Authors: Jennifer Laurent, Céline Frongia, Martine Cazales, Odile Mondesert, Bernard Ducommun and Valérie Lobjois
    Citation: BMC Cancer 2013 13:73
    Content type: Research article Published on:

  29. MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal t...

    Authors: Silvia Prislei, Enrica Martinelli, Marisa Mariani, Giuseppina Raspaglio, Steven Sieber, Gabriella Ferrandina, Shohreh Shahabi, Giovanni Scambia and Cristiano Ferlini
    Citation: BMC Cancer 2013 13:72
    Content type: Research article Published on:

  30. Since the definition of different histologic subtypes of urothelial carcinomas by the World Health Organization (WHO) 2004 classification, description of molecular features and clinical behavior of these varia...

    Authors: Bastian Keck, Sven Wach, Robert Stoehr, Frank Kunath, Simone Bertz, Jan Lehmann, Michael Stöckle, Helge Taubert, Bernd Wullich and Arndt Hartmann
    Citation: BMC Cancer 2013 13:71
    Content type: Research article Published on:

  31. Several prognostic indexes (PI) have been developed in the brain metastases (BM) setting to help physicians tailor treatment options and stratify patients enrolled in clinical studies. The aim of our study was...

    Authors: Antoine-Laurent Braccini, David Azria, Simon Thezenas, Gilles Romieu, Jean-Marc Ferrero and William Jacot
    Citation: BMC Cancer 2013 13:70
    Content type: Research article Published on:

  33. As stereotactic body radiotherapy (SBRT) is a highly dose-dense radiotherapy, adverse events of neighboring normal tissues are a major concern. This study thus aimed to clarify the frequency and degree of clin...

    Authors: Atsushi Nambu, Hiroshi Onishi, Shinichi Aoki, Licht Tominaga, Kengo Kuriyama, Masayuki Araya, Ryoh Saito, Yoshiyasu Maehata, Takafumi Komiyama, Kan Marino, Tsuyota Koshiishi, Eiichi Sawada and Tsutomu Araki
    Citation: BMC Cancer 2013 13:68
    Content type: Research article Published on:

  34. Peritoneal carcinomatosis is regarded as a common sign of advanced tumor stage, tumor progression or local recurrence of appendiceal and colorectal cancer and is generally associated with poor prognosis. Altho...

    Authors: Gabriel Glockzin, Justine Rochon, Dirk Arnold, Sven A Lang, Frank Klebl, Florian Zeman, Michael Koller, Hans J Schlitt and Pompiliu Piso
    Citation: BMC Cancer 2013 13:67
    Content type: Study protocol Published on:

  35. A better understanding of patients’ views on the benefit and burden obtained from palliative chemotherapy would facilitate shared decision making. We evaluated palliative cancer patients’ reported outcomes (PR...

    Authors: Marika Mende, Karolin Trautmann, Anke Rentsch, Beate Hornemann, Ulrich S Schuler, Gerhard Ehninger and Gunnar Folprecht
    Citation: BMC Cancer 2013 13:66
    Content type: Research article Published on:

  36. Tumor suppressor p53 is mutated in a wide variety of human cancers and plays a critical role in anoikis, which is essential for preventing tumorigenesis. Recently, we found that a nucleolar protein, Myb-bindin...

    Authors: Kensuke Akaogi, Wakana Ono, Yuki Hayashi, Hiroyuki Kishimoto and Junn Yanagisawa
    Citation: BMC Cancer 2013 13:65
    Content type: Research article Published on:

  37. The long term outcome of advanced sarcoma patients treated with trabectedin outside of clinical trials and the utility of maintenance treatment has not been reported.

    Authors: Jean-Yves Blay, Antoine Italiano, Isabelle Ray-Coquard, Axel Le Cesne, Florence Duffaud, Maria Rios, Olivier Collard, François Bertucci, Emmanuelle Bompas, Nicolas Isambert, Loic Chaigneau, Philippe Cassier, Binh Bui, Gauthier Decanter, Olfa Derbel, Jean-Michel Coindre…
    Citation: BMC Cancer 2013 13:64
    Content type: Research article Published on:

  38. Rho GTPases are involved in cellular functions relevant to cancer. The roles of RhoA and Rac1 have already been established. However, the role of Rac3 in cancer aggressiveness is less well understood.

    Authors: Caroline Gest, Ulrich Joimel, Limin Huang, Linda-Louise Pritchard, Alexandre Petit, Charlène Dulong, Catherine Buquet, Chao-Quan Hu, Pezhman Mirshahi, Marc Laurent, Françoise Fauvel-Lafève, Lionel Cazin, Jean-Pierre Vannier, He Lu, Jeannette Soria, Hong Li…
    Citation: BMC Cancer 2013 13:63
    Content type: Research article Published on:

  39. TP53 gene mutations can lead to the expression of a dysfunctional protein that in turn may enable genetically unstable cells to survive and change into malignant cells. Mutant p53 accumulates early in cells and ...

