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  1. Gene expression data is abundantly available from the Gene Expression Omnibus (GEO) and various websites. Pathway specific analyses of gene-gene correlations across these datasets remain relatively unexplored,...

    Authors: Tomas Radivoyevitch

    Citation: BMC Cancer 2005 5:95

    Content type: Research article

    Published on:

  2. Breast cancer is one of the most frequent causes of death in Mexican women over 35 years of age. At molecular level, changes in many genetic networks have been reported as associated with this neoplasia. To an...

    Authors: Normand García, Fabio Salamanca, Horacio Astudillo-de la Vega, Everardo Curiel-Quesada, Isabel Alvarado, Rosenda Peñaloza and Diego Arenas

    Citation: BMC Cancer 2005 5:93

    Content type: Research article

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  3. Adenomyoepithelial tumours and myoepithelial carcinomas of the breast are primarily defined by the presence of neoplastic cells with a myoepithelial immunophenotype. Current classification schemes are based on...

    Authors: Daniela Hungermann, Horst Buerger, Christian Oehlschlegel, Hermann Herbst and Werner Boecker

    Citation: BMC Cancer 2005 5:92

    Content type: Research article

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  4. The RTOG 94-13 trial has provided evidence that patients with high risk prostate cancer benefit from an additional radiotherapy to the pelvic nodes combined with concomitant hormonal ablation. Since lymphatic ...

    Authors: Ute Ganswindt, Frank Paulsen, Stefan Corvin, Kai Eichhorn, Stefan Glocker, Ilse Hundt, Mattias Birkner, Markus Alber, Aristotelis Anastasiadis, Arnulf Stenzl, Roland Bares, Wilfried Budach, Michael Bamberg and Claus Belka

    Citation: BMC Cancer 2005 5:91

    Content type: Research article

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  5. Esophagus squamous cell cancer (ESCC) is the most common cancer in women with 20.2% and second in men with 10.7% relative frequency among all cancer cases diagnosed in Van Region in the east of Turkey. Ninety ...

    Authors: Mahmut Ilhan, Tugrul Erbaydar, Necmettin Akdeniz and Sevket Arslan

    Citation: BMC Cancer 2005 5:90

    Content type: Research article

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  6. Bisphosphonate therapy has been readily accepted as standard of care for individuals with bone metastases from breast cancer. In this study we determined whether the proportion of patients experiencing a skele...

    Authors: Winston Liauw, Eva Segelov, Anna Lih, Ms Ruth Dunleavy, Matthew Links and Robyn Ward

    Citation: BMC Cancer 2005 5:89

    Content type: Research article

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  7. Published data suggests that docetaxel combined with 5-fluorouracil (5-FU) may have synergistic activity in treating advanced gastric cancer. We performed a phase I study of docetaxel and 5-FU to determine the...

    Authors: Se Hoon Park, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee, Woon KI Lee and Min Chung

    Citation: BMC Cancer 2005 5:87

    Content type: Research article

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  8. Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain strengths and weaknesses; however, no ...

    Authors: Asa J Oudes, Jared C Roach, Laura S Walashek, Lillian J Eichner, Lawrence D True, Robert L Vessella and Alvin Y Liu

    Citation: BMC Cancer 2005 5:86

    Content type: Research article

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  9. Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder with characteristic features of skin and central nervous system involvement. Gastrointestinal involvement is rare, but the risk of mali...

    Authors: Wan-Sik Lee, Yang-Seok Koh, Jung-Chul Kim, Chang-Hwan Park, Young-Eun Joo, Hyun-Soo Kim, Chol-Kyoon Cho, Sung-Kyu Choi, Jong-Sun Rew and Sei-Jong Kim

    Citation: BMC Cancer 2005 5:85

    Content type: Case report

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  10. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which plays a central role in biologic processes under hypoxic conditions, especially concerning tumour angiogenesis. HIF-1α is the relevant, oxyge...

    Authors: Thomas Fillies, Richard Werkmeister, Paul J van Diest, Burkhard Brandt, Ulrich Joos and Horst Buerger

    Citation: BMC Cancer 2005 5:84

    Content type: Research article

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  11. Currently, no satisfactory biomarkers are available to screen for lung cancer. Surface-Enhanced Laser Desorption/ionization Time-of- Flight Mass Spectrometry ProteinChip system (SELDI-TOF-MS) is one of the cur...

