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  1. Whether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colore...

    Authors: Peng Gao, Yong-xi Song, Zhen-ning Wang, Ying-ying Xu, Lin-lin Tong, Jing-xu Sun, Miao Yu and Hui-mian Xu
    Citation: BMC Cancer 2013 13:123
  2. Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study...

    Authors: Jorge Félix, Filipa Aragão, João M Almeida, Frederico JM Calado, Diana Ferreira, António BS Parreira, Ricardo Rodrigues and João FR Rijo
    Citation: BMC Cancer 2013 13:122
  3. The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcom...

    Authors: Sant P Chawla, Arthur Staddon, Andrew Hendifar, Conrad A Messam, Rita Patwardhan and Yasser Yasser Mostafa Kamel
    Citation: BMC Cancer 2013 13:121
  4. The use of bevacizumab in combination with fluoropyrimidine-containing chemotherapy is a well-established first-line and second-line treatment for patients with metastatic colorectal cancer (mCRC). However, th...

    Authors: Stephen Clarke, Matt Burge, Cassandra Cordwell, Peter Gibbs, William Reece and Niall Tebbutt
    Citation: BMC Cancer 2013 13:120
  5. Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH)2D3 (50-100nM). Our ai...

    Authors: Cintia Milani, Maria Lucia Hirata Katayama, Eduardo Carneiro de Lyra, JoEllen Welsh, Laura Tojeiro Campos, M Mitzi Brentani, Maria do Socorro Maciel, Rosimeire Aparecida Roela, Paulo Roberto del Valle, João Carlos Guedes Sampaio Góes, Suely Nonogaki, Rodrigo Esaki Tamura and Maria Aparecida Azevedo Koike Folgueira
    Citation: BMC Cancer 2013 13:119
  6. The purpose of this study is to evaluate the prognostic value of TFPI-2 expression in breast cancer patients through examining the correlation between TFPI-2 expression and breast cancer clinicopathologic feat...

    Authors: Cheng Xu, Huijun Wang, Hongyu He, Fengyun Zheng, Yating Chen, Jin Zhang, Xiaoyan Lin, Duan Ma and Hongwei Zhang
    Citation: BMC Cancer 2013 13:118
  7. Cytogenetic and gene expression analyses in head and neck squamous cell carcinomas (HNSCC) have allowed identification of genomic aberrations that may contribute to cancer pathophysiology. Nevertheless, the mo...

    Authors: Sandra Bernaldo de Quirós, Anna Merlo, Pablo Secades, Iriana Zambrano, Ines Saenz de Santa María, Nerea Ugidos, Eloisa Jantus-Lewintre, Rafael Sirera, Carlos Suarez and María-Dolores Chiara
    Citation: BMC Cancer 2013 13:116
  8. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of the estrogen receptors (ERs) alpha and beta, is a potential proto-oncogene in hormone dependent gynecological malignancies. To bet...

    Authors: Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller and Stephan Polterauer
    Citation: BMC Cancer 2013 13:115
  9. The management of advanced stage non-small cell lung cancer is increasingly based on diagnostic and predictive analyses performed mostly on limited amounts of tumor tissue. The evaluation of Epidermal Growth F...

    Authors: Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia, Daniela Giachino, Paolo De Giuli, Mara Ardine, Silvia Novello, Marco Volante, Giorgio V Scagliotti and Mauro Papotti
    Citation: BMC Cancer 2013 13:114
  10. Despite the potential of improving the delivery of epigenetic drugs, the subsequent assessment of changes in their epigenetic activity is largely dependent on the availability of a suitable and rapid screening...

    Authors: Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge and David F Callen
    Citation: BMC Cancer 2013 13:113
  11. The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on t...

    Authors: Julia M Langton, Nicole Pesa, Shelley Rushton, Robyn L Ward and Sallie-Anne Pearson
    Citation: BMC Cancer 2013 13:112
  12. We sought to identify high-risk areas of pancreatic cancer incidence, and determine if clusters of persons diagnosed with pancreatic cancer were more likely to be located near arsenic-contaminated drinking wat...

    Authors: Wen Liu-Mares, Jill A MacKinnon, Recinda Sherman, Lora E Fleming, Caio Rocha-Lima, Jennifer J Hu and David J Lee
    Citation: BMC Cancer 2013 13:111
  13. Experimental data suggest that mitochondria is involved in tumorigenesis. However, little is known about the qualitative and quantitative changes of mtDNA in colorectal cancer tissues. We therefore conducted p...

