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  1. In patients with ovarian cancer relapsing at least 6 months after end of primary treatment, the addition of paclitaxel to platinum treatment has been shown to improve survival but at the cost of significant ne...

    Authors: Yun Wang, Jørn Herrstedt, Hanne Havsteen, Rene DePoint Christensen, Mansoor Raza Mirza, Bente Lund, Johanna Maenpaa and Gunnar Kristensen
    Citation: BMC Cancer 2014 14:937
    Content type: Research article Published on:

  2. Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. ...

    Authors: Xue Qin Yu, Roberta De Angelis, Qingwei Luo, Clare Kahn, Nehmat Houssami and Dianne L O’Connell
    Citation: BMC Cancer 2014 14:936
    Content type: Research article Published on:

  3. Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible to endocrine therapy using antiestrogens. However, the majority of TNBCs express the membrane bound estrogen receptor GPR30. W...

    Authors: Rainer Girgert, Günter Emons and Carsten Gründker
    Citation: BMC Cancer 2014 14:935
    Content type: Research article Published on:

  4. Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some pat...

    Authors: Douglas A Hoover, Dante PI Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga…
    Citation: BMC Cancer 2014 14:934
    Content type: Study protocol Published on:

  5. Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected popul...

    Authors: Lizet Sanchez, Patricia Lorenzo-Luaces, Carmen Viada, Yaima Galan, Javier Ballesteros, Tania Crombet and Agustin Lage
    Citation: BMC Cancer 2014 14:933
    Content type: Research article Published on:

  6. Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown.

    Authors: Yuehua Han, Jun Ye, Dang Wu, Pin Wu, Zhigang Chen, Jian Chen, Shunliang Gao and Jian Huang
    Citation: BMC Cancer 2014 14:932
    Content type: Research article Published on:

  7. It is unclear whether patients with few cerebral metastases benefit from whole-brain irradiation added to radiosurgery. Since primary tumors disseminating to the brain show different behavior, this question sh...

    Authors: Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck and Steven E Schild
    Citation: BMC Cancer 2014 14:931
    Content type: Research article Published on:

  9. Despite the preclinical outcomes and biologic significance of the presence of the human epidermal growth factor receptor-2 (HER2) extracellular domain (ECD), there is little evidence supporting the measurement...

    Authors: Sae Byul Lee, Jong Won Lee, Jong Han Yu, Beom Seok Ko, Hee Jeong Kim, Byung Ho Son, Gyungyub Gong, Hee Jin Lee, Sung-Bae Kim, Kyung Hae Jung, Jin-Hee Ahn, Woochang Lee, Joohon Sung and Sei-Hyun Ahn
    Citation: BMC Cancer 2014 14:929
    Content type: Research article Published on:

  10. Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been r...

    Authors: Seunghwan Lim, Byoung Kwon Yoo, Hae-Suk Kim, Hannah L Gilmore, Yonghun Lee, Hyun-pil Lee, Seong-Jin Kim, John Letterio and Hyoung-gon Lee
    Citation: BMC Cancer 2014 14:928
    Content type: Research article Published on:

  11. Disparities by race and neighborhood socioeconomic status exist for many colorectal cancer (CRC) outcomes, including screening use and mortality. We used population-based data to determine if disparities also ...

    Authors: Sandi L Pruitt, Nicholas O Davidson, Samir Gupta, Yan Yan and Mario Schootman
    Citation: BMC Cancer 2014 14:927
    Content type: Research article Published on:

  12. Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts...

    Authors: Sarah E Jackson, Kate Williams, Andrew Steptoe and Jane Wardle
    Citation: BMC Cancer 2014 14:926
    Content type: Research article Published on:

  13. FUSE binding protein1 (FBP1) is a transactivator of transcription of human c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very l...

    Authors: Updesh Dixit, Zhihe Liu, Ashutosh K Pandey, Ramesh Kothari and Virendra N Pandey
    Citation: BMC Cancer 2014 14:925
    Content type: Research article Published on:

  14. Trastuzumab was registered in 2000 for the treatment of metastatic breast cancer, both as monotherapy and combination therapy with paclitaxel. In this prospective, non-interventional observation study, the 10-...

    Authors: Christian Jackisch, Winfried Schoenegg, Dietmar Reichert, Manfred Welslau, Johannes Selbach, Hanns-Detlev Harich, Hans Tesch, Tim Wohlfarth, Heidi Eustermann and Axel Hinke
    Citation: BMC Cancer 2014 14:924
    Content type: Research article Published on:

  15. Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive to radio- and chemotherapy. Here we have investiga...

