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  1. Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a l...

    Authors: Kjeld P van Houwelingen, Boukje AC van Dijk, Christina A Hulsbergen-van de Kaa, Leo J Schouten, Hanneke JM Gorissen, Jack A Schalken, Piet A van den Brandt and Egbert Oosterwijk

    Citation: BMC Cancer 2005 5:57

    Content type: Research article

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  2. Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with peritoneal carcinomatosis of colorectal origin. Animal models are important in the evaluation of n...

    Authors: Joerg OW Pelz, Joerg Doerfer, Werner Hohenberger and Thomas Meyer

    Citation: BMC Cancer 2005 5:56

    Content type: Research article

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  3. Hypofractionated stereotactic radiotherapy (HFSRT) is one salvage treatment option in previously irradiated patients with recurrent malignant glioma. We analyzed the results of HFSRT and prognostic factors in ...

    Authors: Dirk Vordermark, Oliver Kölbl, Klemens Ruprecht, Giles H Vince, Klaus Bratengeier and Michael Flentje

    Citation: BMC Cancer 2005 5:55

    Content type: Research article

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  4. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) selectively induces apoptosis in cancer cells but not in normal cells. Despite this promising feature, TRAIL resistance observed in cancer ...

    Authors: Ahter D Sanlioglu, Ercument Dirice, Cigdem Aydin, Nuray Erin, Sadi Koksoy and Salih Sanlioglu

    Citation: BMC Cancer 2005 5:54

    Content type: Research article

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  5. Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology of sarcomas are needed as current forms of therapy...

    Authors: Iwao Mikami, Liang You, Biao He, Zhidong Xu, Sonny Batra, Amie Y Lee, Julien Mazieres, Noemi Reguart, Kazutsugu Uematsu, Kiyoshi Koizumi and David M Jablons

    Citation: BMC Cancer 2005 5:53

    Content type: Research article

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  6. Over the last two decades time trends in incidence rates of colorectal cancer, changes in the proportions of stage at diagnosis and changes in the anatomic sub-site distribution of colon cancers have been repo...

    Authors: René Scheiden, Paul Pescatore, Yolande Wagener, Nelly Kieffer and Catherine Capesius

    Citation: BMC Cancer 2005 5:52

    Content type: Research article

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  7. Therapeutic gene transfer affords a clinically feasible and safe approach to cancer treatment but a more effective modality is needed to improve clinical outcomes. Combined transfer of therapeutic genes with d...

    Authors: Kyung-Sun Hwang, Won-Kyung Cho, Jinsang Yoo, Hwan-Jung Yun, Samyong Kim and Dong-Soo Im

    Citation: BMC Cancer 2005 5:51

    Content type: Research article

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  8. The present commonly used five-year survival rates are not adequate to represent the statistical cure. In the present study, we established the minimum number of years required for follow-up to estimate statis...

    Authors: Patricia Tai, Edward Yu, Gábor Cserni, Georges Vlastos, Melanie Royce, Ian Kunkler and Vincent Vinh-Hung

    Citation: BMC Cancer 2005 5:48

    Content type: Research article

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  9. Tumor-associated antigens are appreciated as diagnostic markers, but they have also prompted tremendous efforts to develop tumor-specific immunotherapy. A previously cloned tumor-associated antigen, EBAG9, was...

    Authors: Tatiana A Reimer, Ioannis Anagnostopoulos, Bettina Erdmann, Insa Lehmann, Harald Stein, Peter Daniel, Bernd Dörken and Armin Rehm

    Citation: BMC Cancer 2005 5:47

    Content type: Research article

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  10. Typical high throughput microarrays experiments compare gene expression across two specimen classes – an experimental class and baseline (or comparison) class. The choice of specimen classes is a major factor ...

    Authors: Uma R Chandran, Rajiv Dhir, Changqing Ma, George Michalopoulos, Michael Becich and John Gilbertson

    Citation: BMC Cancer 2005 5:45

    Content type: Research article

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  11. The antihypertensive compound hydralazine is a known demethylating agent. This phase I study evaluated the tolerability and its effects upon DNA methylation and gene reactivation in patients with untreated cer...

