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  1. Chronic lymphocytic leukemia (CLL) is a monoclonal disorder, characterized by a progressive proliferation of functionally incompetent B lymphocytes. There is increased evidence of association between CLL and s...

    Authors: KI Papageorgiou and MG Kaniorou-Larai

    Citation: BMC Cancer 2005 5:106

    Content type: Case report

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  2. A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro. In B-type chronic lymphocytic leu...

    Authors: Isrid Sturm, Andrew G Bosanquet, Michael Hummel, Bernd Dörken and Peter T Daniel

    Citation: BMC Cancer 2005 5:105

    Content type: Research article

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  3. Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human brea...

    Authors: Howard K Plummer III, Madhu S Dhar, Maria Cekanova and Hildegard M Schuller

    Citation: BMC Cancer 2005 5:104

    Content type: Research article

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  4. Despite exciting new targeted therapeutics against non-Hodgkin's lymphoma (NHL), chemotherapy remains a cornerstone of therapy. While purine nucleoside analogs have significant activity in low grade NHL, the p...

    Authors: Mitchell R Smith, Indira Joshi, Fang Jin and Coleman Obasaju

    Citation: BMC Cancer 2005 5:103

    Content type: Research article

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  5. The mechanisms of chemoresistance in ovarian cancer patients remain largely to be elucidated. Paclitaxel/cisplatin combination is the standard chemotherapeutic treatment for this disease, although some patient...

    Authors: Bárbara Mesquita, Isabel Veiga, Deolinda Pereira, Ana Tavares, Isabel M Pinto, Carla Pinto, Manuel R Teixeira and Sérgio Castedo

    Citation: BMC Cancer 2005 5:101

    Content type: Research article

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  6. The purpose of our study was to investigate the immunohistochemical expression of TGF-β1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We...

    Authors: Nil Culhaci, Ozgul Sagol, Sedat Karademir, Huseyin Astarcioglu, Ibrahim Astarcioglu, Mujde Soyturk, Ilhan Oztop and Funda Obuz

    Citation: BMC Cancer 2005 5:98

    Content type: Research article

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  7. Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53. It has been shown that curcumin induces tumor cell death and apoptosis. Cur...

    Authors: Melanie Füllbeck, Xiaohua Huang, Renate Dumdey, Cornelius Frommel, Wolfgang Dubiel and Robert Preissner

    Citation: BMC Cancer 2005 5:97

    Content type: Research article

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  8. Gene expression data is abundantly available from the Gene Expression Omnibus (GEO) and various websites. Pathway specific analyses of gene-gene correlations across these datasets remain relatively unexplored,...

    Authors: Tomas Radivoyevitch

    Citation: BMC Cancer 2005 5:95

    Content type: Research article

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  9. Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result o...

    Authors: Nagi S El Saghir, Ihab I Elhajj, Fady B Geara and Mukbil H Hourani

    Citation: BMC Cancer 2005 5:94

    Content type: Case report

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  10. Breast cancer is one of the most frequent causes of death in Mexican women over 35 years of age. At molecular level, changes in many genetic networks have been reported as associated with this neoplasia. To an...

    Authors: Normand García, Fabio Salamanca, Horacio Astudillo-de la Vega, Everardo Curiel-Quesada, Isabel Alvarado, Rosenda Peñaloza and Diego Arenas

    Citation: BMC Cancer 2005 5:93

    Content type: Research article

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  11. Adenomyoepithelial tumours and myoepithelial carcinomas of the breast are primarily defined by the presence of neoplastic cells with a myoepithelial immunophenotype. Current classification schemes are based on...

    Authors: Daniela Hungermann, Horst Buerger, Christian Oehlschlegel, Hermann Herbst and Werner Boecker

    Citation: BMC Cancer 2005 5:92

    Content type: Research article

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  12. The RTOG 94-13 trial has provided evidence that patients with high risk prostate cancer benefit from an additional radiotherapy to the pelvic nodes combined with concomitant hormonal ablation. Since lymphatic ...