    Authors: Celina Garcia, Luiz Gustavo Dubois, Anna Lenice Xavier, Luiz Henrique Geraldo, Anna Carolina Carvalho da Fonseca, Ana Helena Correia, Fernanda Meirelles, Grasiella Ventura, Luciana Romão, Nathalie Henriques Silva Canedo, Jorge Marcondes de Souza, João Ricardo Lacerda de Menezes, Vivaldo Moura-Neto, Fernanda Tovar-Moll and Flavia Regina Souza Lima
    Citation: BMC Cancer 2014 14:923
    Content type: Technical advance Published on:

  16. In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is...

    Authors: Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Teresa Mele, Sandra R Ramírez-Clavijo, Giorgio Scagliotti, Caterina Marchiò and Anna Sapino
    Citation: BMC Cancer 2014 14:922
    Content type: Research article Published on:

  17. There is evidence that calcium (Ca2+) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation betwee...

    Authors: Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Sonia Liberati, Claudio Cardinali, Valerio Farfariello, Daniele Tomassoni, Wilma Quaglia, Alessandro Piergentili, Alessandro Bonifazi, Fabio Del Bello, Matteo Santoni, Gabriele Mammana, Lucilla Servi, Alessandra Filosa, Angela Gismondi…
    Citation: BMC Cancer 2014 14:921
    Content type: Research article Published on:

  18. Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) is a truly novel protein, defining a new class of secreted factors. We have previously reported that ectopic overexpression of hHSS1 has a negative...

    Authors: Katiana S Junes-Gill, Chris E Lawrence, Christopher J Wheeler, Ryan Cordner, Tristan G Gill, Vernon Mar, Liron Shiri and Lena A Basile
    Citation: BMC Cancer 2014 14:920
    Content type: Research article Published on:

  19. Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically ex...

    Authors: Christine M Friedenreich, Sarah MacLaughlin, Heather K Neilson, Frank Z Stanczyk, Yutaka Yasui, Aalo Duha, Brigid M Lynch, Ciara Kallal and Kerry S Courneya
    Citation: BMC Cancer 2014 14:919
    Content type: Study protocol Published on:

  20. Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2014 14:918
    Content type: Research article Published on:

  21. MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer. The aberrant expression of miRNAs may contribute t...

    Authors: Rui Yang, Yongjun Chen, Cong Tang, Hongbo Li, Bing Wang, Qun Yan, Junbo Hu and Shengquan Zou
    Citation: BMC Cancer 2014 14:917
    Content type: Research article Published on:

  22. The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes
    Citation: BMC Cancer 2014 14:916
    Content type: Research article Published on:

  23. Carfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been repor...

    Authors: Ajai Chari and Daher Hajje
    Citation: BMC Cancer 2014 14:915
    Content type: Research article Published on:

  24. Papillary thyroid cancer (PTC) often presents as multifocal. However, the association of multifocality with poor prognosis remains controversial. The aim of this retrospective study was to identify the charact...

    Authors: Ning Qu, Ling Zhang, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Qiang Shen, Yu Wang and Duan-shu Li
    Citation: BMC Cancer 2014 14:914
    Content type: Research article Published on:

  25. The constituents of stable multiprotein complexes are known to dissociate from the complex to play independent regulatory roles. The components of translation elongation complex eEF1H (eEF1A, eEF1Bα, eEF1Bβ, e...

    Authors: Maryna Veremieva, Liudmyla Kapustian, Antonina Khoruzhenko, Valery Zakharychev, Boris Negrutskii and Anna El’skaya
    Citation: BMC Cancer 2014 14:913
    Content type: Research article Published on:

  26. Chronic inflammation is a key feature of colorectal cancer (CRC), meaning that inflammatory biomarkers may be useful for its diagnosis. In particular, high neutrophil gelatinase-associated lipocalin (NGAL) exp...

    Authors: Laurence Duvillard, Pablo Ortega-Deballon, Abderrahmane Bourredjem, Marie-Lorraine Scherrer, Georges Mantion, Jean-Baptiste Delhorme, Sophie Deguelte-Lardière, Jean-Michel Petit and Claire Bonithon-Kopp
    Citation: BMC Cancer 2014 14:912
    Content type: Research article Published on:

  27. Sphingosine-1-phosphate receptor-1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) play important roles in immune responses with potential oncogenic roles.

