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  1. Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by t...

    Authors: Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Katrin Orlowski, Martin Pruschy and Rolf A Stahel
    Citation: BMC Cancer 2012 12:571
  2. Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to m...

    Authors: Isabela Martins Gonzaga, Sheila Coelho Soares-Lima, Paulo Thiago Souza de Santos, Tania Cristina Moita Blanco, Bruno Souza Bianchi de Reis, Danielle Carvalho Quintella, Ivanir Martins de Oliveira, Paulo Antonio Silvestre de Faria, Cleber Dario Pinto Kruel, Nelson Adami Andreollo, Tatiana Almeida de Simão and Luis Felipe Ribeiro Pinto
    Citation: BMC Cancer 2012 12:569
  3. Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile o...

    Authors: Lu Gan, Jian He, Xia Zhang, Yong-Jie Zhang, Guan-Zhen Yu, Ying Chen, Jun Pan, Jie-Jun Wang and Xi Wang
    Citation: BMC Cancer 2012 12:566
  4. Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1,...

    Authors: Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren and Stephen Safe
    Citation: BMC Cancer 2012 12:564
  5. Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for th...

    Authors: Mamduh Khateb, Nili Ruimi, Hazem Khamisie, Yousef Najajreh, Afsar Mian, Anna Metodieva, Martin Ruthardt and Jamal Mahajna
    Citation: BMC Cancer 2012 12:563
  6. Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant sys...

    Authors: Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler and Marcus Schmidt
    Citation: BMC Cancer 2012 12:562
  7. Vaccination against tumor-associated antigens is one promising approach to immunotherapy against malignant gliomas. While previous vaccine efforts have focused exclusively on HLA class I-restricted peptides, c...

    Authors: Shinji Shimato, Lisa M Maier, Richard Maier, Jeffrey N Bruce, Richard CE Anderson and David E Anderson
    Citation: BMC Cancer 2012 12:561
  8. This study aimed to systematically review the evidence from randomized controlled trials (RCTs) and to conduct a meta-analysis of the effects of yoga on physical and psychosocial outcomes in cancer patients an...

    Authors: Laurien M Buffart, Jannique GZ van Uffelen, Ingrid I Riphagen, Johannes Brug, Willem van Mechelen, Wendy J Brown and Mai JM Chinapaw
    Citation: BMC Cancer 2012 12:559
  9. Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) is used for the patients with EGFR-mutant lung cancer. Recently, phase...

    Authors: Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima, Yoshihito Tanaka, Michiko Shimada, Akira Kurose, Shingo Takanashi and Ken Okumura
    Citation: BMC Cancer 2012 12:558
  10. While knowledge and risk perception have been associated with screening for second primary cancer (SPC), there are no clinically useful indicators to identify who is at risk of not being properly screened for ...

    Authors: Beomseok Suh, Dong Wook Shin, So Young Kim, Jae-Hyun Park, Weon Young Chang, Seung Pyung Lim, Chang-Yeol Yim, Be-Long Cho, Eun-Cheol Park and Jong-Hyock Park
    Citation: BMC Cancer 2012 12:557
  11. Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomyci...

    Authors: Selena Z Kuo, Katherine J Blair, Elham Rahimy, Alan Kiang, Eric Abhold, Jian-Bing Fan, Jessica Wang-Rodriguez, Xabier Altuna and Weg M Ongkeko
    Citation: BMC Cancer 2012 12:556
  12. Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in th...

    Authors: Arlene Chan, Adrienne Morey, Belinda Brown, Diana Hastrich, Peter Willsher and David Ingram
    Citation: BMC Cancer 2012 12:555
  13. As high percentage of mammographic densities complicates the assessment of imaging findings, mammographic density may influence the histopathological evaluation of core-biopsies of the breast. We measured the ...

    Authors: Pietro Trocchi, Giske Ursin, Oliver Kuss, Kathrin Ruschke, Andrea Schmidt-Pokrzywniak, Hans-Jürgen Holzhausen, Thomas Löning, Christoph Thomssen, Werner Böcker, Alexander Kluttig and Andreas Stang
    Citation: BMC Cancer 2012 12:554
  14. There is partially conflicting evidence on the influence of the steroid hormones estrogen (E) and progesterone (P) on the development of ovarian cancer (OC). The aim of this study was to assess the expression ...