    Authors: Ute Ganswindt, Frank Paulsen, Stefan Corvin, Kai Eichhorn, Stefan Glocker, Ilse Hundt, Mattias Birkner, Markus Alber, Aristotelis Anastasiadis, Arnulf Stenzl, Roland Bares, Wilfried Budach, Michael Bamberg and Claus Belka

    Citation: BMC Cancer 2005 5:91

    Content type: Research article

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  13. Esophagus squamous cell cancer (ESCC) is the most common cancer in women with 20.2% and second in men with 10.7% relative frequency among all cancer cases diagnosed in Van Region in the east of Turkey. Ninety ...

    Authors: Mahmut Ilhan, Tugrul Erbaydar, Necmettin Akdeniz and Sevket Arslan

    Citation: BMC Cancer 2005 5:90

    Content type: Research article

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  14. Bisphosphonate therapy has been readily accepted as standard of care for individuals with bone metastases from breast cancer. In this study we determined whether the proportion of patients experiencing a skele...

    Authors: Winston Liauw, Eva Segelov, Anna Lih, Ms Ruth Dunleavy, Matthew Links and Robyn Ward

    Citation: BMC Cancer 2005 5:89

    Content type: Research article

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  15. Published data suggests that docetaxel combined with 5-fluorouracil (5-FU) may have synergistic activity in treating advanced gastric cancer. We performed a phase I study of docetaxel and 5-FU to determine the...

    Authors: Se Hoon Park, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee, Woon KI Lee and Min Chung

    Citation: BMC Cancer 2005 5:87

    Content type: Research article

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  16. Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain strengths and weaknesses; however, no ...

    Authors: Asa J Oudes, Jared C Roach, Laura S Walashek, Lillian J Eichner, Lawrence D True, Robert L Vessella and Alvin Y Liu

    Citation: BMC Cancer 2005 5:86

    Content type: Research article

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  17. Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder with characteristic features of skin and central nervous system involvement. Gastrointestinal involvement is rare, but the risk of mali...

    Authors: Wan-Sik Lee, Yang-Seok Koh, Jung-Chul Kim, Chang-Hwan Park, Young-Eun Joo, Hyun-Soo Kim, Chol-Kyoon Cho, Sung-Kyu Choi, Jong-Sun Rew and Sei-Jong Kim

    Citation: BMC Cancer 2005 5:85

    Content type: Case report

    Published on:

  18. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which plays a central role in biologic processes under hypoxic conditions, especially concerning tumour angiogenesis. HIF-1α is the relevant, oxyge...

    Authors: Thomas Fillies, Richard Werkmeister, Paul J van Diest, Burkhard Brandt, Ulrich Joos and Horst Buerger

    Citation: BMC Cancer 2005 5:84

    Content type: Research article

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  19. Currently, no satisfactory biomarkers are available to screen for lung cancer. Surface-Enhanced Laser Desorption/ionization Time-of- Flight Mass Spectrometry ProteinChip system (SELDI-TOF-MS) is one of the cur...

    Authors: Shuan-ying Yang, Xue-yuan Xiao, Wang-gang Zhang, Li-juan Zhang, Wei Zhang, Bin Zhou, Guoan Chen and Da-cheng He

    Citation: BMC Cancer 2005 5:83

    Content type: Research article

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  20. Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Eu...

    Authors: Arild Vaktskjold, Jelena A Lebedintseva, Dmitrij S Korotov, Anatolij V Tkatsjov, Tatjana S Podjakova and Eiliv Lund

    Citation: BMC Cancer 2005 5:82

    Content type: Research article

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  21. EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patie...

    Authors: Patrick R Benusiglio, Fabienne Lesueur, Craig Luccarini, Joan McIntosh, Robert N Luben, Paula Smith, Alison Dunning, Douglas F Easton, Bruce AJ Ponder and Paul D Pharoah

    Citation: BMC Cancer 2005 5:81

    Content type: Research article

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  22. Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiat...

    Authors: Ivan Presta, Franco Arturi, Elisabetta Ferretti, Tiziana Mattei, Daniela Scarpelli, Emanuele Tosi, Angela Scipioni, Marilena Celano, Alberto Gulino, Sebastiano Filetti and Diego Russo

    Citation: BMC Cancer 2005 5:80

    Content type: Research article

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  23. Brachytherapy, interstitial tumor bed irradiation, following conservative surgery has been shown to provide excellent local control and limb preservation in patients with soft tissue sarcomas (STS), whereas li...