    Authors: Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim and Yoon Kyung Jeon
    Citation: BMC Cancer 2014 14:911
    Content type: Research article Published on:

  28. Accumulating evidences suggest that tumors are driven by a small population of cells, termed “cancer stem cells” (CSCs), which may be resistant to current therapeutic approaches. In breast carcinoma, the CSCs ...

    Authors: Refael Peleg, Marianna Romzova, Inga Kogan-Zviagin, Ron N Apte and Esther Priel
    Citation: BMC Cancer 2014 14:910
    Content type: Research article Published on:

  29. Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related mortality in the world. MicroRNAs (miRNAs) are small, noncoding RNAs that play essential roles in vario...

    Authors: Xue-Wei Yang, Guan-Zhu Shen, Liang-Qi Cao, Xiao-Feng Jiang, He-Ping Peng, Gang Shen, De Chen and Ping Xue
    Citation: BMC Cancer 2014 14:909
    Content type: Research article Published on:

  30. PREDICT (http://​www.​predict.​nhs.​uk) is a prognostication and treatment benefit tool for early breast cancer (EBC). The aim of this study was to incorporate t...

    Authors: Gordon C Wishart, Emad Rakha, Andrew Green, Ian Ellis, Hamid Raza Ali, Elena Provenzano, Fiona M Blows, Carlos Caldas and Paul DP Pharoah
    Citation: BMC Cancer 2014 14:908
    Content type: Research article Published on:

  31. Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer...

    Authors: Niamh Lynam-Lennon, Ruth Connaughton, Eibhlin Carr, Ann-Marie Mongan, Naoimh J O’Farrell, Richard K Porter, Lorraine Brennan, Graham P Pidgeon, Joanne Lysaght, John V Reynolds and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:907
    Content type: Research article Published on:

  32. Everolimus was recently introduced as a second-line treatment for renal cell carcinoma (RCC) and many other cancers. Several prospective studies have shown that serum creatinine levels are increased in a signi...

    Authors: Sung Hae Ha, Ji Hyeon Park, Hye Ryoun Jang, Wooseong Huh, Ho-Yeong Lim, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee
    Citation: BMC Cancer 2014 14:906
    Content type: Research article Published on:

  33. Persistent infection with high-risk (HR) human papillomavirus (HPV) causes cervical cancer, the fourth most frequent cancer in the Kingdom of Bahrain, with an annual incidence of four per 100,000 women. The ai...

    Authors: Khairya Moosa, Adel Salman Alsayyad, Wim Quint, Kusuma Gopala and Rodrigo DeAntonio
    Citation: BMC Cancer 2014 14:905
    Content type: Research article Published on:

  34. Routine chemotherapy often cannot achieve good therapeutic effects because of multidrug resistance (MDR). MDR is frequently caused by the elevated expression of the MDR1 gene encoding P-glycoprotein (P-gp). E2...

    Authors: Lin-Hai Yan, Wei-Yuan Wei, Wen-Long Cao, Xiao-Shi Zhang, Yu-Bo Xie and Qiang Xiao
    Citation: BMC Cancer 2014 14:904
    Content type: Research article Published on:

  36. The effect of vascular disrupting agents in tumour therapy depends on both the immediate vascular shutdown, and on the following re-vascularization of the tumour. The aim of this study was to use a tumour mode...

    Authors: Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen and Michael R Horsman
    Citation: BMC Cancer 2014 14:903
    Content type: Research article Published on:

  38. Posttranslational protein modifications are known to modulate key biological processes like proliferation and apoptosis. Accumulating evidence shows that ST6GAL1, an enzyme that catalyzes the transfer of siali...

    Authors: Pia Antony, Michael Rose, Axel Heidenreich, Ruth Knüchel, Nadine T Gaisa and Edgar Dahl
    Citation: BMC Cancer 2014 14:901
    Content type: Research article Published on:

  39. Malignant bone lymphoma can be classified as primary (PBL) or secondary (SBL) bone lymphoma. However, the clinico-pathological characteristics and prognostic factors of PBL versus SBL have not yet been well de...

    Authors: Huanwen Wu, Marilyn M Bui, Douglas G Leston, Haipeng Shao, Lubomir Sokol, Eduardo M Sotomayor and Ling Zhang
    Citation: BMC Cancer 2014 14:900
    Content type: Research article Published on:

  40. Thyroid carcinoma is the leading cause of death among endocrine cancers second to carcinoma of the ovary. Now a day, the incidence of thyroid malignancy is increasing more rapidly than any other malignancy. Bu...