    Authors: HaiHong Cui, Ping Huang, ZhiJing Wang, YunXin Zhang, ZhenHua Zhang, Wei Xu, XiaoPeng Wang, Ying Han and XiaoMing Guo
    Citation: BMC Cancer 2013 13:110
  14. Solitary Fibrous Tumor is a rare type of soft tissue tumor of intermediate malignant potential which may recur or metastasize in 15-20% of cases. Data on the management of patients with advanced SFT is scarce:...

    Authors: Alice Levard, Olfa Derbel, Pierre Méeus, Dominique Ranchère, Isabelle Ray-Coquard, Jean-Yves Blay and Philippe A Cassier
    Citation: BMC Cancer 2013 13:109
  15. High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not bee...

    Authors: Lin Zhang, Gang Huang, Xiaowu Li, Yujun Zhang, Yan Jiang, Junjie Shen, Jia Liu, Qingliang Wang, Jin Zhu, Xiaobin Feng, Jiahong Dong and Cheng Qian
    Citation: BMC Cancer 2013 13:108
  16. Glioblastoma is one of the intractable cancers and is highly resistant to ionizing radiation. This radioresistance is partly due to the presence of a hypoxic region which is widely found in advanced malignant ...

    Authors: Hironobu Yasui, Taketoshi Asanuma, Junichi Kino, Tohru Yamamori, Shunsuke Meike, Masaki Nagane, Nobuo Kubota, Mikinori Kuwabara and Osamu Inanami
    Citation: BMC Cancer 2013 13:106
  17. Europe faces an enormous public health challenge with aging populations and rising cancer incidence. Little is known about what concerns the public across European countries regarding cancer care towards the e...

    Authors: Claudia Bausewein, Natalia Calanzani, Barbara A Daveson, Steffen T Simon, Pedro L Ferreira, Irene J Higginson, Dorothee Bechinger-English, Luc Deliens, Marjolein Gysels, Franco Toscani, Lucas Ceulemans, Richard Harding and Barbara Gomes
    Citation: BMC Cancer 2013 13:105
  18. Aluminum is used in a wide range of applications and is a potential environmental hazard. The known genotoxic effects of aluminum might play a role in the development of breast cancer. However, the data curren...

    Authors: Raquel Mary Rodrigues-Peres, Solange Cadore, Stefanny Febraio, Juliana Karina Heinrich, Katia Piton Serra, Sophie F M Derchain, Jose Vassallo and Luis Otavio Sarian
    Citation: BMC Cancer 2013 13:104
  19. Although both excision repair cross-complementing group 1 (ERCC1) and breast cancer susceptibility gene 1 (BRCA1) can be effective biomarkers for chemosensitivity in primary malignant tumors, their applicabili...

    Authors: Lu Yuanming, Zhang Lineng, Song Baorong, Peng Junjie and Cai Sanjun
    Citation: BMC Cancer 2013 13:103
  20. The purpose of this study was to evaluate the efficacy and tolerability of weekly docetaxel, cisplatin, and S-1 (weekly TPS) as induction chemotherapy for patients with locally advanced head and neck squamous ...

    Authors: Woo Kyun Bae, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Ki Hyeong Lee, Hye Suk Han, Eun-Kee Song, Hwan Jung Yun, In Sung Cho, Joon Kyoo Lee, Sang-Chul Lim, Woong-Ki Chung and Ik-Joo Chung
    Citation: BMC Cancer 2013 13:102
  21. To analyse the prognostic significance of preoperative C-reactive protein (CRP) serum level in patients with upper urinary tract urothelial carcinoma (UUT-UC).

    Authors: Barbara Stein, Andres Jan Schrader, Gerd Wegener, Christoph Seidel, Markus A Kuczyk and Sandra Steffens
    Citation: BMC Cancer 2013 13:101
  22. Atypical teratoid rhabdoid tumor (ATRT) patients display a dismal median overall survival of less than 1 year. A consistent fraction of cases carries de-novo SMARCB1/INI1 constitutional mutations in the setting o...

    Authors: Piergiorgio Modena, Iacopo Sardi, Monica Brenca, Laura Giunti, Anna Maria Buccoliero, Bianca Pollo, Veronica Biassoni, Lorenzo Genitori, Manila Antonelli, Roberta Maestro, Felice Giangaspero and Maura Massimino
    Citation: BMC Cancer 2013 13:100
  23. Many studies support the hypothesis that specific microRNA (miRNA) expression in various human cancers including hepatocarcinogenesis is closely associated with diagnosis and prognosis. In hepatocellular carci...