    Authors: Pilar Zambrano, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucely Cetina, Alma Revilla-Vazquez, Lucía Taja-Chayeb, Alma Chavez-Blanco, Enrique Angeles, Gustavo Cabrera, Karina Sandoval, Catalina Trejo-Becerril, Jose Chanona-Vilchis and Alfonso Duenas-González

    Citation: BMC Cancer 2005 5:44

    Content type: Research article

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  12. The FANCA gene is one of the genes in which mutations lead to Fanconi anaemia, a rare autosomal recessive disorder characterised by congenital abnormalities, bone marrow failure, and predisposition to malignancy....

    Authors: Ella Thompson, Rebecca L Dragovic, Sally-Anne Stephenson, Diana M Eccles, Ian G Campbell and Alexander Dobrovic

    Citation: BMC Cancer 2005 5:43

    Content type: Research article

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  13. Several parameters of the tumor microenvironment, such as hypoxia, inflammation and angiogenesis, play a critical role in tumor aggressiveness and treatment response. A major question remains if these markers ...

    Authors: Harlinde De Schutter, Willy Landuyt, Erik Verbeken, Laurence Goethals, Robert Hermans and Sandra Nuyts

    Citation: BMC Cancer 2005 5:42

    Content type: Research article

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  14. Carbonic anhydrase (CA) isozymes may have an important role in cancer development. Some isozymes control pH homeostasis in tumors that appears to modulate the behaviour of cancer cells. CA XIII is the newest m...

    Authors: Laura Kummola, Jonna M Hämäläinen, Jyrki Kivelä, Antti J Kivelä, Juha Saarnio, Tuomo Karttunen and Seppo Parkkila

    Citation: BMC Cancer 2005 5:41

    Content type: Research article

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  15. Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead...

    Authors: Markos Mihalatos, Angela Apessos, Hans Dauwerse, Voula Velissariou, Aristidis Psychias, Alexander Koliopanos, Konstantinos Petropoulos, John K Triantafillidis, Ioannis Danielidis, George Fountzilas, Niki J Agnantis and Georgios Nasioulas

    Citation: BMC Cancer 2005 5:40

    Content type: Research article

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  16. Aberrant expression of myeloid antigens (MyAgs) on acute lymphoblastic leukemia (ALL) cells is a well-documented phenomenon, although its regulating mechanisms are unclear. MyAgs in ALL are interpreted e.g. as...

    Authors: Tomas Kalina, Martina Vaskova, Ester Mejstrikova, Jozef Madzo, Jan Trka, Jan Stary and Ondrej Hrusak

    Citation: BMC Cancer 2005 5:38

    Content type: Research article

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  17. After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-yea...

    Authors: HP Knaebel, A Märten, J Schmidt, K Hoffmann, C Seiler, K Lindel, H Schmitz-Winnenthal, S Fritz, T Herrmann, H Goldschmidt, R Krempien, U Mansmann, J Debus, V Diehl and MW Büchler

    Citation: BMC Cancer 2005 5:37

    Content type: Study protocol

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  18. The role of genes involved in the control of progression from the G1 to the S phase of the cell cycle in melanoma tumors in not fully known. The aim of our study was to analyse mutations in TP53, CDKN1A, CDKN2...

    Authors: José Luis Soto, Carmen M Cabrera, Salvio Serrano and Miguel Ángel López-Nevot

    Citation: BMC Cancer 2005 5:36

    Content type: Research article

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  19. There appear to be geographical differences in decisions to perform mastectomy or breast conserving surgery for early-stage breast cancer. This study was carried out to evaluate general surgeons' preferences i...

    Authors: Massoome Najafi, Mandana Ebrahimi, Ahmad Kaviani, Esmat Hashemi and Ali Montazeri

    Citation: BMC Cancer 2005 5:35

    Content type: Research article

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  20. There are very few studies that report the incidence of acute leukemias in children in Latin America. This work assesses the incidence of acute leukemias, between 1996 and 2000, in children from 0–14 years old...

    Authors: Juan Manuel Mejía-Aranguré, Miguel Bonilla, Rodolpho Lorenzana, Servando Juárez-Ocaña, Gladys de Reyes, María Luisa Pérez-Saldivar, Guadalupe González-Miranda, Roberto Bernáldez-Ríos, Antonio Ortiz-Fernández, Manuel Ortega-Alvarez, María del Carmen Martínez-García and Arturo Fajardo-Gutiérrez

    Citation: BMC Cancer 2005 5:33

    Content type: Research article

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  21. HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant b...