    Authors: Manlio Mattioni, Patrizia Chinzari, Silvia Soddu, Lidia Strigari, Vincenzo Cilenti and Eliuccia Mastropasqua
    Citation: BMC Cancer 2013 13:62
    Content type: Research article Published on:

  40. Metastatic prostate cancer is a leading cause of cancer-related death in men. Cancer stem cells (CSCs) are involved in tumor progression and metastasis, including in prostate cancer. There is an obvious and ur...

    Authors: Xinlan Fan, Xu Chen, Weixi Deng, Guangzheng Zhong, Qingqing Cai and Tianxin Lin
    Citation: BMC Cancer 2013 13:61
    Content type: Research article Published on:

  41. SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as...

    Authors: Cesarina Giallongo, Piera La Cava, Daniele Tibullo, Ignazio Barbagallo, Nunziatina Parrinello, Alessandra Cupri, Fabio Stagno, Carla Consoli, Annalisa Chiarenza, Giuseppe A Palumbo and Francesco Di Raimondo
    Citation: BMC Cancer 2013 13:60
    Content type: Research article Published on:

  42. It has been previously reported that IL-22, one of the cytokines secreted by Th17 cells, demonstrates both a protective and inflammatory promotion effect in inflammatory bowel disease (IBD) through STAT3 signa...

    Authors: Runqiu Jiang, Haiyang Wang, Lei Deng, Jiajie Hou, Ruihua Shi, Ming Yao, Yun Gao, Aihua Yao, Xuehao Wang, Lianzhen Yu and Beicheng Sun
    Citation: BMC Cancer 2013 13:59
    Content type: Research article Published on:

  43. The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen...

    Authors: Liesbeth Hameetman, Suzan Commandeur, Jan Nico Bouwes Bavinck, Hermina C Wisgerhof, Frank R de Gruijl, Rein Willemze, Leon Mullenders, Cornelis P Tensen and Harry Vrieling
    Citation: BMC Cancer 2013 13:58
    Content type: Research article Published on:

  44. Peritoneal dissemination is the most common type of recurrence in advanced gastric cancer. The main mechanism is thought to be via the exfoliation of free cancer cells (FCCs) from tumor in the gastric serosa. ...

    Authors: Baojun Huang, Zhe Sun, Zhenning Wang, Chong Lu, Chengzhong Xing, Bo Zhao and Huimian Xu
    Citation: BMC Cancer 2013 13:57
    Content type: Research article Published on:

  45. Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to ev...

    Authors: Francesco Russo, Michele Linsalata, Caterina Clemente, Benedetta D’Attoma, Antonella Orlando, Giovanna Campanella, Francesco Giotta and Giuseppe Riezzo
    Citation: BMC Cancer 2013 13:56
    Content type: Research article Published on:

  46. Acute lymphoblastic leukemia (ALL) diagnosed within the first month of life is classified as congenital ALL and has a significantly worse outcome than ALL diagnosed in older children. This suggests that congen...

    Authors: Vivian Y Chang, Giuseppe Basso, Kathleen M Sakamoto and Stanley F Nelson
    Citation: BMC Cancer 2013 13:55
    Content type: Research article Published on:

  47. Obesity has been linked to many adverse health consequences, including breast cancer. This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before...

    Authors: Majed S Alokail, Nasser Al-Daghri, Amal Abdulkareem, Hossam M Draz, Sobhy M Yakout, Abdullah M Alnaami, Shaun Sabico, Amal M Alenad and George P Chrousos
    Citation: BMC Cancer 2013 13:54
    Content type: Research article Published on:

  49. Today, the treatment of choice for high- and low-grade gliomas requires primarily surgical resection to achieve the best survival and quality of life. Nevertheless, many gliomas within highly eloquent cortical...

    Authors: Sandro M Krieg, Lea Schnurbus, Ehab Shiban, Doris Droese, Thomas Obermueller, Niels Buchmann, Jens Gempt, Bernhard Meyer and Florian Ringel
    Citation: BMC Cancer 2013 13:51
    Content type: Research article Published on:

  50. More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in orde...

    Authors: George Pentheroudakis, Vassiliki Kotoula, Wendy De Roock, George Kouvatseas, Pavlos Papakostas, Thomas Makatsoris, Demetris Papamichael, Ioannis Xanthakis, Joseph Sgouros, Despina Televantou, Georgia Kafiri, Athanassios C Tsamandas, Evangelia Razis, Eleni Galani, Dimitrios Bafaloukos, Ioannis Efstratiou…
    Citation: BMC Cancer 2013 13:49
    Content type: Research article Published on:

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