    Authors: Shuan-ying Yang, Xue-yuan Xiao, Wang-gang Zhang, Li-juan Zhang, Wei Zhang, Bin Zhou, Guoan Chen and Da-cheng He

    Citation: BMC Cancer 2005 5:83

    Content type: Research article

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  12. Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Eu...

    Authors: Arild Vaktskjold, Jelena A Lebedintseva, Dmitrij S Korotov, Anatolij V Tkatsjov, Tatjana S Podjakova and Eiliv Lund

    Citation: BMC Cancer 2005 5:82

    Content type: Research article

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  13. EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patie...

    Authors: Patrick R Benusiglio, Fabienne Lesueur, Craig Luccarini, Joan McIntosh, Robert N Luben, Paula Smith, Alison Dunning, Douglas F Easton, Bruce AJ Ponder and Paul D Pharoah

    Citation: BMC Cancer 2005 5:81

    Content type: Research article

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  14. Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiat...

    Authors: Ivan Presta, Franco Arturi, Elisabetta Ferretti, Tiziana Mattei, Daniela Scarpelli, Emanuele Tosi, Angela Scipioni, Marilena Celano, Alberto Gulino, Sebastiano Filetti and Diego Russo

    Citation: BMC Cancer 2005 5:80

    Content type: Research article

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  15. Brachytherapy, interstitial tumor bed irradiation, following conservative surgery has been shown to provide excellent local control and limb preservation in patients with soft tissue sarcomas (STS), whereas li...

    Authors: Tadahiko Kubo, Takashi Sugita, Shoji Shimose, Toshihiro Matsuo, Ken Hirao, Hiroaki Kimura, Masahiro Kenjo and Mitsuo Ochi

    Citation: BMC Cancer 2005 5:79

    Content type: Research article

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  16. Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from exp...

    Authors: Federica Di Nicolantonio, Stuart J Mercer, Louise A Knight, Francis G Gabriel, Pauline A Whitehouse, Sanjay Sharma, Augusta Fernando, Sharon Glaysher, Silvana Di Palma, Penny Johnson, Shaw S Somers, Simon Toh, Bernie Higgins, Alan Lamont, Tim Gulliford, Jeremy Hurren…

    Citation: BMC Cancer 2005 5:78

    Content type: Research article

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  17. Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its lim...

    Authors: Alfredo Hidalgo, Michael Baudis, Iver Petersen, Hugo Arreola, Patricia Piña, Guelaguetza Vázquez-Ortiz, Dulce Hernández, José González, Minerva Lazos, Ricardo López, Carlos Pérez, José García, Karla Vázquez, Brenda Alatorre and Mauricio Salcedo

    Citation: BMC Cancer 2005 5:77

    Content type: Research article

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  18. By modulating the expression levels of specific signal transduction molecules, the 26S proteasome plays a central role in determining cell cycle progression or arrest and cell survival or death in response to ...

    Authors: Frank Pajonk, Arndt van Ophoven, Christian Weissenberger and William H McBride

    Citation: BMC Cancer 2005 5:76

    Content type: Research article

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  19. Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC). St...

    Authors: Anna C Gustafsson, Ilya Kupershmidt, Esther Edlundh-Rose, Giulia Greco, Annalucia Serafino, Eva K Krasnowska, Thomas Lundeberg, Luisa Bracci-Laudiero, Maria-Concetta Romano, Tiziana Parasassi and Joakim Lundeberg

    Citation: BMC Cancer 2005 5:75

    Content type: Research article

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  20. Because of the high resistance rate of fibrosarcomas against cytotoxic agents clinical chemotherapy of these tumors is not established. A better understanding of the diverse modes of tumor cell death following...

    Authors: Marcus Lehnhardt, Ludger Klein-Hitpass, Cornelius Kuhnen, Heinz Herbert Homann, Adrien Daigeler, Hans Ulrich Steinau, Sonja Roehrs, Laura Schnoor, Lars Steinstraesser and Oliver Mueller

    Citation: BMC Cancer 2005 5:74

    Content type: Research article

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  21. Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by...

    Authors: Sandro J Martins, Nelson Ho, Sueli O Cavamura, Cecilia M Harada, Crystina A Yamamoto and Teresa Y Takagaki

    Citation: BMC Cancer 2005 5:72

    Content type: Research article

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  22. Combined chemoradiotherapy (CRT) is the treatment of choice for stage III NSCLC. Gemcitabine (G) is a novel deoxycitidine analogue that has been proven to be a potent radiosensitizer. Twenty-two consecutive pa...