    Authors: Pierre A Robe, Minh Nguyen-Khac, Olivier Jolois, Bernard Rogister, Marie-Paule Merville and Vincent Bours

    Citation: BMC Cancer 2005 5:32

    Content type: Research article

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  22. There is controversy about the effect of the timing of intraperitoneal administration of chemotherapeutic agents on the healing of intestinal anastomosis. We have investigated the effect on intestinal wound he...

    Authors: Ali Uzunkoy, Cengiz Bolukbas, Mehmet Horoz, Fusun F Bolukbas and Abdurrahim Kocyigit

    Citation: BMC Cancer 2005 5:31

    Content type: Research article

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  23. Few data are available on compliance and safety of adjuvant chemotherapy when indicated in elderly breast cancer patients; CMF (cyclophosphamide, methotrexate, fluorouracil) can be reasonably considered the mo...

    Authors: Ermelinda De Maio, Adriano Gravina, Carmen Pacilio, Gerardo Amabile, Vincenzo Labonia, Gabriella Landi, Francesco Nuzzo, Emanuela Rossi, Giuseppe D'Aiuto, Immacolata Capasso, Massimo Rinaldo, Brunello Morrica, Massimo Elmo, Massimo Di Maio, Francesco Perrone and Andrea de Matteis

    Citation: BMC Cancer 2005 5:30

    Content type: Research article

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  24. Activation of the phosphatidylinositol 3-kinase (PI3K) through mutational inactivation of PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported in gastric cancer. Recently, mutations ...

    Authors: Vivian Sze Wing Li, Chi Wai Wong, Tsun Leung Chan, Agnes Sze Wah Chan, Wei Zhao, Kent-Man Chu, Samuel So, Xin Chen, Siu Tsan Yuen and Suet Yi Leung

    Citation: BMC Cancer 2005 5:29

    Content type: Research article

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  25. Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal c...

    Authors: Giorgio Zavagno, Paolo Carcoforo, Renato Marconato, Zeno Franchini, Giuliano Scalco, Paolo Burelli, Paolo Pietrarota, Mario Lise, Roberto Mencarelli, Giovanni Capitanio, Andrea Ballarin, Maria Elena Pierobon, Giorgia Marconato and Donato Nitti

    Citation: BMC Cancer 2005 5:28

    Content type: Research article

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  26. The advent of prostate specific antigen (PSA) testing in the United States of America (USA) has led to a dramatic increase in the incidence of prostate cancer in the United States as well as the number of men ...

    Authors: Richard M Hoffman, S Noell Stone, David Espey and Arnold L Potosky

    Citation: BMC Cancer 2005 5:27

    Content type: Research article

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  27. Epidemiological studies have shown that individuals who regularly consume NSAIDs have lower rates of mortality associated with colorectal cancer. Because COX-2 inhibitors prevent tumor growth through some mech...

    Authors: Hirotoshi Kobayashi, Hiroyuki Uetake, Tetsuro Higuchi, Masayuki Enomoto and Kenichi Sugihara

    Citation: BMC Cancer 2005 5:26

    Content type: Research article

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  28. Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge...

    Authors: Vasilis Karavasilis, Vasiliki Malamou-Mitsi, Evangelos Briasoulis, Elena Tsanou, Evangelia Kitsou, Haralambos Kalofonos, George Fountzilas, Theodore Fotsis and Nicholas Pavlidis

    Citation: BMC Cancer 2005 5:25

    Content type: Research article

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  29. To identify early symptoms of familial adenomatous polyposis with a view to improve early diagnosis and treatment. Diagnosis on the basis of genetic testing is usually limited to where there is a known family ...

    Authors: Roland S Croner, Wolfgang M Brueckl, Bertram Reingruber, Werner Hohenberger and Klaus Guenther

    Citation: BMC Cancer 2005 5:24

    Content type: Research article

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  30. Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defectiv...

    Authors: Kajsa M Ericson, Anna P Isinger, Björn L Isfoss and Mef C Nilbert

    Citation: BMC Cancer 2005 5:23

    Content type: Research article

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  31. Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of ...

    Authors: Chiara Balducci, Cinzia Lilli, Giordano Stabellini, Lorella Marinucci, Giammario Giustozzi, Alessio Becchetti, Lucio Cagini and Paola Locci

    Citation: BMC Cancer 2005 5:22

    Content type: Research article

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  32. Patients with metastatic breast cancer (MBC) are frequently exposed to high cumulative doses of anthracyclines and are at risk of resistance and cardiotoxicity. This phase II trial evaluated the efficacy and t...

