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  1. The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results...

    Authors: Reinhold Graf, Bert Hildebrandt, Wolfgang Tilly, Hanno Riess, Roland Felix, Volker Budach and Peter Wust

    Citation: BMC Cancer 2006 6:30

    Content type: Research article

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  2. The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median survival of glioblas...

    Authors: Pierre A Robe, Didier Martin, Adelin Albert, Manuel Deprez, Alain Chariot and Vincent Bours

    Citation: BMC Cancer 2006 6:29

    Content type: Study protocol

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  3. Former meta-analyses have shown a survival benefit for the addition of chemotherapy (CHX) to radiotherapy (RT) and to some extent also for the use of hyperfractionated radiation therapy (HFRT) and accelerated ...

    Authors: W Budach, T Hehr, V Budach, C Belka and K Dietz

    Citation: BMC Cancer 2006 6:28

    Content type: Research article

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  4. Hypoxia-inducible transcription factor-1α (HIF-1α), which plays an important role in controlling the hypoxia-induced glycolysis pathway, is a "master" gene in the tissue hypoxia response during tumor developme...

    Authors: FengMing Luo, XiaoJing Liu, NaiHong Yan, ShuangQing Li, GuiQun Cao, QingYing Cheng, QingJie Xia and HongJing Wang

    Citation: BMC Cancer 2006 6:26

    Content type: Research article

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  5. Although transforming growth factor β (TGF-β) typically inhibits proliferation of epithelial cells, consistent with a tumor suppressor activity, it paradoxically also exhibits pro-metastatic activity in the la...

    Authors: Christina H Stuelten, Miriam B Buck, Juergen Dippon, Anita B Roberts, Peter Fritz and Cornelius Knabbe

    Citation: BMC Cancer 2006 6:25

    Content type: Research article

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  6. Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV). Although the incidence of genital HPV infection in various population groups is high, most of these regress with...

    Authors: Vandana A Govan, Debbie Constant, Margaret Hoffman and Anna-Lise Williamson

    Citation: BMC Cancer 2006 6:24

    Content type: Research article

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  7. Human sperm protein 17 (Sp17) is a highly conserved protein that was originally isolated from a rabbit epididymal sperm membrane and testis membrane pellet. It has recently been included in the cancer/testis (...

    Authors: Fabio Grizzi, Paolo Gaetani, Barbara Franceschini, Antonio Di Ieva, Piergiuseppe Colombo, Giorgia Ceva-Grimaldi, Angelo Bollati, Eldo E Frezza, E Cobos, Riccardo Rodriguez y Baena, Nicola Dioguardi and Maurizio Chiriva-Internati

    Citation: BMC Cancer 2006 6:23

    Content type: Research article

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  8. Kinesin spindle proteins (KSP) are motor proteins that play an essential role in mitotic spindle formation. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell...

    Authors: David A Davis, Sarah H Sarkar, Maha Hussain, Yiwei Li and Fazlul H Sarkar

    Citation: BMC Cancer 2006 6:22

    Content type: Research article

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  9. Mutations in the mitochondrial DNA (mtDNA) have been reported in a wide variety of human neoplasms. A polynucleotide tract extending from 303 to 315 nucleotide positions (D310) within the non-coding region of ...

    Authors: Cenk Aral, Handan Kaya, Çiğdem Ataizi-Çelikel, Mustafa Akkiprik, Özgür Sönmez, Bahadır M Güllüoğlu and Ayşe Özer

    Citation: BMC Cancer 2006 6:21

    Content type: Technical advance

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  10. Haematological cancer is characterised by chromosomal translocation (e.g. MLL translocation in acute leukaemia) and two models have been proposed to explain the origins of recurrent reciprocal translocation. T...

    Authors: Michaël Gué, Jian-Sheng Sun and Thomas Boudier

    Citation: BMC Cancer 2006 6:20

    Content type: Research article

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  11. BACH1 (BRCA1-associated C-terminal helicase 1; also known as BRCA1-interacting protein 1, BRIP1) is a helicase protein that interacts in vivo with BRCA1, the protein product of one of the major genes for heredita...

    Authors: Pia Vahteristo, Kristiina Yliannala, Anitta Tamminen, Hannaleena Eerola, Carl Blomqvist and Heli Nevanlinna

    Citation: BMC Cancer 2006 6:19

    Content type: Research article

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  12. Members of the matrix metalloproteinase (MMP) family of proteases are required for the degradation of the basement membrane and extracellular matrix in both normal and pathological conditions. In vitro, MT1-MMP (...