    Authors: Miriam Lenhard, Lennerová Tereza, Sabine Heublein, Nina Ditsch, Isabelle Himsl, Doris Mayr, Klaus Friese and Udo Jeschke
    Citation: BMC Cancer 2012 12:553
  15. Rare, heterozygous germline mutations in the RAD51C gene have been found in breast and ovarian cancer families. In the Finnish population, we have identified two founder mutations in RAD51C that increase the risk...

    Authors: Liisa M Pelttari, Riikka Nurminen, Alexandra Gylfe, Lauri A Aaltonen, Johanna Schleutker and Heli Nevanlinna
    Citation: BMC Cancer 2012 12:552
  16. Quantitative methylation-specific PCR (qMSP) analysis for determining the methylation status of (candidate) tumor suppressor genes has potential as objective and valuable test to triage high-risk human papillo...

    Authors: Suzanne Snellenberg, Lise MA De Strooper, Albertus T Hesselink, Chris JLM Meijer, Peter JF Snijders, Daniëlle AM Heideman and Renske DM Steenbergen
    Citation: BMC Cancer 2012 12:551
  17. Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Ne...

    Authors: Arturo Aguilar-Rojas, Maira Huerta-Reyes, Guadalupe Maya-Núñez, Fabián Arechavaleta-Velásco, P Michael Conn, Alfredo Ulloa-Aguirre and Jesús Valdés
    Citation: BMC Cancer 2012 12:550
  18. The primary objective of this study was to test whether oncolytic herpes simplex virus type 1 (HSV1) could eradicate chemoresistant cancer stem cells (CSCs).

    Authors: Xiufen Zhuang, Wen Zhang, Yatong Chen, Xiangping Han, Jie Li, Yu Zhang, Youhui Zhang, Shuren Zhang and Binlei Liu
    Citation: BMC Cancer 2012 12:549
  19. Cancer is an extremely heterogeneous group of diseases traditionally categorized according to tissue of origin. However, even among patients with the same cancer subtype the cellular alterations at the molecul...

    Authors: Lasse Sommer Kristensen, Tina Ellegaard Kjeldsen, Henrik Hager and Lise Lotte Hansen
    Citation: BMC Cancer 2012 12:548
  20. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Current therapies are insufficient, making HCC an intractable disease. Our previous studies confirmed that inhibi...

    Authors: Wei Li, Dao-Ming Li, Kai Chen, Zheng Chen, Yang Zong, Hong Yin, Ze-Kuan Xu, Yi Zhu, Fei-Ran Gong and Min Tao
    Citation: BMC Cancer 2012 12:547
  21. A growing body of evidence suggests that microRNAs (miRNAs) play an important role in cancer diagnosis and therapy. MicroRNA-99a (miR-99a), a potential tumor suppressor, is downregulated in several human malig...

    Authors: Li Cui, Hua Zhou, Hu Zhao, Yaojun Zhou, Renfang Xu, Xianlin Xu, Lu Zheng, Zhong Xue, Wei Xia, Bo Zhang, Tao Ding, Yunjie Cao, Zinong Tian, Qianqian Shi and Xiaozhou He
    Citation: BMC Cancer 2012 12:546

    The Correction to this article has been published in BMC Cancer 2021 21:103

  22. Obesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pat...

    Authors: Andreas Hillenbrand, Juliane Fassler, Nadine Huber, Pengfei Xu, Doris Henne-Bruns, Markus Templin, Hubert Schrezenmeier, Anna Maria Wolf and Uwe Knippschild
    Citation: BMC Cancer 2012 12:545
  23. High interstitial fluid pressure (IFP) in the primary tumor is associated with poor disease-free survival in locally advanced cervical carcinoma. A noninvasive assay is needed to identify cervical cancer patie...

    Authors: Tord Hompland, Christine Ellingsen and Einar K Rofstad
    Citation: BMC Cancer 2012 12:544
  24. Prostate cancer (PCa), a leading cause of cancer death in North American men, displays a broad range of clinical outcome from relatively indolent to lethal metastatic disease. Several genomic alterations have ...

    Authors: Khalil Choucair, Joshua Ejdelman, Fadi Brimo, Armen Aprikian, Simone Chevalier and Jacques Lapointe
    Citation: BMC Cancer 2012 12:543
  25. In 2006, we reported the effectiveness of chemoradiotherapy for postoperative recurrent esophageal cancer with a median observation period of 18 months. The purpose of the present study was to update the resul...