    Authors: Se Hoon Park, Eun Kyung Cho, Soo-Mee Bang, Dong Bok Shin, Jae Hoon Lee and Young Don Lee

    Citation: BMC Cancer 2005 5:21

    Content type: Research article

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  33. Leukemia is a clonal disorder characterized by uncontrolled proliferation of haematopoietic cells, and represents the most common form of cancer in children. Advances in therapy for childhood leukemia have rel...

    Authors: Silvija Jarnjak-Jankovic, Rolf D Pettersen, Stein Sæbøe-Larssen, Finn Wesenberg and Gustav Gaudernack

    Citation: BMC Cancer 2005 5:20

    Content type: Research article

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  34. p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with...

    Authors: Charles G Eberhart, Aneeka Chaudhry, Richard W Daniel, Leila Khaki, Keerti V Shah and Patti E Gravitt

    Citation: BMC Cancer 2005 5:19

    Content type: Research article

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  35. There is a growing awareness among providers of the symptom burden experienced by cancer patients. Systematic symptom screening is difficult. Our plan was to evaluate a technology-based symptom screening proce...

    Authors: Ma'n Abdullah, Dale E Theobald, Donna Butler, Kurt Kroenke, Anthony Perkins, Sara Edgerton and William M Dugan Jr

    Citation: BMC Cancer 2005 5:18

    Content type: Research article

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  36. The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of t...

    Authors: Meghan Webb, Ethan D Emberley, Michael Lizardo, Salem Alowami, Gefei Qing, Abdullah Alfia'ar, Linda J Snell-Curtis, Yulian Niu, Alberto Civetta, Yvonne Myal, Robert Shiu, Leigh C Murphy and Peter H Watson

    Citation: BMC Cancer 2005 5:17

    Content type: Research article

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  37. Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expresse...

    Authors: Ivaylo Gentschev, Joachim Fensterle, Andreas Schmidt, Tamara Potapenko, Jakob Troppmair, Werner Goebel and Ulf R Rapp

    Citation: BMC Cancer 2005 5:15

    Content type: Research article

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  38. Modeling the complex development and growth of tumor angiogenesis using mathematics and biological data is a burgeoning area of cancer research. Architectural complexity is the main feature of every anatomical...

    Authors: Fabio Grizzi, Carlo Russo, Piergiuseppe Colombo, Barbara Franceschini, Eldo E Frezza, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: BMC Cancer 2005 5:14

    Content type: Research article

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  39. Recent studies relating to the association between DNA repair-gene polymorphisms and colorectal cancer risk would, to the best of our knowledge, appear to be very limited. This study was designed to examine th...

    Authors: Chih-Ching Yeh, Fung-Chang Sung, Reiping Tang, Chung Rong Chang-Chieh and Ling-Ling Hsieh

    Citation: BMC Cancer 2005 5:12

    Content type: Research article

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  40. Suction drains are routinely used after modified radical mastectomy and are an important factor contributing to increased hospital stay as the patients are often discharged only after their removal. Amongst va...

    Authors: Chintamani, Vinay Singhal, JP Singh, Anju Bansal and Sunita Saxena

    Citation: BMC Cancer 2005 5:11

    Content type: Research article

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  41. Both paclitaxel (P) and carboplatin (C) have significant activity in non-small cell lung cancer (NSCLC). The weekly administration of P is active, dose intense, and has a favorable toxicity profile. We retrosp...

    Authors: Perran F Yumuk, Nazim S Turhal, Mahmut Gumus, Nilgun F Hatabay, Orhan Turken, Alper Ozkan, Taflan Salepci, Mehmet Aliustaoglu and Rengin Ahiskali

    Citation: BMC Cancer 2005 5:10

    Content type: Research article

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  42. Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported...

    Authors: Tadashi Hanafusa, Toshiyuki Shinji, Hidenori Shiraha, Kazuhiro Nouso, Yoshiaki Iwasaki, Eichiro Yumoto, Toshiro Ono and Norio Koide

    Citation: BMC Cancer 2005 5:9

    Content type: Research article

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  43. Molecular markers for localized colon tumours and for prognosis following therapy are needed. Proteomics research is currently producing numerous biomarker studies with clinical potential. We investigate the p...

    Authors: Jakob Albrethsen, Rikke Bøgebo, Steen Gammeltoft, Jesper Olsen, Benny Winther and Hans Raskov

    Citation: BMC Cancer 2005 5:8

    Content type: Research article

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