    Authors: Larisa M Haupt, Erik W Thompson, Ann EO Trezise, Rachel E Irving, Michael G Irving and Lyn R Griffiths

    Citation: BMC Cancer 2006 6:18

    Content type: Research article

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  13. The reduced mortality rate from breast carcinoma among women offered screening mammography is demonstrated after 15–20 years of follow-up. However, the assessment of 5-year overall and event-free survival coul...

    Authors: Laura Cortesi, Vincenzo E Chiuri, Silvia Ruscelli, Valeria Bellelli, Rossella Negri, Ivan Rashid, Claudia Cirilli, Antonella Fracca, Ennio Gallo and Massimo Federico

    Citation: BMC Cancer 2006 6:17

    Content type: Research article

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  14. Angiomotin is a newly discovered molecule that regulates the migration and tubule formation of endothelial cells. It therefore has been implicated in the control of angiogenesis under physiological and patholo...

    Authors: Wen G Jiang, Gareth Watkins, Anthony Douglas-Jones, Lars Holmgren and Robert E Mansel

    Citation: BMC Cancer 2006 6:16

    Content type: Research article

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  15. After development of hormone-refractory metastatic disease, prostate cancer is incurable. The recent history of chemotherapy has shown that with difficult disease targets, combinatorial therapy frequently offe...

    Authors: Kristen D Brubaker, Lisha G Brown, Robert L Vessella and Eva Corey

    Citation: BMC Cancer 2006 6:15

    Content type: Research article

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  16. The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid chelidonine and the alkylans thiotepa was reported to exert se...

    Authors: Daniel Habermehl, Bernd Kammerer, René Handrick, Therese Eldh, Charlotte Gruber, Nils Cordes, Peter T Daniel, Ludwig Plasswilm, Michael Bamberg, Claus Belka and Verena Jendrossek

    Citation: BMC Cancer 2006 6:14

    Content type: Research article

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  17. Mediterranean societies, with diets rich in vitamin E isoforms, have a lower risk for colon cancer than those of northern Europe and the Americas. Vitamin E rich diets may neutralize free radicals generated by...

    Authors: Sharon E Campbell, William L Stone, Steven Lee, Sarah Whaley, Hongsong Yang, Min Qui, Paige Goforth, Devin Sherman, Derek McHaffie and Koyamangalath Krishnan

    Citation: BMC Cancer 2006 6:13

    Content type: Research article

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  18. The extracellular matrix has a major effect upon the malignant properties of bladder cancer cells both in vitro in 3-dimensional culture and in vivo. Comparing gene expression of several bladder cancer cells line...

    Authors: Mikhail G Dozmorov, Kimberly D Kyker, Ricardo Saban, Nicholas Knowlton, Igor Dozmorov, Michael B Centola and Robert E Hurst

    Citation: BMC Cancer 2006 6:12

    Content type: Research article

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  19. Intermediary filaments are involved in cell motility and cancer progression. In a variety of organs, the expression of distinct intermediary filaments are associated with patient prognosis. In this study, we s...

    Authors: Thomas Fillies, Richard Werkmeister, Jens Packeisen, Burkhard Brandt, Philippe Morin, Dieter Weingart, Ulrich Joos and Horst Buerger

    Citation: BMC Cancer 2006 6:10

    Content type: Research article

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  20. The inhibition of angiogenesis is a promising strategy for the treatment of malignant primary and secondary tumors in addition to established therapies such as surgery, chemotherapy, and radiation. There is st...

    Authors: Frank Michael Klenke, Martha-Maria Gebhard, Volker Ewerbeck, Amir Abdollahi, Peter E Huber and Axel Sckell

    Citation: BMC Cancer 2006 6:9

    Content type: Research article

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  21. Previously we have generated the monoclonal antibody SM5-1 by using a subtractive immunization protocol of human melanoma. This antibody exhibits a high sensitivity for primary melanomas of 99% (248/250 tested...

    Authors: Uwe Trefzer, Yingwen Chen, Gunda Herberth, Maja Ann Hofmann, Felix Kiecker, Yajun Guo and Wolfram Sterry

    Citation: BMC Cancer 2006 6:8

    Content type: Research article

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  22. Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA) as a promising treatment for atopic dermatitis, it has been approved in more than 30 additional countries, including numero...

    Authors: Jürgen C Becker, Roland Houben, Claudia S Vetter and Eva B Bröcker

    Citation: BMC Cancer 2006 6:7

    Content type: Case report

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  23. We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the generation of endopolyploid cells. A proport...