    Authors: Ufuk Abacioglu, Perran F Yumuk, Hale Caglar, Meric Sengoz and Nazim S Turhal

    Citation: BMC Cancer 2005 5:71

    Content type: Research article

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  23. The clinical and pathological characteristics and the clinical course of patients with breast cancer and BRCA 1–2 mutation are poorly known.

    Authors: Andrea Veronesi, Clelia de Giacomi, Maria D Magri, Davide Lombardi, Martina Zanetti, Cristina Scuderi, Riccardo Dolcetti, Alessandra Viel, Diana Crivellari, Ettore Bidoli and Mauro Boiocchi

    Citation: BMC Cancer 2005 5:70

    Content type: Research article

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  24. Cervical carcinoma (CC) is one of the most common cancers among women worldwide and the first cause of death among the Mexican female population. CC progression shows a continuum of neoplastic transitions unti...

    Authors: Guelaguetza Vazquez-Ortiz, Patricia Pina-Sanchez, Karla Vazquez, Alfonso Duenas, Lucia Taja, Patricia Mendoza, José A Garcia and Mauricio Salcedo

    Citation: BMC Cancer 2005 5:68

    Content type: Research article

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    The Erratum to this article has been published in BMC Cancer 2005 5:164

  25. APC (Adenomatous polyposis coli) plays an important role in the pathogenesis of both familial and sporadic colorectal cancer. Patients carrying germline APC mutations develop multiple colonic adenomas at younger...

    Authors: Sima Salahshor, Jason Goncalves, Runjan Chetty, Steven Gallinger and James R Woodgett

    Citation: BMC Cancer 2005 5:66

    Content type: Research article

    Published on:

  26. It has been shown that free DNA circulates in serum plasma of patients with cancer and that at least part is present in the form of oligo- and monucleosomes, a marker of cell death. Preliminary data has shown ...

    Authors: Catalina Trejo-Becerril, Luis F Oñate-Ocaña, Lucía Taja-Chayeb, América Vanoye-Carlo, Lucely Cetina and Alfonso Duenas-Gonzalez

    Citation: BMC Cancer 2005 5:65

    Content type: Research article

    Published on:

  27. The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrang...

    Authors: María I Nunez, Daniel G Rosen, John H Ludes-Meyers, Martín C Abba, Hyunsuk Kil, Robert Page, Andres JP Klein-Szanto, Andrew K Godwin, Jinsong Liu, Gordon B Mills and C Marcelo Aldaz

    Citation: BMC Cancer 2005 5:64

    Content type: Research article

    Published on:

  28. P-cadherin (P-cad) is a transmembrane molecule involved in the cell-cell adhesion and similar to E-cadherin (E-cad), but less investigated in oncology, especially in in vivo studies. Aims of the present study wer...

    Authors: Lorenzo Lo Muzio, Giuseppina Campisi, Antonio Farina, Corrado Rubini, Giuseppe Pannone, Rosario Serpico, Gregorio Laino, Alfredo De Lillo and Francesco Carinci

    Citation: BMC Cancer 2005 5:63

    Content type: Research article

    Published on:

  29. Epidermal growth factor receptor (EGFR) represents a major target for current radiosensitizing strategies. We wished to ascertain whether a correlation exists between the expression of EGFR and treatment outco...

    Authors: David Azria, Frederic Bibeau, Nicolas Barbier, Abderrahim Zouhair, Claire Lemanski, Philippe Rouanet, Marc Ychou, Pierre Senesse, Mahmut Ozsahin, André Pèlegrin, Jean-Bernard Dubois and Simon Thèzenas

    Citation: BMC Cancer 2005 5:62

    Content type: Research article

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  30. Patients with advanced gallbladder and biliary tract carcinoma face a dismal prognosis, as no effective palliative chemotherapy exists. The antitumor effect of gemcitabine is schedule-dependent rather than dos...

    Authors: Stefan von Delius, Christian Lersch, Ewert Schulte-Frohlinde, Martina Mayr, Roland M Schmid and Florian Eckel

    Citation: BMC Cancer 2005 5:61

    Content type: Research article

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  31. Ex-vivo chemosensitivity tests that measure cell death induction may predict treatment outcome and, therefore, represent a powerful instrument for clinical decision making in cancer therapy. Such tests are, ho...

    Authors: Peter Staib, Jan Tiehen, Timo Strunk and Timo Schinköthe

    Citation: BMC Cancer 2005 5:60

    Content type: Research article

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  32. Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury. Ultimately, complete structural ablation will ens...