    Authors: Tadahiko Kubo, Takashi Sugita, Shoji Shimose, Toshihiro Matsuo, Ken Hirao, Hiroaki Kimura, Masahiro Kenjo and Mitsuo Ochi

    Citation: BMC Cancer 2005 5:79

    Content type: Research article

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  24. Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from exp...

    Authors: Federica Di Nicolantonio, Stuart J Mercer, Louise A Knight, Francis G Gabriel, Pauline A Whitehouse, Sanjay Sharma, Augusta Fernando, Sharon Glaysher, Silvana Di Palma, Penny Johnson, Shaw S Somers, Simon Toh, Bernie Higgins, Alan Lamont, Tim Gulliford, Jeremy Hurren…

    Citation: BMC Cancer 2005 5:78

    Content type: Research article

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  25. Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its lim...

    Authors: Alfredo Hidalgo, Michael Baudis, Iver Petersen, Hugo Arreola, Patricia Piña, Guelaguetza Vázquez-Ortiz, Dulce Hernández, José González, Minerva Lazos, Ricardo López, Carlos Pérez, José García, Karla Vázquez, Brenda Alatorre and Mauricio Salcedo

    Citation: BMC Cancer 2005 5:77

    Content type: Research article

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  26. By modulating the expression levels of specific signal transduction molecules, the 26S proteasome plays a central role in determining cell cycle progression or arrest and cell survival or death in response to ...

    Authors: Frank Pajonk, Arndt van Ophoven, Christian Weissenberger and William H McBride

    Citation: BMC Cancer 2005 5:76

    Content type: Research article

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  27. Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC). St...

    Authors: Anna C Gustafsson, Ilya Kupershmidt, Esther Edlundh-Rose, Giulia Greco, Annalucia Serafino, Eva K Krasnowska, Thomas Lundeberg, Luisa Bracci-Laudiero, Maria-Concetta Romano, Tiziana Parasassi and Joakim Lundeberg

    Citation: BMC Cancer 2005 5:75

    Content type: Research article

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  28. Because of the high resistance rate of fibrosarcomas against cytotoxic agents clinical chemotherapy of these tumors is not established. A better understanding of the diverse modes of tumor cell death following...

    Authors: Marcus Lehnhardt, Ludger Klein-Hitpass, Cornelius Kuhnen, Heinz Herbert Homann, Adrien Daigeler, Hans Ulrich Steinau, Sonja Roehrs, Laura Schnoor, Lars Steinstraesser and Oliver Mueller

    Citation: BMC Cancer 2005 5:74

    Content type: Research article

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  29. Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by...

    Authors: Sandro J Martins, Nelson Ho, Sueli O Cavamura, Cecilia M Harada, Crystina A Yamamoto and Teresa Y Takagaki

    Citation: BMC Cancer 2005 5:72

    Content type: Research article

    Published on:

  30. Combined chemoradiotherapy (CRT) is the treatment of choice for stage III NSCLC. Gemcitabine (G) is a novel deoxycitidine analogue that has been proven to be a potent radiosensitizer. Twenty-two consecutive pa...

    Authors: Ufuk Abacioglu, Perran F Yumuk, Hale Caglar, Meric Sengoz and Nazim S Turhal

    Citation: BMC Cancer 2005 5:71

    Content type: Research article

    Published on:

  31. The clinical and pathological characteristics and the clinical course of patients with breast cancer and BRCA 1–2 mutation are poorly known.

    Authors: Andrea Veronesi, Clelia de Giacomi, Maria D Magri, Davide Lombardi, Martina Zanetti, Cristina Scuderi, Riccardo Dolcetti, Alessandra Viel, Diana Crivellari, Ettore Bidoli and Mauro Boiocchi

    Citation: BMC Cancer 2005 5:70

    Content type: Research article

    Published on:

  32. Cervical carcinoma (CC) is one of the most common cancers among women worldwide and the first cause of death among the Mexican female population. CC progression shows a continuum of neoplastic transitions unti...