    Authors: Tadele Melak, Biniam Mathewos, Bamlaku Enawgaw and Debasu Damtie
    Citation: BMC Cancer 2014 14:899
    Content type: Research article Published on:

  41. Recent studies have suggested that adenosine generated by ecto-5′-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulati...

    Authors: Sandra Burghoff, Xuan Gong, Claudia Viethen, Christoph Jacoby, Ulrich Flögel, Sabine Bongardt, Anne Schorr, Andreas Hippe, Bernhard Homey and Jürgen Schrader
    Citation: BMC Cancer 2014 14:898
    Content type: Research article Published on:

  42. In colorectal cancer (CRC), unresectable liver metastases are linked to poor prognosis. Systemic chemotherapy with regimens such as FOLFOX (combination of infusional 5-fluorouracil, leucovorin and oxaliplatin)...

    Authors: Peter Gibbs, Val Gebski, Mark Van Buskirk, Kenneth Thurston, David N Cade and Guy A Van Hazel
    Citation: BMC Cancer 2014 14:897
    Content type: Study protocol Published on:

  43. The aim of the present study was to evaluate the predictive value of a novel quantitative measure for the spatial heterogeneity of FDG uptake, the asphericity (ASP) in patients with non-small cell lung cancer ...

    Authors: Ivayla Apostolova, Julian Rogasch, Ralph Buchert, Heinz Wertzel, H Jost Achenbach, Jens Schreiber, Sandra Riedel, Christian Furth, Alexandr Lougovski, Georg Schramm, Frank Hofheinz, Holger Amthauer and Ingo G Steffen
    Citation: BMC Cancer 2014 14:896
    Content type: Research article Published on:

  44. In contrast with breast cancers (BCs) in other parts of the world, most previous studies reported that the majority of BCs in sub-Saharan Africa are estrogen-receptor (ER) negative. However, a recent study usi...

    Authors: Eva Johanna Kantelhardt, Assefa Mathewos, Abreha Aynalem, Tigeneh Wondemagegnehu, Ahmedin Jemal, Martina Vetter, Erdme Knauf, Anne Reeler, Solomon Bogale, Christoph Thomssen, Andreas Stang, Tufa Gemechu, Pietro Trocchi and Bekuretsion Yonas
    Citation: BMC Cancer 2014 14:895
    Content type: Research article Published on:

  45. Two-dimensional high-dose-rate brachytherapy (2D-HDR-BT) is an effective method of dose escalation for local tumor control in early T-stage nasopharyngeal carcinoma (NPC). Treatment outcomes for 3D-image-guide...

    Authors: YuFeng Ren, QuanCheng Zhao, Hui Liu, YingJuan Huang, ZhenYu Wang, XinPing Cao, Bin S Teh and BiXiu Wen
    Citation: BMC Cancer 2014 14:894
    Content type: Research article Published on:

  46. The reasons for the worldwide sex disparity in the incidence of hepatocellular carcinoma (HCC) remain elusive. We investigated the role of multiple pregnancies on the associations between viral hepatitis C (HC...

    Authors: Sania Amr, Emily A Iarocci, Ghada R Nasr, Doa’a Saleh, Jan Blancato, Kirti Shetty and Christopher A Loffredo
    Citation: BMC Cancer 2014 14:893
    Content type: Research article Published on:

  47. There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage....

    Authors: Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz and Ashraf EK Ibrahim
    Citation: BMC Cancer 2014 14:891
    Content type: Research article Published on:

  49. A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-co...

    Authors: Yang Ming Liu, Yu Xia, Wei Dai, Hua Ye Han, Yu Xue Dong, Jiong Cai, Xuan Zeng, Feng Yu Luo, Tao Yang, Yuan Zhi Li, Jie Chen and Jian Guan
    Citation: BMC Cancer 2014 14:889
    Content type: Research article Published on:

  50. Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatment. The ai...

    Authors: Petra Martin, Sinead Noonan, Michael P Mullen, Caitriona Scaife, Miriam Tosetto, Blathnaid Nolan, Kieran Wynne, John Hyland, Kieran Sheahan, Giuliano Elia, Diarmuid O’Donoghue, David Fennelly and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:887
    Content type: Research article Published on:

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