    Authors: Keiichi Jingu, Haruo Matsushita, Ken Takeda, Rei Umezawa, Chiaki Takahashi, Toshiyuki Sugawara, Masaki Kubozono, Keiko Abe, Takaya Tanabe, Yuko Shirata, Takaya Yamamoto, Youjirou Ishikawa and Kenji Nemoto
    Citation: BMC Cancer 2012 12:542
  26. It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. Mcl-1 is a critical survival...

    Authors: Chander Peddaboina, Daniel Jupiter, Steven Fletcher, Jeremy L Yap, Arun Rai, Richard P Tobin, Weihua Jiang, Philip Rascoe, M Karen Newell Rogers, W Roy Smythe and Xiaobo Cao
    Citation: BMC Cancer 2012 12:541
  27. Circulating tumour cells (CTC) are an important indicator of metastasis and associated with a poor prognosis. Detection sensitivity and specificity of CTC in the peripheral blood of metastatic cancer patient r...

    Authors: Ranjana Mitra, Olivia Chao, Yasuyo Urasaki, Oscar B Goodman and Thuc T Le
    Citation: BMC Cancer 2012 12:540
  28. Malignant breast neoplasms are among the most frequent forms of cancer in the Western world. Conventional treatment of breast cancer may include surgery, hormonal therapy, chemotherapy, radiation and/or immuno...

    Authors: Gustav J Dobos, Petra Voiss, Ilka Schwidde, Kyung-Eun Choi, Anna Paul, Barbara Kirschbaum, Felix J Saha and Sherko Kuemmel
    Citation: BMC Cancer 2012 12:539
  29. Clear cell sarcoma (CCS) and malignant melanoma share overlapping immunohistochemistry with regard to the melanocytic markers HMB45, S100, and Melan-A. However, the translocation t(12; 22)(q13; q12) is specifi...

    Authors: Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Yuji Hirata, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji and Toshiaki Hanafusa
    Citation: BMC Cancer 2012 12:538
  30. Small-cell lung carcinoma (SCLC) is a neuroendocrine tumor subtype and comprises approximately 15% of lung cancers. Because SCLC is still a disease with a poor prognosis and limited treatment options, there is...

    Authors: Hideki Makinoshima, Genichiro Ishii, Motohiro Kojima, Satoshi Fujii, Youichi Higuchi, Takeshi Kuwata and Atsushi Ochiai
    Citation: BMC Cancer 2012 12:537
  31. A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, ...

    Authors: D Alan Anthoney, Jay Naik, Iain RJ MacPherson, Donna Crawford, John M Hartley, Janet A Hartley, Tomohisa Saito, Masaichi Abe, Keith Jones, Masanori Miwa, Christopher Twelves and TRJ Evans
    Citation: BMC Cancer 2012 12:536
  32. Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site (LCS6) within the 3untranslated region (3UTR) of KRAS (rs61764370) and clinical outcome in metastatic co...

    Authors: Janne B Kjersem, Tone Ikdahl, Tormod Guren, Eva Skovlund, Halfdan Sorbye, Julian Hamfjord, Per Pfeiffer, Bengt Glimelius, Christian Kersten, Hiroko Solvang, Kjell M Tveit and Elin H Kure
    Citation: BMC Cancer 2012 12:534
  33. Human Papillomavirus (HPV) genotype distribution and co-infection occurrence was studied in cervical specimens from the city of Madrid (Spain), as a contribution to the knowledge of Human Papillomavirus genoty...

    Authors: Benjamín García-Espinosa, Ernesto Moro-Rodríguez and Emilio Álvarez-Fernández
    Citation: BMC Cancer 2012 12:533
  34. Pituitary tumor-transforming gene (PTTG) is an oncogene that is overexpressed in variety of tumors and exhibits characteristics of a transforming gene. Previous transgenic mouse models to access the tumorigeni...

    Authors: Miranda Y Fong, Hanan Farghaly and Sham S Kakar
    Citation: BMC Cancer 2012 12:532
  35. Hereditary Breast and Ovarian Cancer Syndrome (HBOCS) and Hereditary Non-Polyposis Colorectal Cancer Syndrome (HNPCC, Lynch Syndrome) are two tumor predisposition syndromes responsible for the majority of here...

    Authors: Karin Kast, Teresa M Neuhann, Heike Görgens, Kerstin Becker, Katja Keller, Barbara Klink, Daniela Aust, Wolfgang Distler, Evelin Schröck and Hans K Schackert
    Citation: BMC Cancer 2012 12:531
  36. One third of all cancer patients will develop bone metastases and the vertebral column is involved in approximately 70% of these patients. Conventional radiotherapy with of 1–10 fractions and total doses of 8-...