    Authors: Zahid N Rabbani, Mitchell S Anscher, Rodney J Folz, Emerald Archer, Hong Huang, Liguang Chen, Maria L Golson, Thaddeus S Samulski, Mark W Dewhirst and Zeljko Vujaskovic

    Citation: BMC Cancer 2005 5:59

    Content type: Research article

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  33. Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase do...

    Authors: Martin Deichmann, Marianne Thome, Axel Benner, Martin Kirschner, Judith Hassanzadeh and Hjalmar Kurzen

    Citation: BMC Cancer 2005 5:58

    Content type: Research article

    Published on:

  34. Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a l...

    Authors: Kjeld P van Houwelingen, Boukje AC van Dijk, Christina A Hulsbergen-van de Kaa, Leo J Schouten, Hanneke JM Gorissen, Jack A Schalken, Piet A van den Brandt and Egbert Oosterwijk

    Citation: BMC Cancer 2005 5:57

    Content type: Research article

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  35. Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with peritoneal carcinomatosis of colorectal origin. Animal models are important in the evaluation of n...

    Authors: Joerg OW Pelz, Joerg Doerfer, Werner Hohenberger and Thomas Meyer

    Citation: BMC Cancer 2005 5:56

    Content type: Research article

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  36. Hypofractionated stereotactic radiotherapy (HFSRT) is one salvage treatment option in previously irradiated patients with recurrent malignant glioma. We analyzed the results of HFSRT and prognostic factors in ...

    Authors: Dirk Vordermark, Oliver Kölbl, Klemens Ruprecht, Giles H Vince, Klaus Bratengeier and Michael Flentje

    Citation: BMC Cancer 2005 5:55

    Content type: Research article

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  37. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) selectively induces apoptosis in cancer cells but not in normal cells. Despite this promising feature, TRAIL resistance observed in cancer ...

    Authors: Ahter D Sanlioglu, Ercument Dirice, Cigdem Aydin, Nuray Erin, Sadi Koksoy and Salih Sanlioglu

    Citation: BMC Cancer 2005 5:54

    Content type: Research article

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  38. Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology of sarcomas are needed as current forms of therapy...

    Authors: Iwao Mikami, Liang You, Biao He, Zhidong Xu, Sonny Batra, Amie Y Lee, Julien Mazieres, Noemi Reguart, Kazutsugu Uematsu, Kiyoshi Koizumi and David M Jablons

    Citation: BMC Cancer 2005 5:53

    Content type: Research article

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  39. Over the last two decades time trends in incidence rates of colorectal cancer, changes in the proportions of stage at diagnosis and changes in the anatomic sub-site distribution of colon cancers have been repo...

    Authors: René Scheiden, Paul Pescatore, Yolande Wagener, Nelly Kieffer and Catherine Capesius

    Citation: BMC Cancer 2005 5:52

    Content type: Research article

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  40. Therapeutic gene transfer affords a clinically feasible and safe approach to cancer treatment but a more effective modality is needed to improve clinical outcomes. Combined transfer of therapeutic genes with d...

    Authors: Kyung-Sun Hwang, Won-Kyung Cho, Jinsang Yoo, Hwan-Jung Yun, Samyong Kim and Dong-Soo Im

    Citation: BMC Cancer 2005 5:51

    Content type: Research article

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  41. The present commonly used five-year survival rates are not adequate to represent the statistical cure. In the present study, we established the minimum number of years required for follow-up to estimate statis...

    Authors: Patricia Tai, Edward Yu, Gábor Cserni, Georges Vlastos, Melanie Royce, Ian Kunkler and Vincent Vinh-Hung

    Citation: BMC Cancer 2005 5:48

    Content type: Research article

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  42. Tumor-associated antigens are appreciated as diagnostic markers, but they have also prompted tremendous efforts to develop tumor-specific immunotherapy. A previously cloned tumor-associated antigen, EBAG9, was...

    Authors: Tatiana A Reimer, Ioannis Anagnostopoulos, Bettina Erdmann, Insa Lehmann, Harald Stein, Peter Daniel, Bernd Dörken and Armin Rehm

    Citation: BMC Cancer 2005 5:47

    Content type: Research article

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  43. Typical high throughput microarrays experiments compare gene expression across two specimen classes – an experimental class and baseline (or comparison) class. The choice of specimen classes is a major factor ...

    Authors: Uma R Chandran, Rajiv Dhir, Changqing Ma, George Michalopoulos, Michael Becich and John Gilbertson

    Citation: BMC Cancer 2005 5:45

    Content type: Research article

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