    Authors: Martins Kalejs, Andrey Ivanov, Gregory Plakhins, Mark S Cragg, Dzintars Emzinsh, Timothy M Illidge and Jekaterina Erenpreisa

    Citation: BMC Cancer 2006 6:6

    Content type: Research article

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  24. Carboplatin/paclitaxel is the chemotherapy of choice for advanced ovarian cancer, both in first line and in platinum-sensitive recurrence. Although a significant proportion of patients have some neurotoxicity ...

    Authors: Sandro Pignata, Sabino De Placido, Rosalbino Biamonte, Giovanni Scambia, Giovanni Di Vagno, Giuseppe Colucci, Antonio Febbraro, Marco Marinaccio, Alessandra Vernaglia Lombardi, Luigi Manzione, Giacomo Cartenì, Mario Nardi, Saverio Danese, Maria Rosaria Valerio, Andrea de Matteis, Bruno Massidda…

    Citation: BMC Cancer 2006 6:5

    Content type: Research article

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  25. Pleuropulmonary blastoma (PPB) is a rare childhood dysontogenetic intrathoracic neoplasm associated with an unfavourable clinical behaviour.

    Authors: Benoit Quilichini, Nicolas Andre, Corinne Bouvier, Marie-Anne Chrestian, Angelique Rome, Dominique Intagliata, Carole Coze, Gabriel Lena and Helene Zattara

    Citation: BMC Cancer 2006 6:4

    Content type: Case report

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  26. Although numerous chemotherapeutic agents have been tested, the role of systemic chemotherapy for hepatocellular carcinoma (HCC) has not been clarified. New therapeutic strategies are thus needed to improve ou...

    Authors: Se Hoon Park, Yuna Lee, Sang Hoon Han, So Young Kwon, Oh Sang Kwon, Sun Suk Kim, Ju Hyun Kim, Yeon Ho Park, Jeong Nam Lee, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin and Jae Hoon Lee

    Citation: BMC Cancer 2006 6:3

    Content type: Research article

    Published on:

  27. Glioblastoma multiforme is the most malignant form of brain tumor. Despite treatment including surgical resection, adjuvant chemotherapy, and radiation, these tumors typically recur. The recurrent tumor is oft...

    Authors: Nicole C Hank, Joan Rankin Shapiro and Adrienne C Scheck

    Citation: BMC Cancer 2006 6:2

    Content type: Research article

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  28. Cisplatin is widely used as an antineoplastic agent since it is effective against a broad spectrum of different tumours. Nevertheless, it has several potential side effects affecting different organ systems an...

    Authors: Guenter Hofmann, Thomas Bauernhofer, Peter Krippl, Doris Lang-Loidolt, Sabine Horn, Walter Goessler, Walter Schippinger, Ferdinand Ploner, Herbert Stoeger and Hellmut Samonigg

    Citation: BMC Cancer 2006 6:1

    Content type: Case report

    Published on:

  29. Minichromosome maintenance (MCM) proteins are essential for the initiation of DNA replication and have been found to be relevant markers for prognosis in a variety of tumours. The aim of this study was to asse...

    Authors: Ellen C Obermann, Philip Went, Annette Zimpfer, Alexandar Tzankov, Peter J Wild, Robert Stoehr, Stefano A Pileri and Stephan Dirnhofer

    Citation: BMC Cancer 2005 5:162

    Content type: Research article

    Published on:

  30. The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch rep...

    Authors: Margreet Lüchtenborg, Matty P Weijenberg, Petra A Wark, A Merdan Saritas, Guido MJM Roemen, Goos NP van Muijen, Adriaan P de Bruïne, Piet A van den Brandt and Anton FPM de Goeij

    Citation: BMC Cancer 2005 5:160

    Content type: Research article

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  31. Eighty percent of all breast cancers and almost 90% of breast cancer deaths occur among post-menopausal women. We used a nested case control design to examine the association between nonsteroidal anti-inflamma...

    Authors: Elham Rahme, Joumana Ghosn, Kaberi Dasgupta, Raghu Rajan and Marie Hudson

    Citation: BMC Cancer 2005 5:159

    Content type: Research article

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  32. Lung cancer is relatively resistant to radiation treatment and radiation pneumonitis is a major obstacle to increasing the radiation dose. We previously showed that Caffeic acid phenethyl ester (CAPE) induces ...