    Authors: Matthias Guckenberger, Maria Hawkins, Michael Flentje and Reinhart A Sweeney
    Citation: BMC Cancer 2012 12:530
  37. Gail and others developed a model (GAIL) using age-at-menarche, age-at-birth of first live child, number of previous benign breast biopsy examinations, and number of first-degree-relatives with breast cancer a...

    Authors: Fei Gao, David Machin, Khuan-Yew Chow, Yu-Fan Sim, Stephen W Duffy, David B Matchar, Chien-Hui Goh and Kee-Seng Chia
    Citation: BMC Cancer 2012 12:529
  38. Genetic polymorphism (rs762551A>C) in gene encoding cytochrome P450 1A2 (CYP1A2) has been shown to influence the inducibility of CYP1A2 expression and thus might be associated with risk of several types of human ...

    Authors: Hongge Wang, Zhi Zhang, Sugui Han, Yujuan Lu, Fumin Feng and Juxiang Yuan
    Citation: BMC Cancer 2012 12:528
  39. Most cancer deaths are caused by metastases, resulting from circulating tumor cells (CTC) that detach from the primary cancer and survive in distant organs. The aim of the present study was to develop a CTC ge...

    Authors: Gregory Sergeant, Rudy van Eijsden, Tania Roskams, Victor Van Duppen and Baki Topal
    Citation: BMC Cancer 2012 12:527
  40. In this meta-analysis we aimed to determine the effectiveness and safety of hyperthermic intraperitoneal chemotherapy (HIPC) for patients with advanced gastric cancer who underwent gastrectomy.

    Authors: Jingxu Sun, Yongxi Song, Zhenning Wang, Peng Gao, Xiaowan Chen, Yingying Xu, Jiwang Liang and Huimian Xu
    Citation: BMC Cancer 2012 12:526
  41. Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the Alberta Moving Be

    Authors: Kerry S Courneya, Jeff K Vallance, S Nicole Culos-Reed, Margaret L McNeely, Gordon J Bell, John R Mackey, Yutaka Yasui, Yan Yuan, Charles E Matthews, David CW Lau, Diane Cook and Christine M Friedenreich
    Citation: BMC Cancer 2012 12:525
  42. The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. However, its prognostic role in metastatic gastric or gastroesophageal junction (GE) cancer has not be...

    Authors: Akin Atmaca, Dominique Werner, Claudia Pauligk, Kristina Steinmetz, Ralph Wirtz, Hans-Michael Altmannsberger, Elke Jäger and Salah-Eddin Al-Batran
    Citation: BMC Cancer 2012 12:524
  43. Thyroid cancer is among the fastest growing malignancies; almost fifty-percent of these rapidly increasing incidence tumors are less than or equal to 1cm in size, termed papillary thyroid microcarcinoma (PTMC)...

    Authors: Tada Kunavisarut, Ipshita Kak, Christina MacMillan, Ranju Ralhan and Paul G Walfish
    Citation: BMC Cancer 2012 12:523
  44. Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to ...

    Authors: Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam, Vijayaragavan Muralidharan and Christopher Christophi
    Citation: BMC Cancer 2012 12:522
  45. Identification of new cancer antigens is necessary for the efficient diagnosis and immunotherapy. A variety of tumor antigens have been identified by several methodologies. Among those antigens, cancer/testis ...

    Authors: Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama and Toshiro Ono
    Citation: BMC Cancer 2012 12:520
  46. A population-based breast cancer screening programme was implemented in the Central Denmark Region in 2008–09. The objective of this registry-based study was to examine the association between socio-demographi...

    Authors: Line Flytkjær Jensen, Anette Fischer Pedersen, Berit Andersen and Peter Vedsted
    Citation: BMC Cancer 2012 12:518
  47. The histone demethylase GASC1 (JMJD2C) is an epigenetic factor suspected of involvement in development of different cancers, including breast cancer. It is thought to be overexpressed in the more aggressive br...

    Authors: Bozena Berdel, Kaisa Nieminen, Ylermi Soini, Maria Tengström, Marjo Malinen, Veli-Matti Kosma, Jorma J Palvimo and Arto Mannermaa
    Citation: BMC Cancer 2012 12:516

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