    Authors: Yoshiki Murakami, Akihiro Tamori, Saori Itami, Toshihito Tanahashi, Hidenori Toyoda, Masami Tanaka, Weihong Wu, Nariso Brojigin, Yuji Kaneoka, Atsuyuki Maeda, Takashi Kumada, Norifumi Kawada, Shoji Kubo and Masahiko Kuroda
    Citation: BMC Cancer 2013 13:99
  24. Intraoperative detection of 18F-FDG-avid tissue sites during 18F-FDG-directed surgery can be very challenging when utilizing gamma detection probes that rely on a fixed target-to-background (T/B) ratio (ratiometr...

    Authors: Stephen P Povoski, Gregg J Chapman, Douglas A Murrey, Robert Lee, Edward W Martin and Nathan C Hall
    Citation: BMC Cancer 2013 13:98
  25. The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinica...

    Authors: Maria C Katapodi, Laurel L Northouse, Ann M Schafenacker, Debra Duquette, Sonia A Duffy, David L Ronis, Beth Anderson, Nancy K Janz, Jennifer McLosky, Kara J Milliron, Sofia D Merajver, Linh M Duong and Glenn Copeland
    Citation: BMC Cancer 2013 13:97
  26. The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an exce...

    Authors: Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, Georg Schäfer, Sara Lehmusvaara, Tapio Visakorpi, Helmut Klocker, Andrew C B Cato and Danilo Maddalo
    Citation: BMC Cancer 2013 13:96
  27. Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer related death. It is lethal in nearly all patients, due to an almost complete chemoresistance. Most if not all drugs that pass ...

    Authors: Paola Longati, Xiaohui Jia, Johannes Eimer, Annika Wagman, Michael-Robin Witt, Stefan Rehnmark, Caroline Verbeke, Rune Toftgård, Matthias Löhr and Rainer L Heuchel
    Citation: BMC Cancer 2013 13:95
  28. Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, ther...

    Authors: Melony G King, Sara H Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez and Elisa V Bandera
    Citation: BMC Cancer 2013 13:94
  29. The development of resistance to chemotherapies represents a significant barrier to successful cancer treatment. Resistance mechanisms are complex, can involve diverse and often unexpected cellular processes, ...

    Authors: Li Chen, Lynda Stuart, Toshiro K Ohsumi, Shawn Burgess, Gaurav K Varshney, Anahita Dastur, Mark Borowsky, Cyril Benes, Adam Lacy-Hulbert and Emmett V Schmidt
    Citation: BMC Cancer 2013 13:93
  30. Prostaglandin (PG) E2 plays a critical role in colorectal cancer (CRC) progression, including epithelial-mesenchymal transition (EMT). Activity of the rate-limiting enzyme for PGE2 catabolism (15-hydroxyprostagla...

    Authors: Alastair L Young, Claire R Chalmers, Gillian Hawcroft, Sarah L Perry, Darren Treanor, Giles J Toogood, Pamela F Jones and Mark A Hull
    Citation: BMC Cancer 2013 13:92
  31. Recent studies suggest that bacterial endotoxins may be associated with various chronic diseases, including colorectal adenomas and cancer. Given the evidence linking inflammation and colorectal cancer, we sou...

    Authors: Melissa Kang, Patrick Edmundson, Felix Araujo-Perez, Amber N McCoy, Joseph Galanko and Temitope O Keku
    Citation: BMC Cancer 2013 13:91
  32. Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapi...

    Authors: Fang-Fang Bi, Da Li and Qing Yang
    Citation: BMC Cancer 2013 13:90
  33. Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate c...

    Authors: Suzanne K Chambers, David P Smith, Martin Berry, Stephen J Lepore, Elizabeth Foley, Samantha Clutton, Robert McDowall, Stefano Occhipinti, Mark Frydenberg and Robert A Gardiner
    Citation: BMC Cancer 2013 13:89
  34. Colorectal cancer (CRC) survival depends mostly on stage at the time of diagnosis. However, symptom duration at diagnosis or treatment have also been considered as predictors of stage and survival. This study ...

    Authors: Magdalena Esteva, Alfonso Leiva, María Ramos, Salvador Pita-Fernández, Luis González-Luján, Montse Casamitjana, María A Sánchez, Sonia Pértega-Díaz, Amador Ruiz, Paloma Gonzalez-Santamaría, María Martín-Rabadán, Ana M Costa-Alcaraz, Alejandro Espí, Francesc Macià, Josep M Segura, Sergio Lafita…
    Citation: BMC Cancer 2013 13:87
  35. Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by it...