    Authors: Guelaguetza Vazquez-Ortiz, Patricia Pina-Sanchez, Karla Vazquez, Alfonso Duenas, Lucia Taja, Patricia Mendoza, José A Garcia and Mauricio Salcedo

    Citation: BMC Cancer 2005 5:68

    Content type: Research article

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    The Erratum to this article has been published in BMC Cancer 2005 5:164

  33. APC (Adenomatous polyposis coli) plays an important role in the pathogenesis of both familial and sporadic colorectal cancer. Patients carrying germline APC mutations develop multiple colonic adenomas at younger...

    Authors: Sima Salahshor, Jason Goncalves, Runjan Chetty, Steven Gallinger and James R Woodgett

    Citation: BMC Cancer 2005 5:66

    Content type: Research article

    Published on:

  34. It has been shown that free DNA circulates in serum plasma of patients with cancer and that at least part is present in the form of oligo- and monucleosomes, a marker of cell death. Preliminary data has shown ...

    Authors: Catalina Trejo-Becerril, Luis F Oñate-Ocaña, Lucía Taja-Chayeb, América Vanoye-Carlo, Lucely Cetina and Alfonso Duenas-Gonzalez

    Citation: BMC Cancer 2005 5:65

    Content type: Research article

    Published on:

  35. The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrang...

    Authors: María I Nunez, Daniel G Rosen, John H Ludes-Meyers, Martín C Abba, Hyunsuk Kil, Robert Page, Andres JP Klein-Szanto, Andrew K Godwin, Jinsong Liu, Gordon B Mills and C Marcelo Aldaz

    Citation: BMC Cancer 2005 5:64

    Content type: Research article

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  36. P-cadherin (P-cad) is a transmembrane molecule involved in the cell-cell adhesion and similar to E-cadherin (E-cad), but less investigated in oncology, especially in in vivo studies. Aims of the present study wer...

    Authors: Lorenzo Lo Muzio, Giuseppina Campisi, Antonio Farina, Corrado Rubini, Giuseppe Pannone, Rosario Serpico, Gregorio Laino, Alfredo De Lillo and Francesco Carinci

    Citation: BMC Cancer 2005 5:63

    Content type: Research article

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  37. Epidermal growth factor receptor (EGFR) represents a major target for current radiosensitizing strategies. We wished to ascertain whether a correlation exists between the expression of EGFR and treatment outco...

    Authors: David Azria, Frederic Bibeau, Nicolas Barbier, Abderrahim Zouhair, Claire Lemanski, Philippe Rouanet, Marc Ychou, Pierre Senesse, Mahmut Ozsahin, André Pèlegrin, Jean-Bernard Dubois and Simon Thèzenas

    Citation: BMC Cancer 2005 5:62

    Content type: Research article

    Published on:

  38. Patients with advanced gallbladder and biliary tract carcinoma face a dismal prognosis, as no effective palliative chemotherapy exists. The antitumor effect of gemcitabine is schedule-dependent rather than dos...

    Authors: Stefan von Delius, Christian Lersch, Ewert Schulte-Frohlinde, Martina Mayr, Roland M Schmid and Florian Eckel

    Citation: BMC Cancer 2005 5:61

    Content type: Research article

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  39. Ex-vivo chemosensitivity tests that measure cell death induction may predict treatment outcome and, therefore, represent a powerful instrument for clinical decision making in cancer therapy. Such tests are, ho...

    Authors: Peter Staib, Jan Tiehen, Timo Strunk and Timo Schinköthe

    Citation: BMC Cancer 2005 5:60

    Content type: Research article

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  40. Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury. Ultimately, complete structural ablation will ens...

    Authors: Zahid N Rabbani, Mitchell S Anscher, Rodney J Folz, Emerald Archer, Hong Huang, Liguang Chen, Maria L Golson, Thaddeus S Samulski, Mark W Dewhirst and Zeljko Vujaskovic

    Citation: BMC Cancer 2005 5:59

    Content type: Research article

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  41. Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase do...

    Authors: Martin Deichmann, Marianne Thome, Axel Benner, Martin Kirschner, Judith Hassanzadeh and Hjalmar Kurzen

    Citation: BMC Cancer 2005 5:58

    Content type: Research article

    Published on:

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