    Authors: Miao-Fen Chen, Peter C Keng, Paul-Yang Lin, Cheng-Ta Yang, Shuen-Kuei Liao and Wen-Cheng Chen

    Citation: BMC Cancer 2005 5:158

    Content type: Research article

    Published on:

  33. Several malignancies have been described in association with inflammatory bowel diseases, the most common being adenocarcinoma. Carcinoid tumor and Crohn disease has also been previously reported, however the ...

    Authors: Ugo Cioffi, Matilde De Simone, Stefano Ferrero, Michele M Ciulla, Alessandro Lemos and Ettore Contessini Avesani

    Citation: BMC Cancer 2005 5:157

    Content type: Case report

    Published on:

  34. The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathol...

    Authors: Jay W Tichelaar, Yu Zhang, Jean C leRiche, Paul W Biddinger, Stephen Lam and Marshall W Anderson

    Citation: BMC Cancer 2005 5:155

    Content type: Research article

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  35. Neogenin is expressed in cap cells that have been suggested to be mammary stem or precursor cells. Neogenin is known to play an important role in mammary morphogenesis; however its relationship to tumorigenesi...

    Authors: Jeong Eon Lee, Hee Joung Kim, Ji Yeon Bae, Seok Won Kim, Joon-Suk Park, Hyuk Jai Shin, Wonshik Han, Sung-Won Kim, Kyung-Sun Kang and Dong-Young Noh

    Citation: BMC Cancer 2005 5:154

    Content type: Research article

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  36. Hypoxia compromises local control in patients with head-and-neck cancer (HNC). In order to determine the value of [18F]-fluoromisonidazole (Fmiso) with regard to tumor hypoxia, a patient study with dynamic Fmiso ...

    Authors: Daniela Thorwarth, Susanne-Martina Eschmann, Jutta Scheiderbauer, Frank Paulsen and Markus Alber

    Citation: BMC Cancer 2005 5:152

    Content type: Research article

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  37. This phase II study evaluated the efficacy and safety of gemcitabine (G) plus paclitaxel (T) as first-line therapy in recurrent or metastatic breast cancer.

    Authors: Djelila Allouache, Sulochana R Gawande, Michele Tubiana-Hulin, Nicole Tubiana-Mathieu, Sophie Piperno-Neumann, Fawzia Mefti, Laurence Bozec and Jean-Yves Genot

    Citation: BMC Cancer 2005 5:151

    Content type: Research article

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  38. Squamous cell carcinomos may arise from chronic ulcerating wounds in scars, most commonly postburn scars. Tumour growth usually takes place over months to years. Localization on the scalp is a relatively rare ...

    Authors: Raymund E Horch, G Bjoern Stark and Justus P Beier

    Citation: BMC Cancer 2005 5:150

    Content type: Case report

    Published on:

  39. The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.

    Authors: George N Tzimas, Eric Chevet, Sarah Jenna, Duc Thang Nguyên, Abdel M Khatib, Victoria Marcus, Yi Zhang, Michel Chrétien, Nabil Seidah and Peter Metrakos

    Citation: BMC Cancer 2005 5:149

    Content type: Research article

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  40. Steroid action is mediated, in addition to classical intracellular receptors, by recently identified membrane sites, that generate rapid non-genomic effects. We have recently identified a membrane androgen rec...

    Authors: Constantina Dambaki, Christina Kogia, Marilena Kampa, Katherine Darivianaki, Michael Nomikos, Ploutarchos Anezinis, Panayiotis A Theodoropoulos, Elias Castanas and Efstathios N Stathopoulos

    Citation: BMC Cancer 2005 5:148

    Content type: Research article

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  41. Median survival of metastatic malignant melanoma is 6.0 to 7.5 months, with a 5-year survival of ~6.0%. Although long-term complete remissions are rare, few reports describe cases after chemotherapy. Fifty-thr...

    Authors: Xavier Durando, Emilie Thivat, Michel D'Incan, Anne Sinsard, Jean-Claude Madelmont and Philippe Chollet

    Citation: BMC Cancer 2005 5:147

    Content type: Case report

    Published on:

  42. Inflammation is commonly associated with lung tumors. Since inflammatory mediators, including members of the interleukin-6 (IL-6) cytokine family, suppress proliferation of normal epithelial cells, we hypothes...

    Authors: Gregory M Loewen, Erin Tracy, Frédéric Blanchard, Dongfeng Tan, Jihnhee Yu, Sameera Raza, Sei-Ichi Matsui and Heinz Baumann

    Citation: BMC Cancer 2005 5:145

    Content type: Research article

    Published on:

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