    Authors: Anahid Ehteda, Peter Galettis, Krishna Pillai and David L Morris
    Citation: BMC Cancer 2013 13:86
  36. Experimental data suggest that catecholamine hormones are involved in stimulating the aggressiveness of ovarian cancer, but few population-based studies have examined this association. We therefore conducted a...

    Authors: Sigrun A Johannesdottir, Morten Schmidt, Gary Phillips, Ronald Glaser, Eric V Yang, Michael Blumenfeld and Stanley Lemeshow
    Citation: BMC Cancer 2013 13:85
  37. Failure of locoregional control is the main cause of recurrence in advanced head and neck cancer. This multi-center trial aims to improve outcome in two ways. Firstly, by redistribution of the radiation dose t...

    Authors: Jolien Heukelom, Olga Hamming, Harry Bartelink, Frank Hoebers, Jordi Giralt, Teresa Herlestam, Marcel Verheij, Michiel van den Brekel, Wouter Vogel, Nick Slevin, Eric Deutsch, Jan-Jakob Sonke, Philippe Lambin and Coen Rasch
    Citation: BMC Cancer 2013 13:84
  38. Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2.

    Authors: Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum and Sandeep Mittal
    Citation: BMC Cancer 2013 13:83
  39. OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well c...

    Authors: Lu Cao, Chunguang Li, Shuwen Shen, Yan Yan, Weidan Ji, Jinghan Wang, Haihua Qian, Xiaoqing Jiang, Zhigang Li, Mengchao Wu, Ying Zhang and Changqing Su
    Citation: BMC Cancer 2013 13:82
  40. The human ERBB2 gene is frequently amplified in breast tumors, and its high expression is associated with poor prognosis. We previously reported a significant inverse correlation between Myc promoter-binding p...

    Authors: Flavia Contino, Claudia Mazzarella, Arianna Ferro, Mariavera Lo Presti, Elena Roz, Carmelo Lupo, Giovanni Perconti, Agata Giallongo and Salvatore Feo
    Citation: BMC Cancer 2013 13:81
  41. Phosphatase of regenerating liver-3 (PRL-3), a protein tyrosine phosphatase, is highly expressed in multiple human cancers and strongly implicated in tumor progression and cancer metastasis. However, the mecha...

    Authors: Hao Liu, Abdul Qader Omer Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang and Qi Zeng
    Citation: BMC Cancer 2013 13:80
  42. Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Rece...

    Authors: Juliana Carvalho Santos, André Uchimura Bastos, Janete Maria Cerutti and Marcelo Lima Ribeiro
    Citation: BMC Cancer 2013 13:79
  43. Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis of various ...

    Authors: Byong Sun Oh, Jeong Won Jang, Jung Hyun Kwon, Chan Ran You, Kyu Won Chung, Chul Seung Kay, Hyun Suk Jung and Seungok Lee
    Citation: BMC Cancer 2013 13:78
  44. We have recently reported on the changes in plasma free amino acid (PFAA) profiles in lung cancer patients and the efficacy of a PFAA-based, multivariate discrimination index for the early detection of lung ca...

    Authors: Masato Shingyoji, Toshihiko Iizasa, Masahiko Higashiyama, Fumio Imamura, Nobuhiro Saruki, Akira Imaizumi, Hiroshi Yamamoto, Takashi Daimon, Osamu Tochikubo, Toru Mitsushima, Minoru Yamakado and Hideki Kimura
    Citation: BMC Cancer 2013 13:77
  45. Randomized controlled trials (RCTs) that are inappropriately designed or executed may provide biased findings and mislead clinical practice. In view of recent interest in the treatment and prevention of thromb...

    Authors: Gabriel Rada, Holger J Schünemann, Nawman Labedi, Pierre El-Hachem, Victor F Kairouz and Elie A Akl
    Citation: BMC Cancer 2013 13:76
  46. This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenoc...

    Authors: Markus Moehler, Ines Gockel, Hans-Peter Roessler, Dirk Arnold, Tanja Trarbach, Thomas Thomaidis, Gunther Klautke, Claus Rödel, Baruch Brenner, Hauke Lang, Peter R Galle, Carl C Schimanski and Heinz Schmidberger
    Citation: BMC Cancer 2013 13:75
  47. Recent evidence indicates that methyl jasmonate (MJ), a plant stress hormone, exhibits anti-cancer activity on human cancer cells. The aim of this study is to determine whether sub-cytotoxic MJ can abolish the...

    Authors: Liduan Zheng, Dan Li, Xuan Xiang, Ling Tong, Meng Qi, Jiarui Pu, Kai Huang and Qiangsong Tong
    Citation: BMC Cancer 2013 13:74

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